Motif ID: NR1I2

Z-value: 2.417


Transcription factors associated with NR1I2:

Gene SymbolEntrez IDGene Name
NR1I2 ENSG00000144852.12 NR1I2



Activity profile for motif NR1I2.

activity profile for motif NR1I2


Sorted Z-values histogram for motif NR1I2

Sorted Z-values for motif NR1I2



Network of associatons between targets according to the STRING database.



First level regulatory network of NR1I2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_-_91576429 7.196 ENST00000552145.1
ENST00000546745.1
DCN

decorin

chr11_+_117073850 5.866 ENST00000529622.1
TAGLN
transgelin
chr3_+_157154578 5.433 ENST00000295927.3
PTX3
pentraxin 3, long
chr1_-_151965048 5.107 ENST00000368809.1
S100A10
S100 calcium binding protein A10
chr15_+_39873268 5.004 ENST00000397591.2
ENST00000260356.5
THBS1

thrombospondin 1

chrX_+_135278908 4.428 ENST00000539015.1
ENST00000370683.1
FHL1

four and a half LIM domains 1

chr11_-_111783595 4.081 ENST00000528628.1
CRYAB
crystallin, alpha B
chrX_+_135279179 4.017 ENST00000370676.3
FHL1
four and a half LIM domains 1
chr5_+_125695805 4.015 ENST00000513040.1
GRAMD3
GRAM domain containing 3
chr7_+_134576151 3.691 ENST00000393118.2
CALD1
caldesmon 1
chr7_-_107642348 3.324 ENST00000393561.1
LAMB1
laminin, beta 1
chr10_-_33625154 3.152 ENST00000265371.4
NRP1
neuropilin 1
chr12_-_91576561 3.134 ENST00000547568.2
ENST00000552962.1
DCN

decorin

chr17_-_46682321 3.011 ENST00000225648.3
ENST00000484302.2
HOXB6

homeobox B6

chr2_-_86790593 2.888 ENST00000263856.4
ENST00000409225.2
CHMP3

charged multivesicular body protein 3

chr12_-_91576750 2.730 ENST00000228329.5
ENST00000303320.3
ENST00000052754.5
DCN


decorin


chr13_-_110959478 2.722 ENST00000543140.1
ENST00000375820.4
COL4A1

collagen, type IV, alpha 1

chr8_-_18666360 2.674 ENST00000286485.8
PSD3
pleckstrin and Sec7 domain containing 3
chr5_+_34656569 2.576 ENST00000428746.2
RAI14
retinoic acid induced 14
chr15_+_96875657 2.544 ENST00000559679.1
ENST00000394171.2
NR2F2

nuclear receptor subfamily 2, group F, member 2

chr2_-_158732340 2.501 ENST00000539637.1
ENST00000413751.1
ENST00000434821.1
ENST00000424669.1
ACVR1



activin A receptor, type I



chr11_-_111794446 2.481 ENST00000527950.1
CRYAB
crystallin, alpha B
chr2_+_192141611 2.438 ENST00000392316.1
MYO1B
myosin IB
chr1_-_120612240 2.394 ENST00000256646.2
NOTCH2
notch 2
chr12_-_6665200 2.390 ENST00000336604.4
ENST00000396840.2
ENST00000356896.4
IFFO1


intermediate filament family orphan 1


chrX_+_102840408 2.361 ENST00000468024.1
ENST00000472484.1
ENST00000415568.2
ENST00000490644.1
ENST00000459722.1
ENST00000472745.1
ENST00000494801.1
ENST00000434216.2
ENST00000425011.1
TCEAL4








transcription elongation factor A (SII)-like 4








chr3_-_114343039 2.317 ENST00000481632.1
ZBTB20
zinc finger and BTB domain containing 20
chr15_+_96876340 2.281 ENST00000453270.2
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr2_+_30454390 2.113 ENST00000395323.3
ENST00000406087.1
ENST00000404397.1
LBH


limb bud and heart development


chr3_+_8543393 2.087 ENST00000157600.3
ENST00000415597.1
ENST00000535732.1
LMCD1


LIM and cysteine-rich domains 1


chr2_-_235405168 2.056 ENST00000339728.3
ARL4C
ADP-ribosylation factor-like 4C
chr6_-_167040731 1.995 ENST00000265678.4
RPS6KA2
ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr3_+_8543561 1.919 ENST00000397386.3
LMCD1
LIM and cysteine-rich domains 1
chr9_-_14313641 1.880 ENST00000380953.1
NFIB
nuclear factor I/B
chr12_-_56106060 1.866 ENST00000452168.2
ITGA7
integrin, alpha 7
chr9_-_14313893 1.861 ENST00000380921.3
ENST00000380959.3
NFIB

nuclear factor I/B

chrX_+_135251835 1.849 ENST00000456445.1
FHL1
four and a half LIM domains 1
chr13_-_33859819 1.701 ENST00000336934.5
STARD13
StAR-related lipid transfer (START) domain containing 13
chr8_-_18541603 1.614 ENST00000428502.2
PSD3
pleckstrin and Sec7 domain containing 3
chr6_+_142622991 1.611 ENST00000230173.6
ENST00000367608.2
GPR126

