Motif ID: NKX3-1
Z-value: 1.807
Transcription factors associated with NKX3-1:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
NKX3-1 | ENSG00000167034.9 | NKX3-1 |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.1 | 6.3 | GO:0007499 | ectoderm and mesoderm interaction(GO:0007499) |
0.6 | 2.8 | GO:0051611 | negative regulation of neurotransmitter uptake(GO:0051581) negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495) |
0.5 | 2.1 | GO:0006663 | platelet activating factor biosynthetic process(GO:0006663) positive regulation of vesicle fusion(GO:0031340) regulation of prostaglandin biosynthetic process(GO:0031392) positive regulation of prostaglandin biosynthetic process(GO:0031394) regulation of unsaturated fatty acid biosynthetic process(GO:2001279) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280) |
0.5 | 3.1 | GO:0006931 | substrate-dependent cell migration, cell attachment to substrate(GO:0006931) |
0.4 | 2.8 | GO:0016255 | attachment of GPI anchor to protein(GO:0016255) |
0.3 | 1.9 | GO:0060242 | contact inhibition(GO:0060242) |
0.2 | 1.2 | GO:0021535 | cell migration in hindbrain(GO:0021535) |
0.2 | 0.7 | GO:0019046 | release from viral latency(GO:0019046) |
0.1 | 0.3 | GO:0048670 | regulation of collateral sprouting(GO:0048670) |
0.1 | 0.4 | GO:0007028 | cytoplasm organization(GO:0007028) ribonucleoprotein complex disassembly(GO:0032988) |
0.1 | 2.1 | GO:0060391 | positive regulation of SMAD protein import into nucleus(GO:0060391) |
0.1 | 0.4 | GO:0006982 | response to lipid hydroperoxide(GO:0006982) |
0.1 | 0.7 | GO:0006011 | UDP-glucose metabolic process(GO:0006011) UDP-glucuronate biosynthetic process(GO:0006065) |
0.1 | 0.4 | GO:0009609 | response to symbiont(GO:0009608) response to symbiotic bacterium(GO:0009609) |
0.1 | 1.0 | GO:0019885 | antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885) |
0.1 | 0.6 | GO:0022614 | membrane to membrane docking(GO:0022614) |
0.1 | 6.7 | GO:0030521 | androgen receptor signaling pathway(GO:0030521) |
0.1 | 3.4 | GO:0030837 | negative regulation of actin filament polymerization(GO:0030837) |
0.1 | 0.3 | GO:0051877 | pigment granule aggregation in cell center(GO:0051877) |
0.1 | 1.7 | GO:0031424 | keratinization(GO:0031424) |
0.1 | 0.4 | GO:0006610 | ribosomal protein import into nucleus(GO:0006610) |
0.0 | 0.9 | GO:0007520 | myoblast fusion(GO:0007520) |
0.0 | 0.6 | GO:0097031 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
0.0 | 2.4 | GO:0007193 | adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway(GO:0007193) |
0.0 | 0.2 | GO:0070995 | NADPH oxidation(GO:0070995) |
0.0 | 0.3 | GO:0019614 | phenol-containing compound catabolic process(GO:0019336) catechol-containing compound catabolic process(GO:0019614) catecholamine catabolic process(GO:0042424) |
0.0 | 0.3 | GO:0044818 | mitotic G2/M transition checkpoint(GO:0044818) protein neddylation(GO:0045116) |
0.0 | 0.3 | GO:0009249 | protein lipoylation(GO:0009249) |
0.0 | 0.1 | GO:0051958 | methotrexate transport(GO:0051958) |
0.0 | 0.2 | GO:0006422 | aspartyl-tRNA aminoacylation(GO:0006422) |
0.0 | 1.6 | GO:0006308 | DNA catabolic process(GO:0006308) |
0.0 | 0.5 | GO:0016601 | Rac protein signal transduction(GO:0016601) |
0.0 | 0.2 | GO:0006346 | methylation-dependent chromatin silencing(GO:0006346) |
0.0 | 0.5 | GO:0007128 | meiotic prophase I(GO:0007128) |
0.0 | 0.5 | GO:0019369 | arachidonic acid metabolic process(GO:0019369) |
0.0 | 0.6 | GO:0007271 | synaptic transmission, cholinergic(GO:0007271) |
0.0 | 2.3 | GO:0007229 | integrin-mediated signaling pathway(GO:0007229) |
