Motif ID: NFKB2

Z-value: 1.247


Transcription factors associated with NFKB2:

Gene SymbolEntrez IDGene Name
NFKB2 ENSG00000077150.13 NFKB2



Activity profile for motif NFKB2.

activity profile for motif NFKB2


Sorted Z-values histogram for motif NFKB2

Sorted Z-values for motif NFKB2



Network of associatons between targets according to the STRING database.



First level regulatory network of NFKB2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_209824643 3.087 ENST00000391911.1
ENST00000415782.1
LAMB3

laminin, beta 3

chr22_-_37640277 1.981 ENST00000401529.3
ENST00000249071.6
RAC2

ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)

chr16_+_81812863 1.905 ENST00000359376.3
PLCG2
phospholipase C, gamma 2 (phosphatidylinositol-specific)
chr6_+_32605195 1.871 ENST00000374949.2
HLA-DQA1
major histocompatibility complex, class II, DQ alpha 1
chr6_+_32605134 1.859 ENST00000343139.5
ENST00000395363.1
ENST00000496318.1
HLA-DQA1


major histocompatibility complex, class II, DQ alpha 1


chr1_+_111770278 1.857 ENST00000369748.4
CHI3L2
chitinase 3-like 2
chr6_+_14117872 1.838 ENST00000379153.3
CD83
CD83 molecule
chr1_+_111770232 1.822 ENST00000369744.2
CHI3L2
chitinase 3-like 2
chr22_-_37640456 1.717 ENST00000405484.1
ENST00000441619.1
ENST00000406508.1
RAC2


ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)


chr8_+_54793454 1.630 ENST00000276500.4
RGS20
regulator of G-protein signaling 20
chr8_+_54793425 1.623 ENST00000522225.1
RGS20
regulator of G-protein signaling 20
chr9_-_123691047 1.528 ENST00000373887.3
TRAF1
TNF receptor-associated factor 1
chr18_+_21529811 1.472 ENST00000588004.1
LAMA3
laminin, alpha 3
chr19_+_42381173 1.417 ENST00000221972.3
CD79A
CD79a molecule, immunoglobulin-associated alpha
chr1_-_27961720 1.400 ENST00000545953.1
ENST00000374005.3
FGR

feline Gardner-Rasheed sarcoma viral oncogene homolog

chr19_-_6591113 1.389 ENST00000423145.3
ENST00000245903.3
CD70

CD70 molecule

chr19_+_42381337 1.362 ENST00000597454.1
ENST00000444740.2
CD79A

CD79a molecule, immunoglobulin-associated alpha

chr20_+_49411543 1.255 ENST00000609336.1
ENST00000445038.1
BCAS4

breast carcinoma amplified sequence 4

chr1_-_183559693 1.240 ENST00000367535.3
ENST00000413720.1
ENST00000418089.1
NCF2


neutrophil cytosolic factor 2


chr11_-_57335750 1.221 ENST00000340573.4
UBE2L6
ubiquitin-conjugating enzyme E2L 6
chr1_-_183560011 1.173 ENST00000367536.1
NCF2
neutrophil cytosolic factor 2
chr17_+_72462525 1.149 ENST00000360141.3
CD300A
CD300a molecule
chr6_+_106959718 1.094 ENST00000369066.3
AIM1
absent in melanoma 1
chr17_-_34207295 1.073 ENST00000463941.1
ENST00000293272.3
CCL5

chemokine (C-C motif) ligand 5

chr12_+_7055631 1.043 ENST00000543115.1
ENST00000399448.1
PTPN6

protein tyrosine phosphatase, non-receptor type 6

chr3_+_53195136 1.022 ENST00000394729.2
ENST00000330452.3
PRKCD

protein kinase C, delta

chr17_+_72462766 1.011 ENST00000392625.3
ENST00000361933.3
ENST00000310828.5
CD300A


CD300a molecule


chr17_-_39928106 0.952 ENST00000540235.1
JUP
junction plakoglobin
chr6_-_31324943 0.938 ENST00000412585.2
ENST00000434333.1
HLA-B

major histocompatibility complex, class I, B

chr6_+_31540056 0.934 ENST00000418386.2
LTA
lymphotoxin alpha
chr8_+_86376081 0.922 ENST00000285379.5
CA2
carbonic anhydrase II
chr11_+_67351019 0.894 ENST00000398606.3
GSTP1
glutathione S-transferase pi 1
chr17_+_76164639 0.893 ENST00000225777.3
ENST00000585591.1
ENST00000589711.1
ENST00000588282.1
ENST00000589168.1
SYNGR2




synaptogyrin 2




chr16_+_50776021 0.847 ENST00000566679.2
ENST00000564634.1
ENST00000398568.2
CYLD


cylindromatosis (turban tumor syndrome)


chr17_+_76165213 0.820 ENST00000590201.1
SYNGR2
synaptogyrin 2
chr20_+_49411431 0.764 ENST00000358791.5
ENST00000262591.5
BCAS4