G protein-coupled receptor 126

chr9_-_129885010 1.598 ENST00000373425.3
ANGPTL2
angiopoietin-like 2
chr20_+_43343886 1.542 ENST00000190983.4
WISP2
WNT1 inducible signaling pathway protein 2
chr2_+_69240415 1.519 ENST00000409829.3
ANTXR1
anthrax toxin receptor 1
chr7_+_128399002 1.518 ENST00000493278.1
CALU
calumenin
chr5_+_140810132 1.510 ENST00000252085.3
PCDHGA12
protocadherin gamma subfamily A, 12
chr2_+_223916862 1.468 ENST00000604125.1
KCNE4
potassium voltage-gated channel, Isk-related family, member 4
chr2_+_69240302 1.468 ENST00000303714.4
ANTXR1
anthrax toxin receptor 1
chr2_+_69240511 1.467 ENST00000409349.3
ANTXR1
anthrax toxin receptor 1
chr9_-_129884902 1.452 ENST00000373417.1
ANGPTL2
angiopoietin-like 2
chr6_+_142623063 1.420 ENST00000296932.8
ENST00000367609.3
GPR126

G protein-coupled receptor 126

chr7_-_151433342 1.409 ENST00000433631.2
PRKAG2
protein kinase, AMP-activated, gamma 2 non-catalytic subunit
chr9_-_14314066 1.406 ENST00000397575.3
NFIB
nuclear factor I/B
chr7_-_151433393 1.398 ENST00000492843.1
PRKAG2
protein kinase, AMP-activated, gamma 2 non-catalytic subunit
chr7_-_27169801 1.364 ENST00000511914.1
HOXA4
homeobox A4
chr7_-_76247617 1.342 ENST00000441393.1
POMZP3
POM121 and ZP3 fusion
chr19_-_43690674 1.340 ENST00000342951.6
ENST00000366175.3
PSG5

pregnancy specific beta-1-glycoprotein 5

chr7_-_131241361 1.337 ENST00000378555.3
ENST00000322985.9
ENST00000541194.1
ENST00000537928.1
PODXL



podocalyxin-like



chr6_-_46293378 1.331 ENST00000330430.6
RCAN2
regulator of calcineurin 2
chr7_-_94285402 1.305 ENST00000428696.2
ENST00000445866.2
SGCE

sarcoglycan, epsilon

chr13_-_30424821 1.285 ENST00000380680.4
UBL3
ubiquitin-like 3
chr4_+_30721968 1.264 ENST00000361762.2
PCDH7
protocadherin 7
chr14_+_23340822 1.253 ENST00000359591.4
LRP10
low density lipoprotein receptor-related protein 10
chr5_+_92919043 1.238 ENST00000327111.3
NR2F1
nuclear receptor subfamily 2, group F, member 1
chr1_+_160097462 1.236 ENST00000447527.1
ATP1A2
ATPase, Na+/K+ transporting, alpha 2 polypeptide
chr8_-_93115445 1.231 ENST00000523629.1
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr13_+_115000556 1.221 ENST00000252458.6
CDC16
cell division cycle 16
chrX_+_149531524 1.194 ENST00000370401.2
MAMLD1
mastermind-like domain containing 1
chr3_+_8543533 1.193 ENST00000454244.1
LMCD1
LIM and cysteine-rich domains 1
chr4_-_159094194 1.182 ENST00000592057.1
ENST00000585682.1
ENST00000393807.5
FAM198B


family with sequence similarity 198, member B


chr6_+_139456226 1.177 ENST00000367658.2
HECA
headcase homolog (Drosophila)
chr19_+_16187816 1.163 ENST00000588410.1
TPM4
tropomyosin 4
chr13_+_115000339 1.125 ENST00000360383.3
ENST00000375312.3
CDC16

cell division cycle 16

chr13_+_32605437 1.109 ENST00000380250.3
FRY
furry homolog (Drosophila)
chr1_+_218519577 1.081 ENST00000366930.4
ENST00000366929.4
TGFB2

transforming growth factor, beta 2

chr1_+_196788887 1.076 ENST00000367421.3
ENST00000320493.5
ENST00000367424.4
CFHR2
CFHR1

complement factor H-related 2
complement factor H-related 1

chr3_-_126373929 1.066 ENST00000523403.1
ENST00000524230.2
TXNRD3

thioredoxin reductase 3

chr4_+_124317940 1.004 ENST00000505319.1
ENST00000339241.1
SPRY1

sprouty homolog 1, antagonist of FGF signaling (Drosophila)

chr10_-_125851961 0.985 ENST00000346248.5
CHST15
carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
chr1_+_25944341 0.980 ENST00000263979.3
MAN1C1
mannosidase, alpha, class 1C, member 1
chr15_+_43809797 0.978 ENST00000399453.1
ENST00000300231.5
MAP1A

microtubule-associated protein 1A

chr3_+_37284668 0.965 ENST00000361924.2
ENST00000444882.1
ENST00000356847.4
ENST00000450863.2
ENST00000429018.1
GOLGA4




golgin A4




chr8_-_13372395 0.956 ENST00000276297.4
ENST00000511869.1
DLC1

deleted in liver cancer 1

chr2_+_172543919 0.941 ENST00000452242.1
ENST00000340296.4
DYNC1I2

dynein, cytoplasmic 1, intermediate chain 2

chr17_-_9479128 0.939 ENST00000574431.1
STX8
syntaxin 8
chr19_+_2977444 0.939 ENST00000246112.4
ENST00000453329.1
ENST00000482627.1
ENST00000452088.1
TLE6



transducin-like enhancer of split 6 (E(sp1) homolog, Drosophila)



