Motif ID: NR1D1

Z-value: 0.826


Transcription factors associated with NR1D1:

Gene SymbolEntrez IDGene Name
NR1D1 ENSG00000126368.5 NR1D1



Activity profile for motif NR1D1.

activity profile for motif NR1D1


Sorted Z-values histogram for motif NR1D1

Sorted Z-values for motif NR1D1



Network of associatons between targets according to the STRING database.



First level regulatory network of NR1D1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_+_46740730 0.950 ENST00000311907.5
ENST00000530231.1
ENST00000442468.1
F2


coagulation factor II (thrombin)


chr9_+_103790991 0.891 ENST00000374874.3
LPPR1
Lipid phosphate phosphatase-related protein type 1
chr17_+_79968655 0.780 ENST00000583744.1
ASPSCR1
alveolar soft part sarcoma chromosome region, candidate 1
chr11_+_7534999 0.736 ENST00000528947.1
ENST00000299492.4
PPFIBP2

PTPRF interacting protein, binding protein 2 (liprin beta 2)

chr8_+_11561660 0.722 ENST00000526716.1
ENST00000335135.4
ENST00000528027.1
GATA4


GATA binding protein 4


chr2_-_64371546 0.636 ENST00000358912.4
PELI1
pellino E3 ubiquitin protein ligase 1
chr18_-_19284724 0.570 ENST00000580981.1
ENST00000289119.2
ABHD3

abhydrolase domain containing 3

chr6_+_31543334 0.539 ENST00000449264.2
TNF
tumor necrosis factor
chr1_+_20915409 0.495 ENST00000375071.3
CDA
cytidine deaminase
chr17_-_76128488 0.468 ENST00000322914.3
TMC6
transmembrane channel-like 6
chr19_-_23578220 0.440 ENST00000595533.1
ENST00000397082.2
ENST00000599743.1
ENST00000300619.7
ZNF91



zinc finger protein 91



chr17_-_3599327 0.426 ENST00000551178.1
ENST00000552276.1
ENST00000547178.1
P2RX5


purinergic receptor P2X, ligand-gated ion channel, 5


chrX_+_68725084 0.394 ENST00000252338.4
FAM155B
family with sequence similarity 155, member B
chr13_+_113622757 0.380 ENST00000375604.2
MCF2L
MCF.2 cell line derived transforming sequence-like
chr1_+_44398943 0.379 ENST00000372359.5
ENST00000414809.3
ARTN

artemin

chr17_-_3599492 0.378 ENST00000435558.1
ENST00000345901.3
P2RX5

purinergic receptor P2X, ligand-gated ion channel, 5

chr19_+_21324827 0.376 ENST00000600692.1
ENST00000599296.1
ENST00000594425.1
ENST00000311048.7
ZNF431



zinc finger protein 431



chr11_+_125365110 0.366 ENST00000527818.1
AP000708.1
AP000708.1
chr1_-_147245484 0.325 ENST00000271348.2
GJA5
gap junction protein, alpha 5, 40kDa
chr13_+_113622810 0.313 ENST00000397030.1
MCF2L
MCF.2 cell line derived transforming sequence-like
chr3_+_58223228 0.295 ENST00000478253.1
ENST00000295962.4
ABHD6

abhydrolase domain containing 6

chr16_+_67233007 0.293 ENST00000360833.1
ENST00000393997.2
ELMO3

engulfment and cell motility 3

chr17_-_38074842 0.286 ENST00000309481.7
GSDMB
gasdermin B
chr17_-_38074859 0.280 ENST00000520542.1
ENST00000418519.1
ENST00000394179.1
GSDMB


gasdermin B


chr16_+_67233412 0.273 ENST00000477898.1
ELMO3
engulfment and cell motility 3
chr7_+_64126535 0.269 ENST00000344930.3
ZNF107
zinc finger protein 107
chr14_-_23770683 0.266 ENST00000561437.1
ENST00000559942.1
ENST00000560913.1
ENST00000559314.1
ENST00000558058.1
PPP1R3E




protein phosphatase 1, regulatory subunit 3E




chr7_+_94139105 0.263 ENST00000297273.4
CASD1
CAS1 domain containing 1
chr6_+_167525277 0.262 ENST00000400926.2
CCR6
chemokine (C-C motif) receptor 6
chr9_+_126773880 0.250 ENST00000373615.4
LHX2
LIM homeobox 2
chr17_-_79139817 0.247 ENST00000326724.4
AATK
apoptosis-associated tyrosine kinase
chr19_-_14629224 0.228 ENST00000254322.2
DNAJB1
DnaJ (Hsp40) homolog, subfamily B, member 1
chr22_+_37415700 0.209 ENST00000397129.1
MPST
mercaptopyruvate sulfurtransferase
chr22_+_37415728 0.202 ENST00000404802.3
MPST
mercaptopyruvate sulfurtransferase
chr2_+_63816295 0.198 ENST00000539945.1
ENST00000544381.1
MDH1

