Motif ID: NKX2-4

Z-value: 0.882


Transcription factors associated with NKX2-4:

Gene SymbolEntrez IDGene Name
NKX2-4 ENSG00000125816.4 NKX2-4



Activity profile for motif NKX2-4.

activity profile for motif NKX2-4


Sorted Z-values histogram for motif NKX2-4

Sorted Z-values for motif NKX2-4



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX2-4

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr21_-_15918618 1.939 ENST00000400564.1
ENST00000400566.1
SAMSN1

SAM domain, SH3 domain and nuclear localization signals 1

chrX_-_154563889 1.902 ENST00000369449.2
ENST00000321926.4
CLIC2

chloride intracellular channel 2

chr3_-_107777208 1.352 ENST00000398258.3
CD47
CD47 molecule
chr11_+_60223225 1.337 ENST00000524807.1
ENST00000345732.4
MS4A1

membrane-spanning 4-domains, subfamily A, member 1

chr11_+_60223312 1.289 ENST00000532491.1
ENST00000532073.1
ENST00000534668.1
ENST00000528313.1
ENST00000533306.1
MS4A1




membrane-spanning 4-domains, subfamily A, member 1




chrX_+_49294472 1.076 ENST00000361446.5
GAGE12B
G antigen 12B
chr10_-_121296045 1.073 ENST00000392865.1
RGS10
regulator of G-protein signaling 10
chr15_-_55541227 0.985 ENST00000566877.1
RAB27A
RAB27A, member RAS oncogene family
chrX_+_49178536 0.819 ENST00000442437.2
GAGE12J
G antigen 12J
chr17_-_29641104 0.805 ENST00000577894.1
ENST00000330927.4
EVI2B

ecotropic viral integration site 2B

chr16_+_12059091 0.791 ENST00000562385.1
TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chr6_+_12958137 0.790 ENST00000457702.2
ENST00000379345.2
PHACTR1

phosphatase and actin regulator 1

chr12_+_48516357 0.766 ENST00000549022.1
ENST00000547587.1
ENST00000312352.7
PFKM


phosphofructokinase, muscle


chr6_+_26158343 0.754 ENST00000377777.4
ENST00000289316.2
HIST1H2BD

histone cluster 1, H2bd

chr1_+_161632937 0.745 ENST00000236937.9
ENST00000367961.4
ENST00000358671.5
FCGR2B


Fc fragment of IgG, low affinity IIb, receptor (CD32)


chrX_+_78200913 0.742 ENST00000171757.2
P2RY10
purinergic receptor P2Y, G-protein coupled, 10
chrX_+_78200829 0.738 ENST00000544091.1
P2RY10
purinergic receptor P2Y, G-protein coupled, 10
chr15_-_20193370 0.703 ENST00000558565.2
IGHV3OR15-7
immunoglobulin heavy variable 3/OR15-7 (pseudogene)
chr14_+_75988851 0.670 ENST00000555504.1
BATF
basic leucine zipper transcription factor, ATF-like
chr20_-_43280325 0.658 ENST00000537820.1
ADA
adenosine deaminase
chr16_+_28943260 0.617 ENST00000538922.1
ENST00000324662.3
ENST00000567541.1
CD19


CD19 molecule


chr17_-_29641084 0.610 ENST00000544462.1
EVI2B
ecotropic viral integration site 2B
chr11_-_5255861 0.608 ENST00000380299.3
HBD
hemoglobin, delta
chr5_-_176836577 0.594 ENST00000253496.3
F12
coagulation factor XII (Hageman factor)
chr16_+_1730338 0.582 ENST00000566691.1
ENST00000382710.4
HN1L

hematological and neurological expressed 1-like

chr15_+_75315896 0.572 ENST00000342932.3
ENST00000564923.1
ENST00000569562.1
ENST00000568649.1
PPCDC



phosphopantothenoylcysteine decarboxylase



chr5_-_34919094 0.567 ENST00000341754.4
RAD1
RAD1 homolog (S. pombe)
chr7_+_116139424 0.545 ENST00000222693.4
CAV2
caveolin 2
chr12_+_10658201 0.538 ENST00000322446.3
EIF2S3L
Putative eukaryotic translation initiation factor 2 subunit 3-like protein
chr1_+_32716857 0.531 ENST00000482949.1
ENST00000495610.2
LCK

lymphocyte-specific protein tyrosine kinase

chr19_-_55669093 0.524 ENST00000344887.5
TNNI3
troponin I type 3 (cardiac)
chrX_-_124097620 0.519 ENST00000371130.3
ENST00000422452.2
TENM1

teneurin transmembrane protein 1

chr1_+_15986364 0.510 ENST00000345034.1
RSC1A1
regulatory solute carrier protein, family 1, member 1
chr10_+_35484053 0.508 ENST00000487763.1
ENST00000473940.1
ENST00000488328.1
ENST00000356917.5
CREM



cAMP responsive element modulator



chr9_+_93589734 0.481 ENST00000375746.1
SYK
spleen tyrosine kinase
chr11_+_118958689 0.454 ENST00000535253.1
ENST00000392841.1
HMBS

hydroxymethylbilane synthase

chrX_-_110655306 0.447 ENST00000371993.2
DCX
doublecortin
chr12_-_53601055 0.446 ENST00000552972.1
ENST00000422257.3
ENST00000267082.5
ITGB7


integrin, beta 7


chr1_-_197036364 0.444 ENST00000367412.1
F13B
coagulation factor XIII, B polypeptide
chr11_-_19263145 0.444 ENST00000532666.1
ENST00000527884.1
E2F8