chr3_+_128968437 0.923 ENST00000314797.6
COPG1
coatomer protein complex, subunit gamma 1
chr12_-_49582978 0.918 ENST00000301071.7
TUBA1A
tubulin, alpha 1a
chr9_+_33795533 0.917 ENST00000379405.3
PRSS3
protease, serine, 3
chr16_-_28937027 0.914 ENST00000358201.4
RABEP2
rabaptin, RAB GTPase binding effector protein 2
chr7_+_22766766 0.909 ENST00000426291.1
ENST00000401651.1
ENST00000258743.5
ENST00000420258.2
ENST00000407492.1
ENST00000401630.3
ENST00000406575.1
IL6






interleukin 6 (interferon, beta 2)






chr2_+_109237717 0.903 ENST00000409441.1
LIMS1
LIM and senescent cell antigen-like domains 1
chr8_+_37654424 0.890 ENST00000315215.7
GPR124
G protein-coupled receptor 124
chr11_+_118478313 0.888 ENST00000356063.5
PHLDB1
pleckstrin homology-like domain, family B, member 1
chr1_-_144995002 0.864 ENST00000369356.4
PDE4DIP
phosphodiesterase 4D interacting protein
chr13_+_115000384 0.857 ENST00000356221.3
ENST00000375310.1
CDC16

cell division cycle 16

chr5_-_82969405 0.818 ENST00000510978.1
HAPLN1
hyaluronan and proteoglycan link protein 1
chr9_-_23825956 0.798 ENST00000397312.2
ELAVL2
ELAV like neuron-specific RNA binding protein 2
chr16_+_28875126 0.790 ENST00000359285.5
ENST00000538342.1
SH2B1

SH2B adaptor protein 1

chr14_+_55034599 0.784 ENST00000392067.3
ENST00000357634.3
SAMD4A

sterile alpha motif domain containing 4A

chr5_+_149569520 0.781 ENST00000230671.2
ENST00000524041.1
SLC6A7

solute carrier family 6 (neurotransmitter transporter), member 7

chr3_-_114790179 0.779 ENST00000462705.1
ZBTB20
zinc finger and BTB domain containing 20
chr3_+_37284824 0.774 ENST00000431105.1
GOLGA4
golgin A4
chr1_-_53387386 0.755 ENST00000467988.1
ENST00000358358.5
ENST00000371522.4
ECHDC2


enoyl CoA hydratase domain containing 2


chr9_-_34620440 0.754 ENST00000421919.1
ENST00000378911.3
ENST00000477738.2
ENST00000341694.2
ENST00000259632.7
ENST00000378913.2
ENST00000378916.4
ENST00000447983.2
DCTN3







dynactin 3 (p22)







chr13_-_33112823 0.750 ENST00000504114.1
N4BP2L2
NEDD4 binding protein 2-like 2
chr3_+_12330560 0.728 ENST00000397026.2
PPARG
peroxisome proliferator-activated receptor gamma
chr1_+_25943959 0.726 ENST00000374332.4
MAN1C1
mannosidase, alpha, class 1C, member 1
chr13_+_115000521 0.703 ENST00000252457.5
ENST00000375308.1
CDC16

cell division cycle 16

chr20_-_44485835 0.698 ENST00000457981.1
ENST00000426915.1
ENST00000217455.4
ACOT8


acyl-CoA thioesterase 8


chr2_+_234621551 0.689 ENST00000373414.3
ENST00000608381.1
UGT1A5
UGT1A1
UDP glucuronosyltransferase 1 family, polypeptide A5
UDP glucuronosyltransferase 1 family, polypeptide A8
chr8_-_120685608 0.683 ENST00000427067.2
ENPP2
ectonucleotide pyrophosphatase/phosphodiesterase 2
chr2_-_192711968 0.678 ENST00000304141.4
SDPR
serum deprivation response
chrX_+_49832231 0.669 ENST00000376108.3
CLCN5
chloride channel, voltage-sensitive 5
chr22_-_38699003 0.661 ENST00000451964.1
CSNK1E
casein kinase 1, epsilon
chrX_+_38420623 0.655 ENST00000378482.2
TSPAN7
tetraspanin 7
chr16_+_67207838 0.650 ENST00000566871.1
ENST00000268605.7
NOL3

nucleolar protein 3 (apoptosis repressor with CARD domain)

chr1_-_229569834 0.639 ENST00000366684.3
ENST00000366683.2
ACTA1

actin, alpha 1, skeletal muscle

chrX_+_64887512 0.639 ENST00000360270.5
MSN
moesin
chr11_+_65687158 0.636 ENST00000532933.1
DRAP1
DR1-associated protein 1 (negative cofactor 2 alpha)
chr2_+_234627424 0.629 ENST00000373409.3
UGT1A4
UDP glucuronosyltransferase 1 family, polypeptide A4
chr12_-_16759711 0.618 ENST00000447609.1
LMO3
LIM domain only 3 (rhombotin-like 2)
chr9_+_139981379 0.617 ENST00000371589.4
MAN1B1
mannosidase, alpha, class 1B, member 1
chr20_+_3776936 0.616 ENST00000439880.2
CDC25B
cell division cycle 25B
chr17_+_41323204 0.589 ENST00000542611.1
ENST00000590996.1
ENST00000389312.4
ENST00000589872.1
NBR1



neighbor of BRCA1 gene 1



chr11_+_308143 0.588 ENST00000399817.4
IFITM2
interferon induced transmembrane protein 2
chr1_+_196912902 0.585 ENST00000476712.2
ENST00000367415.5
CFHR2

complement factor H-related 2

chr4_-_149363662 0.584 ENST00000355292.3
ENST00000358102.3
NR3C2

nuclear receptor subfamily 3, group C, member 2

chr1_+_236849754 0.563 ENST00000542672.1
ENST00000366578.4
ACTN2

actinin, alpha 2

chr11_+_108093559 0.559 ENST00000278616.4
ATM
ataxia telangiectasia mutated
chr1_+_201979645 0.557 ENST00000367284.5
ENST00000367283.3
ELF3