breast carcinoma amplified sequence 4

chr20_+_43803517 0.743 ENST00000243924.3
PI3
peptidase inhibitor 3, skin-derived
chr2_+_61108650 0.738 ENST00000295025.8
REL
v-rel avian reticuloendotheliosis viral oncogene homolog
chr11_+_67351213 0.718 ENST00000398603.1
GSTP1
glutathione S-transferase pi 1
chr2_-_89292422 0.691 ENST00000495489.1
IGKV1-8
immunoglobulin kappa variable 1-8
chr3_-_56717246 0.681 ENST00000355628.5
FAM208A
family with sequence similarity 208, member A
chr20_+_49411523 0.675 ENST00000371608.2
BCAS4
breast carcinoma amplified sequence 4
chr1_+_65613217 0.657 ENST00000545314.1
AK4
adenylate kinase 4
chr2_+_61108771 0.644 ENST00000394479.3
REL
v-rel avian reticuloendotheliosis viral oncogene homolog
chr5_+_67511524 0.613 ENST00000521381.1
ENST00000521657.1
PIK3R1

phosphoinositide-3-kinase, regulatory subunit 1 (alpha)

chr2_+_64681641 0.599 ENST00000409537.2
LGALSL
lectin, galactoside-binding-like
chr10_+_112257596 0.596 ENST00000369583.3
DUSP5
dual specificity phosphatase 5
chr3_+_52232102 0.588 ENST00000469224.1
ENST00000394965.2
ENST00000310271.2
ENST00000484952.1
ALAS1



aminolevulinate, delta-, synthase 1



chr16_+_15737124 0.583 ENST00000396355.1
ENST00000396353.2
NDE1

nudE neurodevelopment protein 1

chr1_-_209979375 0.574 ENST00000367021.3
IRF6
interferon regulatory factor 6
chr16_-_68269971 0.572 ENST00000565858.1
ESRP2
epithelial splicing regulatory protein 2
chr6_+_135502408 0.570 ENST00000341911.5
ENST00000442647.2
ENST00000316528.8
MYB


v-myb avian myeloblastosis viral oncogene homolog


chr11_+_706113 0.552 ENST00000318562.8
ENST00000533256.1
ENST00000534755.1
EPS8L2


EPS8-like 2


chr20_-_4795747 0.524 ENST00000379376.2
RASSF2
Ras association (RalGDS/AF-6) domain family member 2
chr10_+_89622870 0.521 ENST00000371953.3
PTEN
phosphatase and tensin homolog
chrX_+_49028265 0.499 ENST00000376322.3
ENST00000376327.5
PLP2

proteolipid protein 2 (colonic epithelium-enriched)

chr11_+_58910201 0.496 ENST00000528737.1
FAM111A
family with sequence similarity 111, member A
chr10_-_36813162 0.484 ENST00000440465.1
NAMPTL
nicotinamide phosphoribosyltransferase-like
chr1_+_42922173 0.476 ENST00000455780.1
ENST00000372560.3
ENST00000372561.3
ENST00000372556.3
PPCS



phosphopantothenoylcysteine synthetase



chr1_+_42921761 0.469 ENST00000372562.1
PPCS
phosphopantothenoylcysteine synthetase
chr16_+_50775971 0.466 ENST00000311559.9
ENST00000564326.1
ENST00000566206.1
CYLD


cylindromatosis (turban tumor syndrome)


chr4_+_4387983 0.461 ENST00000397958.1
NSG1
Homo sapiens neuron specific gene family member 1 (NSG1), transcript variant 3, mRNA.
chrX_+_64887512 0.450 ENST00000360270.5
MSN
moesin
chr2_+_219081817 0.448 ENST00000315717.5
ENST00000420104.1
ENST00000295685.10
ARPC2


actin related protein 2/3 complex, subunit 2, 34kDa


chr16_+_2867164 0.442 ENST00000455114.1
ENST00000450020.3
PRSS21

protease, serine, 21 (testisin)

chr14_+_66975213 0.441 ENST00000543237.1
ENST00000305960.9
GPHN

gephyrin

chr1_-_182573514 0.441 ENST00000367558.5
RGS16
regulator of G-protein signaling 16
chr3_-_182698381 0.437 ENST00000292782.4
DCUN1D1
DCN1, defective in cullin neddylation 1, domain containing 1
chr11_-_104840093 0.432 ENST00000417440.2
ENST00000444739.2
CASP4

caspase 4, apoptosis-related cysteine peptidase

chr1_+_2487800 0.431 ENST00000355716.4
TNFRSF14
tumor necrosis factor receptor superfamily, member 14
chr2_+_74056066 0.431 ENST00000339566.3
ENST00000409707.1
ENST00000452725.1
ENST00000432295.2
ENST00000424659.1
ENST00000394073.1
STAMBP





STAM binding protein





chr2_+_74056147 0.430 ENST00000394070.2
ENST00000536064.1
STAMBP

STAM binding protein

chrX_+_47050236 0.422 ENST00000377351.4
UBA1
ubiquitin-like modifier activating enzyme 1
chr11_+_64949158 0.419 ENST00000527739.1
ENST00000526966.1
ENST00000533129.1
ENST00000524773.1
CAPN1



calpain 1, (mu/I) large subunit



chr15_-_43559055 0.413 ENST00000220420.5
ENST00000349114.4
TGM5

transglutaminase 5

chr14_-_24615805 0.411 ENST00000560410.1
PSME2
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr15_+_92396920 0.408 ENST00000318445.6
SLCO3A1
solute carrier organic anion transporter family, member 3A1
chr20_+_4667094 0.404 ENST00000424424.1
ENST00000457586.1
PRNP

prion protein

chr11_+_66247478 0.402 ENST00000531863.1
ENST00000532677.1
DPP3

dipeptidyl-peptidase 3

chr3_+_23847394 0.398 ENST00000306627.3
UBE2E1
ubiquitin-conjugating enzyme E2E 1
chr9_+_130911770 0.395 ENST00000372998.1
LCN2
lipocalin 2
chr1_-_205744574 0.390 ENST00000367139.3
ENST00000235932.4
ENST00000437324.2
ENST00000414729.1
RAB7L1



