Motif ID: NKX2-4
Z-value: 0.882
Transcription factors associated with NKX2-4:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
NKX2-4 | ENSG00000125816.4 | NKX2-4 |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.2 | 0.7 | GO:0002901 | mature B cell apoptotic process(GO:0002901) regulation of mature B cell apoptotic process(GO:0002905) negative regulation of mature B cell apoptotic process(GO:0002906) purine nucleotide salvage(GO:0032261) nucleotide salvage(GO:0043173) inosine metabolic process(GO:0046102) xanthine metabolic process(GO:0046110) |
0.2 | 0.6 | GO:0002541 | activation of plasma proteins involved in acute inflammatory response(GO:0002541) |
0.2 | 1.0 | GO:0043316 | natural killer cell activation involved in immune response(GO:0002323) cytotoxic T cell degranulation(GO:0043316) natural killer cell degranulation(GO:0043320) |
0.2 | 0.5 | GO:0043366 | beta selection(GO:0043366) |
0.2 | 0.5 | GO:0097237 | response to cobalt ion(GO:0032025) cellular response to antibiotic(GO:0071236) cellular response to toxic substance(GO:0097237) |
0.1 | 0.4 | GO:0006478 | peptidyl-tyrosine sulfation(GO:0006478) |
0.1 | 0.4 | GO:0006432 | phenylalanyl-tRNA aminoacylation(GO:0006432) |
0.1 | 0.5 | GO:0044854 | membrane raft assembly(GO:0001765) plasma membrane raft assembly(GO:0044854) plasma membrane raft organization(GO:0044857) positive regulation of dopamine receptor signaling pathway(GO:0060161) caveola assembly(GO:0070836) membrane assembly(GO:0071709) |
0.1 | 0.5 | GO:0050862 | positive regulation of T cell receptor signaling pathway(GO:0050862) |
0.1 | 0.5 | GO:0032780 | negative regulation of ATPase activity(GO:0032780) |
0.1 | 0.4 | GO:0051013 | microtubule severing(GO:0051013) |
0.1 | 0.4 | GO:0060025 | regulation of synaptic activity(GO:0060025) |
0.1 | 0.4 | GO:0001831 | trophectodermal cellular morphogenesis(GO:0001831) |
0.1 | 0.4 | GO:0032929 | negative regulation of superoxide anion generation(GO:0032929) |
0.1 | 0.4 | GO:0008588 | release of cytoplasmic sequestered NF-kappaB(GO:0008588) |
0.1 | 0.4 | GO:0015693 | magnesium ion transport(GO:0015693) |
0.1 | 0.8 | GO:0006002 | fructose 6-phosphate metabolic process(GO:0006002) |
0.1 | 0.3 | GO:1902414 | protein localization to adherens junction(GO:0071896) protein localization to cell junction(GO:1902414) |
0.1 | 0.2 | GO:0045938 | regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) positive regulation of circadian sleep/wake cycle, sleep(GO:0045938) |
0.1 | 0.4 | GO:0043615 | astrocyte cell migration(GO:0043615) |
0.1 | 0.2 | GO:0018243 | protein O-linked glycosylation via serine(GO:0018242) protein O-linked glycosylation via threonine(GO:0018243) |
0.1 | 0.6 | GO:0015937 | coenzyme A biosynthetic process(GO:0015937) |
0.1 | 0.7 | GO:0020027 | hemoglobin metabolic process(GO:0020027) |
0.1 | 0.3 | GO:0006177 | GMP biosynthetic process(GO:0006177) |
0.0 | 0.1 | GO:0070171 | negative regulation of tooth mineralization(GO:0070171) |
0.0 | 0.3 | GO:0060219 | camera-type eye photoreceptor cell differentiation(GO:0060219) |
0.0 | 0.2 | GO:0046037 | GMP metabolic process(GO:0046037) |
0.0 | 0.3 | GO:0007499 | ectoderm and mesoderm interaction(GO:0007499) |
0.0 | 0.7 | GO:0046827 | positive regulation of protein export from nucleus(GO:0046827) |
0.0 | 0.1 | GO:0009992 | cellular water homeostasis(GO:0009992) |