E74-like factor 3 (ets domain transcription factor, epithelial-specific )

chr18_-_52989525 0.550 ENST00000457482.3
TCF4
transcription factor 4
chr19_-_46285646 0.549 ENST00000458663.2
DMPK
dystrophia myotonica-protein kinase
chr17_-_18161870 0.544 ENST00000579294.1
ENST00000545457.2
ENST00000379450.4
ENST00000578558.1
FLII



flightless I homolog (Drosophila)



chr16_+_67207872 0.537 ENST00000563258.1
ENST00000568146.1
NOL3

nucleolar protein 3 (apoptosis repressor with CARD domain)

chr7_+_6414128 0.521 ENST00000348035.4
ENST00000356142.4
RAC1

ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)

chr7_+_110731062 0.508 ENST00000308478.5
ENST00000451085.1
ENST00000422987.3
ENST00000421101.1
LRRN3



leucine rich repeat neuronal 3



chr4_+_71600144 0.501 ENST00000502653.1
RUFY3
RUN and FYVE domain containing 3
chr4_-_70361579 0.495 ENST00000512583.1
UGT2B4
UDP glucuronosyltransferase 2 family, polypeptide B4
chr7_-_100183742 0.485 ENST00000310300.6
LRCH4
leucine-rich repeats and calponin homology (CH) domain containing 4
chr12_-_114843889 0.485 ENST00000405440.2
TBX5
T-box 5
chr17_-_7145106 0.484 ENST00000577035.1
GABARAP
GABA(A) receptor-associated protein
chr9_+_115983808 0.479 ENST00000374210.6
ENST00000374212.4
SLC31A1

solute carrier family 31 (copper transporter), member 1

chr11_-_64013663 0.476 ENST00000392210.2
PPP1R14B
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr5_+_177027101 0.475 ENST00000029410.5
ENST00000510761.1
ENST00000505468.1
B4GALT7


xylosylprotein beta 1,4-galactosyltransferase, polypeptide 7


chr9_+_17135016 0.474 ENST00000425824.1
ENST00000262360.5
ENST00000380641.4
CNTLN


centlein, centrosomal protein


chr4_-_111119804 0.470 ENST00000394607.3
ENST00000302274.3
ELOVL6

ELOVL fatty acid elongase 6

chr3_+_69985734 0.468 ENST00000314557.6
ENST00000394351.3
MITF

microphthalmia-associated transcription factor

chr11_+_120207787 0.467 ENST00000397843.2
ENST00000356641.3
ARHGEF12

Rho guanine nucleotide exchange factor (GEF) 12

chr17_-_34344991 0.462 ENST00000591423.1
CCL23
chemokine (C-C motif) ligand 23
chr17_-_2169425 0.461 ENST00000570606.1
ENST00000354901.4
SMG6

SMG6 nonsense mediated mRNA decay factor

chr17_-_34345002 0.459 ENST00000293280.2
CCL23
chemokine (C-C motif) ligand 23
chr15_-_81616446 0.456 ENST00000302824.6
STARD5
StAR-related lipid transfer (START) domain containing 5
chr20_+_3776371 0.443 ENST00000245960.5
CDC25B
cell division cycle 25B
chr11_+_120107344 0.442 ENST00000260264.4
POU2F3
POU class 2 homeobox 3
chr3_-_116164306 0.433 ENST00000490035.2
LSAMP
limbic system-associated membrane protein
chr15_+_101420028 0.431 ENST00000557963.1
ENST00000346623.6
ALDH1A3

aldehyde dehydrogenase 1 family, member A3

chr4_+_5712898 0.428 ENST00000264956.6
ENST00000382674.2
EVC

Ellis van Creveld syndrome

chr3_+_137906154 0.427 ENST00000466749.1
ENST00000358441.2
ENST00000489213.1
ARMC8


armadillo repeat containing 8


chr8_-_110986918 0.421 ENST00000297404.1
KCNV1
potassium channel, subfamily V, member 1
chr3_+_137906353 0.420 ENST00000461822.1
ENST00000485396.1
ENST00000471453.1
ENST00000470821.1
ENST00000471709.1
ENST00000538260.1
ENST00000393058.3
ENST00000463485.1
ARMC8







armadillo repeat containing 8







chr1_-_47407111 0.413 ENST00000371904.4
CYP4A11
cytochrome P450, family 4, subfamily A, polypeptide 11
chr6_-_106773491 0.411 ENST00000360666.4
ATG5
autophagy related 5
chr11_+_66624527 0.407 ENST00000393952.3
LRFN4
leucine rich repeat and fibronectin type III domain containing 4
chr1_+_202995611 0.406 ENST00000367240.2
PPFIA4
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4
chr11_+_308217 0.403 ENST00000602569.1
IFITM2
interferon induced transmembrane protein 2
chr10_+_80828774 0.402 ENST00000334512.5
ZMIZ1
zinc finger, MIZ-type containing 1
chr18_+_61442629 0.398 ENST00000398019.2
ENST00000540675.1
SERPINB7