malate dehydrogenase 1, NAD (soluble)

chr19_+_21264980 0.194 ENST00000596053.1
ENST00000597086.1
ENST00000596143.1
ENST00000596367.1
ENST00000601416.1
ZNF714




zinc finger protein 714




chr5_-_43313574 0.192 ENST00000325110.6
ENST00000433297.2
HMGCS1

3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)

chr7_-_128694927 0.186 ENST00000471166.1
ENST00000265388.5
TNPO3

transportin 3

chrX_+_24167746 0.179 ENST00000428571.1
ENST00000539115.1
ZFX

zinc finger protein, X-linked

chr19_-_23433144 0.179 ENST00000418100.1
ENST00000597537.1
ENST00000597037.1
ZNF724P


zinc finger protein 724, pseudogene


chr22_+_45898712 0.174 ENST00000455233.1
ENST00000348697.2
ENST00000402984.3
ENST00000262722.7
ENST00000327858.6
ENST00000442170.2
ENST00000340923.5
ENST00000439835.1
FBLN1







fibulin 1







chr22_+_37415776 0.169 ENST00000341116.3
ENST00000429360.2
ENST00000404393.1
MPST


mercaptopyruvate sulfurtransferase


chr3_+_171758344 0.164 ENST00000336824.4
ENST00000423424.1
FNDC3B

fibronectin type III domain containing 3B

chr1_+_168545711 0.160 ENST00000367818.3
XCL1
chemokine (C motif) ligand 1
chr19_+_22235310 0.158 ENST00000600162.1
ZNF257
zinc finger protein 257
chr7_-_100493744 0.156 ENST00000428317.1
ENST00000441605.1
ACHE

acetylcholinesterase (Yt blood group)

chr1_-_168513229 0.152 ENST00000367819.2
XCL2
chemokine (C motif) ligand 2
chr16_-_18468926 0.151 ENST00000545114.1
RP11-1212A22.4
LOC339047 protein; Nuclear pore complex-interacting protein family member A3; Nuclear pore complex-interacting protein family member A5; Protein PKD1P1
chrX_+_24167828 0.136 ENST00000379188.3
ENST00000419690.1
ENST00000379177.1
ENST00000304543.5
ZFX



zinc finger protein, X-linked



chr19_-_38806560 0.135 ENST00000591755.1
ENST00000337679.8
ENST00000339413.6
YIF1B


Yip1 interacting factor homolog B (S. cerevisiae)


chr3_-_48723268 0.134 ENST00000439518.1
ENST00000416649.2
ENST00000341520.4
ENST00000294129.2
NCKIPSD



NCK interacting protein with SH3 domain



chr8_+_105235572 0.133 ENST00000523362.1
RIMS2
regulating synaptic membrane exocytosis 2
chr17_-_38256973 0.132 ENST00000246672.3
NR1D1
nuclear receptor subfamily 1, group D, member 1
chr1_-_11865982 0.123 ENST00000418034.1
MTHFR
methylenetetrahydrofolate reductase (NAD(P)H)
chr2_+_63816087 0.122 ENST00000409908.1
ENST00000442225.1
ENST00000409476.1
ENST00000436321.1
MDH1



malate dehydrogenase 1, NAD (soluble)



chr2_-_89513402 0.121 ENST00000498435.1
IGKV1-27
immunoglobulin kappa variable 1-27
chr1_+_2398876 0.115 ENST00000449969.1
PLCH2
phospholipase C, eta 2
chr2_-_103353277 0.114 ENST00000258436.5
MFSD9
major facilitator superfamily domain containing 9
chr17_+_6899366 0.108 ENST00000251535.6
ALOX12
arachidonate 12-lipoxygenase
chr1_-_111991850 0.107 ENST00000411751.2
WDR77
WD repeat domain 77
chr15_-_81282133 0.105 ENST00000261758.4
MESDC2
mesoderm development candidate 2
chr7_-_142630820 0.105 ENST00000442623.1
ENST00000265310.1
TRPV5

transient receptor potential cation channel, subfamily V, member 5

chrY_+_2803322 0.099 ENST00000383052.1
ENST00000155093.3
ENST00000449237.1
ENST00000443793.1
ZFY



zinc finger protein, Y-linked



chr7_-_100493482 0.098 ENST00000411582.1
ENST00000419336.2
ENST00000241069.5
ENST00000302913.4
ACHE



acetylcholinesterase (Yt blood group)