0.0 | 0.4 | GO:0015705 | iodide transport(GO:0015705) |
0.0 | 0.1 | GO:0050942 | positive regulation of melanocyte differentiation(GO:0045636) positive regulation of pigment cell differentiation(GO:0050942) |
0.0 | 0.2 | GO:0010447 | response to acidic pH(GO:0010447) |
0.0 | 0.2 | GO:0006122 | mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122) |
0.0 | 0.2 | GO:0031580 | membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580) |
0.0 | 0.1 | GO:0019056 | modulation by virus of host transcription(GO:0019056) regulation of sprouting of injured axon(GO:0048686) positive regulation of sprouting of injured axon(GO:0048687) regulation of axon extension involved in regeneration(GO:0048690) positive regulation of axon extension involved in regeneration(GO:0048691) modulation by symbiont of host transcription(GO:0052026) |
0.0 | 0.2 | GO:0042866 | pyruvate biosynthetic process(GO:0042866) |
0.0 | 0.4 | GO:0016180 | snRNA processing(GO:0016180) |
0.0 | 0.1 | GO:1904037 | positive regulation of epithelial cell apoptotic process(GO:1904037) positive regulation of endothelial cell apoptotic process(GO:2000353) |
0.0 | 0.5 | GO:0048268 | negative regulation of receptor-mediated endocytosis(GO:0048261) clathrin coat assembly(GO:0048268) |
0.0 | 0.5 | GO:0007128 | meiotic prophase I(GO:0007128) |
0.0 | 0.3 | GO:0007258 | JUN phosphorylation(GO:0007258) |
0.0 | 0.2 | GO:0033119 | negative regulation of RNA splicing(GO:0033119) |
0.0 | 0.1 | GO:0042118 | endothelial cell activation(GO:0042118) |
0.0 | 0.3 | GO:0006030 | chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032) |
0.0 | 1.9 | GO:0006821 | chloride transport(GO:0006821) |
0.0 | 0.1 | GO:0001550 | ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165) |
0.0 | 0.2 | GO:0019372 | lipoxygenase pathway(GO:0019372) |
0.0 | 0.8 | GO:0033209 | tumor necrosis factor-mediated signaling pathway(GO:0033209) |
0.0 | 0.6 | GO:0050853 | B cell receptor signaling pathway(GO:0050853) |
0.0 | 0.3 | GO:0033261 | obsolete regulation of S phase(GO:0033261) |
0.0 | 0.2 | GO:0070189 | kynurenine metabolic process(GO:0070189) |
0.0 | 0.2 | GO:1901984 | negative regulation of histone acetylation(GO:0035067) negative regulation of protein acetylation(GO:1901984) negative regulation of peptidyl-lysine acetylation(GO:2000757) |
0.0 | 0.4 | GO:0030252 | growth hormone secretion(GO:0030252) |
0.0 | 0.1 | GO:0042769 | DNA damage response, detection of DNA damage(GO:0042769) |
0.0 | 0.1 | GO:0018343 | protein farnesylation(GO:0018343) |
0.0 | 0.5 | GO:0050892 | intestinal absorption(GO:0050892) |
0.0 | 0.1 | GO:0015722 | canalicular bile acid transport(GO:0015722) |
0.0 | 0.3 | GO:0007096 | regulation of exit from mitosis(GO:0007096) |
0.0 | 0.1 | GO:0045003 | DNA recombinase assembly(GO:0000730) double-strand break repair via synthesis-dependent strand annealing(GO:0045003) |
0.0 | 0.1 | GO:2000008 | regulation of protein localization to cell surface(GO:2000008) |
0.0 | 0.1 | GO:0019509 | L-methionine biosynthetic process from methylthioadenosine(GO:0019509) |
0.0 | 0.2 | GO:0060750 | epithelial cell proliferation involved in mammary gland duct elongation(GO:0060750) branch elongation involved in mammary gland duct branching(GO:0060751) |
0.0 | 2.4 | GO:0042113 | B cell activation(GO:0042113) |
