Motif ID: NKX6-3

Z-value: 0.720


Transcription factors associated with NKX6-3:

Gene SymbolEntrez IDGene Name
NKX6-3 ENSG00000165066.11 NKX6-3



Activity profile for motif NKX6-3.

activity profile for motif NKX6-3


Sorted Z-values histogram for motif NKX6-3

Sorted Z-values for motif NKX6-3



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX6-3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_-_64225508 1.142 ENST00000205948.6
 APOH
apolipoprotein H (beta-2-glycoprotein I)
chr18_+_32558208 0.970 ENST00000436190.2
 MAPRE2
microtubule-associated protein, RP/EB family, member 2
chr11_+_22689648 0.846 ENST00000278187.3
 GAS2
growth arrest-specific 2
chr7_+_138145076 0.838 ENST00000343526.4
 TRIM24
tripartite motif containing 24
chrX_-_130423200 0.589 ENST00000361420.3
 IGSF1
immunoglobulin superfamily, member 1
chr20_-_33735070 0.570 ENST00000374491.3
ENST00000542871.1
ENST00000374492.3
 EDEM2


ER degradation enhancer, mannosidase alpha-like 2


chr4_+_80584903 0.529 ENST00000506460.1
 RP11-452C8.1
RP11-452C8.1
chr1_-_151431647 0.455 ENST00000368863.2
ENST00000409503.1
ENST00000491586.1
ENST00000533351.1
ENST00000540984.1
 POGZ




pogo transposable element with ZNF domain




chr1_-_151431909 0.423 ENST00000361398.3
ENST00000271715.2
 POGZ

pogo transposable element with ZNF domain

chrX_+_43515467 0.363 ENST00000338702.3
ENST00000542639.1
 MAOA

monoamine oxidase A

chr20_+_30697298 0.350 ENST00000398022.2
 TM9SF4
transmembrane 9 superfamily protein member 4
chr3_-_141747950 0.325 ENST00000497579.1
 TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr7_-_25268104 0.321 ENST00000222674.2
 NPVF
neuropeptide VF precursor
chr19_+_50016610 0.214 ENST00000596975.1
 FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr15_+_93443419 0.190 ENST00000557381.1
ENST00000420239.2
 CHD2

chromodomain helicase DNA binding protein 2

chr16_-_67517716 0.184 ENST00000290953.2
 AGRP
agouti related protein homolog (mouse)
chr2_+_234826016 0.177 ENST00000324695.4
ENST00000433712.2
 TRPM8

transient receptor potential cation channel, subfamily M, member 8

chrX_-_110655306 0.166 ENST00000371993.2
 DCX
doublecortin
chr5_-_58295712 0.151 ENST00000317118.8
 PDE4D
phosphodiesterase 4D, cAMP-specific
chr17_-_10372875 0.138 ENST00000255381.2
 MYH4
myosin, heavy chain 4, skeletal muscle
chrX_+_107288197 0.120 ENST00000415430.3
 VSIG1
V-set and immunoglobulin domain containing 1
chr11_-_13517565 0.109 ENST00000282091.1
ENST00000529816.1
 PTH

parathyroid hormone

chr14_-_51027838 0.104 ENST00000555216.1
 MAP4K5
mitogen-activated protein kinase kinase kinase kinase 5
chr12_-_52761262 0.091 ENST00000257901.3
 KRT85
keratin 85
chr8_-_90769422 0.082 ENST00000524190.1
ENST00000523859.1
 RP11-37B2.1

RP11-37B2.1

chr4_-_123542224 0.073 ENST00000264497.3
 IL21
interleukin 21
chr19_+_4402659 0.073 ENST00000301280.5
ENST00000585854.1
 CHAF1A

chromatin assembly factor 1, subunit A (p150)

chrX_+_107288239 0.072 ENST00000217957.5
 VSIG1
V-set and immunoglobulin domain containing 1
chr3_+_138340049 0.055 ENST00000464668.1
 FAIM
Fas apoptotic inhibitory molecule
chr8_+_77593448 0.050 ENST00000521891.2
 ZFHX4
zinc finger homeobox 4
chr10_+_18549645 0.038 ENST00000396576.2
 CACNB2
calcium channel, voltage-dependent, beta 2 subunit
chrX_+_47696275 0.034 ENST00000376954.1
ENST00000338637.7
 ZNF81

zinc finger protein 81

chr3_+_136649311 0.002 ENST00000469404.1
ENST00000467911.1
 NCK1

NCK adaptor protein 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:1901419 regulation of response to alcohol(GO:1901419)
0.1 1.1 GO:0034392 negative regulation of smooth muscle cell apoptotic process(GO:0034392)
0.1 0.9 GO:0007064 mitotic sister chromatid cohesion(GO:0007064) kinetochore assembly(GO:0051382) kinetochore organization(GO:0051383)
0.1 0.4 GO:0042420 dopamine catabolic process(GO:0042420)
0.0 0.2 GO:0060259 regulation of feeding behavior(GO:0060259)
0.0 0.2 GO:0050955 thermoception(GO:0050955)
0.0 0.1 GO:0008628 hormone-mediated apoptotic signaling pathway(GO:0008628)
0.0 0.1 GO:0034723 DNA replication-dependent nucleosome organization(GO:0034723)
0.0 0.1 GO:0032825 regulation of natural killer cell differentiation(GO:0032823) positive regulation of natural killer cell differentiation(GO:0032825)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0005726 perichromatin fibrils(GO:0005726)
0.1 1.1 GO:0042627 chylomicron(GO:0042627)
0.0 0.8 GO:0005884 actin filament(GO:0005884)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.1 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
0.1 0.6 GO:0034711 inhibin binding(GO:0034711)
0.1 0.8 GO:0034056 estrogen response element binding(GO:0034056)
0.1 0.4 GO:0008131 primary amine oxidase activity(GO:0008131)
0.1 0.2 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.1 0.6 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)