chr1_-_11866034 0.096 ENST00000376590.3
MTHFR
methylenetetrahydrofolate reductase (NAD(P)H)
chr2_+_113342163 0.096 ENST00000409719.1
CHCHD5
coiled-coil-helix-coiled-coil-helix domain containing 5
chr4_+_1873100 0.091 ENST00000508803.1
WHSC1
Wolf-Hirschhorn syndrome candidate 1
chr7_-_128695147 0.089 ENST00000482320.1
ENST00000393245.1
ENST00000471234.1
TNPO3


transportin 3


chr2_-_89442621 0.088 ENST00000492167.1
IGKV3-20
immunoglobulin kappa variable 3-20
chr1_-_11865351 0.087 ENST00000413656.1
ENST00000376585.1
ENST00000423400.1
ENST00000431243.1
MTHFR



methylenetetrahydrofolate reductase (NAD(P)H)



chr1_+_168250194 0.087 ENST00000367821.3
TBX19
T-box 19
chr19_-_12833164 0.078 ENST00000356861.5
TNPO2
transportin 2
chr14_+_74815116 0.076 ENST00000256362.4
VRTN
vertebrae development associated
chr7_+_97736197 0.066 ENST00000297293.5
LMTK2
lemur tyrosine kinase 2
chr13_+_100741269 0.060 ENST00000376286.4
ENST00000376279.3
ENST00000376285.1
PCCA


propionyl CoA carboxylase, alpha polypeptide


chr2_-_73053126 0.060 ENST00000272427.6
ENST00000410104.1
EXOC6B

exocyst complex component 6B

chr7_+_139025875 0.059 ENST00000297534.6
C7orf55
chromosome 7 open reading frame 55
chr1_+_203764742 0.059 ENST00000432282.1
ENST00000453771.1
ENST00000367214.1
ENST00000367212.3
ENST00000332127.4
ZC3H11A




zinc finger CCCH-type containing 11A




chr1_+_218519577 0.056 ENST00000366930.4
ENST00000366929.4
TGFB2

transforming growth factor, beta 2

chr17_-_36347030 0.054 ENST00000518551.1
TBC1D3
TBC1 domain family, member 3
chr19_-_22605136 0.054 ENST00000357774.5
ENST00000601553.1
ENST00000593657.1
ZNF98


zinc finger protein 98


chr16_+_1832902 0.049 ENST00000262302.9
ENST00000563136.1
ENST00000565987.1
ENST00000543305.1
ENST00000568287.1
ENST00000565134.1
NUBP2





nucleotide binding protein 2





chr2_+_90153696 0.032 ENST00000417279.2
IGKV3D-15
immunoglobulin kappa variable 3D-15 (gene/pseudogene)
chr1_+_197382957 0.031 ENST00000367397.1
CRB1
crumbs homolog 1 (Drosophila)
chr19_-_12833361 0.031 ENST00000592287.1
TNPO2
transportin 2
chr19_+_21265028 0.031 ENST00000291770.7
ZNF714
zinc finger protein 714
chr1_-_156918806 0.027 ENST00000315174.8
ARHGEF11
Rho guanine nucleotide exchange factor (GEF) 11
chr1_+_110210644 0.025 ENST00000369831.2
ENST00000442650.1
ENST00000369827.3
ENST00000460717.3
ENST00000241337.4
ENST00000467579.3
ENST00000414179.2
ENST00000369829.2
GSTM2







glutathione S-transferase mu 2 (muscle)







chr19_-_52035044 0.017 ENST00000359982.4
ENST00000436458.1
ENST00000425629.3
ENST00000391797.3
ENST00000343300.4
SIGLEC6




sialic acid binding Ig-like lectin 6




chr16_-_70712229 0.015 ENST00000562883.2
MTSS1L
metastasis suppressor 1-like
chr2_+_203776937 0.013 ENST00000402905.3
ENST00000414490.1
ENST00000431787.1
ENST00000444724.1
ENST00000414857.1
ENST00000430899.1
ENST00000445120.1
ENST00000441569.1
ENST00000432024.1
ENST00000443740.1
ENST00000414439.1
ENST00000428585.1
ENST00000545253.1
ENST00000545262.1
ENST00000447539.1
ENST00000456821.2
ENST00000434998.1
ENST00000320443.8
CARF

















calcium responsive transcription factor

















chr16_+_71392616 0.013 ENST00000349553.5
ENST00000302628.4
ENST00000562305.1
CALB2


calbindin 2


chr19_-_19932501 0.011 ENST00000540806.2
ENST00000590766.1
ENST00000587452.1
ENST00000545006.1
ENST00000590319.1
ENST00000587461.1
ENST00000450683.2
ENST00000443905.2
ENST00000590274.1
ZNF506