0.0 | 0.1 | GO:0030382 | sperm mitochondrion organization(GO:0030382) |
0.0 | 1.5 | GO:0007229 | integrin-mediated signaling pathway(GO:0007229) |
0.0 | 0.1 | GO:0006452 | translational frameshifting(GO:0006452) positive regulation of translational elongation(GO:0045901) positive regulation of translational termination(GO:0045905) |
0.0 | 0.1 | GO:0010988 | regulation of low-density lipoprotein particle clearance(GO:0010988) regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045714) positive regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045716) regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter(GO:0072369) |
0.0 | 0.4 | GO:0006611 | protein export from nucleus(GO:0006611) |
0.0 | 0.1 | GO:0031282 | regulation of guanylate cyclase activity(GO:0031282) |
0.0 | 0.3 | GO:0032784 | regulation of DNA-templated transcription, elongation(GO:0032784) |
0.0 | 0.1 | GO:0030422 | production of siRNA involved in RNA interference(GO:0030422) |
0.0 | 0.1 | GO:0006069 | ethanol metabolic process(GO:0006067) ethanol oxidation(GO:0006069) |
0.0 | 0.1 | GO:0003416 | endochondral bone growth(GO:0003416) growth plate cartilage development(GO:0003417) bone growth(GO:0098868) |
0.0 | 0.1 | GO:0045943 | positive regulation of transcription from RNA polymerase I promoter(GO:0045943) |
0.0 | 0.1 | GO:0002051 | osteoblast fate commitment(GO:0002051) |
0.0 | 0.0 | GO:0006530 | asparagine catabolic process(GO:0006530) asparagine catabolic process via L-aspartate(GO:0033345) |
0.0 | 0.0 | GO:0001552 | ovarian follicle atresia(GO:0001552) |
0.0 | 0.1 | GO:0006562 | proline catabolic process(GO:0006562) |
0.0 | 0.3 | GO:0002026 | regulation of the force of heart contraction(GO:0002026) |
0.0 | 0.3 | GO:0071577 | zinc II ion transmembrane transport(GO:0071577) |
0.0 | 0.0 | GO:0010919 | regulation of inositol phosphate biosynthetic process(GO:0010919) positive regulation of inositol phosphate biosynthetic process(GO:0060732) |
0.0 | 0.1 | GO:0007064 | mitotic sister chromatid cohesion(GO:0007064) |
0.0 | 0.1 | GO:0002921 | negative regulation of humoral immune response(GO:0002921) negative regulation of complement activation(GO:0045916) negative regulation of protein activation cascade(GO:2000258) |
0.0 | 0.1 | GO:0090080 | positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway(GO:0090080) |
0.0 | 0.1 | GO:0006379 | mRNA cleavage(GO:0006379) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 0.8 | GO:0005945 | 6-phosphofructokinase complex(GO:0005945) |
0.1 | 1.3 | GO:0005833 | hemoglobin complex(GO:0005833) |
0.1 | 0.5 | GO:0019815 | immunoglobulin complex(GO:0019814) B cell receptor complex(GO:0019815) |
0.1 | 0.4 | GO:0031205 | endoplasmic reticulum Sec complex(GO:0031205) |
0.1 | 0.7 | GO:0032839 | dendrite cytoplasm(GO:0032839) |
0.1 | 0.4 | GO:0005827 | polar microtubule(GO:0005827) |
0.0 | 0.2 | GO:0019718 | obsolete rough microsome(GO:0019718) |
0.0 | 0.1 | GO:0042622 | photoreceptor outer segment membrane(GO:0042622) |
0.0 | 0.5 | GO:0000242 | pericentriolar material(GO:0000242) |
0.0 | 0.2 | GO:0031304 | intrinsic component of mitochondrial inner membrane(GO:0031304) |
0.0 | 0.5 | GO:0030122 | AP-2 adaptor complex(GO:0030122) clathrin coat of endocytic vesicle(GO:0030128) |
0.0 | 1.0 | GO:0005811 | lipid particle(GO:0005811) |