E2F transcription factor 8

chrX_+_48542168 0.430 ENST00000376701.4
WAS
Wiskott-Aldrich syndrome
chr13_+_111767650 0.425 ENST00000449979.1
ENST00000370623.3
ARHGEF7

Rho guanine nucleotide exchange factor (GEF) 7

chr22_-_26961328 0.419 ENST00000398110.2
TPST2
tyrosylprotein sulfotransferase 2
chr6_+_5261225 0.418 ENST00000324331.6
FARS2
phenylalanyl-tRNA synthetase 2, mitochondrial
chr11_-_19223523 0.414 ENST00000265968.3
CSRP3
cysteine and glycine-rich protein 3 (cardiac LIM protein)
chr14_-_23451467 0.414 ENST00000361265.4
ENST00000555074.1
AJUBA
RP11-298I3.5
ajuba LIM protein
RP11-298I3.5
chr7_-_7782204 0.413 ENST00000418534.2
AC007161.5
AC007161.5
chr12_-_53601000 0.413 ENST00000338737.4
ENST00000549086.2
ITGB7

integrin, beta 7

chr19_-_6670128 0.400 ENST00000245912.3
TNFSF14
tumor necrosis factor (ligand) superfamily, member 14
chr6_+_83073334 0.396 ENST00000369750.3
TPBG
trophoblast glycoprotein
chr11_-_62439012 0.395 ENST00000532208.1
ENST00000377954.2
ENST00000415855.2
ENST00000431002.2
ENST00000354588.3
C11orf48




chromosome 11 open reading frame 48




chr19_-_20748541 0.380 ENST00000427401.4
ENST00000594419.1
ZNF737

zinc finger protein 737

chr5_-_88119580 0.376 ENST00000539796.1
MEF2C
myocyte enhancer factor 2C
chr2_-_225434538 0.374 ENST00000409096.1
CUL3
cullin 3
chr19_-_11688500 0.370 ENST00000433365.2
ACP5
acid phosphatase 5, tartrate resistant
chr2_-_175462456 0.368 ENST00000409891.1
ENST00000410117.1
WIPF1

WAS/WASL interacting protein family, member 1

chr6_+_83072923 0.365 ENST00000535040.1
TPBG
trophoblast glycoprotein
chr8_-_28747424 0.363 ENST00000523436.1
ENST00000397363.4
ENST00000521777.1
ENST00000520184.1
ENST00000521022.1
INTS9




integrator complex subunit 9




chr19_+_41117770 0.356 ENST00000601032.1
LTBP4
latent transforming growth factor beta binding protein 4
chr9_+_134065506 0.354 ENST00000483497.2
NUP214
nucleoporin 214kDa
chr16_+_31539197 0.346 ENST00000564707.1
AHSP
alpha hemoglobin stabilizing protein
chr12_-_102591604 0.340 ENST00000329406.4
PMCH
pro-melanin-concentrating hormone
chr19_+_44100544 0.337 ENST00000391965.2
ENST00000525771.1
ZNF576

zinc finger protein 576

chr6_+_35265586 0.332 ENST00000542066.1
ENST00000316637.5
DEF6

differentially expressed in FDCP 6 homolog (mouse)

chr1_+_161551101 0.318 ENST00000367962.4
ENST00000367960.5
ENST00000403078.3
ENST00000428605.2
FCGR2B



Fc fragment of IgG, low affinity IIb, receptor (CD32)



chr14_+_74353320 0.314 ENST00000540593.1
ENST00000555730.1
ZNF410

zinc finger protein 410

chr16_+_31539183 0.314 ENST00000302312.4
AHSP
alpha hemoglobin stabilizing protein
chr5_-_11588907 0.311 ENST00000513598.1
ENST00000503622.1
CTNND2

catenin (cadherin-associated protein), delta 2

chr18_+_21032781 0.310 ENST00000339486.3
RIOK3
RIO kinase 3
chr2_-_175462934 0.309 ENST00000392546.2
ENST00000436221.1
WIPF1

WAS/WASL interacting protein family, member 1

chr3_-_49066811 0.305 ENST00000442157.1
ENST00000326739.4
IMPDH2

IMP (inosine 5'-monophosphate) dehydrogenase 2

chr11_-_85780853 0.304 ENST00000531930.1
ENST00000528398.1
PICALM

phosphatidylinositol binding clathrin assembly protein

chr19_+_44100632 0.304 ENST00000533118.1
ZNF576
zinc finger protein 576
chr9_-_32573130 0.301 ENST00000350021.2
ENST00000379847.3
NDUFB6

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa

chrX_-_110655391 0.290 ENST00000356915.2
ENST00000356220.3
DCX

doublecortin

chr1_-_153643442 0.287 ENST00000368681.1
ENST00000361891.4
ILF2

interleukin enhancer binding factor 2

chr18_-_28622699 0.286 ENST00000360428.4
DSC3
desmocollin 3
chr10_+_105005644 0.283 ENST00000441178.2
RP11-332O19.5
ribulose-5-phosphate-3-epimerase-like 1
chr7_+_120629653 0.281 ENST00000450913.2
ENST00000340646.5
CPED1

cadherin-like and PC-esterase domain containing 1

chr20_-_4804244 0.280 ENST00000379400.3
RASSF2
Ras association (RalGDS/AF-6) domain family member 2
chr12_+_123011776 0.275 ENST00000450485.2
ENST00000333479.7
KNTC1

kinetochore associated 1

chr12_-_56843161 0.272 ENST00000554616.1
ENST00000553532.1
ENST00000229201.4
TIMELESS


timeless circadian clock


chr12_+_58176525 0.268 ENST00000543727.1
ENST00000540550.1
ENST00000323833.8
ENST00000350762.5
ENST00000550559.1
ENST00000548851.1
ENST00000434359.1
ENST00000457189.1
TSFM