CTC-559E9.4
zinc finger protein 506







CTC-559E9.4
chr6_-_31938700 0.009 ENST00000495340.1
DXO
decapping exoribonuclease
chr1_-_41131326 0.007 ENST00000372684.3
RIMS3
regulating synaptic membrane exocytosis 3
chr19_+_21203426 0.003 ENST00000261560.5
ENST00000599548.1
ENST00000594110.1
ZNF430


zinc finger protein 430


chr8_+_101162812 0.001 ENST00000353107.3
ENST00000522439.1
POLR2K

polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0003289 septum primum development(GO:0003284) atrial septum primum morphogenesis(GO:0003289)
0.2 0.9 GO:0007262 STAT protein import into nucleus(GO:0007262)
0.2 0.6 GO:0034139 regulation of toll-like receptor 3 signaling pathway(GO:0034139)
0.2 0.5 GO:0060557 positive regulation of chronic inflammatory response(GO:0002678) regulation of chronic inflammatory response to antigenic stimulus(GO:0002874) positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559) necroptotic process(GO:0070266) programmed necrotic cell death(GO:0097300)
0.2 0.5 GO:0019858 cytosine metabolic process(GO:0019858)
0.1 0.6 GO:0009439 cyanate metabolic process(GO:0009439) cyanate catabolic process(GO:0009440)
0.1 0.3 GO:0032223 negative regulation of synaptic transmission, cholinergic(GO:0032223) neurotransmitter receptor biosynthetic process(GO:0045212)
0.1 0.1 GO:0032196 transposition, DNA-mediated(GO:0006313) transposition(GO:0032196)
0.1 0.7 GO:0015074 DNA integration(GO:0015074)
0.1 0.8 GO:0035590 purinergic nucleotide receptor signaling pathway(GO:0035590)
0.0 0.2 GO:0033197 response to vitamin E(GO:0033197)
0.0 0.3 GO:0005981 regulation of glycogen catabolic process(GO:0005981)
0.0 0.1 GO:0045603 positive regulation of endothelial cell differentiation(GO:0045603)
0.0 0.1 GO:0034122 negative regulation of toll-like receptor signaling pathway(GO:0034122)
0.0 0.2 GO:0046642 negative regulation of alpha-beta T cell proliferation(GO:0046642)
0.0 0.3 GO:0021978 telencephalon regionalization(GO:0021978)
0.0 0.3 GO:0006108 malate metabolic process(GO:0006108) NADH metabolic process(GO:0006734)
0.0 0.2 GO:0051085 chaperone mediated protein folding requiring cofactor(GO:0051085)
0.0 0.1 GO:0045726 negative regulation of macrophage cytokine production(GO:0010936) regulation of integrin biosynthetic process(GO:0045113) positive regulation of integrin biosynthetic process(GO:0045726)
0.0 0.3 GO:0046655 folic acid metabolic process(GO:0046655)
0.0 0.1 GO:0015904 tetracycline transport(GO:0015904)
0.0 0.8 GO:0046324 regulation of glucose import(GO:0046324)
0.0 0.1 GO:0060528 secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.0 0.4 GO:0007405 neuroblast proliferation(GO:0007405)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 GO:0000300 obsolete peripheral to membrane of membrane fraction(GO:0000300)
0.1 0.5 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.3 GO:0042587 glycogen granule(GO:0042587)
0.0 0.9 GO:0005796 Golgi lumen(GO:0005796)
0.0 0.3 GO:0005922 connexon complex(GO:0005922)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0008907 integrase activity(GO:0008907)
0.1 0.6 GO:0016784 3-mercaptopyruvate sulfurtransferase activity(GO:0016784)
0.1 0.5 GO:0004126 cytidine deaminase activity(GO:0004126)
0.1 0.9 GO:0070053 thrombospondin receptor activity(GO:0070053)
0.1 0.3 GO:0030060 L-malate dehydrogenase activity(GO:0030060)
0.1 0.8 GO:0035381 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.1 0.3 GO:0003990 acetylcholinesterase activity(GO:0003990)
0.1 0.3 GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)
0.0 0.1 GO:0047977 hepoxilin-epoxide hydrolase activity(GO:0047977)
0.0 0.2 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.0 0.7 GO:0033613 activating transcription factor binding(GO:0033613)
0.0 0.3 GO:0005243 gap junction channel activity(GO:0005243)
0.0 0.1 GO:0015520 tetracycline:proton antiporter activity(GO:0015520)
0.0 0.3 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 0.5 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.3 GO:0016493 C-C chemokine receptor activity(GO:0016493)
0.0 0.1 GO:0004803 transposase activity(GO:0004803)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.9 ST_GA12_PATHWAY G alpha 12 Pathway
0.0 0.6 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.