Motif ID: NKX1-2_RAX

Z-value: 0.731

Transcription factors associated with NKX1-2_RAX:

Gene SymbolEntrez IDGene Name
NKX1-2 ENSG00000229544.6 NKX1-2
RAX ENSG00000134438.9 RAX






Network of associatons between targets according to the STRING database.



First level regulatory network of NKX1-2_RAX

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_-_62521614 1.871 ENST00000527994.1
ENST00000394807.3
ZBTB3

zinc finger and BTB domain containing 3

chr7_-_87856280 1.562 ENST00000490437.1
ENST00000431660.1
SRI

sorcin

chr7_-_87856303 1.546 ENST00000394641.3
SRI
sorcin
chr4_-_25865159 1.440 ENST00000502949.1
ENST00000264868.5
ENST00000513691.1
ENST00000514872.1
SEL1L3



sel-1 suppressor of lin-12-like 3 (C. elegans)



chr3_-_151034734 1.407 ENST00000260843.4
GPR87
G protein-coupled receptor 87
chr5_+_66300446 0.751 ENST00000261569.7
MAST4
microtubule associated serine/threonine kinase family member 4
chr6_+_34204642 0.584 ENST00000347617.6
ENST00000401473.3
ENST00000311487.5
ENST00000447654.1
ENST00000395004.3
HMGA1




high mobility group AT-hook 1




chr12_-_10022735 0.531 ENST00000228438.2
CLEC2B
C-type lectin domain family 2, member B
chr10_-_105845674 0.445 ENST00000353479.5
ENST00000369733.3
COL17A1

collagen, type XVII, alpha 1

chr12_+_32832203 0.399 ENST00000553257.1
ENST00000549701.1
ENST00000358214.5
ENST00000266481.6
ENST00000551476.1
ENST00000550154.1
ENST00000547312.1
ENST00000414834.2
ENST00000381000.4
ENST00000548750.1
DNM1L









dynamin 1-like









chr11_+_5710919 0.379 ENST00000379965.3
ENST00000425490.1
TRIM22

tripartite motif containing 22

chr11_-_102651343 0.373 ENST00000279441.4
ENST00000539681.1
MMP10

matrix metallopeptidase 10 (stromelysin 2)

chr2_+_90077680 0.345 ENST00000390270.2
IGKV3D-20
immunoglobulin kappa variable 3D-20
chr17_-_41466555 0.286 ENST00000586231.1
LINC00910
long intergenic non-protein coding RNA 910
chr1_+_155278539 0.277 ENST00000447866.1
FDPS
farnesyl diphosphate synthase
chr3_+_183853052 0.259 ENST00000273783.3
ENST00000432569.1
ENST00000444495.1
EIF2B5


eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa


chr6_-_111927062 0.255 ENST00000359831.4
TRAF3IP2
TRAF3 interacting protein 2
chr1_+_155278625 0.250 ENST00000368356.4
ENST00000356657.6
FDPS

farnesyl diphosphate synthase

chr12_-_112279694 0.241 ENST00000443596.1
ENST00000442119.1
MAPKAPK5-AS1

MAPKAPK5 antisense RNA 1

chrX_+_43515467 0.236 ENST00000338702.3
ENST00000542639.1
MAOA

monoamine oxidase A

chr10_+_124914285 0.234 ENST00000407911.2
BUB3
BUB3 mitotic checkpoint protein
chr20_-_50722183 0.233 ENST00000371523.4
ZFP64
ZFP64 zinc finger protein
chr2_+_217524323 0.219 ENST00000456764.1
IGFBP2
insulin-like growth factor binding protein 2, 36kDa
chrX_-_77225135 0.214 ENST00000458128.1
PGAM4
phosphoglycerate mutase family member 4
chr11_-_59383617 0.199 ENST00000263847.1
OSBP
oxysterol binding protein
chr15_+_64680003 0.198 ENST00000261884.3
TRIP4
thyroid hormone receptor interactor 4
chr6_+_26402517 0.195 ENST00000414912.2
BTN3A1
butyrophilin, subfamily 3, member A1
chr1_-_190446759 0.163 ENST00000367462.3
BRINP3
bone morphogenetic protein/retinoic acid inducible neural-specific 3
chr8_-_102803163 0.163 ENST00000523645.1
ENST00000520346.1
ENST00000220931.6
ENST00000522448.1
ENST00000522951.1
ENST00000522252.1
ENST00000519098.1
NCALD