serpin peptidase inhibitor, clade B (ovalbumin), member 7

chr1_+_196743943 0.390 ENST00000471440.2
ENST00000391985.3
CFHR3

complement factor H-related 3

chr2_+_18059906 0.384 ENST00000304101.4
KCNS3
potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3
chr18_-_53253112 0.379 ENST00000568673.1
ENST00000562847.1
ENST00000568147.1
TCF4


transcription factor 4


chr9_+_17134980 0.376 ENST00000380647.3
CNTLN
centlein, centrosomal protein
chr8_-_121824374 0.374 ENST00000517992.1
SNTB1
syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)
chr2_+_109223595 0.373 ENST00000410093.1
LIMS1
LIM and senescent cell antigen-like domains 1
chr16_-_28936493 0.373 ENST00000544477.1
ENST00000357573.6
RABEP2

rabaptin, RAB GTPase binding effector protein 2

chr14_-_76447494 0.369 ENST00000238682.3
TGFB3
transforming growth factor, beta 3
chr5_-_73937244 0.366 ENST00000302351.4
ENST00000510316.1
ENST00000508331.1
ENC1


ectodermal-neural cortex 1 (with BTB domain)


chr2_-_75426183 0.364 ENST00000409848.3
TACR1
tachykinin receptor 1
chr2_-_69870747 0.362 ENST00000409068.1
AAK1
AP2 associated kinase 1
chr7_-_72936608 0.362 ENST00000404251.1
BAZ1B
bromodomain adjacent to zinc finger domain, 1B
chr19_+_36236514 0.356 ENST00000222266.2
PSENEN
presenilin enhancer gamma secretase subunit
chr15_+_42697065 0.354 ENST00000565559.1
CAPN3
calpain 3, (p94)
chr6_+_158733692 0.350 ENST00000367094.2
ENST00000367097.3
TULP4

tubby like protein 4

chr1_-_144994909 0.346 ENST00000369347.4
ENST00000369354.3
PDE4DIP

phosphodiesterase 4D interacting protein

chr1_+_236305826 0.344 ENST00000366592.3
ENST00000366591.4
GPR137B

G protein-coupled receptor 137B

chr1_+_15479021 0.339 ENST00000428417.1
TMEM51
transmembrane protein 51
chr13_-_33112899 0.337 ENST00000267068.3
ENST00000357505.6
ENST00000399396.3
N4BP2L2


NEDD4 binding protein 2-like 2


chr11_-_66445219 0.317 ENST00000525754.1
ENST00000531969.1
ENST00000524637.1
ENST00000531036.2
ENST00000310046.4
RBM4B




RNA binding motif protein 4B




chr3_+_183894566 0.303 ENST00000439647.1
AP2M1
adaptor-related protein complex 2, mu 1 subunit
chr3_+_33840050 0.303 ENST00000457054.2
ENST00000413073.1
PDCD6IP

programmed cell death 6 interacting protein

chr6_-_106773610 0.299 ENST00000369076.3
ENST00000369070.1
ATG5

autophagy related 5

chr5_+_66124590 0.295 ENST00000490016.2
ENST00000403666.1
ENST00000450827.1
MAST4


microtubule associated serine/threonine kinase family member 4


chr8_-_59412717 0.294 ENST00000301645.3
CYP7A1
cytochrome P450, family 7, subfamily A, polypeptide 1
chr17_-_7167279 0.282 ENST00000571932.2
CLDN7
claudin 7
chr1_+_15479054 0.282 ENST00000376014.3
ENST00000451326.2
TMEM51

transmembrane protein 51

chr17_-_27503770 0.281 ENST00000533112.1
MYO18A
myosin XVIIIA
chr7_-_74221288 0.279 ENST00000451013.2
GTF2IRD2
GTF2I repeat domain containing 2
chr16_-_47495170 0.275 ENST00000320640.6
ENST00000544001.2
ITFG1

integrin alpha FG-GAP repeat containing 1

chr12_-_27167233 0.274 ENST00000535819.1
ENST00000543803.1
ENST00000535423.1
ENST00000539741.1
ENST00000343028.4
ENST00000545600.1
ENST00000543088.1
TM7SF3






transmembrane 7 superfamily member 3






chr1_+_22962948 0.274 ENST00000374642.3
C1QA
complement component 1, q subcomponent, A chain
chr18_+_3252206 0.268 ENST00000578562.2
MYL12A
myosin, light chain 12A, regulatory, non-sarcomeric

