Motif ID: NKX2-5
Z-value: 0.695
Transcription factors associated with NKX2-5:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
NKX2-5 | ENSG00000183072.9 | NKX2-5 |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.3 | 1.0 | GO:0019886 | antigen processing and presentation of exogenous peptide antigen via MHC class II(GO:0019886) |
0.1 | 1.2 | GO:0007130 | synaptonemal complex assembly(GO:0007130) |
0.1 | 0.4 | GO:0006663 | platelet activating factor biosynthetic process(GO:0006663) positive regulation of vesicle fusion(GO:0031340) regulation of prostaglandin biosynthetic process(GO:0031392) positive regulation of prostaglandin biosynthetic process(GO:0031394) regulation of unsaturated fatty acid biosynthetic process(GO:2001279) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280) |
0.1 | 0.5 | GO:0045722 | positive regulation of gluconeogenesis(GO:0045722) |
0.1 | 0.3 | GO:0002331 | immature B cell differentiation(GO:0002327) pre-B cell differentiation(GO:0002329) pre-B cell allelic exclusion(GO:0002331) |
0.1 | 0.2 | GO:0006655 | phosphatidylglycerol biosynthetic process(GO:0006655) cardiolipin metabolic process(GO:0032048) cardiolipin biosynthetic process(GO:0032049) phosphatidylglycerol metabolic process(GO:0046471) |
0.1 | 0.5 | GO:0034638 | phosphatidylcholine catabolic process(GO:0034638) |
0.1 | 0.4 | GO:0060665 | regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665) |
0.0 | 0.4 | GO:0046831 | regulation of RNA export from nucleus(GO:0046831) |
0.0 | 0.2 | GO:0090224 | regulation of spindle organization(GO:0090224) |
0.0 | 0.1 | GO:0048670 | regulation of collateral sprouting(GO:0048670) |
0.0 | 0.3 | GO:0006013 | mannose metabolic process(GO:0006013) |
0.0 | 0.5 | GO:0046827 | positive regulation of protein export from nucleus(GO:0046827) |
0.0 | 0.1 | GO:0021896 | forebrain astrocyte differentiation(GO:0021896) forebrain astrocyte development(GO:0021897) |
0.0 | 0.5 | GO:0050930 | induction of positive chemotaxis(GO:0050930) |
0.0 | 0.1 | GO:0060454 | positive regulation of gastric acid secretion(GO:0060454) regulation of establishment of blood-brain barrier(GO:0090210) negative regulation of establishment of blood-brain barrier(GO:0090212) |
0.0 | 0.2 | GO:0031639 | plasminogen activation(GO:0031639) |
0.0 | 0.1 | GO:0006857 | oligopeptide transport(GO:0006857) |
0.0 | 0.1 | GO:0050957 | equilibrioception(GO:0050957) |
0.0 | 0.4 | GO:0016601 | Rac protein signal transduction(GO:0016601) |
0.0 | 0.2 | GO:1900087 | traversing start control point of mitotic cell cycle(GO:0007089) positive regulation of G1/S transition of mitotic cell cycle(GO:1900087) positive regulation of cell cycle G1/S phase transition(GO:1902808) |
0.0 | 0.1 | GO:0050765 | negative regulation of phagocytosis(GO:0050765) |
0.0 | 0.1 | GO:0048627 | myoblast development(GO:0048627) |
0.0 | 0.1 | GO:0032020 | ISG15-protein conjugation(GO:0032020) |
0.0 | 0.1 | GO:0008628 | hormone-mediated apoptotic signaling pathway(GO:0008628) |
0.0 | 0.1 | GO:0007498 | mesoderm development(GO:0007498) |
0.0 | 0.8 | GO:0042632 | cholesterol homeostasis(GO:0042632) sterol homeostasis(GO:0055092) |
0.0 | 0.3 | GO:0006891 | intra-Golgi vesicle-mediated transport(GO:0006891) retrograde transport, endosome to Golgi(GO:0042147) |
0.0 | 0.1 | GO:0060155 | platelet dense granule organization(GO:0060155) |
0.0 | 0.1 | GO:0009450 | gamma-aminobutyric acid catabolic process(GO:0009450) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.4 | 1.2 | GO:0000802 | transverse filament(GO:0000802) |
0.1 | 0.2 | GO:0000806 | Y chromosome(GO:0000806) |
0.0 | 1.0 | GO:0042613 | MHC class II protein complex(GO:0042613) |
0.0 | 0.4 | GO:0042588 | zymogen granule(GO:0042588) |
0.0 | 0.1 | GO:0042629 | mast cell granule(GO:0042629) |
0.0 | 0.2 | GO:0070652 | HAUS complex(GO:0070652) |
0.0 | 0.8 | GO:0005791 | rough endoplasmic reticulum(GO:0005791) |
0.0 | 0.1 | GO:0032144 | 4-aminobutyrate transaminase complex(GO:0032144) |
0.0 | 0.2 | GO:0042555 | MCM complex(GO:0042555) |
0.0 | 0.3 | GO:0031201 | SNARE complex(GO:0031201) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.3 | 1.0 | GO:0042289 | MHC class II protein binding(GO:0042289) |
0.2 | 0.5 | GO:0047391 | alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391) |
0.1 | 0.3 | GO:0004476 | mannose-6-phosphate isomerase activity(GO:0004476) |
0.1 | 0.3 | GO:0004677 | DNA-dependent protein kinase activity(GO:0004677) |
0.1 | 0.4 | GO:0008486 | diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) |
0.1 | 0.2 | GO:0050613 | delta14-sterol reductase activity(GO:0050613) |
0.1 | 0.2 | GO:0032183 | SUMO binding(GO:0032183) |
0.0 | 0.4 | GO:0047498 | calcium-dependent phospholipase A2 activity(GO:0047498) |
0.0 | 0.1 | GO:0042910 | xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910) |
0.0 | 0.5 | GO:0005522 | profilin binding(GO:0005522) |
0.0 | 0.1 | GO:0042296 | ISG15 transferase activity(GO:0042296) |
0.0 | 0.5 | GO:0005095 | GTPase inhibitor activity(GO:0005095) |
0.0 | 0.2 | GO:0004457 | lactate dehydrogenase activity(GO:0004457) L-lactate dehydrogenase activity(GO:0004459) |
0.0 | 0.1 | GO:0016509 | long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0016509) |
0.0 | 0.2 | GO:0042605 | peptide antigen binding(GO:0042605) |
0.0 | 0.1 | GO:0032145 | 4-aminobutyrate transaminase activity(GO:0003867) succinate-semialdehyde dehydrogenase binding(GO:0032145) (S)-3-amino-2-methylpropionate transaminase activity(GO:0047298) |
0.0 | 0.1 | GO:0015185 | gamma-aminobutyric acid:sodium symporter activity(GO:0005332) gamma-aminobutyric acid transmembrane transporter activity(GO:0015185) |
0.0 | 0.1 | GO:0035673 | oligopeptide transmembrane transporter activity(GO:0035673) |
0.0 | 0.2 | GO:0016409 | palmitoyltransferase activity(GO:0016409) |
0.0 | 0.1 | GO:0016802 | adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802) |
0.0 | 0.3 | GO:0005484 | SNAP receptor activity(GO:0005484) |
0.0 | 0.2 | GO:0035173 | histone kinase activity(GO:0035173) |
0.0 | 0.1 | GO:0050811 | GABA receptor binding(GO:0050811) |
0.0 | 0.1 | GO:0015057 | thrombin receptor activity(GO:0015057) |
0.0 | 0.2 | GO:0004623 | phospholipase A2 activity(GO:0004623) |