neurocalcin delta






chr19_+_48949030 0.163 ENST00000253237.5
GRWD1
glutamate-rich WD repeat containing 1
chr12_-_12837423 0.158 ENST00000540510.1
GPR19
G protein-coupled receptor 19
chr1_-_67266939 0.152 ENST00000304526.2
INSL5
insulin-like 5
chr17_-_45266542 0.151 ENST00000531206.1
ENST00000527547.1
ENST00000446365.2
ENST00000575483.1
ENST00000066544.3
CDC27




cell division cycle 27




chr3_+_23851928 0.147 ENST00000467766.1
ENST00000424381.1
UBE2E1

ubiquitin-conjugating enzyme E2E 1

chrX_+_30261847 0.146 ENST00000378981.3
ENST00000397550.1
MAGEB1

melanoma antigen family B, 1

chr14_+_103851712 0.145 ENST00000440884.3
ENST00000416682.2
ENST00000429436.2
ENST00000303622.9
MARK3



MAP/microtubule affinity-regulating kinase 3



chrX_+_44703249 0.144 ENST00000339042.4
DUSP21
dual specificity phosphatase 21
chrX_+_77154935 0.134 ENST00000481445.1
COX7B
cytochrome c oxidase subunit VIIb
chr6_-_94129244 0.128 ENST00000369303.4
ENST00000369297.1
EPHA7

EPH receptor A7

chr11_+_73498898 0.127 ENST00000535529.1
ENST00000497094.2
ENST00000411840.2
ENST00000535277.1
ENST00000398483.3
ENST00000542303.1
MRPL48





mitochondrial ribosomal protein L48





chr11_-_3859089 0.125 ENST00000396979.1
RHOG
ras homolog family member G
chr19_-_6424783 0.125 ENST00000398148.3
KHSRP
KH-type splicing regulatory protein
chr8_-_42623747 0.124 ENST00000534622.1
CHRNA6
cholinergic receptor, nicotinic, alpha 6 (neuronal)
chr1_+_153747746 0.109 ENST00000368661.3
SLC27A3
solute carrier family 27 (fatty acid transporter), member 3
chrX_+_135730373 0.109 ENST00000370628.2
CD40LG
CD40 ligand
chr1_+_186265399 0.108 ENST00000367486.3
ENST00000367484.3
ENST00000533951.1
ENST00000367482.4
ENST00000367483.4
ENST00000367485.4
ENST00000445192.2
PRG4






proteoglycan 4






chr6_-_111927449 0.108 ENST00000368761.5
ENST00000392556.4
ENST00000340026.6
TRAF3IP2


TRAF3 interacting protein 2


chr1_+_62439037 0.102 ENST00000545929.1
INADL
InaD-like (Drosophila)
chr10_+_124913930 0.085 ENST00000368858.5
BUB3
BUB3 mitotic checkpoint protein
chrX_+_135618258 0.084 ENST00000440515.1
ENST00000456412.1
VGLL1

vestigial like 1 (Drosophila)

chr5_-_20575959 0.083 ENST00000507958.1
CDH18
cadherin 18, type 2
chr8_+_105235572 0.083 ENST00000523362.1
RIMS2
regulating synaptic membrane exocytosis 2
chr1_+_100818156 0.078 ENST00000336454.3
CDC14A
cell division cycle 14A
chr9_+_125133315 0.074 ENST00000223423.4
ENST00000362012.2
PTGS1

prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)

chr1_+_153746683 0.073 ENST00000271857.2
SLC27A3
solute carrier family 27 (fatty acid transporter), member 3
chrX_-_6453159 0.072 ENST00000381089.3
ENST00000398729.1
VCX3A

variable charge, X-linked 3A

chr17_-_40337470 0.072 ENST00000293330.1
HCRT
hypocretin (orexin) neuropeptide precursor
chr19_-_14785622 0.069 ENST00000443157.2
EMR3
egf-like module containing, mucin-like, hormone receptor-like 3
chr9_-_21202204 0.067 ENST00000239347.3
IFNA7
interferon, alpha 7
chr7_+_50348268 0.065 ENST00000438033.1
ENST00000439701.1
IKZF1