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 5.2 GO:0070886 positive regulation of calcineurin-NFAT signaling cascade(GO:0070886)
1.7 5.0 GO:0010757 negative regulation of plasminogen activation(GO:0010757)
1.2 4.8 GO:0009956 radial pattern formation(GO:0009956)
1.2 13.1 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.9 5.4 GO:0008228 opsonization(GO:0008228)
0.5 7.8 GO:0034446 substrate adhesion-dependent cell spreading(GO:0034446)
0.4 2.5 GO:0032926 negative regulation of activin receptor signaling pathway(GO:0032926)
0.4 1.5 GO:0010936 negative regulation of macrophage cytokine production(GO:0010936)
0.4 3.2 GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.3 2.7 GO:0007351 tripartite regional subdivision(GO:0007351) anterior/posterior axis specification, embryo(GO:0008595)
0.3 0.9 GO:0002384 hepatic immune response(GO:0002384) positive regulation of transmission of nerve impulse(GO:0051971)
0.3 2.8 GO:0010799 regulation of peptidyl-threonine phosphorylation(GO:0010799) positive regulation of peptidyl-threonine phosphorylation(GO:0010800)
0.3 1.3 GO:0033632 regulation of cell-cell adhesion mediated by integrin(GO:0033632)
0.2 0.4 GO:0002072 optic cup morphogenesis involved in camera-type eye development(GO:0002072)
0.2 4.3 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.2 1.1 GO:0007144 female meiosis I(GO:0007144)
0.2 0.5 GO:0032707 negative regulation of interleukin-23 production(GO:0032707)
0.2 1.0 GO:0051387 negative regulation of neurotrophin TRK receptor signaling pathway(GO:0051387)
0.2 0.5 GO:0061117 cardiac left ventricle formation(GO:0003218) negative regulation of cardiac muscle tissue growth(GO:0055022) negative regulation of cardiac muscle tissue development(GO:0055026) negative regulation of cardiac muscle cell proliferation(GO:0060044) negative regulation of heart growth(GO:0061117)
0.2 2.9 GO:0007220 Notch receptor processing(GO:0007220)
0.2 0.6 GO:0043501 skeletal muscle adaptation(GO:0043501)
0.2 0.5 GO:0042759 fatty acid elongation, saturated fatty acid(GO:0019367) long-chain fatty acid biosynthetic process(GO:0042759)
0.2 1.2 GO:0051481 negative regulation of cytosolic calcium ion concentration(GO:0051481)
0.1 0.3 GO:0033484 nitric oxide homeostasis(GO:0033484)
0.1 0.7 GO:0055098 response to low-density lipoprotein particle(GO:0055098) regulation of cholesterol transporter activity(GO:0060694)
0.1 0.6 GO:0030035 microspike assembly(GO:0030035)
0.1 0.6 GO:0002331 immature B cell differentiation(GO:0002327) pre-B cell differentiation(GO:0002329) pre-B cell allelic exclusion(GO:0002331)
0.1 0.7 GO:0006789 bilirubin conjugation(GO:0006789) biphenyl metabolic process(GO:0018879) biphenyl catabolic process(GO:0070980)
0.1 2.1 GO:0032456 endocytic recycling(GO:0032456)
0.1 0.4 GO:0007028 cytoplasm organization(GO:0007028)
0.1 0.8 GO:0015824 proline transport(GO:0015824)
0.1 0.4 GO:0045760 mechanosensory behavior(GO:0007638) response to auditory stimulus(GO:0010996) operant conditioning(GO:0035106) positive regulation of action potential(GO:0045760)
0.1 0.6 GO:0022614 membrane to membrane docking(GO:0022614)
0.1 0.3 GO:0070857 regulation of bile acid biosynthetic process(GO:0070857) regulation of bile acid metabolic process(GO:1904251)
0.1 0.5 GO:0014819 regulation of skeletal muscle contraction(GO:0014819)
0.1 0.4 GO:0043922 negative regulation by host of viral transcription(GO:0043922)
0.1 1.0 GO:0051497 negative regulation of stress fiber assembly(GO:0051497)
0.1 3.9 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.1 0.3 GO:0009822 alkaloid catabolic process(GO:0009822)
0.1 0.5 GO:0048147 negative regulation of fibroblast proliferation(GO:0048147)
0.1 6.3 GO:0032387 negative regulation of intracellular transport(GO:0032387)
0.1 0.7 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.1 0.7 GO:0055015 ventricular cardiac muscle cell development(GO:0055015)
0.1 0.2 GO:0007518 myoblast fate determination(GO:0007518)
0.1 0.9 GO:0043542 endothelial cell migration(GO:0043542)
0.1 0.2 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.1 18.2 GO:0007517 muscle organ development(GO:0007517)
0.0 0.4 GO:0051174 regulation of phosphorus metabolic process(GO:0051174)
0.0 0.9 GO:0002040 sprouting angiogenesis(GO:0002040)
0.0 0.5 GO:0035434 copper ion transmembrane transport(GO:0035434)
0.0 0.6 GO:0060056 mammary gland involution(GO:0060056)
0.0 0.5 GO:0042447 hormone catabolic process(GO:0042447)
0.0 0.2 GO:0050774 negative regulation of dendrite morphogenesis(GO:0050774)
0.0 0.2 GO:0007616 long-term memory(GO:0007616)
0.0 0.7 GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540)
0.0 0.0 GO:0009441 glycolate metabolic process(GO:0009441)
0.0 1.2 GO:0030049 muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275)
0.0 0.5 GO:0006700 C21-steroid hormone biosynthetic process(GO:0006700)
0.0 2.4 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.0 0.0 GO:0090281 negative regulation of calcium ion import(GO:0090281)
0.0 0.4 GO:0001881 receptor recycling(GO:0001881)
0.0 0.7 GO:0016236 macroautophagy(GO:0016236)
0.0 0.2 GO:0050665 hydrogen peroxide biosynthetic process(GO:0050665)
0.0 0.2 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.0 0.3 GO:0048024 regulation of mRNA splicing, via spliceosome(GO:0048024)
0.0 1.3 GO:0007569 cell aging(GO:0007569)
