Motif ID: NKX2-1
Z-value: 1.048
Transcription factors associated with NKX2-1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| NKX2-1 | ENSG00000136352.13 | NKX2-1 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 3.3 | GO:0000738 | DNA catabolic process, exonucleolytic(GO:0000738) |
| 0.9 | 3.8 | GO:0006089 | lactate metabolic process(GO:0006089) |
| 0.2 | 4.1 | GO:0006906 | vesicle fusion(GO:0006906) |
| 0.1 | 0.8 | GO:0045722 | positive regulation of gluconeogenesis(GO:0045722) |
| 0.1 | 0.8 | GO:0016584 | nucleosome positioning(GO:0016584) |
| 0.1 | 0.9 | GO:0046831 | regulation of RNA export from nucleus(GO:0046831) |
| 0.1 | 0.3 | GO:0032020 | ISG15-protein conjugation(GO:0032020) |
| 0.1 | 0.3 | GO:0045347 | negative regulation of MHC class II biosynthetic process(GO:0045347) |
| 0.1 | 0.3 | GO:0071436 | sodium ion export(GO:0071436) |
| 0.1 | 0.9 | GO:1901797 | negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518) negative regulation of signal transduction by p53 class mediator(GO:1901797) |
| 0.1 | 0.4 | GO:0042635 | positive regulation of hair cycle(GO:0042635) positive regulation of hair follicle development(GO:0051798) |
| 0.1 | 10.3 | GO:0042113 | B cell activation(GO:0042113) |
| 0.0 | 0.5 | GO:0016180 | snRNA processing(GO:0016180) |
| 0.0 | 0.6 | GO:0060351 | cartilage development involved in endochondral bone morphogenesis(GO:0060351) |
| 0.0 | 0.1 | GO:0042320 | regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) |
| 0.0 | 0.1 | GO:0003077 | obsolete negative regulation of diuresis(GO:0003077) |
| 0.0 | 1.3 | GO:0007257 | activation of JUN kinase activity(GO:0007257) |
| 0.0 | 0.7 | GO:0007158 | neuron cell-cell adhesion(GO:0007158) |
| 0.0 | 0.7 | GO:0032012 | regulation of ARF protein signal transduction(GO:0032012) |
| 0.0 | 0.4 | GO:0006105 | succinate metabolic process(GO:0006105) |
| 0.0 | 0.1 | GO:0044321 | cellular response to leptin stimulus(GO:0044320) response to leptin(GO:0044321) |
| 0.0 | 0.2 | GO:0040037 | negative regulation of fibroblast growth factor receptor signaling pathway(GO:0040037) |
| 0.0 | 0.2 | GO:0033145 | positive regulation of intracellular steroid hormone receptor signaling pathway(GO:0033145) |
| 0.0 | 0.1 | GO:0048102 | autophagic cell death(GO:0048102) |
| 0.0 | 0.3 | GO:0015939 | pantothenate metabolic process(GO:0015939) |
| 0.0 | 0.1 | GO:0010957 | negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137) |
| 0.0 | 0.3 | GO:0031293 | membrane protein intracellular domain proteolysis(GO:0031293) |
| 0.0 | 0.1 | GO:0034501 | protein localization to kinetochore(GO:0034501) |
| 0.0 | 0.1 | GO:0006848 | pyruvate transport(GO:0006848) |
| 0.0 | 0.4 | GO:0060113 | inner ear receptor cell differentiation(GO:0060113) |
| 0.0 | 0.3 | GO:0046135 | pyrimidine nucleoside catabolic process(GO:0046135) |
| 0.0 | 1.1 | GO:0050680 | negative regulation of epithelial cell proliferation(GO:0050680) |
| 0.0 | 0.2 | GO:0030539 | male genitalia development(GO:0030539) |
| 0.0 | 0.3 | GO:0001947 | heart looping(GO:0001947) embryonic heart tube morphogenesis(GO:0003143) determination of heart left/right asymmetry(GO:0061371) |
| 0.0 | 0.1 | GO:0070389 | chaperone cofactor-dependent protein refolding(GO:0070389) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.4 | GO:0045257 | mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283) |
| 0.1 | 0.2 | GO:0001650 | fibrillar center(GO:0001650) |
| 0.1 | 0.7 | GO:0031095 | platelet dense tubular network membrane(GO:0031095) |
| 0.0 | 0.5 | GO:0032039 | integrator complex(GO:0032039) |