0.0 | 0.4 | GO:0042403 | thyroid hormone metabolic process(GO:0042403) |
0.0 | 0.1 | GO:1902414 | protein localization to adherens junction(GO:0071896) protein localization to cell junction(GO:1902414) |
0.0 | 0.7 | GO:0006887 | exocytosis(GO:0006887) |
0.0 | 0.3 | GO:0006968 | cellular defense response(GO:0006968) |
0.0 | 0.3 | GO:0021513 | spinal cord dorsal/ventral patterning(GO:0021513) |
0.0 | 0.8 | GO:0000188 | inactivation of MAPK activity(GO:0000188) |
0.0 | 0.5 | GO:0048168 | regulation of neuronal synaptic plasticity(GO:0048168) |
0.0 | 0.4 | GO:0051865 | protein autoubiquitination(GO:0051865) |
0.0 | 2.2 | GO:0010951 | negative regulation of endopeptidase activity(GO:0010951) |
0.0 | 0.7 | GO:0070979 | protein K11-linked ubiquitination(GO:0070979) |
0.0 | 0.3 | GO:0034199 | activation of protein kinase A activity(GO:0034199) |
0.0 | 0.5 | GO:0042733 | embryonic digit morphogenesis(GO:0042733) |
0.0 | 0.3 | GO:0019933 | cAMP-mediated signaling(GO:0019933) |
0.0 | 0.1 | GO:0002862 | negative regulation of inflammatory response to antigenic stimulus(GO:0002862) |
0.0 | 0.1 | GO:0006122 | mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122) |
0.0 | 0.2 | GO:0006657 | CDP-choline pathway(GO:0006657) |
0.0 | 1.1 | GO:0030814 | regulation of cAMP metabolic process(GO:0030814) |
0.0 | 0.1 | GO:0042693 | muscle cell fate commitment(GO:0042693) |
0.0 | 0.1 | GO:0071478 | cellular response to radiation(GO:0071478) |
0.0 | 0.1 | GO:0060218 | hematopoietic stem cell differentiation(GO:0060218) |
0.0 | 0.5 | GO:0032480 | negative regulation of type I interferon production(GO:0032480) |
0.0 | 0.8 | GO:0006921 | cellular component disassembly involved in execution phase of apoptosis(GO:0006921) execution phase of apoptosis(GO:0097194) |
0.0 | 2.1 | GO:0006470 | protein dephosphorylation(GO:0006470) |
0.0 | 0.3 | GO:0008299 | isoprenoid biosynthetic process(GO:0008299) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.4 | 3.1 | GO:0005593 | FACIT collagen trimer(GO:0005593) |
0.2 | 1.9 | GO:0005587 | collagen type IV trimer(GO:0005587) |
0.1 | 2.8 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
0.1 | 2.1 | GO:0042588 | zymogen granule(GO:0042588) |
0.1 | 0.7 | GO:0000145 | exocyst(GO:0000145) |
0.1 | 1.8 | GO:0001533 | cornified envelope(GO:0001533) |
0.1 | 0.2 | GO:0042765 | GPI-anchor transamidase complex(GO:0042765) |
0.1 | 0.7 | GO:0048188 | Set1C/COMPASS complex(GO:0048188) |
0.1 | 2.7 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
0.0 | 0.2 | GO:0005602 | complement component C1 complex(GO:0005602) |
0.0 | 0.6 | GO:0031254 | uropod(GO:0001931) cell trailing edge(GO:0031254) |
0.0 | 1.0 | GO:0098644 | complex of collagen trimers(GO:0098644) |
0.0 | 3.6 | GO:0030136 | clathrin-coated vesicle(GO:0030136) |
0.0 | 0.3 | GO:0060170 | BBSome(GO:0034464) ciliary membrane(GO:0060170) |
0.0 | 0.4 | GO:0035253 | ciliary rootlet(GO:0035253) |
0.0 | 3.5 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
0.0 | 0.3 | GO:0043202 | lysosomal lumen(GO:0043202) |
0.0 | 3.1 | GO:0001726 | ruffle(GO:0001726) |
0.0 | 0.5 | GO:0016281 | eukaryotic translation initiation factor 4F complex(GO:0016281) |
0.0 | 0.7 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
0.0 | 0.7 | GO:0005680 | anaphase-promoting complex(GO:0005680) |
0.0 | 0.2 | GO:0030897 | HOPS complex(GO:0030897) |
0.0 | 0.2 | GO:0005790 | smooth endoplasmic reticulum(GO:0005790) |
0.0 | 0.9 | GO:0005625 | obsolete soluble fraction(GO:0005625) |
0.0 | 1.0 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