0.0 1.2 GO:0001764 neuron migration(GO:0001764)
0.0 0.9 GO:0051101 regulation of DNA binding(GO:0051101)
0.0 0.7 GO:0035303 regulation of dephosphorylation(GO:0035303)
0.0 0.2 GO:0043508 negative regulation of JUN kinase activity(GO:0043508)
0.0 0.1 GO:0071285 cellular response to lithium ion(GO:0071285)
0.0 0.7 GO:0090263 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436) positive regulation of canonical Wnt signaling pathway(GO:0090263) positive regulation of proteasomal protein catabolic process(GO:1901800)
0.0 1.3 GO:0019722 calcium-mediated signaling(GO:0019722)
0.0 1.3 GO:0006956 complement activation(GO:0006956)
0.0 2.1 GO:0018279 peptidyl-asparagine modification(GO:0018196) protein N-linked glycosylation via asparagine(GO:0018279)
0.0 0.6 GO:0001676 long-chain fatty acid metabolic process(GO:0001676)
0.0 1.1 GO:0045454 cell redox homeostasis(GO:0045454)
0.0 0.1 GO:0033327 Leydig cell differentiation(GO:0033327)
0.0 0.9 GO:0051084 'de novo' posttranslational protein folding(GO:0051084)
0.0 0.1 GO:0045079 negative regulation of chemokine production(GO:0032682) negative regulation of chemokine biosynthetic process(GO:0045079)
0.0 0.1 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.0 0.1 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
0.0 1.2 GO:0001906 cell killing(GO:0001906)
0.0 0.8 GO:0045727 positive regulation of translation(GO:0045727)
0.0 1.3 GO:0002756 MyD88-independent toll-like receptor signaling pathway(GO:0002756)
0.0 1.8 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 0.5 GO:0050771 negative regulation of axonogenesis(GO:0050771)
0.0 0.1 GO:0034723 DNA replication-dependent nucleosome organization(GO:0034723)
0.0 0.6 GO:0006821 chloride transport(GO:0006821)
0.0 2.4 GO:0006936 muscle contraction(GO:0006936)
0.0 0.7 GO:0048704 embryonic skeletal system morphogenesis(GO:0048704)
0.0 3.3 GO:0006260 DNA replication(GO:0006260)
0.0 1.2 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)
0.0 0.1 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.0 0.1 GO:0007210 serotonin receptor signaling pathway(GO:0007210)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 3.3 GO:0005607 laminin-2 complex(GO:0005607)
0.9 13.1 GO:0098647 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.5 5.0 GO:0005577 fibrinogen complex(GO:0005577)
0.3 4.5 GO:0031527 filopodium membrane(GO:0031527)
0.3 2.7 GO:0005587 collagen type IV trimer(GO:0005587)
0.2 2.8 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.2 0.9 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.2 1.7 GO:0033018 sarcoplasmic reticulum lumen(GO:0033018)
0.2 1.3 GO:0016012 sarcoglycan complex(GO:0016012)
0.1 2.0 GO:0031528 microvillus membrane(GO:0031528)
0.1 3.9 GO:0005680 anaphase-promoting complex(GO:0005680)
0.1 1.2 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.1 0.8 GO:0005869 dynactin complex(GO:0005869)
0.1 0.7 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.1 3.0 GO:0030175 filopodium(GO:0030175)
0.1 2.4 GO:0005796 Golgi lumen(GO:0005796)
0.1 1.2 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.1 0.7 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.1 1.7 GO:0005811 lipid particle(GO:0005811)
0.1 0.3 GO:0005602 complement component C1 complex(GO:0005602)
0.0 1.1 GO:0005776 autophagosome(GO:0005776)
0.0 1.9 GO:0098636 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.0 0.1 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.0 3.4 GO:0030426 growth cone(GO:0030426)
0.0 2.8 GO:0016459 myosin complex(GO:0016459)
0.0 0.2 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.0 1.8 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 1.6 GO:0001725 stress fiber(GO:0001725) actin filament(GO:0005884) contractile actin filament bundle(GO:0097517)
0.0 4.1 GO:0005925 focal adhesion(GO:0005925)
0.0 3.5 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.0 0.2 GO:0070069 cytochrome complex(GO:0070069)
0.0 2.0 GO:0098802 plasma membrane receptor complex(GO:0098802)
0.0 0.9 GO:0030286 dynein complex(GO:0030286)
0.0 0.4 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 1.9 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 0.4 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 1.7 GO:0005802 trans-Golgi network(GO:0005802)
0.0 2.5 GO:0005938 cell cortex(GO:0005938)
0.0 0.8 GO:0005814 centriole(GO:0005814)
0.0 0.2 GO:0030897 HOPS complex(GO:0030897)
0.0 1.0 GO:0030027 lamellipodium(GO:0030027)
0.0 1.0 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 1.4 GO:0005882 intermediate filament(GO:0005882)
0.0 0.1 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937) histone pre-mRNA 3'end processing complex(GO:0071204)
0.0 0.7 GO:0044853 caveola(GO:0005901) plasma membrane raft(GO:0044853)
0.0 0.3 GO:0016328 lateral plasma membrane(GO:0016328)
0.0 0.1 GO:0042788 polysomal ribosome(GO:0042788)
0.0 1.0 GO:0005875 microtubule associated complex(GO:0005875)
0.0 0.2 GO:0005922 connexon complex(GO:0005922)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 5.0 GO:0070052 collagen V binding(GO:0070052)
0.8 2.5 GO:0048184 obsolete follistatin binding(GO:0048184)
0.6 8.5 GO:0003706 obsolete ligand-regulated transcription factor activity(GO:0003706)
0.5 6.1 GO:0030247 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.3 12.8 GO:0050840 extracellular matrix binding(GO:0050840)