Ts translation elongation factor, mitochondrial







chr18_-_33702078 0.266 ENST00000586829.1
SLC39A6
solute carrier family 39 (zinc transporter), member 6
chr3_+_118905564 0.265 ENST00000460625.1
UPK1B
uroplakin 1B
chrX_-_133792480 0.263 ENST00000359237.4
PLAC1
placenta-specific 1
chr5_+_150040403 0.259 ENST00000517768.1
ENST00000297130.4
MYOZ3

myozenin 3

chr12_-_104532062 0.259 ENST00000240055.3
NFYB
nuclear transcription factor Y, beta
chr10_+_22605374 0.255 ENST00000448361.1
COMMD3
COMM domain containing 3
chr10_-_28571015 0.253 ENST00000375719.3
ENST00000375732.1
MPP7

membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)

chr12_+_123237321 0.253 ENST00000280557.6
ENST00000455982.2
DENR

density-regulated protein

chr4_-_87028478 0.250 ENST00000515400.1
ENST00000395157.3
MAPK10

mitogen-activated protein kinase 10

chr12_+_56435637 0.250 ENST00000356464.5
ENST00000552361.1
RPS26

ribosomal protein S26

chr21_+_40823753 0.248 ENST00000333634.4
SH3BGR
SH3 domain binding glutamic acid-rich protein
chr10_-_61900762 0.248 ENST00000355288.2
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr4_+_646960 0.247 ENST00000488061.1
ENST00000429163.2
PDE6B

phosphodiesterase 6B, cGMP-specific, rod, beta

chr1_+_161136180 0.247 ENST00000352210.5
ENST00000367999.4
ENST00000544598.1
ENST00000535223.1
ENST00000432542.2
PPOX




protoporphyrinogen oxidase




chr14_-_71067360 0.244 ENST00000554963.1
ENST00000430055.2
ENST00000440435.2
ENST00000256379.5
MED6



mediator complex subunit 6



chr3_+_4535155 0.242 ENST00000544951.1
ITPR1
inositol 1,4,5-trisphosphate receptor, type 1
chr18_-_28622774 0.240 ENST00000434452.1
DSC3
desmocollin 3
chr10_-_69455873 0.240 ENST00000433211.2
CTNNA3
catenin (cadherin-associated protein), alpha 3
chr3_+_15045419 0.239 ENST00000406272.2
NR2C2
nuclear receptor subfamily 2, group C, member 2
chr9_+_131445928 0.234 ENST00000372692.4
SET
SET nuclear oncogene
chr3_+_189349162 0.234 ENST00000264731.3
ENST00000382063.4
ENST00000418709.2
ENST00000320472.5
ENST00000392460.3
ENST00000440651.2
TP63





tumor protein p63





chr5_+_159436120 0.228 ENST00000522793.1
ENST00000231238.5
TTC1

tetratricopeptide repeat domain 1

chr17_+_60501228 0.227 ENST00000311506.5
METTL2A
methyltransferase like 2A
chr1_+_144989309 0.226 ENST00000596396.1
AL590452.1
Uncharacterized protein
chr4_+_39699664 0.223 ENST00000261427.5
ENST00000510934.1
ENST00000295963.6
UBE2K


ubiquitin-conjugating enzyme E2K


chr6_-_149969871 0.218 ENST00000335643.8
ENST00000444282.1
KATNA1

katanin p60 (ATPase containing) subunit A 1

chr12_+_50451331 0.213 ENST00000228468.4
ASIC1
acid-sensing (proton-gated) ion channel 1
chrX_+_148622138 0.212 ENST00000450602.2
ENST00000441248.1
CXorf40A

chromosome X open reading frame 40A

chr7_+_117120017 0.211 ENST00000003084.6
ENST00000454343.1
CFTR

cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)

chr10_+_22605304 0.211 ENST00000456711.1
ENST00000444869.1
ENST00000475460.2
ENST00000602390.1
ENST00000489125.2
COMMD3

COMMD3-BMI1


COMM domain containing 3

COMMD3-BMI1 readthrough


chr6_-_29343068 0.207 ENST00000396806.3
OR12D3
olfactory receptor, family 12, subfamily D, member 3
chr12_-_71182695 0.206 ENST00000342084.4
PTPRR
protein tyrosine phosphatase, receptor type, R
chr14_+_88471468 0.205 ENST00000267549.3
GPR65
G protein-coupled receptor 65
chr17_-_40264692 0.204 ENST00000591220.1
ENST00000251642.3
DHX58