0.0 | 0.6 | GO:0030057 | desmosome(GO:0030057) |
0.0 | 0.3 | GO:0005828 | kinetochore microtubule(GO:0005828) |
0.0 | 0.3 | GO:0032039 | integrator complex(GO:0032039) |
0.0 | 0.2 | GO:0005750 | mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275) |
0.0 | 0.3 | GO:0005916 | fascia adherens(GO:0005916) |
0.0 | 2.0 | GO:0034707 | chloride channel complex(GO:0034707) |
0.0 | 0.2 | GO:0031095 | platelet dense tubular network membrane(GO:0031095) |
0.0 | 0.2 | GO:0005683 | U7 snRNP(GO:0005683) |
0.0 | 0.3 | GO:0016602 | CCAAT-binding factor complex(GO:0016602) |
0.0 | 0.5 | GO:0005861 | troponin complex(GO:0005861) |
0.0 | 0.1 | GO:0032311 | angiogenin-PRI complex(GO:0032311) |
0.0 | 0.9 | GO:0098636 | integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636) |
0.0 | 0.1 | GO:0005594 | collagen type IX trimer(GO:0005594) |
0.0 | 0.3 | GO:0031258 | lamellipodium membrane(GO:0031258) |
0.0 | 0.1 | GO:0005847 | mRNA cleavage and polyadenylation specificity factor complex(GO:0005847) |
0.0 | 0.8 | GO:0000786 | nucleosome(GO:0000786) |
0.0 | 0.9 | GO:0030667 | secretory granule membrane(GO:0030667) |
0.0 | 0.1 | GO:0046581 | intercellular canaliculus(GO:0046581) |
0.0 | 0.6 | GO:0030018 | Z disc(GO:0030018) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.3 | 1.9 | GO:0001784 | phosphotyrosine binding(GO:0001784) |
0.2 | 0.5 | GO:0042610 | CD8 receptor binding(GO:0042610) |
0.2 | 0.5 | GO:0008200 | ion channel inhibitor activity(GO:0008200) channel inhibitor activity(GO:0016248) |
0.1 | 0.4 | GO:0008476 | protein-tyrosine sulfotransferase activity(GO:0008476) |
0.1 | 1.4 | GO:0070053 | thrombospondin receptor activity(GO:0070053) |
0.1 | 0.8 | GO:0003872 | 6-phosphofructokinase activity(GO:0003872) |
0.1 | 0.4 | GO:0015095 | magnesium ion transmembrane transporter activity(GO:0015095) |
0.1 | 0.4 | GO:0005224 | ATP-binding and phosphorylation-dependent chloride channel activity(GO:0005224) channel-conductance-controlling ATPase activity(GO:0005260) |
0.1 | 0.5 | GO:0032050 | clathrin heavy chain binding(GO:0032050) |
0.1 | 0.5 | GO:0004852 | uroporphyrinogen-III synthase activity(GO:0004852) |
0.1 | 1.0 | GO:0031489 | myosin V binding(GO:0031489) |
0.1 | 0.4 | GO:0004826 | phenylalanine-tRNA ligase activity(GO:0004826) |
0.1 | 0.6 | GO:0008853 | exodeoxyribonuclease III activity(GO:0008853) |
0.1 | 0.6 | GO:0030492 | hemoglobin binding(GO:0030492) |
0.1 | 1.1 | GO:0019864 | IgG binding(GO:0019864) |
0.1 | 0.5 | GO:0019855 | calcium channel inhibitor activity(GO:0019855) |
0.1 | 0.3 | GO:0003938 | IMP dehydrogenase activity(GO:0003938) |
0.1 | 1.9 | GO:0005247 | voltage-gated chloride channel activity(GO:0005247) |
0.1 | 0.4 | GO:0008568 | microtubule-severing ATPase activity(GO:0008568) |
0.1 | 0.7 | GO:0004000 | adenosine deaminase activity(GO:0004000) |
0.1 | 1.5 | GO:0045028 | G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028) |
0.1 | 0.6 | GO:0005344 | oxygen transporter activity(GO:0005344) |
0.0 | 0.2 | GO:0047315 | kynurenine-glyoxylate transaminase activity(GO:0047315) |
0.0 | 0.2 | GO:0005220 | inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220) |
0.0 | 0.5 | GO:0050780 | dopamine receptor binding(GO:0050780) |
0.0 | 0.1 | GO:0005174 | CD40 receptor binding(GO:0005174) |
0.0 | 0.8 | GO:0005031 | tumor necrosis factor-activated receptor activity(GO:0005031) |