0.3 3.2 GO:0017154 semaphorin receptor activity(GO:0017154)
0.3 2.8 GO:0008607 phosphorylase kinase regulator activity(GO:0008607)
0.3 0.8 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
0.2 2.7 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.2 6.2 GO:0005212 structural constituent of eye lens(GO:0005212)
0.2 2.3 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.2 1.0 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)
0.2 4.3 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.2 0.6 GO:0010861 thyroid hormone receptor activator activity(GO:0010861) thyroid hormone receptor coactivator activity(GO:0030375)
0.2 0.6 GO:0004677 DNA-dependent protein kinase activity(GO:0004677)
0.2 1.1 GO:0004791 thioredoxin-disulfide reductase activity(GO:0004791)
0.2 0.7 GO:0018685 alkane 1-monooxygenase activity(GO:0018685)
0.1 1.5 GO:0005114 type II transforming growth factor beta receptor binding(GO:0005114)
0.1 3.7 GO:0005523 tropomyosin binding(GO:0005523)
0.1 4.5 GO:0005518 collagen binding(GO:0005518)
0.1 0.9 GO:0005138 interleukin-6 receptor binding(GO:0005138)
0.1 0.4 GO:0070324 thyroid hormone binding(GO:0070324)
0.1 2.1 GO:0043014 alpha-tubulin binding(GO:0043014)
0.1 1.3 GO:0030346 protein phosphatase 2B binding(GO:0030346)
0.1 0.5 GO:0009922 fatty acid elongase activity(GO:0009922)
0.1 1.2 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, RNA polymerase II basal transcription factor binding(GO:0001083) transcription factor activity, TFIIB-class binding(GO:0001087) RNA polymerase II basal transcription factor binding(GO:0001091) TFIIB-class transcription factor binding(GO:0001093)
0.1 0.8 GO:0030371 translation repressor activity(GO:0030371)
0.1 0.3 GO:0033867 Fas-activated serine/threonine kinase activity(GO:0033867)
0.1 0.3 GO:0070643 vitamin D3 25-hydroxylase activity(GO:0030343) vitamin D 25-hydroxylase activity(GO:0070643)
0.1 1.2 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391)
0.1 0.7 GO:1901567 icosanoid binding(GO:0050542) arachidonic acid binding(GO:0050544) fatty acid derivative binding(GO:1901567)
0.1 0.2 GO:0000150 recombinase activity(GO:0000150)
0.1 1.3 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.1 0.5 GO:0031996 thioesterase binding(GO:0031996)
0.1 0.4 GO:0004995 tachykinin receptor activity(GO:0004995)
0.1 1.0 GO:0043274 phospholipase binding(GO:0043274)
0.1 0.5 GO:0050811 GABA receptor binding(GO:0050811)
0.1 1.5 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.1 0.7 GO:0047617 acyl-CoA hydrolase activity(GO:0047617)
0.0 1.8 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.0 0.7 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 0.5 GO:0005375 copper ion transmembrane transporter activity(GO:0005375)
0.0 0.2 GO:0005078 MAP-kinase scaffold activity(GO:0005078) protein tyrosine/threonine phosphatase activity(GO:0008330)
0.0 0.2 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.0 0.5 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.0 3.1 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.4 GO:0016563 obsolete transcription activator activity(GO:0016563)
0.0 0.6 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.5 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0 0.2 GO:0004982 N-formyl peptide receptor activity(GO:0004982)
0.0 0.4 GO:0017091 AU-rich element binding(GO:0017091)
0.0 0.1 GO:0005319 lipid transporter activity(GO:0005319)
0.0 0.1 GO:0061659 ubiquitin-ubiquitin ligase activity(GO:0034450) ubiquitin protein ligase activity(GO:0061630) ubiquitin-like protein ligase activity(GO:0061659)
0.0 0.7 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 0.6 GO:0042162 telomeric DNA binding(GO:0042162)
0.0 0.3 GO:0048487 beta-tubulin binding(GO:0048487)
0.0 0.8 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 0.4 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 0.6 GO:0043531 ADP binding(GO:0043531)
0.0 0.5 GO:0035250 UDP-galactosyltransferase activity(GO:0035250)
0.0 3.9 GO:0003774 motor activity(GO:0003774)
0.0 0.2 GO:0015288 porin activity(GO:0015288)
0.0 0.5 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 0.2 GO:0016301 kinase activity(GO:0016301)
0.0 0.8 GO:0016829 lyase activity(GO:0016829)
0.0 0.4 GO:0008200 ion channel inhibitor activity(GO:0008200)
0.0 0.9 GO:0008009 chemokine activity(GO:0008009)
0.0 0.3 GO:0008395 steroid hydroxylase activity(GO:0008395)
0.0 8.0 GO:0003779 actin binding(GO:0003779)
0.0 3.5 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 0.1 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
0.0 0.3 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.0 0.2 GO:0005243 gap junction channel activity(GO:0005243)
0.0 0.8 GO:0004871 signal transducer activity(GO:0004871)
0.0 3.2 GO:0030528 obsolete transcription regulator activity(GO:0030528)
0.0 0.9 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
0.0 0.3 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 5.8 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.1 1.1 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 3.3 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.9 ST_STAT3_PATHWAY STAT3 Pathway
0.0 2.0 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.0 1.1 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 1.9 ST_INTEGRIN_SIGNALING_PATHWAY Integrin Signaling Pathway