RAB7, member RAS oncogene family-like 1



chr2_-_70781087 0.389 ENST00000394241.3
ENST00000295400.6
TGFA

transforming growth factor, alpha

chr13_-_111214015 0.388 ENST00000267328.3
RAB20
RAB20, member RAS oncogene family
chr3_+_111718173 0.388 ENST00000494932.1
TAGLN3
transgelin 3
chr1_-_183604794 0.387 ENST00000367534.1
ENST00000359856.6
ENST00000294742.6
ARPC5


actin related protein 2/3 complex, subunit 5, 16kDa


chrX_+_150151824 0.381 ENST00000455596.1
ENST00000448905.2
HMGB3

high mobility group box 3

chr3_+_23847432 0.377 ENST00000346855.3
UBE2E1
ubiquitin-conjugating enzyme E2E 1
chr11_+_58910295 0.374 ENST00000420244.1
FAM111A
family with sequence similarity 111, member A
chr5_-_150466692 0.373 ENST00000315050.7
ENST00000523338.1
ENST00000522100.1
TNIP1


TNFAIP3 interacting protein 1


chr11_+_64949343 0.372 ENST00000279247.6
ENST00000532285.1
ENST00000534373.1
CAPN1


calpain 1, (mu/I) large subunit


chr21_+_27011584 0.370 ENST00000400532.1
ENST00000480456.1
ENST00000312957.5
JAM2


junctional adhesion molecule 2


chr9_+_130911723 0.370 ENST00000277480.2
ENST00000373013.2
ENST00000540948.1
LCN2


lipocalin 2


chr2_-_38604398 0.369 ENST00000443098.1
ENST00000449130.1
ENST00000378954.4
ENST00000539122.1
ENST00000419554.2
ENST00000451483.1
ENST00000406122.1
ATL2






atlastin GTPase 2






chr1_-_40042416 0.365 ENST00000372857.3
ENST00000372856.3
ENST00000531243.2
ENST00000451091.2
PABPC4



poly(A) binding protein, cytoplasmic 4 (inducible form)



chr14_+_97263641 0.361 ENST00000216639.3
VRK1
vaccinia related kinase 1
chr11_+_66247880 0.361 ENST00000360510.2
ENST00000453114.1
ENST00000541961.1
ENST00000532019.1
ENST00000526515.1
ENST00000530165.1
ENST00000533725.1
DPP3






dipeptidyl-peptidase 3






chr16_+_2867228 0.359 ENST00000005995.3
ENST00000574813.1
PRSS21

protease, serine, 21 (testisin)

chr10_+_64133934 0.358 ENST00000395254.3
ENST00000395255.3
ENST00000410046.3
ZNF365


zinc finger protein 365


chr4_-_169239921 0.357 ENST00000514995.1
ENST00000393743.3
DDX60

DEAD (Asp-Glu-Ala-Asp) box polypeptide 60

chr1_-_93426998 0.351 ENST00000370310.4
FAM69A
family with sequence similarity 69, member A
chrX_+_103173457 0.339 ENST00000419165.1
TMSB15B
thymosin beta 15B
chr6_+_149068464 0.336 ENST00000367463.4
UST
uronyl-2-sulfotransferase
chr19_+_45504688 0.331 ENST00000221452.8
ENST00000540120.1
ENST00000505236.1
RELB


v-rel avian reticuloendotheliosis viral oncogene homolog B


chr11_+_64949899 0.331 ENST00000531068.1
ENST00000527699.1
ENST00000533909.1
ENST00000527323.1
CAPN1



calpain 1, (mu/I) large subunit



chr15_+_85923856 0.325 ENST00000560302.1
ENST00000394518.2
ENST00000361243.2
ENST00000560256.1
AKAP13



A kinase (PRKA) anchor protein 13



chr8_+_22857048 0.324 ENST00000251822.6
RHOBTB2
Rho-related BTB domain containing 2
chr16_+_50775948 0.321 ENST00000569681.1
ENST00000569418.1
ENST00000540145.1
CYLD


cylindromatosis (turban tumor syndrome)


chr17_+_66244071 0.319 ENST00000580548.1
ENST00000580753.1
ENST00000392720.2
ENST00000359783.4
ENST00000584837.1
ENST00000579724.1
ENST00000584494.1
ENST00000580837.1
AMZ2







archaelysin family metallopeptidase 2







chr1_-_205744205 0.316 ENST00000446390.2
RAB7L1
RAB7, member RAS oncogene family-like 1
chr3_+_111718036 0.314 ENST00000455401.2
TAGLN3
transgelin 3
chr21_+_27011899 0.314 ENST00000425221.2
JAM2
junctional adhesion molecule 2
chr19_+_30302805 0.310 ENST00000262643.3
ENST00000575243.1
ENST00000357943.5
CCNE1