0.0 | 0.5 | GO:0008140 | cAMP response element binding protein binding(GO:0008140) |
0.0 | 0.3 | GO:0016909 | JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909) |
0.0 | 0.7 | GO:0005522 | profilin binding(GO:0005522) |
0.0 | 0.2 | GO:0016404 | 15-hydroxyprostaglandin dehydrogenase (NAD+) activity(GO:0016404) |
0.0 | 0.6 | GO:0051787 | misfolded protein binding(GO:0051787) |
0.0 | 0.2 | GO:0005113 | patched binding(GO:0005113) |
0.0 | 0.1 | GO:0004660 | protein farnesyltransferase activity(GO:0004660) |
0.0 | 1.0 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) |
0.0 | 0.1 | GO:0008428 | ribonuclease inhibitor activity(GO:0008428) |
0.0 | 0.4 | GO:0003993 | acid phosphatase activity(GO:0003993) |
0.0 | 0.3 | GO:0004568 | chitinase activity(GO:0004568) |
0.0 | 0.1 | GO:0004024 | alcohol dehydrogenase activity, zinc-dependent(GO:0004024) |
0.0 | 0.2 | GO:0030955 | potassium ion binding(GO:0030955) |
0.0 | 0.5 | GO:0045295 | gamma-catenin binding(GO:0045295) |
0.0 | 0.1 | GO:0015185 | gamma-aminobutyric acid:sodium symporter activity(GO:0005332) gamma-aminobutyric acid transmembrane transporter activity(GO:0015185) |
0.0 | 0.2 | GO:0016681 | ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681) |
0.0 | 0.2 | GO:0061659 | ubiquitin-ubiquitin ligase activity(GO:0034450) ubiquitin protein ligase activity(GO:0061630) ubiquitin-like protein ligase activity(GO:0061659) |
0.0 | 0.5 | GO:0004716 | receptor signaling protein tyrosine kinase activity(GO:0004716) |
0.0 | 0.2 | GO:0016634 | oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634) |
0.0 | 0.4 | GO:0030332 | cyclin binding(GO:0030332) |
0.0 | 0.3 | GO:0003711 | obsolete transcription elongation regulator activity(GO:0003711) |
0.0 | 0.1 | GO:0008020 | G-protein coupled photoreceptor activity(GO:0008020) |
0.0 | 0.1 | GO:0004657 | proline dehydrogenase activity(GO:0004657) |
0.0 | 0.1 | GO:0008048 | calcium sensitive guanylate cyclase activator activity(GO:0008048) |
0.0 | 0.2 | GO:0030284 | estrogen receptor activity(GO:0030284) estrogen response element binding(GO:0034056) |
0.0 | 0.4 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
0.0 | 0.1 | GO:0008113 | peptide-methionine (S)-S-oxide reductase activity(GO:0008113) |
0.0 | 0.4 | GO:0005487 | nucleocytoplasmic transporter activity(GO:0005487) |
0.0 | 0.5 | GO:0003725 | double-stranded RNA binding(GO:0003725) |
0.0 | 0.6 | GO:0016831 | carboxy-lyase activity(GO:0016831) |
0.0 | 0.1 | GO:0030020 | extracellular matrix structural constituent conferring tensile strength(GO:0030020) |
0.0 | 0.2 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
0.0 | 0.3 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
0.0 | 0.3 | GO:0070491 | repressing transcription factor binding(GO:0070491) |
0.0 | 0.2 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
0.0 | 0.1 | GO:0008107 | galactoside 2-alpha-L-fucosyltransferase activity(GO:0008107) alpha-(1,2)-fucosyltransferase activity(GO:0031127) |
0.0 | 0.2 | GO:0071855 | neuropeptide receptor binding(GO:0071855) |
0.0 | 0.8 | GO:0003743 | translation initiation factor activity(GO:0003743) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.0 | 1.3 | SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES | Genes related to PIP3 signaling in B lymphocytes |