| 0.0 | 3.4 | GO:0016605 | PML body(GO:0016605) |
| 0.0 | 6.1 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.0 | 0.5 | GO:0001527 | microfibril(GO:0001527) |
| 0.0 | 0.1 | GO:0005594 | collagen type IX trimer(GO:0005594) |
| 0.0 | 0.5 | GO:0043034 | costamere(GO:0043034) |
| 0.0 | 0.2 | GO:0033179 | proton-transporting V-type ATPase, V0 domain(GO:0033179) |
| 0.0 | 0.8 | GO:0000786 | nucleosome(GO:0000786) |
| 0.0 | 0.1 | GO:0051233 | spindle midzone(GO:0051233) |
| 0.0 | 0.0 | GO:0014701 | junctional sarcoplasmic reticulum membrane(GO:0014701) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 3.3 | GO:0008310 | single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310) exoribonuclease II activity(GO:0008859) |
| 0.5 | 3.8 | GO:0004457 | lactate dehydrogenase activity(GO:0004457) L-lactate dehydrogenase activity(GO:0004459) |
| 0.3 | 4.0 | GO:0005068 | transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068) |
| 0.2 | 0.9 | GO:0008486 | diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) |
| 0.1 | 0.7 | GO:0005220 | inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220) |
| 0.1 | 0.3 | GO:0042296 | ISG15 transferase activity(GO:0042296) |
| 0.1 | 0.8 | GO:0004439 | phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity(GO:0004439) |
| 0.1 | 0.4 | GO:0048039 | succinate dehydrogenase activity(GO:0000104) oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor(GO:0016635) ubiquinone binding(GO:0048039) |
| 0.1 | 0.3 | GO:0008384 | IkappaB kinase activity(GO:0008384) |
| 0.1 | 0.2 | GO:0043398 | HLH domain binding(GO:0043398) |
| 0.1 | 1.3 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
| 0.1 | 0.5 | GO:0016671 | oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor(GO:0016671) |
| 0.0 | 0.5 | GO:0002162 | dystroglycan binding(GO:0002162) |
| 0.0 | 0.3 | GO:0003810 | protein-glutamine gamma-glutamyltransferase activity(GO:0003810) |
| 0.0 | 0.4 | GO:0070513 | death domain binding(GO:0070513) |
| 0.0 | 0.7 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
| 0.0 | 0.9 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.0 | 0.4 | GO:0005104 | fibroblast growth factor receptor binding(GO:0005104) |
| 0.0 | 0.1 | GO:0005000 | vasopressin receptor activity(GO:0005000) |
| 0.0 | 0.2 | GO:0070700 | BMP receptor binding(GO:0070700) |
| 0.0 | 0.1 | GO:0030020 | extracellular matrix structural constituent conferring tensile strength(GO:0030020) |
| 0.0 | 0.1 | GO:0047631 | ADP-ribose diphosphatase activity(GO:0047631) |
| 0.0 | 0.3 | GO:0004190 | aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001) |
| 0.0 | 0.2 | GO:0008553 | hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553) |
| 0.0 | 0.1 | GO:0050833 | pyruvate secondary active transmembrane transporter activity(GO:0005477) pyruvate transmembrane transporter activity(GO:0050833) |
| 0.0 | 0.3 | GO:0016780 | phosphotransferase activity, for other substituted phosphate groups(GO:0016780) |
| 0.0 | 0.2 | GO:0004065 | arylsulfatase activity(GO:0004065) |
| 0.0 | 0.1 | GO:0051428 | peptide hormone receptor binding(GO:0051428) |
| 0.0 | 0.3 | GO:0005242 | inward rectifier potassium channel activity(GO:0005242) |
| 0.0 | 0.3 | GO:0019003 | GDP binding(GO:0019003) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.9 | SA_B_CELL_RECEPTOR_COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
| 0.0 | 0.9 | SA_MMP_CYTOKINE_CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.0 | 0.7 | ST_MYOCYTE_AD_PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 0.0 | 1.3 | ST_JNK_MAPK_PATHWAY | JNK MAPK Pathway |