0.0 | 1.3 | GO:0016363 | nuclear matrix(GO:0016363) |
0.0 | 0.1 | GO:0030131 | clathrin adaptor complex(GO:0030131) |
0.0 | 0.3 | GO:0042612 | MHC class I protein complex(GO:0042612) |
0.0 | 0.5 | GO:0055037 | recycling endosome(GO:0055037) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.9 | 2.6 | GO:0030377 | urokinase plasminogen activator receptor activity(GO:0030377) |
0.6 | 2.8 | GO:0060961 | phospholipase D inhibitor activity(GO:0060961) |
0.5 | 1.8 | GO:0008112 | nicotinamide N-methyltransferase activity(GO:0008112) pyridine N-methyltransferase activity(GO:0030760) |
0.4 | 2.1 | GO:0008330 | protein tyrosine/threonine phosphatase activity(GO:0008330) |
0.4 | 2.4 | GO:0031821 | G-protein coupled serotonin receptor binding(GO:0031821) |
0.2 | 0.7 | GO:0003983 | UTP:glucose-1-phosphate uridylyltransferase activity(GO:0003983) UTP-monosaccharide-1-phosphate uridylyltransferase activity(GO:0051748) |
0.2 | 6.8 | GO:0050699 | WW domain binding(GO:0050699) |
0.2 | 2.1 | GO:0047498 | calcium-dependent phospholipase A2 activity(GO:0047498) |
0.1 | 0.9 | GO:0010859 | calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859) |
0.1 | 2.7 | GO:0008143 | poly(A) binding(GO:0008143) |
0.1 | 1.2 | GO:0017154 | semaphorin receptor activity(GO:0017154) |
0.1 | 1.6 | GO:0016888 | endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888) |
0.1 | 0.8 | GO:0016290 | palmitoyl-CoA hydrolase activity(GO:0016290) |
0.1 | 1.9 | GO:0070064 | proline-rich region binding(GO:0070064) |
0.1 | 1.1 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
0.1 | 0.2 | GO:0003923 | GPI-anchor transamidase activity(GO:0003923) |
0.0 | 0.6 | GO:0004128 | cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128) |
0.0 | 0.3 | GO:0016206 | catechol O-methyltransferase activity(GO:0016206) |
0.0 | 0.8 | GO:0004602 | glutathione peroxidase activity(GO:0004602) |
0.0 | 0.5 | GO:0050780 | dopamine receptor binding(GO:0050780) |
0.0 | 3.6 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
0.0 | 0.1 | GO:0015350 | methotrexate transporter activity(GO:0015350) |
0.0 | 0.5 | GO:0000339 | RNA cap binding(GO:0000339) |
0.0 | 0.5 | GO:0005522 | profilin binding(GO:0005522) |
0.0 | 3.6 | GO:0005178 | integrin binding(GO:0005178) |
0.0 | 0.2 | GO:0004105 | choline-phosphate cytidylyltransferase activity(GO:0004105) |
0.0 | 0.2 | GO:0004815 | aspartate-tRNA ligase activity(GO:0004815) |
0.0 | 0.4 | GO:0004062 | aryl sulfotransferase activity(GO:0004062) |
0.0 | 0.4 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
0.0 | 0.2 | GO:0008253 | 5'-nucleotidase activity(GO:0008253) |
0.0 | 0.9 | GO:0051539 | 4 iron, 4 sulfur cluster binding(GO:0051539) |
0.0 | 0.5 | GO:0070330 | aromatase activity(GO:0070330) |
0.0 | 0.7 | GO:0030552 | cAMP binding(GO:0030552) |
0.0 | 0.3 | GO:0008641 | small protein activating enzyme activity(GO:0008641) |
0.0 | 0.2 | GO:0050682 | AF-2 domain binding(GO:0050682) |
0.0 | 0.2 | GO:0050811 | GABA receptor binding(GO:0050811) |
0.0 | 1.9 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
0.0 | 0.6 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) |
0.0 | 0.2 | GO:0004499 | N,N-dimethylaniline monooxygenase activity(GO:0004499) |
0.0 | 0.2 | GO:0048531 | beta-1,3-galactosyltransferase activity(GO:0048531) |
0.0 | 0.2 | GO:0015301 | anion:anion antiporter activity(GO:0015301) |
0.0 | 0.3 | GO:0008373 | sialyltransferase activity(GO:0008373) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 0.8 | ST_IL_13_PATHWAY | Interleukin 13 (IL-13) Pathway |
0.1 | 2.4 | ST_MYOCYTE_AD_PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |