Motif ID: NKX6-2
Z-value: 1.164
Transcription factors associated with NKX6-2:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| NKX6-2 | ENSG00000148826.6 | NKX6-2 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 2.6 | GO:0021836 | chemorepulsion involved in postnatal olfactory bulb interneuron migration(GO:0021836) regulation of negative chemotaxis(GO:0050923) |
| 0.4 | 1.3 | GO:0007412 | axon target recognition(GO:0007412) |
| 0.2 | 0.7 | GO:0001907 | cytolysis by symbiont of host cells(GO:0001897) killing by symbiont of host cells(GO:0001907) hemolysis by symbiont of host erythrocytes(GO:0019836) disruption by symbiont of host cell(GO:0044004) hemolysis in other organism(GO:0044179) positive regulation of circadian sleep/wake cycle, non-REM sleep(GO:0046010) cytolysis in other organism(GO:0051715) cytolysis in other organism involved in symbiotic interaction(GO:0051801) hemolysis in other organism involved in symbiotic interaction(GO:0052331) |
| 0.1 | 0.6 | GO:0015917 | aminophospholipid transport(GO:0015917) |
| 0.1 | 0.8 | GO:0043569 | negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569) |
| 0.1 | 0.5 | GO:0032509 | endosome transport via multivesicular body sorting pathway(GO:0032509) plasma membrane to endosome transport(GO:0048227) |
| 0.1 | 0.7 | GO:0018345 | protein palmitoylation(GO:0018345) |
| 0.1 | 0.7 | GO:0060325 | face morphogenesis(GO:0060325) |
| 0.1 | 0.3 | GO:0071400 | cellular response to oleic acid(GO:0071400) |
| 0.1 | 0.4 | GO:0006216 | cytidine catabolic process(GO:0006216) cytidine deamination(GO:0009972) cytidine metabolic process(GO:0046087) |
| 0.1 | 0.6 | GO:0007185 | transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185) |
| 0.1 | 0.4 | GO:0045722 | response to muscle activity(GO:0014850) positive regulation of gluconeogenesis(GO:0045722) |
| 0.1 | 0.6 | GO:0015074 | DNA integration(GO:0015074) |
| 0.1 | 1.2 | GO:0031000 | response to caffeine(GO:0031000) |
| 0.0 | 0.7 | GO:0046697 | decidualization(GO:0046697) |
| 0.0 | 0.2 | GO:0015824 | proline transport(GO:0015824) |
| 0.0 | 0.1 | GO:0010837 | regulation of keratinocyte proliferation(GO:0010837) |
| 0.0 | 0.1 | GO:0015722 | canalicular bile acid transport(GO:0015722) |
| 0.0 | 0.4 | GO:0071230 | cellular response to amino acid stimulus(GO:0071230) |
| 0.0 | 0.7 | GO:0042147 | retrograde transport, endosome to Golgi(GO:0042147) |
| 0.0 | 0.4 | GO:0006906 | vesicle fusion(GO:0006906) |
| 0.0 | 0.3 | GO:0019228 | neuronal action potential(GO:0019228) |
| 0.0 | 0.1 | GO:0060025 | regulation of synaptic activity(GO:0060025) |
| 0.0 | 0.4 | GO:0043508 | negative regulation of JUN kinase activity(GO:0043508) |
| 0.0 | 0.1 | GO:0048669 | collateral sprouting in absence of injury(GO:0048669) |
| 0.0 | 0.6 | GO:0030866 | cortical actin cytoskeleton organization(GO:0030866) |
| 0.0 | 0.1 | GO:0006422 | aspartyl-tRNA aminoacylation(GO:0006422) |
| 0.0 | 0.3 | GO:0045123 | cellular extravasation(GO:0045123) |
| 0.0 | 0.3 | GO:0060736 | prostate gland growth(GO:0060736) |
| 0.0 | 0.3 | GO:0007128 | meiotic prophase I(GO:0007128) |
| 0.0 | 0.3 | GO:0007398 | ectoderm development(GO:0007398) |
| 0.0 | 3.8 | GO:0007517 | muscle organ development(GO:0007517) |
| 0.0 | 0.3 | GO:0051881 | regulation of mitochondrial membrane potential(GO:0051881) |
| 0.0 | 0.1 | GO:0045652 | regulation of megakaryocyte differentiation(GO:0045652) regulation of hematopoietic progenitor cell differentiation(GO:1901532) |
| 0.0 | 0.2 | GO:0006704 | glucocorticoid biosynthetic process(GO:0006704) |
| 0.0 | 0.2 | GO:0016601 | Rac protein signal transduction(GO:0016601) |
| 0.0 | 0.2 | GO:0006596 | polyamine biosynthetic process(GO:0006596) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 2.9 | GO:0098647 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 0.1 | 0.8 | GO:0016942 | insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454) |
| 0.1 | 1.3 | GO:0043073 | germ cell nucleus(GO:0043073) |
| 0.1 | 0.4 | GO:0016012 | sarcoglycan complex(GO:0016012) |
| 0.1 | 0.7 | GO:0000808 | origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664) |
| 0.0 | 0.6 | GO:0008091 | spectrin(GO:0008091) |
| 0.0 | 0.8 | GO:0005811 | lipid particle(GO:0005811) |
| 0.0 | 0.2 | GO:0005853 | eukaryotic translation elongation factor 1 complex(GO:0005853) |
| 0.0 | 0.5 | GO:0030140 | trans-Golgi network transport vesicle(GO:0030140) |
| 0.0 | 0.4 | GO:0005665 | DNA-directed RNA polymerase II, core complex(GO:0005665) |
| 0.0 | 0.1 | GO:0097651 | phosphatidylinositol 3-kinase complex, class IA(GO:0005943) phosphatidylinositol 3-kinase complex, class I(GO:0097651) |
| 0.0 | 0.1 | GO:0051233 | spindle midzone(GO:0051233) |
| 0.0 | 0.3 | GO:0016281 | eukaryotic translation initiation factor 4F complex(GO:0016281) |
| 0.0 | 2.5 | GO:0043025 | neuronal cell body(GO:0043025) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 2.6 | GO:0008046 | axon guidance receptor activity(GO:0008046) |
| 0.3 | 1.3 | GO:0031694 | alpha-2A adrenergic receptor binding(GO:0031694) |
| 0.2 | 0.7 | GO:0005017 | platelet-derived growth factor-activated receptor activity(GO:0005017) |
| 0.2 | 0.6 | GO:0015247 | aminophospholipid transporter activity(GO:0015247) |
| 0.2 | 0.6 | GO:0008907 | integrase activity(GO:0008907) |
| 0.1 | 0.8 | GO:0031994 | insulin-like growth factor I binding(GO:0031994) |
| 0.1 | 0.5 | GO:0048406 | nerve growth factor binding(GO:0048406) |
| 0.1 | 0.6 | GO:0042731 | PH domain binding(GO:0042731) |
| 0.1 | 0.4 | GO:0004126 | cytidine deaminase activity(GO:0004126) |
| 0.1 | 0.2 | GO:0003870 | 5-aminolevulinate synthase activity(GO:0003870) N-succinyltransferase activity(GO:0016749) |
| 0.1 | 0.2 | GO:0003845 | 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845) |
| 0.1 | 0.7 | GO:0015643 | toxic substance binding(GO:0015643) |
| 0.0 | 0.7 | GO:0016409 | palmitoyltransferase activity(GO:0016409) |
| 0.0 | 0.3 | GO:0001846 | opsonin binding(GO:0001846) |
| 0.0 | 0.1 | GO:0031493 | nucleosomal histone binding(GO:0031493) SAM domain binding(GO:0032093) |
| 0.0 | 0.2 | GO:0051371 | muscle alpha-actinin binding(GO:0051371) |
| 0.0 | 0.2 | GO:0017034 | Rap guanyl-nucleotide exchange factor activity(GO:0017034) |
| 0.0 | 0.3 | GO:0016595 | glutamate binding(GO:0016595) |
| 0.0 | 3.2 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 0.2 | GO:0042978 | ornithine decarboxylase inhibitor activity(GO:0008073) ornithine decarboxylase activator activity(GO:0042978) |
| 0.0 | 0.4 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
| 0.0 | 1.3 | GO:0005080 | protein kinase C binding(GO:0005080) |
| 0.0 | 0.1 | GO:0005111 | type 2 fibroblast growth factor receptor binding(GO:0005111) |
| 0.0 | 0.4 | GO:0016922 | ligand-dependent nuclear receptor binding(GO:0016922) |
| 0.0 | 0.7 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.0 | 0.3 | GO:0000339 | RNA cap binding(GO:0000339) |
| 0.0 | 0.6 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) |
| 0.0 | 1.2 | GO:0030165 | PDZ domain binding(GO:0030165) |
| 0.0 | 0.1 | GO:0004815 | aspartate-tRNA ligase activity(GO:0004815) |
| 0.0 | 0.3 | GO:0051537 | 2 iron, 2 sulfur cluster binding(GO:0051537) |
| 0.0 | 0.3 | GO:0015269 | calcium-activated potassium channel activity(GO:0015269) |
| 0.0 | 0.4 | GO:0003730 | mRNA 3'-UTR binding(GO:0003730) |
| 0.0 | 0.3 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 0.0 | 0.1 | GO:0043559 | insulin binding(GO:0043559) |
| 0.0 | 0.2 | GO:0005328 | neurotransmitter:sodium symporter activity(GO:0005328) |