DEXH (Asp-Glu-X-His) box polypeptide 58

chr1_+_95583479 0.204 ENST00000455656.1
ENST00000604534.1
TMEM56
RP11-57H12.6
transmembrane protein 56
TMEM56-RWDD3 readthrough
chr5_+_43602750 0.202 ENST00000505678.2
ENST00000512422.1
ENST00000264663.5
NNT


nicotinamide nucleotide transhydrogenase


chr3_+_190105909 0.202 ENST00000456423.1
CLDN16
claudin 16
chr7_+_75932863 0.199 ENST00000429938.1
HSPB1
heat shock 27kDa protein 1
chr1_-_89458287 0.198 ENST00000370485.2
CCBL2
cysteine conjugate-beta lyase 2
chr9_+_140083099 0.196 ENST00000322310.5
SSNA1
Sjogren syndrome nuclear autoantigen 1
chr12_+_96252706 0.193 ENST00000266735.5
ENST00000553192.1
ENST00000552085.1
SNRPF


small nuclear ribonucleoprotein polypeptide F


chr2_-_176046391 0.191 ENST00000392541.3
ENST00000409194.1
ATP5G3

ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9)

chr16_+_81272287 0.190 ENST00000425577.2
ENST00000564552.1
BCMO1

beta-carotene 15,15'-monooxygenase 1

chr6_-_149969829 0.189 ENST00000367411.2
KATNA1
katanin p60 (ATPase containing) subunit A 1
chr18_+_29769978 0.186 ENST00000269202.6
ENST00000581447.1
MEP1B

meprin A, beta

chr14_+_39703112 0.184 ENST00000555143.1
ENST00000280082.3
MIA2

melanoma inhibitory activity 2

chr17_-_62493131 0.183 ENST00000539111.2
POLG2
polymerase (DNA directed), gamma 2, accessory subunit
chr1_-_85040090 0.183 ENST00000370630.5
CTBS
chitobiase, di-N-acetyl-
chr2_-_166651191 0.182 ENST00000392701.3
GALNT3
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3)
chr6_+_27925019 0.172 ENST00000244623.1
OR2B6
olfactory receptor, family 2, subfamily B, member 6
chr11_+_19138670 0.171 ENST00000446113.2
ENST00000399351.3
ZDHHC13

zinc finger, DHHC-type containing 13

chr2_-_219925189 0.170 ENST00000295731.6
IHH
indian hedgehog
chr2_-_37899323 0.169 ENST00000295324.3
ENST00000457889.1
CDC42EP3

CDC42 effector protein (Rho GTPase binding) 3

chr5_+_140235469 0.169 ENST00000506939.2
ENST00000307360.5
PCDHA10

protocadherin alpha 10

chr19_+_13135386 0.167 ENST00000360105.4
ENST00000588228.1
ENST00000591028.1
NFIX


nuclear factor I/X (CCAAT-binding transcription factor)


chr7_-_86849883 0.164 ENST00000433078.1
TMEM243
transmembrane protein 243, mitochondrial
chr2_-_37544209 0.163 ENST00000234179.2
PRKD3
protein kinase D3
chr12_+_54422142 0.163 ENST00000243108.4
HOXC6
homeobox C6
chr1_-_156721502 0.162 ENST00000357325.5
HDGF
hepatoma-derived growth factor
chr1_+_147374915 0.160 ENST00000240986.4
GJA8
gap junction protein, alpha 8, 50kDa
chr7_+_107384142 0.160 ENST00000440859.3
CBLL1
Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase
chr6_+_152011628 0.157 ENST00000404742.1
ENST00000440973.1
ESR1

estrogen receptor 1

chr11_+_62439126 0.157 ENST00000377953.3
C11orf83
chromosome 11 open reading frame 83
chr19_-_41942344 0.157 ENST00000594660.1
ATP5SL
ATP5S-like
chr1_+_46769303 0.156 ENST00000311672.5
UQCRH
ubiquinol-cytochrome c reductase hinge protein
chr1_+_117297007 0.155 ENST00000369478.3
ENST00000369477.1
CD2

CD2 molecule

chr7_+_117120106 0.154 ENST00000426809.1
CFTR
cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
chr4_-_175443943 0.153 ENST00000296522.6
HPGD
hydroxyprostaglandin dehydrogenase 15-(NAD)
chr16_-_3450963 0.153 ENST00000573327.1
ENST00000571906.1
ENST00000573830.1
ENST00000439568.2
ENST00000422427.2
ENST00000304926.3
ENST00000396852.4
ZSCAN32






zinc finger and SCAN domain containing 32






chr1_-_155271213 0.152 ENST00000342741.4
PKLR
pyruvate kinase, liver and RBC
chr11_-_119993979 0.152 ENST00000524816.3
ENST00000525327.1
TRIM29

tripartite motif containing 29

chr13_-_36944307 0.150 ENST00000355182.4
SPG20
spastic paraplegia 20 (Troyer syndrome)
chr9_-_95244781 0.149 ENST00000375544.3
ENST00000375543.1
ENST00000395538.3
ENST00000450139.2
ASPN



asporin



chr6_-_41703952 0.149 ENST00000358871.2
ENST00000403298.4
TFEB

transcription factor EB

chr7_-_55606346 0.147 ENST00000545390.1
VOPP1
vesicular, overexpressed in cancer, prosurvival protein 1
chr15_+_40987327 0.147 ENST00000423169.2
ENST00000267868.3
ENST00000557850.1
ENST00000532743.1
ENST00000382643.3
RAD51