cyclin E1


chr1_-_202129105 0.309 ENST00000367279.4
PTPN7
protein tyrosine phosphatase, non-receptor type 7
chr2_-_89340242 0.305 ENST00000480492.1
IGKV1-12
immunoglobulin kappa variable 1-12
chr15_+_92397051 0.305 ENST00000424469.2
SLCO3A1
solute carrier organic anion transporter family, member 3A1
chr18_-_19283649 0.298 ENST00000584464.1
ENST00000578270.1
ABHD3

abhydrolase domain containing 3

chr6_-_143266297 0.297 ENST00000367603.2
HIVEP2
human immunodeficiency virus type I enhancer binding protein 2
chr19_-_41859814 0.293 ENST00000221930.5
TGFB1
transforming growth factor, beta 1
chr19_+_48824711 0.292 ENST00000599704.1
EMP3
epithelial membrane protein 3
chr19_-_10450328 0.285 ENST00000160262.5
ICAM3
intercellular adhesion molecule 3
chr21_-_45079341 0.280 ENST00000443485.1
ENST00000291560.2
HSF2BP

heat shock transcription factor 2 binding protein

chr3_+_51705222 0.275 ENST00000457573.1
ENST00000341333.5
ENST00000412249.1
ENST00000425781.1
ENST00000415259.1
ENST00000395057.1
ENST00000416589.1
TEX264






testis expressed 264






chrX_-_2418596 0.271 ENST00000381218.3
ZBED1
zinc finger, BED-type containing 1
chr1_-_202129704 0.268 ENST00000476061.1
ENST00000544762.1
ENST00000467283.1
ENST00000464870.1
ENST00000435759.2
ENST00000486116.1
ENST00000543735.1
ENST00000308986.5
ENST00000477625.1
PTPN7








protein tyrosine phosphatase, non-receptor type 7








chr15_+_85923797 0.262 ENST00000559362.1
AKAP13
A kinase (PRKA) anchor protein 13
chr8_-_130951940 0.262 ENST00000522250.1
ENST00000522941.1
ENST00000522746.1
ENST00000520204.1
ENST00000519070.1
ENST00000520254.1
ENST00000519824.2
ENST00000519540.1
FAM49B







family with sequence similarity 49, member B







chr9_+_100745615 0.257 ENST00000339399.4
ANP32B
acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
chr19_+_10216899 0.254 ENST00000253107.7
ENST00000556468.1
ENST00000393793.1
ENST00000428358.1
ENST00000393796.4
PPAN


PPAN-P2RY11

peter pan homolog (Drosophila)


PPAN-P2RY11 readthrough

chr14_-_24615523 0.247 ENST00000559056.1
PSME2
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr6_+_90142884 0.243 ENST00000369408.5
ENST00000339746.4
ENST00000447838.2
ANKRD6


ankyrin repeat domain 6


chr10_+_104154229 0.242 ENST00000428099.1
ENST00000369966.3
NFKB2

nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)

chr1_+_33283043 0.242 ENST00000373476.1
ENST00000373475.5
ENST00000529027.1
ENST00000398243.3
S100PBP



S100P binding protein



chr6_+_137143694 0.240 ENST00000367756.4
ENST00000541292.1
ENST00000318471.4
PEX7


peroxisomal biogenesis factor 7


chr19_-_4338838 0.237 ENST00000594605.1
STAP2
signal transducing adaptor family member 2
chr5_+_612387 0.234 ENST00000264935.5
ENST00000444221.1
CEP72

centrosomal protein 72kDa

chr2_+_231280954 0.233 ENST00000409824.1
ENST00000409341.1
ENST00000409112.1
ENST00000340126.4
ENST00000341950.4
SP100




SP100 nuclear antigen




chr3_+_111717600 0.232 ENST00000273368.4
TAGLN3
transgelin 3
chr14_+_106355918 0.231 ENST00000414005.1
AL122127.25
AL122127.25
chr19_-_4338783 0.229 ENST00000601482.1
ENST00000600324.1
STAP2

signal transducing adaptor family member 2

chrX_+_68048803 0.227 ENST00000204961.4
EFNB1
ephrin-B1
chr1_+_27114418 0.225 ENST00000078527.4
PIGV
phosphatidylinositol glycan anchor biosynthesis, class V
chr17_+_26698677 0.223 ENST00000457710.3
SARM1
sterile alpha and TIR motif containing 1
chr1_-_89458415 0.223 ENST00000370491.3
ENST00000321792.5
CCBL2
RBMXL1
cysteine conjugate-beta lyase 2
RNA binding motif protein, X-linked-like 1
chr17_+_8924837 0.221 ENST00000173229.2
NTN1
netrin 1
chr1_+_26503894 0.216 ENST00000361530.6
ENST00000374253.5
CNKSR1

connector enhancer of kinase suppressor of Ras 1

chr9_-_139948468 0.213 ENST00000312665.5
ENTPD2
ectonucleoside triphosphate diphosphohydrolase 2
chr2_-_99771373 0.212 ENST00000393483.3
TSGA10
testis specific, 10
chr12_+_125549925 0.211 ENST00000316519.6
AACS
acetoacetyl-CoA synthetase
chr19_+_1450112 0.209 ENST00000590469.1
ENST00000233607.2
ENST00000238483.4
ENST00000590877.1
APC2