IKAROS family zinc finger 1 (Ikaros)

chr19_-_14785698 0.065 ENST00000344373.4
ENST00000595472.1
EMR3

egf-like module containing, mucin-like, hormone receptor-like 3

chr1_-_152386732 0.063 ENST00000271835.3
CRNN
cornulin
chr8_-_30670384 0.062 ENST00000221138.4
ENST00000518243.1
PPP2CB

protein phosphatase 2, catalytic subunit, beta isozyme

chr2_+_27008865 0.062 ENST00000335756.4
ENST00000233505.8
CENPA

centromere protein A

chr1_-_211307404 0.061 ENST00000367007.4
KCNH1
potassium voltage-gated channel, subfamily H (eag-related), member 1
chr19_+_11071546 0.061 ENST00000358026.2
SMARCA4
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
chr2_-_169887827 0.060 ENST00000263817.6
ABCB11
ATP-binding cassette, sub-family B (MDR/TAP), member 11
chr2_+_166095898 0.060 ENST00000424833.1
ENST00000375437.2
ENST00000357398.3
SCN2A


sodium channel, voltage-gated, type II, alpha subunit


chr22_+_22730353 0.060 ENST00000390296.2
IGLV5-45
immunoglobulin lambda variable 5-45
chr19_-_14785674 0.056 ENST00000253673.5
EMR3
egf-like module containing, mucin-like, hormone receptor-like 3
chr1_-_28969517 0.055 ENST00000263974.4
ENST00000373824.4
TAF12

TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa

chr9_-_21239978 0.055 ENST00000380222.2
IFNA14
interferon, alpha 14
chr4_-_66536196 0.049 ENST00000511294.1
EPHA5
EPH receptor A5
chr3_+_129247479 0.049 ENST00000296271.3
RHO
rhodopsin
chr3_+_186560462 0.046 ENST00000412955.2
ADIPOQ
adiponectin, C1Q and collagen domain containing
chr3_+_186560476 0.046 ENST00000320741.2
ENST00000444204.2
ADIPOQ

adiponectin, C1Q and collagen domain containing

chr2_-_89597542 0.046 ENST00000465170.1
IGKV1-37
immunoglobulin kappa variable 1-37 (non-functional)
chr9_-_21368075 0.044 ENST00000449498.1
IFNA13
interferon, alpha 13
chr6_+_30687978 0.043 ENST00000327892.8
ENST00000435534.1
TUBB

tubulin, beta class I

chrX_-_18690210 0.042 ENST00000379984.3
RS1
retinoschisin 1
chr4_+_80584903 0.040 ENST00000506460.1
RP11-452C8.1
RP11-452C8.1
chr17_-_10372875 0.039 ENST00000255381.2
MYH4
myosin, heavy chain 4, skeletal muscle
chr10_-_114206649 0.039 ENST00000369404.3
ENST00000369405.3
ZDHHC6

zinc finger, DHHC-type containing 6

chr14_+_32798547 0.038 ENST00000557354.1
ENST00000557102.1
ENST00000557272.1
AKAP6


A kinase (PRKA) anchor protein 6


chr1_+_28261492 0.034 ENST00000373894.3
SMPDL3B
sphingomyelin phosphodiesterase, acid-like 3B
chr4_-_74486347 0.031 ENST00000342081.3
RASSF6
Ras association (RalGDS/AF-6) domain family member 6
chr6_+_154360357 0.030 ENST00000330432.7
ENST00000360422.4
OPRM1

opioid receptor, mu 1

chr1_+_100818009 0.030 ENST00000370125.2
ENST00000361544.6
ENST00000370124.3
CDC14A


cell division cycle 14A


chr4_+_110736659 0.030 ENST00000394631.3
ENST00000226796.6
GAR1

GAR1 ribonucleoprotein

chr12_-_25348007 0.028 ENST00000354189.5
ENST00000545133.1
ENST00000554347.1
ENST00000395987.3
ENST00000320267.9
ENST00000395990.2
ENST00000537577.1
CASC1






cancer susceptibility candidate 1






chr15_+_93443419 0.028 ENST00000557381.1
ENST00000420239.2
CHD2

chromodomain helicase DNA binding protein 2

chr4_-_66536057 0.025 ENST00000273854.3
EPHA5
EPH receptor A5
chr16_-_20702578 0.021 ENST00000307493.4
ENST00000219151.4
ACSM1