RAD51 recombinase




chr11_-_85779971 0.145 ENST00000393346.3
PICALM
phosphatidylinositol binding clathrin assembly protein
chrX_-_119445306 0.144 ENST00000371369.4
ENST00000440464.1
ENST00000519908.1
TMEM255A


transmembrane protein 255A


chr2_+_166326157 0.144 ENST00000421875.1
ENST00000314499.7
ENST00000409664.1
CSRNP3


cysteine-serine-rich nuclear protein 3


chr7_+_65552756 0.142 ENST00000450043.1
AC068533.7
AC068533.7
chr12_-_322504 0.142 ENST00000424061.2
SLC6A12
solute carrier family 6 (neurotransmitter transporter), member 12
chr19_+_36235964 0.139 ENST00000587708.2
PSENEN
presenilin enhancer gamma secretase subunit
chr7_-_86849025 0.137 ENST00000257637.3
TMEM243
transmembrane protein 243, mitochondrial
chr7_-_92463210 0.135 ENST00000265734.4
CDK6
cyclin-dependent kinase 6
chr10_+_81272287 0.135 ENST00000520547.2
EIF5AL1
eukaryotic translation initiation factor 5A-like 1
chr19_+_37998031 0.135 ENST00000586138.1
ENST00000588578.1
ENST00000587986.1
ZNF793


zinc finger protein 793


chr4_+_109541772 0.134 ENST00000506397.1
ENST00000394668.2
RPL34

ribosomal protein L34

chr10_+_21823079 0.134 ENST00000377100.3
ENST00000377072.3
ENST00000446906.2
MLLT10


myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10


chr4_+_96012614 0.133 ENST00000264568.4
BMPR1B
bone morphogenetic protein receptor, type IB
chr4_-_69434245 0.130 ENST00000317746.2
UGT2B17
UDP glucuronosyltransferase 2 family, polypeptide B17
chr4_-_100242549 0.129 ENST00000305046.8
ENST00000394887.3
ADH1B

alcohol dehydrogenase 1B (class I), beta polypeptide

chr10_-_11574274 0.128 ENST00000277575.5
USP6NL
USP6 N-terminal like
chr1_-_110155671 0.128 ENST00000351050.3
GNAT2
guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
chr4_-_168155169 0.126 ENST00000534949.1
ENST00000535728.1
SPOCK3

sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3

chr12_+_27863706 0.124 ENST00000081029.3
ENST00000538315.1
ENST00000542791.1
MRPS35


mitochondrial ribosomal protein S35


chrX_+_49091920 0.124 ENST00000376227.3
CCDC22
coiled-coil domain containing 22
chr7_-_14028488 0.124 ENST00000405358.4
ETV1
ets variant 1
chr2_+_89998789 0.124 ENST00000453166.2
IGKV2D-28
immunoglobulin kappa variable 2D-28
chr14_+_65381079 0.123 ENST00000549987.1
ENST00000542227.1
ENST00000447296.2
ENST00000549115.1
ENST00000607599.1
ENST00000548752.2
ENST00000359118.2
ENST00000552002.2
ENST00000551947.1
ENST00000551093.1
CHURC1-FNTB
FNTB

CHURC1






CHURC1-FNTB readthrough
farnesyltransferase, CAAX box, beta

churchill domain containing 1






chr1_+_70671363 0.122 ENST00000370951.1
ENST00000370950.3
ENST00000405432.1
ENST00000454435.2
SRSF11



serine/arginine-rich splicing factor 11



chr4_+_75480629 0.120 ENST00000380846.3
AREGB
amphiregulin B
chr4_-_68411275 0.118 ENST00000273853.6
CENPC
centromere protein C
chr12_+_12878829 0.118 ENST00000326765.6
APOLD1
apolipoprotein L domain containing 1
chr2_-_179315786 0.116 ENST00000457633.1
ENST00000438687.3
ENST00000325748.4
PRKRA


protein kinase, interferon-inducible double stranded RNA dependent activator


chr15_-_88799661 0.116 ENST00000360948.2
ENST00000357724.2
ENST00000355254.2
ENST00000317501.3
NTRK3



neurotrophic tyrosine kinase, receptor, type 3



chr11_-_506316 0.116 ENST00000532055.1
ENST00000531540.1
RNH1

ribonuclease/angiogenin inhibitor 1

chr1_-_203198790 0.115 ENST00000367229.1
ENST00000255427.3
ENST00000535569.1
CHIT1


chitinase 1 (chitotriosidase)


chr1_-_70671216 0.112 ENST00000370952.3
LRRC40
leucine rich repeat containing 40
chr6_-_31088214 0.112 ENST00000376288.2
CDSN
corneodesmosin
chr8_-_74206673 0.111 ENST00000396465.1
RPL7
ribosomal protein L7
chr12_+_21590549 0.111 ENST00000545178.1
ENST00000240651.9
PYROXD1

pyridine nucleotide-disulphide oxidoreductase domain 1

chr19_+_45504688 0.111 ENST00000221452.8
ENST00000540120.1
ENST00000505236.1
RELB


v-rel avian reticuloendotheliosis viral oncogene homolog B


chr11_-_111383064 0.109 ENST00000525791.1
ENST00000456861.2
ENST00000356018.2
BTG4


B-cell translocation gene 4


chr5_+_140227048 0.108 ENST00000532602.1
PCDHA9
protocadherin alpha 9
chr11_-_106889250 0.105 ENST00000526355.2
GUCY1A2
guanylate cyclase 1, soluble, alpha 2
chr4_+_111397216 0.105 ENST00000265162.5
ENPEP
glutamyl aminopeptidase (aminopeptidase A)
chr17_-_67138015 0.104 ENST00000284425.2
ENST00000590645.1
ABCA6