adenomatosis polyposis coli 2



chrX_-_1572629 0.209 ENST00000534940.1
ASMTL
acetylserotonin O-methyltransferase-like
chr2_+_86947296 0.207 ENST00000283632.4
RMND5A
required for meiotic nuclear division 5 homolog A (S. cerevisiae)
chr8_+_26149007 0.205 ENST00000380737.3
ENST00000524169.1
PPP2R2A

protein phosphatase 2, regulatory subunit B, alpha

chr8_-_87520849 0.199 ENST00000430676.2
ENST00000519966.1
RMDN1

regulator of microtubule dynamics 1

chr14_+_24605361 0.197 ENST00000206451.6
ENST00000559123.1
PSME1

proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)

chr19_+_22235310 0.195 ENST00000600162.1
ZNF257
zinc finger protein 257
chr9_-_139948487 0.193 ENST00000355097.2
ENTPD2
ectonucleoside triphosphate diphosphohydrolase 2
chr19_-_14628645 0.191 ENST00000598235.1
DNAJB1
DnaJ (Hsp40) homolog, subfamily B, member 1
chr15_-_64648273 0.189 ENST00000607537.1
ENST00000303052.7
ENST00000303032.6
CSNK1G1


casein kinase 1, gamma 1


chr2_-_197036289 0.188 ENST00000263955.4
STK17B
serine/threonine kinase 17b
chr19_-_49401990 0.188 ENST00000221399.3
TULP2
tubby like protein 2
chr1_-_150207017 0.186 ENST00000369119.3
ANP32E
acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
chr10_+_30722866 0.184 ENST00000263056.1
MAP3K8
mitogen-activated protein kinase kinase kinase 8
chr22_+_35796056 0.183 ENST00000216122.4
MCM5
minichromosome maintenance complex component 5
chr7_+_47694842 0.177 ENST00000408988.2
C7orf65
chromosome 7 open reading frame 65
chr12_-_54673871 0.176 ENST00000209875.4
CBX5
chromobox homolog 5
chr12_+_7023491 0.174 ENST00000541477.1
ENST00000229277.1
ENO2

enolase 2 (gamma, neuronal)

chr2_+_242127924 0.172 ENST00000402530.3
ENST00000274979.8
ENST00000402430.3
ANO7


anoctamin 7


chr14_+_96152754 0.170 ENST00000340722.7
TCL1B
T-cell leukemia/lymphoma 1B
chr5_-_14871866 0.170 ENST00000284268.6
ANKH
ANKH inorganic pyrophosphate transport regulator
chr7_+_87505544 0.168 ENST00000265728.1
DBF4
DBF4 homolog (S. cerevisiae)
chr5_+_130599735 0.168 ENST00000503291.1
ENST00000360515.3
ENST00000505065.1
CDC42SE2


CDC42 small effector 2


chr16_-_15736953 0.167 ENST00000548025.1
ENST00000551742.1
ENST00000602337.1
ENST00000344181.3
ENST00000396368.3
KIAA0430




KIAA0430




chr7_-_143059780 0.167 ENST00000409578.1
ENST00000409346.1
FAM131B

family with sequence similarity 131, member B

chr19_-_4831701 0.166 ENST00000248244.5
TICAM1
toll-like receptor adaptor molecule 1
chrX_-_49041242 0.166 ENST00000453382.1
ENST00000540849.1
ENST00000536904.1
ENST00000432913.1
PRICKLE3



prickle homolog 3 (Drosophila)



chr16_-_15736881 0.163 ENST00000540441.2
KIAA0430
KIAA0430
chr11_-_3862206 0.163 ENST00000351018.4
RHOG
ras homolog family member G
chr9_-_116139255 0.162 ENST00000374180.3
HDHD3
haloacid dehalogenase-like hydrolase domain containing 3
chr10_-_133795416 0.161 ENST00000540159.1
ENST00000368636.4
BNIP3

BCL2/adenovirus E1B 19kDa interacting protein 3

chr12_+_120502441 0.161 ENST00000446727.2
CCDC64
coiled-coil domain containing 64
chr17_+_7462103 0.160 ENST00000396545.4
TNFSF13
tumor necrosis factor (ligand) superfamily, member 13
chr12_+_56473910 0.159 ENST00000411731.2
ERBB3
v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3
chr19_-_45927097 0.157 ENST00000340192.7
ERCC1
excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
chr19_+_33072373 0.156 ENST00000586035.1
PDCD5
programmed cell death 5
chr22_+_35796108 0.151 ENST00000382011.5
ENST00000416905.1
MCM5

minichromosome maintenance complex component 5

chr2_-_70780770 0.149 ENST00000444975.1
ENST00000445399.1
ENST00000418333.2
TGFA


transforming growth factor, alpha


chr8_+_90770008 0.149 ENST00000540020.1
RIPK2
receptor-interacting serine-threonine kinase 2
chr12_+_57998595 0.148 ENST00000337737.3
ENST00000548198.1
ENST00000551632.1
DTX3


deltex homolog 3 (Drosophila)


chr8_+_32406179 0.147 ENST00000405005.3
NRG1
neuregulin 1
chr1_+_45965725 0.146 ENST00000401061.4
MMACHC
methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria
chr1_-_89458287 0.146 ENST00000370485.2
CCBL2
cysteine conjugate-beta lyase 2
chr3_+_107241783 0.146 ENST00000415149.2
ENST00000402543.1
ENST00000325805.8
ENST00000427402.1
BBX