acyl-CoA synthetase medium-chain family member 1

chr10_+_124913793 0.019 ENST00000368865.4
ENST00000538238.1
ENST00000368859.2
BUB3


BUB3 mitotic checkpoint protein


chr11_+_33061543 0.019 ENST00000432887.1
ENST00000528898.1
ENST00000531632.2
TCP11L1


t-complex 11, testis-specific-like 1


chr12_-_10959892 0.019 ENST00000240615.2
TAS2R8
taste receptor, type 2, member 8
chr10_+_18549645 0.019 ENST00000396576.2
CACNB2
calcium channel, voltage-dependent, beta 2 subunit
chr2_+_113763031 0.018 ENST00000259211.6
IL36A
interleukin 36, alpha
chr9_+_34646651 0.017 ENST00000378842.3
GALT
galactose-1-phosphate uridylyltransferase
chrX_-_8139308 0.016 ENST00000317103.4
VCX2
variable charge, X-linked 2
chr7_-_86849883 0.013 ENST00000433078.1
TMEM243
transmembrane protein 243, mitochondrial
chr1_-_151804314 0.012 ENST00000318247.6
RORC
RAR-related orphan receptor C
chr18_+_22040620 0.010 ENST00000426880.2
HRH4
histamine receptor H4
chr9_+_34646624 0.007 ENST00000450095.2
ENST00000556278.1
GALT
GALT
galactose-1-phosphate uridylyltransferase
Uncharacterized protein
chr20_-_1447467 0.003 ENST00000353088.2
ENST00000350991.4
NSFL1C

NSFL1 (p97) cofactor (p47)

chrX_-_13835147 0.002 ENST00000493677.1
ENST00000355135.2
GPM6B

glycoprotein M6B

chr1_+_192605252 0.002 ENST00000391995.2
ENST00000543215.1
RGS13

regulator of G-protein signaling 13

chr18_+_22040593 0.002 ENST00000256906.4
HRH4
histamine receptor H4
chr2_+_74682150 0.001 ENST00000233331.7
ENST00000431187.1
ENST00000409917.1
ENST00000409493.2
INO80B



INO80 complex subunit B




Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 3.1 GO:0006880 intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577)
0.1 0.6 GO:0031936 negative regulation of chromatin silencing(GO:0031936)
0.1 0.4 GO:0043653 mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.0 0.3 GO:0032057 negative regulation of translational initiation in response to stress(GO:0032057) positive regulation of translational initiation(GO:0045948)
0.0 0.2 GO:0042420 dopamine catabolic process(GO:0042420)
0.0 0.1 GO:0071639 heterotypic cell-cell adhesion(GO:0034113) regulation of heterotypic cell-cell adhesion(GO:0034114) positive regulation of monocyte chemotactic protein-1 production(GO:0071639)
0.0 0.1 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.0 0.1 GO:1904037 positive regulation of epithelial cell apoptotic process(GO:1904037) positive regulation of endothelial cell apoptotic process(GO:2000353)
0.0 0.1 GO:0051971 positive regulation of transmission of nerve impulse(GO:0051971)
0.0 0.3 GO:0008608 attachment of spindle microtubules to kinetochore(GO:0008608)
0.0 0.5 GO:0008299 isoprenoid biosynthetic process(GO:0008299)
0.0 0.4 GO:0070206 protein trimerization(GO:0070206)
0.0 0.1 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 0.4 GO:0031581 hemidesmosome assembly(GO:0031581)
0.0 0.4 GO:0030574 collagen catabolic process(GO:0030574)
0.0 0.1 GO:0015722 canalicular bile acid transport(GO:0015722)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.1 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 0.4 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.3 GO:0005851 eukaryotic translation initiation factor 2B complex(GO:0005851)
0.0 0.0 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.0 0.4 GO:0005801 cis-Golgi network(GO:0005801)
0.0 0.2 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.0 0.1 GO:0000778 condensed nuclear chromosome kinetochore(GO:0000778)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0003680 AT DNA binding(GO:0003680)
0.1 3.1 GO:0005246 calcium channel regulator activity(GO:0005246)
0.1 0.5 GO:0004337 dimethylallyltranstransferase activity(GO:0004161) geranyltranstransferase activity(GO:0004337)
0.1 1.4 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.1 0.2 GO:0004083 bisphosphoglycerate mutase activity(GO:0004082) bisphosphoglycerate 2-phosphatase activity(GO:0004083) phosphoglycerate mutase activity(GO:0004619)
0.0 0.1 GO:0042296 ISG15 transferase activity(GO:0042296)
0.0 0.2 GO:0008131 primary amine oxidase activity(GO:0008131)
0.0 0.2 GO:0004321 fatty-acyl-CoA synthase activity(GO:0004321)
0.0 0.2 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 0.1 GO:0005174 CD40 receptor binding(GO:0005174)
0.0 0.1 GO:0045499 chemorepellent activity(GO:0045499)
0.0 0.3 GO:0031369 translation initiation factor binding(GO:0031369)
0.0 0.1 GO:0005132 type I interferon receptor binding(GO:0005132)
0.0 0.1 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.0 0.2 GO:0030276 clathrin binding(GO:0030276)