ATP-binding cassette, sub-family A (ABC1), member 6


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0002901 mature B cell apoptotic process(GO:0002901) regulation of mature B cell apoptotic process(GO:0002905) negative regulation of mature B cell apoptotic process(GO:0002906) purine nucleotide salvage(GO:0032261) nucleotide salvage(GO:0043173) inosine metabolic process(GO:0046102) xanthine metabolic process(GO:0046110)
0.2 0.6 GO:0002541 activation of plasma proteins involved in acute inflammatory response(GO:0002541)
0.2 1.0 GO:0043316 natural killer cell activation involved in immune response(GO:0002323) cytotoxic T cell degranulation(GO:0043316) natural killer cell degranulation(GO:0043320)
0.2 0.5 GO:0043366 beta selection(GO:0043366)
0.2 0.5 GO:0097237 response to cobalt ion(GO:0032025) cellular response to antibiotic(GO:0071236) cellular response to toxic substance(GO:0097237)
0.1 0.4 GO:0006478 peptidyl-tyrosine sulfation(GO:0006478)
0.1 0.4 GO:0006432 phenylalanyl-tRNA aminoacylation(GO:0006432)
0.1 0.5 GO:0044854 membrane raft assembly(GO:0001765) plasma membrane raft assembly(GO:0044854) plasma membrane raft organization(GO:0044857) positive regulation of dopamine receptor signaling pathway(GO:0060161) caveola assembly(GO:0070836) membrane assembly(GO:0071709)
0.1 0.5 GO:0050862 positive regulation of T cell receptor signaling pathway(GO:0050862)
0.1 0.5 GO:0032780 negative regulation of ATPase activity(GO:0032780)
0.1 0.4 GO:0051013 microtubule severing(GO:0051013)
0.1 0.4 GO:0060025 regulation of synaptic activity(GO:0060025)
0.1 0.4 GO:0001831 trophectodermal cellular morphogenesis(GO:0001831)
0.1 0.4 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
0.1 0.4 GO:0008588 release of cytoplasmic sequestered NF-kappaB(GO:0008588)
0.1 0.4 GO:0015693 magnesium ion transport(GO:0015693)
0.1 0.8 GO:0006002 fructose 6-phosphate metabolic process(GO:0006002)
0.1 0.3 GO:1902414 protein localization to adherens junction(GO:0071896) protein localization to cell junction(GO:1902414)
0.1 0.2 GO:0045938 regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) positive regulation of circadian sleep/wake cycle, sleep(GO:0045938)
0.1 0.4 GO:0043615 astrocyte cell migration(GO:0043615)
0.1 0.2 GO:0018243 protein O-linked glycosylation via serine(GO:0018242) protein O-linked glycosylation via threonine(GO:0018243)
0.1 0.6 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.1 0.7 GO:0020027 hemoglobin metabolic process(GO:0020027)
0.1 0.3 GO:0006177 GMP biosynthetic process(GO:0006177)
0.0 0.1 GO:0070171 negative regulation of tooth mineralization(GO:0070171)
0.0 0.3 GO:0060219 camera-type eye photoreceptor cell differentiation(GO:0060219)
0.0 0.2 GO:0046037 GMP metabolic process(GO:0046037)
0.0 0.3 GO:0007499 ectoderm and mesoderm interaction(GO:0007499)
0.0 0.7 GO:0046827 positive regulation of protein export from nucleus(GO:0046827)
0.0 0.1 GO:0009992 cellular water homeostasis(GO:0009992)
0.0 0.4 GO:0015705 iodide transport(GO:0015705)
0.0 0.1 GO:0050942 positive regulation of melanocyte differentiation(GO:0045636) positive regulation of pigment cell differentiation(GO:0050942)
0.0 0.2 GO:0010447 response to acidic pH(GO:0010447)
0.0 0.2 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.0 0.2 GO:0031580 membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.0 0.1 GO:0019056 modulation by virus of host transcription(GO:0019056) regulation of sprouting of injured axon(GO:0048686) positive regulation of sprouting of injured axon(GO:0048687) regulation of axon extension involved in regeneration(GO:0048690) positive regulation of axon extension involved in regeneration(GO:0048691) modulation by symbiont of host transcription(GO:0052026)
0.0 0.2 GO:0042866 pyruvate biosynthetic process(GO:0042866)
0.0 0.4 GO:0016180 snRNA processing(GO:0016180)
0.0 0.1 GO:1904037 positive regulation of epithelial cell apoptotic process(GO:1904037) positive regulation of endothelial cell apoptotic process(GO:2000353)
0.0 0.5 GO:0048268 negative regulation of receptor-mediated endocytosis(GO:0048261) clathrin coat assembly(GO:0048268)
0.0 0.5 GO:0007128 meiotic prophase I(GO:0007128)
0.0 0.3 GO:0007258 JUN phosphorylation(GO:0007258)
0.0 0.2 GO:0033119 negative regulation of RNA splicing(GO:0033119)
0.0 0.1 GO:0042118 endothelial cell activation(GO:0042118)
0.0 0.3 GO:0006030 chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.0 1.9 GO:0006821 chloride transport(GO:0006821)
0.0 0.1 GO:0001550 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.0 0.2 GO:0019372 lipoxygenase pathway(GO:0019372)
0.0 0.8 GO:0033209 tumor necrosis factor-mediated signaling pathway(GO:0033209)
0.0 0.6 GO:0050853 B cell receptor signaling pathway(GO:0050853)
0.0 0.3 GO:0033261 obsolete regulation of S phase(GO:0033261)
0.0 0.2 GO:0070189 kynurenine metabolic process(GO:0070189)