bobby sox homolog (Drosophila)



chr9_+_115913222 0.141 ENST00000259392.3
SLC31A2
solute carrier family 31 (copper transporter), member 2
chr4_-_860950 0.141 ENST00000511980.1
ENST00000510799.1
GAK

cyclin G associated kinase

chr17_+_16318909 0.140 ENST00000577397.1
TRPV2
transient receptor potential cation channel, subfamily V, member 2
chr19_-_45926739 0.139 ENST00000589381.1
ENST00000591636.1
ENST00000013807.5
ENST00000592023.1
ERCC1



excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)



chr10_+_22605374 0.137 ENST00000448361.1
COMMD3
COMM domain containing 3
chr20_-_50808525 0.135 ENST00000216923.4
ZFP64
ZFP64 zinc finger protein
chr8_+_128427857 0.135 ENST00000391675.1
POU5F1B
POU class 5 homeobox 1B

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 3.7 GO:0060263 regulation of respiratory burst(GO:0060263)
0.5 1.6 GO:0071460 negative regulation of necrotic cell death(GO:0060547) cellular response to cell-matrix adhesion(GO:0071460)
0.4 2.7 GO:0034616 response to laminar fluid shear stress(GO:0034616)
0.4 1.9 GO:0032959 inositol trisphosphate biosynthetic process(GO:0032959) positive regulation of calcium ion transmembrane transporter activity(GO:1901021) positive regulation of cation channel activity(GO:2001259)
0.4 1.1 GO:0072677 eosinophil chemotaxis(GO:0048245) eosinophil migration(GO:0072677)
0.3 3.7 GO:0006030 chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.3 1.0 GO:0071603 negative regulation of Wnt signaling pathway involved in heart development(GO:0003308) endothelial cell-cell adhesion(GO:0071603)
0.3 0.9 GO:0002678 positive regulation of chronic inflammatory response(GO:0002678) regulation of chronic inflammatory response to antigenic stimulus(GO:0002874)
0.3 0.8 GO:0009635 response to herbicide(GO:0009635)
0.2 0.9 GO:0032849 positive regulation of cellular pH reduction(GO:0032849)
0.2 1.8 GO:0032713 negative regulation of interleukin-4 production(GO:0032713)
0.2 4.6 GO:0031581 hemidesmosome assembly(GO:0031581)
0.2 3.7 GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002504)
0.2 0.8 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.2 1.4 GO:0045084 positive regulation of interleukin-12 biosynthetic process(GO:0045084)
0.1 0.4 GO:0009134 nucleoside diphosphate catabolic process(GO:0009134) ribonucleoside diphosphate catabolic process(GO:0009191)
0.1 0.1 GO:0003307 regulation of Wnt signaling pathway involved in heart development(GO:0003307)
0.1 0.5 GO:0060292 phosphorylated carbohydrate dephosphorylation(GO:0046838) inositol phosphate dephosphorylation(GO:0046855) negative regulation of phagocytosis(GO:0050765) long term synaptic depression(GO:0060292)
0.1 0.3 GO:0033197 response to vitamin E(GO:0033197)
0.1 1.6 GO:0070536 protein K63-linked deubiquitination(GO:0070536)
0.1 0.6 GO:0010459 negative regulation of heart rate(GO:0010459)
0.1 2.1 GO:0050732 negative regulation of peptidyl-tyrosine phosphorylation(GO:0050732)
0.1 2.8 GO:0050853 B cell receptor signaling pathway(GO:0050853)
0.1 0.5 GO:0022614 membrane to membrane docking(GO:0022614)
0.1 0.2 GO:0070427 positive regulation of immature T cell proliferation(GO:0033091) nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070427) response to interleukin-12(GO:0070671)
0.1 0.6 GO:0051294 establishment of mitotic spindle orientation(GO:0000132) establishment of spindle orientation(GO:0051294)
0.1 0.9 GO:0015939 pantothenate metabolic process(GO:0015939)
0.1 0.2 GO:0034629 cellular protein complex localization(GO:0034629)
0.1 0.6 GO:0001706 endoderm formation(GO:0001706)
0.1 0.2 GO:0002268 follicular dendritic cell activation(GO:0002266) follicular dendritic cell differentiation(GO:0002268)
0.0 0.3 GO:0006295 nucleotide-excision repair, DNA incision, 3'-to lesion(GO:0006295)
0.0 0.4 GO:0043545 Mo-molybdopterin cofactor biosynthetic process(GO:0006777) Mo-molybdopterin cofactor metabolic process(GO:0019720) molybdopterin cofactor biosynthetic process(GO:0032324) molybdopterin cofactor metabolic process(GO:0043545) prosthetic group metabolic process(GO:0051189)
0.0 0.5 GO:0045741 positive regulation of epidermal growth factor-activated receptor activity(GO:0045741)
0.0 0.3 GO:0042989 sequestering of actin monomers(GO:0042989)
0.0 0.3 GO:0006477 protein sulfation(GO:0006477)
0.0 0.3 GO:0045063 T-helper 1 cell differentiation(GO:0045063)
0.0 0.4 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.0 0.4 GO:0070189 kynurenine metabolic process(GO:0070189)
0.0 0.6 GO:0060644 mammary gland epithelial cell differentiation(GO:0060644)
0.0 0.9 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
0.0 0.2 GO:0034201 response to oleic acid(GO:0034201)
0.0 0.2 GO:0035414 negative regulation of catenin import into nucleus(GO:0035414)
0.0 0.2 GO:0030186 melatonin metabolic process(GO:0030186) melatonin biosynthetic process(GO:0030187)
0.0 0.2 GO:0032897 negative regulation of viral transcription(GO:0032897)