0.0 0.2 GO:1901984 negative regulation of histone acetylation(GO:0035067) negative regulation of protein acetylation(GO:1901984) negative regulation of peptidyl-lysine acetylation(GO:2000757)
0.0 0.4 GO:0030252 growth hormone secretion(GO:0030252)
0.0 0.1 GO:0042769 DNA damage response, detection of DNA damage(GO:0042769)
0.0 0.1 GO:0018343 protein farnesylation(GO:0018343)
0.0 0.5 GO:0050892 intestinal absorption(GO:0050892)
0.0 0.1 GO:0015722 canalicular bile acid transport(GO:0015722)
0.0 0.3 GO:0007096 regulation of exit from mitosis(GO:0007096)
0.0 0.1 GO:0045003 DNA recombinase assembly(GO:0000730) double-strand break repair via synthesis-dependent strand annealing(GO:0045003)
0.0 0.1 GO:2000008 regulation of protein localization to cell surface(GO:2000008)
0.0 0.1 GO:0019509 L-methionine biosynthetic process from methylthioadenosine(GO:0019509)
0.0 0.2 GO:0060750 epithelial cell proliferation involved in mammary gland duct elongation(GO:0060750) branch elongation involved in mammary gland duct branching(GO:0060751)
0.0 2.4 GO:0042113 B cell activation(GO:0042113)
0.0 0.1 GO:0030382 sperm mitochondrion organization(GO:0030382)
0.0 1.5 GO:0007229 integrin-mediated signaling pathway(GO:0007229)
0.0 0.1 GO:0006452 translational frameshifting(GO:0006452) positive regulation of translational elongation(GO:0045901) positive regulation of translational termination(GO:0045905)
0.0 0.1 GO:0010988 regulation of low-density lipoprotein particle clearance(GO:0010988) regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045714) positive regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045716) regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter(GO:0072369)
0.0 0.4 GO:0006611 protein export from nucleus(GO:0006611)
0.0 0.1 GO:0031282 regulation of guanylate cyclase activity(GO:0031282)
0.0 0.3 GO:0032784 regulation of DNA-templated transcription, elongation(GO:0032784)
0.0 0.1 GO:0030422 production of siRNA involved in RNA interference(GO:0030422)
0.0 0.1 GO:0006069 ethanol metabolic process(GO:0006067) ethanol oxidation(GO:0006069)
0.0 0.1 GO:0003416 endochondral bone growth(GO:0003416) growth plate cartilage development(GO:0003417) bone growth(GO:0098868)
0.0 0.1 GO:0045943 positive regulation of transcription from RNA polymerase I promoter(GO:0045943)
0.0 0.1 GO:0002051 osteoblast fate commitment(GO:0002051)
0.0 0.0 GO:0006530 asparagine catabolic process(GO:0006530) asparagine catabolic process via L-aspartate(GO:0033345)
0.0 0.0 GO:0001552 ovarian follicle atresia(GO:0001552)
0.0 0.1 GO:0006562 proline catabolic process(GO:0006562)
0.0 0.3 GO:0002026 regulation of the force of heart contraction(GO:0002026)
0.0 0.3 GO:0071577 zinc II ion transmembrane transport(GO:0071577)
0.0 0.0 GO:0010919 regulation of inositol phosphate biosynthetic process(GO:0010919) positive regulation of inositol phosphate biosynthetic process(GO:0060732)
0.0 0.1 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
0.0 0.1 GO:0002921 negative regulation of humoral immune response(GO:0002921) negative regulation of complement activation(GO:0045916) negative regulation of protein activation cascade(GO:2000258)
0.0 0.1 GO:0090080 positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway(GO:0090080)
0.0 0.1 GO:0006379 mRNA cleavage(GO:0006379)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.1 1.3 GO:0005833 hemoglobin complex(GO:0005833)
0.1 0.5 GO:0019815 immunoglobulin complex(GO:0019814) B cell receptor complex(GO:0019815)
0.1 0.4 GO:0031205 endoplasmic reticulum Sec complex(GO:0031205)
0.1 0.7 GO:0032839 dendrite cytoplasm(GO:0032839)
0.1 0.4 GO:0005827 polar microtubule(GO:0005827)
0.0 0.2 GO:0019718 obsolete rough microsome(GO:0019718)
0.0 0.1 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.0 0.5 GO:0000242 pericentriolar material(GO:0000242)
0.0 0.2 GO:0031304 intrinsic component of mitochondrial inner membrane(GO:0031304)
0.0 0.5 GO:0030122 AP-2 adaptor complex(GO:0030122) clathrin coat of endocytic vesicle(GO:0030128)
0.0 1.0 GO:0005811 lipid particle(GO:0005811)
0.0 0.6 GO:0030057 desmosome(GO:0030057)
0.0 0.3 GO:0005828 kinetochore microtubule(GO:0005828)
0.0 0.3 GO:0032039 integrator complex(GO:0032039)
0.0 0.2 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.0 0.3 GO:0005916 fascia adherens(GO:0005916)
0.0 2.0 GO:0034707 chloride channel complex(GO:0034707)
0.0 0.2 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.0 0.2 GO:0005683 U7 snRNP(GO:0005683)
0.0 0.3 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 0.5 GO:0005861 troponin complex(GO:0005861)
0.0 0.1 GO:0032311 angiogenin-PRI complex(GO:0032311)
0.0 0.9 GO:0098636 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.0 0.1 GO:0005594 collagen type IX trimer(GO:0005594)
0.0 0.3 GO:0031258 lamellipodium membrane(GO:0031258)