0.0 0.2 GO:0045350 interferon-beta biosynthetic process(GO:0045350) regulation of interferon-beta biosynthetic process(GO:0045357) positive regulation of interferon-beta biosynthetic process(GO:0045359)
0.0 0.1 GO:0046007 negative regulation of activated T cell proliferation(GO:0046007)
0.0 0.2 GO:1901503 ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
0.0 0.2 GO:0048296 isotype switching to IgA isotypes(GO:0048290) regulation of isotype switching to IgA isotypes(GO:0048296) positive regulation of isotype switching to IgA isotypes(GO:0048298)
0.0 0.1 GO:0071294 cellular response to zinc ion(GO:0071294)
0.0 1.0 GO:0050830 defense response to Gram-positive bacterium(GO:0050830)
0.0 0.7 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.0 0.1 GO:0035434 copper ion transmembrane transport(GO:0035434)
0.0 0.1 GO:0097237 autophagic cell death(GO:0048102) cellular response to antibiotic(GO:0071236) cellular response to toxic substance(GO:0097237)
0.0 0.0 GO:1903514 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum(GO:0010880) regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion(GO:0010881) release of sequestered calcium ion into cytosol by sarcoplasmic reticulum(GO:0014808) calcium ion transport from endoplasmic reticulum to cytosol(GO:1903514)
0.0 0.7 GO:0007620 copulation(GO:0007620)
0.0 2.7 GO:0008277 regulation of G-protein coupled receptor protein signaling pathway(GO:0008277)
0.0 0.2 GO:0043497 regulation of protein heterodimerization activity(GO:0043497)
0.0 1.2 GO:0032480 negative regulation of type I interferon production(GO:0032480)
0.0 0.4 GO:0007029 endoplasmic reticulum organization(GO:0007029)
0.0 0.1 GO:0036072 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.0 0.1 GO:0014049 positive regulation of glutamate secretion(GO:0014049)
0.0 0.5 GO:0030838 positive regulation of actin filament polymerization(GO:0030838)
0.0 0.1 GO:0045085 negative regulation of interleukin-2 biosynthetic process(GO:0045085)
0.0 0.8 GO:0014070 response to organic cyclic compound(GO:0014070)
0.0 0.6 GO:0006783 heme biosynthetic process(GO:0006783)
0.0 0.4 GO:0033209 tumor necrosis factor-mediated signaling pathway(GO:0033209)
0.0 0.1 GO:0016559 peroxisome membrane biogenesis(GO:0016557) peroxisome fission(GO:0016559)
0.0 0.5 GO:0007212 dopamine receptor signaling pathway(GO:0007212)
0.0 0.1 GO:0060662 tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662)
0.0 0.2 GO:0051085 chaperone mediated protein folding requiring cofactor(GO:0051085)
0.0 0.2 GO:0046902 regulation of mitochondrial membrane permeability(GO:0046902) regulation of membrane permeability(GO:0090559)
0.0 1.0 GO:0051092 positive regulation of NF-kappaB transcription factor activity(GO:0051092)
0.0 0.1 GO:0006422 aspartyl-tRNA aminoacylation(GO:0006422)
0.0 0.1 GO:0060351 cartilage development involved in endochondral bone morphogenesis(GO:0060351)
0.0 1.5 GO:0000216 obsolete M/G1 transition of mitotic cell cycle(GO:0000216)
0.0 0.2 GO:0040023 establishment of nucleus localization(GO:0040023)
0.0 0.1 GO:2000171 negative regulation of dendrite development(GO:2000171)
0.0 0.3 GO:0016254 preassembly of GPI anchor in ER membrane(GO:0016254)
0.0 0.1 GO:0032528 microvillus assembly(GO:0030033) microvillus organization(GO:0032528)
0.0 0.6 GO:0043484 regulation of RNA splicing(GO:0043484)
0.0 0.4 GO:0018149 peptide cross-linking(GO:0018149)
0.0 0.1 GO:0032916 transforming growth factor beta3 production(GO:0032907) regulation of transforming growth factor beta3 production(GO:0032910) positive regulation of transforming growth factor beta3 production(GO:0032916)
0.0 0.2 GO:1903078 positive regulation of establishment of protein localization to plasma membrane(GO:0090004) positive regulation of protein localization to plasma membrane(GO:1903078) positive regulation of protein localization to cell periphery(GO:1904377)
0.0 0.1 GO:0006491 N-glycan processing(GO:0006491)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 3.1 GO:0005610 laminin-5 complex(GO:0005610)
0.5 2.8 GO:0019815 immunoglobulin complex(GO:0019814) B cell receptor complex(GO:0019815)
0.2 2.4 GO:0043020 NADPH oxidase complex(GO:0043020)
0.2 3.7 GO:0042613 MHC class II protein complex(GO:0042613)
0.2 1.0 GO:0008537 proteasome activator complex(GO:0008537)
0.2 0.6 GO:0097651 phosphatidylinositol 3-kinase complex, class IA(GO:0005943) phosphatidylinositol 3-kinase complex, class I(GO:0097651)
0.1 1.2 GO:0016342 catenin complex(GO:0016342)
0.1 1.1 GO:0005606 laminin-1 complex(GO:0005606)
0.1 0.9 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.1 0.6 GO:0031616 spindle pole centrosome(GO:0031616)
0.1 0.2 GO:0033257 Bcl3/NF-kappaB2 complex(GO:0033257)
0.0 1.4 GO:0000299 obsolete integral to membrane of membrane fraction(GO:0000299)
0.0 0.9 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 1.6 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 0.4 GO:0005605 basal lamina(GO:0005605)
0.0 0.5 GO:0031528 microvillus membrane(GO:0031528)
0.0 0.3 GO:0042555 MCM complex(GO:0042555)
0.0 0.2 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.0 0.2 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.2 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 0.2 GO:0001917 photoreceptor inner segment(GO:0001917)
0.0 0.1 GO:0000796 condensin complex(GO:0000796)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 3.7 GO:0004568 chitinase activity(GO:0004568)
0.3 1.1 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.3 3.7 GO:0032395 MHC class II receptor activity(GO:0032395)
0.3 0.8 GO:0042296 ISG15 transferase activity(GO:0042296)
0.2 0.6 GO:0003870 5-aminolevulinate synthase activity(GO:0003870) N-succinyltransferase activity(GO:0016749)
0.2 2.4 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
0.2 0.5 GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.2 1.6 GO:0008432 JUN kinase binding(GO:0008432)
0.1 0.4 GO:0017130 poly(C) RNA binding(GO:0017130)
0.1 1.0 GO:0042153 obsolete RPTP-like protein binding(GO:0042153) alpha-catenin binding(GO:0045294)
0.1 0.6 GO:0043559 insulin binding(GO:0043559)
0.1 0.5 GO:0019956 chemokine binding(GO:0019956)
0.1 0.4 GO:0047315 kynurenine-glyoxylate transaminase activity(GO:0047315)
0.1 2.5 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.1 0.2 GO:0004376 glycolipid mannosyltransferase activity(GO:0004376)
0.1 1.6 GO:0070064 proline-rich region binding(GO:0070064)
0.1 0.9 GO:0032393 MHC class I receptor activity(GO:0032393)
0.1 1.0 GO:0043560 insulin receptor substrate binding(GO:0043560)
0.1 1.9 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.1 0.4 GO:0017110 nucleoside-diphosphatase activity(GO:0017110)
0.1 0.9 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.1 0.4 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0 0.2 GO:0000268 peroxisome targeting sequence binding(GO:0000268)
0.0 0.7 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.0 0.7 GO:0004017 adenylate kinase activity(GO:0004017)
0.0 0.2 GO:0004803 transposase activity(GO:0004803)
0.0 0.1 GO:0035198 miRNA binding(GO:0035198)
0.0 0.8 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.0 0.2 GO:0017096 acetylserotonin O-methyltransferase activity(GO:0017096)
0.0 1.1 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.6 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.5 GO:0050780 dopamine receptor binding(GO:0050780)
0.0 0.2 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.0 0.4 GO:0008641 small protein activating enzyme activity(GO:0008641)
0.0 0.2 GO:0008967 phosphoglycolate phosphatase activity(GO:0008967)
0.0 0.5 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 0.1 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.0 0.3 GO:0005114 type II transforming growth factor beta receptor binding(GO:0005114)
0.0 0.2 GO:0070087 chromo shadow domain binding(GO:0070087)
0.0 0.2 GO:0034452 dynactin binding(GO:0034452)
0.0 0.2 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.0 0.4 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031)
0.0 0.3 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.0 0.2 GO:0047760 butyrate-CoA ligase activity(GO:0047760)
0.0 0.2 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.2 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.0 0.1 GO:0005329 dopamine transmembrane transporter activity(GO:0005329)
0.0 0.1 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.0 2.0 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.0 0.1 GO:0016499 orexin receptor activity(GO:0016499)
0.0 0.1 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105) type 2 fibroblast growth factor receptor binding(GO:0005111)
0.0 0.1 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0 0.4 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 0.4 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 0.1 GO:0046920 alpha-(1->3)-fucosyltransferase activity(GO:0046920)
0.0 0.1 GO:0031419 cobalamin binding(GO:0031419)
0.0 0.1 GO:0005375 copper ion transmembrane transporter activity(GO:0005375)
0.0 0.1 GO:0004815 aspartate-tRNA ligase activity(GO:0004815)
0.0 0.3 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.0 0.2 GO:0016565 obsolete general transcriptional repressor activity(GO:0016565)
0.0 0.1 GO:0030274 LIM domain binding(GO:0030274)
0.0 1.3 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 0.0 GO:0030156 benzodiazepine receptor binding(GO:0030156)
0.0 0.7 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 1.2 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.6 ST_G_ALPHA_I_PATHWAY G alpha i Pathway
0.0 2.4 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.0 0.7 ST_B_CELL_ANTIGEN_RECEPTOR B Cell Antigen Receptor
0.0 0.4 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.