0.0 0.1 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0 0.8 GO:0000786 nucleosome(GO:0000786)
0.0 0.9 GO:0030667 secretory granule membrane(GO:0030667)
0.0 0.1 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 0.6 GO:0030018 Z disc(GO:0030018)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.9 GO:0001784 phosphotyrosine binding(GO:0001784)
0.2 0.5 GO:0042610 CD8 receptor binding(GO:0042610)
0.2 0.5 GO:0008200 ion channel inhibitor activity(GO:0008200) channel inhibitor activity(GO:0016248)
0.1 0.4 GO:0008476 protein-tyrosine sulfotransferase activity(GO:0008476)
0.1 1.4 GO:0070053 thrombospondin receptor activity(GO:0070053)
0.1 0.8 GO:0003872 6-phosphofructokinase activity(GO:0003872)
0.1 0.4 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.1 0.4 GO:0005224 ATP-binding and phosphorylation-dependent chloride channel activity(GO:0005224) channel-conductance-controlling ATPase activity(GO:0005260)
0.1 0.5 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.1 0.5 GO:0004852 uroporphyrinogen-III synthase activity(GO:0004852)
0.1 1.0 GO:0031489 myosin V binding(GO:0031489)
0.1 0.4 GO:0004826 phenylalanine-tRNA ligase activity(GO:0004826)
0.1 0.6 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)
0.1 0.6 GO:0030492 hemoglobin binding(GO:0030492)
0.1 1.1 GO:0019864 IgG binding(GO:0019864)
0.1 0.5 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.1 0.3 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.1 1.9 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.1 0.4 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.1 0.7 GO:0004000 adenosine deaminase activity(GO:0004000)
0.1 1.5 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.1 0.6 GO:0005344 oxygen transporter activity(GO:0005344)
0.0 0.2 GO:0047315 kynurenine-glyoxylate transaminase activity(GO:0047315)
0.0 0.2 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0 0.5 GO:0050780 dopamine receptor binding(GO:0050780)
0.0 0.1 GO:0005174 CD40 receptor binding(GO:0005174)
0.0 0.8 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031)
0.0 0.5 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.0 0.3 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0 0.7 GO:0005522 profilin binding(GO:0005522)
0.0 0.2 GO:0016404 15-hydroxyprostaglandin dehydrogenase (NAD+) activity(GO:0016404)
0.0 0.6 GO:0051787 misfolded protein binding(GO:0051787)
0.0 0.2 GO:0005113 patched binding(GO:0005113)
0.0 0.1 GO:0004660 protein farnesyltransferase activity(GO:0004660)
0.0 1.0 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 0.1 GO:0008428 ribonuclease inhibitor activity(GO:0008428)
0.0 0.4 GO:0003993 acid phosphatase activity(GO:0003993)
0.0 0.3 GO:0004568 chitinase activity(GO:0004568)
0.0 0.1 GO:0004024 alcohol dehydrogenase activity, zinc-dependent(GO:0004024)
0.0 0.2 GO:0030955 potassium ion binding(GO:0030955)
0.0 0.5 GO:0045295 gamma-catenin binding(GO:0045295)
0.0 0.1 GO:0015185 gamma-aminobutyric acid:sodium symporter activity(GO:0005332) gamma-aminobutyric acid transmembrane transporter activity(GO:0015185)
0.0 0.2 GO:0016681 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0 0.2 GO:0061659 ubiquitin-ubiquitin ligase activity(GO:0034450) ubiquitin protein ligase activity(GO:0061630) ubiquitin-like protein ligase activity(GO:0061659)
0.0 0.5 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.0 0.2 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634)
0.0 0.4 GO:0030332 cyclin binding(GO:0030332)
0.0 0.3 GO:0003711 obsolete transcription elongation regulator activity(GO:0003711)
0.0 0.1 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.0 0.1 GO:0004657 proline dehydrogenase activity(GO:0004657)
0.0 0.1 GO:0008048 calcium sensitive guanylate cyclase activator activity(GO:0008048)
0.0 0.2 GO:0030284 estrogen receptor activity(GO:0030284) estrogen response element binding(GO:0034056)
0.0 0.4 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 0.1 GO:0008113 peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.0 0.4 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.0 0.5 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 0.6 GO:0016831 carboxy-lyase activity(GO:0016831)
0.0 0.1 GO:0030020 extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.0 0.2 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.3 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.3 GO:0070491 repressing transcription factor binding(GO:0070491)
0.0 0.2 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.1 GO:0008107 galactoside 2-alpha-L-fucosyltransferase activity(GO:0008107) alpha-(1,2)-fucosyltransferase activity(GO:0031127)
0.0 0.2 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 0.8 GO:0003743 translation initiation factor activity(GO:0003743)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.3 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes