Motif ID: NR4A1

Z-value: 1.446


Transcription factors associated with NR4A1:

Gene SymbolEntrez IDGene Name
NR4A1 ENSG00000123358.15 NR4A1



Activity profile for motif NR4A1.

activity profile for motif NR4A1


Sorted Z-values histogram for motif NR4A1

Sorted Z-values for motif NR4A1



Network of associatons between targets according to the STRING database.



First level regulatory network of NR4A1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_+_228678550 4.740 ENST00000409189.3
ENST00000358813.4
 CCL20

chemokine (C-C motif) ligand 20

chr11_+_116700614 3.645 ENST00000375345.1
 APOC3
apolipoprotein C-III
chr11_+_116700600 3.626 ENST00000227667.3
 APOC3
apolipoprotein C-III
chrX_-_43741594 2.294 ENST00000536181.1
ENST00000378069.4
 MAOB

monoamine oxidase B

chr4_+_100495864 2.273 ENST00000265517.5
ENST00000422897.2
 MTTP

microsomal triglyceride transfer protein

chr1_+_64059332 2.089 ENST00000540265.1
 PGM1
phosphoglucomutase 1
chr5_-_74162605 1.921 ENST00000389156.4
ENST00000510496.1
ENST00000380515.3
 FAM169A


family with sequence similarity 169, member A


chr17_+_1646130 1.849 ENST00000453066.1
ENST00000324015.3
ENST00000450523.2
ENST00000453723.1
ENST00000382061.4
 SERPINF2




serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2




chr6_+_31895467 1.808 ENST00000556679.1
ENST00000456570.1
 CFB
CFB
complement factor B
Complement factor B; Uncharacterized protein; cDNA FLJ55673, highly similar to Complement factor B
chr6_+_31895254 1.801 ENST00000299367.5
ENST00000442278.2
 C2

complement component 2

chr10_+_101542462 1.760 ENST00000370449.4
ENST00000370434.1
 ABCC2

ATP-binding cassette, sub-family C (CFTR/MRP), member 2

chr6_+_31895480 1.732 ENST00000418949.2
ENST00000383177.3
ENST00000477310.1
 C2

CFB
complement component 2

Complement factor B; Uncharacterized protein; cDNA FLJ55673, highly similar to Complement factor B
chr1_+_212738676 1.668 ENST00000366981.4
ENST00000366987.2
 ATF3

activating transcription factor 3

chr19_-_41256207 1.613 ENST00000598485.2
ENST00000470681.1
ENST00000339153.3
ENST00000598729.1
 C19orf54



chromosome 19 open reading frame 54



chr11_+_7618413 1.532 ENST00000528883.1
 PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr8_+_123793633 1.428 ENST00000314393.4
 ZHX2
zinc fingers and homeoboxes 2
chr14_-_95623607 1.312 ENST00000531162.1
ENST00000529720.1
ENST00000343455.3
 DICER1


dicer 1, ribonuclease type III


chr14_-_95624227 1.276 ENST00000526495.1
 DICER1
dicer 1, ribonuclease type III
chr6_+_64346386 1.243 ENST00000509330.1
 PHF3
PHD finger protein 3
chr17_-_66287257 1.149 ENST00000327268.4
 SLC16A6
solute carrier family 16, member 6
chr8_-_120685608 1.035 ENST00000427067.2
 ENPP2
ectonucleotide pyrophosphatase/phosphodiesterase 2
chr19_+_54926601 0.953 ENST00000301194.4
 TTYH1
tweety family member 1
chr12_+_109577202 0.931 ENST00000377848.3
ENST00000377854.5
 ACACB

acetyl-CoA carboxylase beta

chr19_+_54926621 0.859 ENST00000376530.3
ENST00000445095.1
ENST00000391739.3
ENST00000376531.3
 TTYH1



tweety family member 1



chr1_-_111743285 0.811 ENST00000357640.4
 DENND2D
DENN/MADD domain containing 2D
chr4_-_89744365 0.771 ENST00000513837.1
ENST00000503556.1
 FAM13A

family with sequence similarity 13, member A

chr2_-_44223138 0.749 ENST00000260665.7
 LRPPRC
leucine-rich pentatricopeptide repeat containing
chr4_-_89744314 0.742 ENST00000508369.1
 FAM13A
family with sequence similarity 13, member A
chr17_+_4855053 0.742 ENST00000518175.1
 ENO3
enolase 3 (beta, muscle)
chr4_-_89744457 0.710 ENST00000395002.2
 FAM13A
family with sequence similarity 13, member A
chr4_-_74088800 0.693 ENST00000509867.2
 ANKRD17
ankyrin repeat domain 17
chr1_+_174769006 0.683 ENST00000489615.1
 RABGAP1L
RAB GTPase activating protein 1-like
chr12_-_53320245 0.680 ENST00000552150.1
 KRT8
keratin 8
chr12_+_6644443 0.628 ENST00000396858.1
 GAPDH
glyceraldehyde-3-phosphate dehydrogenase
chr7_+_119913688 0.621 ENST00000331113.4
 KCND2
potassium voltage-gated channel, Shal-related subfamily, member 2
chr11_+_86748863 0.564 ENST00000340353.7
 TMEM135
transmembrane protein 135
chrX_+_2746850 0.479 ENST00000381163.3
ENST00000338623.5
ENST00000542787.1
 GYG2


glycogenin 2


chr2_+_162016916 0.477 ENST00000405852.1
 TANK
TRAF family member-associated NFKB activator
chr22_-_31364187 0.475 ENST00000215862.4
ENST00000397641.3
 MORC2

MORC family CW-type zinc finger 2

chr14_-_21567009 0.460 ENST00000556174.1
ENST00000554478.1
ENST00000553980.1
ENST00000421093.2
 ZNF219



zinc finger protein 219



chr17_+_4854375 0.445 ENST00000521811.1
ENST00000519602.1
ENST00000323997.6
ENST00000522249.1
ENST00000519584.1
 ENO3




enolase 3 (beta, muscle)




chr9_-_75567962 0.436 ENST00000297785.3
ENST00000376939.1
 ALDH1A1

aldehyde dehydrogenase 1 family, member A1

chr2_+_162016827 0.436 ENST00000429217.1
ENST00000406287.1
ENST00000402568.1
 TANK


TRAF family member-associated NFKB activator


chr14_-_35591433 0.429 ENST00000261475.5
ENST00000555644.1
 PPP2R3C

protein phosphatase 2, regulatory subunit B'', gamma

chr2_+_162016804 0.405 ENST00000392749.2
ENST00000440506.1
 TANK

TRAF family member-associated NFKB activator

chr11_+_3876859 0.398 ENST00000300737.4
 STIM1
stromal interaction molecule 1
chr19_+_11546093 0.394 ENST00000591462.1
 PRKCSH
protein kinase C substrate 80K-H
chr19_+_11546153 0.392 ENST00000591946.1
ENST00000252455.2
ENST00000412601.1
 PRKCSH


protein kinase C substrate 80K-H


chr5_-_27038683 0.343 ENST00000511822.1
ENST00000231021.4
 CDH9

cadherin 9, type 2 (T1-cadherin)

chr19_+_11546440 0.332 ENST00000589126.1
ENST00000588269.1
ENST00000587509.1
ENST00000592741.1
ENST00000593101.1
ENST00000587327.1
 PRKCSH





protein kinase C substrate 80K-H





chr20_+_11898507 0.323 ENST00000378226.2
 BTBD3
BTB (POZ) domain containing 3
chr16_+_21312170 0.308 ENST00000338573.5
ENST00000561968.1
 CRYM-AS1

CRYM antisense RNA 1

chr2_-_207024233 0.305 ENST00000423725.1
ENST00000233190.6
 NDUFS1

NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)

chr2_-_207024134 0.282 ENST00000457011.1
ENST00000440274.1
ENST00000432169.1
 NDUFS1


NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)


chr2_+_178257372 0.281 ENST00000264167.4
ENST00000409888.1
 AGPS

alkylglycerone phosphate synthase

chr22_-_51016846 0.270 ENST00000312108.7
ENST00000395650.2
 CPT1B

carnitine palmitoyltransferase 1B (muscle)

chr22_-_51017084 0.270 ENST00000360719.2
ENST00000457250.1
ENST00000440709.1
 CPT1B


carnitine palmitoyltransferase 1B (muscle)


chr7_-_81399329 0.267 ENST00000453411.1
ENST00000444829.2
 HGF

hepatocyte growth factor (hepapoietin A; scatter factor)

chr20_+_37590942 0.265 ENST00000373325.2
ENST00000252011.3
ENST00000373323.4
 DHX35


DEAH (Asp-Glu-Ala-His) box polypeptide 35


chr7_-_37488834 0.265 ENST00000310758.4
 ELMO1
engulfment and cell motility 1
chr17_+_7123125 0.261 ENST00000356839.5
ENST00000583312.1
ENST00000350303.5
 ACADVL


acyl-CoA dehydrogenase, very long chain


chr13_-_33112823 0.254 ENST00000504114.1
 N4BP2L2
NEDD4 binding protein 2-like 2
chr7_-_72936531 0.237 ENST00000339594.4
 BAZ1B
bromodomain adjacent to zinc finger domain, 1B
chr11_+_120971882 0.212 ENST00000392793.1
 TECTA
tectorin alpha
chr6_-_152489484 0.209 ENST00000354674.4
ENST00000539504.1
 SYNE1

spectrin repeat containing, nuclear envelope 1

chr3_-_30936153 0.191 ENST00000454381.3
ENST00000282538.5
 GADL1

glutamate decarboxylase-like 1

chr17_+_41150479 0.184 ENST00000589913.1
 RPL27
ribosomal protein L27
chr14_+_35591735 0.181 ENST00000604948.1
ENST00000605201.1
ENST00000250377.7
ENST00000321130.10
ENST00000534898.4
 KIAA0391




KIAA0391




chr20_+_3052264 0.176 ENST00000217386.2
 OXT
oxytocin/neurophysin I prepropeptide
chr4_+_176986978 0.164 ENST00000508596.1
ENST00000393643.2
 WDR17

WD repeat domain 17

chr17_+_41150290 0.160 ENST00000589037.1
ENST00000253788.5
 RPL27

ribosomal protein L27

chr14_-_21566731 0.157 ENST00000360947.3
 ZNF219
zinc finger protein 219
chr6_-_43595039 0.142 ENST00000307114.7
 GTPBP2
GTP binding protein 2
chr17_+_41150793 0.141 ENST00000586277.1
 RPL27
ribosomal protein L27
chr13_-_33112956 0.138 ENST00000505213.1
 N4BP2L2
NEDD4 binding protein 2-like 2
chr6_+_118869452 0.130 ENST00000357525.5
 PLN
phospholamban
chr10_+_12110963 0.129 ENST00000263035.4
ENST00000437298.1
 DHTKD1

dehydrogenase E1 and transketolase domain containing 1

chr7_-_81399355 0.128 ENST00000457544.2
 HGF
hepatocyte growth factor (hepapoietin A; scatter factor)
chr17_+_79670386 0.115 ENST00000541223.1
ENST00000571730.1
ENST00000333676.3
 SLC25A10
SLC25A10
MRPL12
solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
Mitochondrial dicarboxylate carrier; Uncharacterized protein; cDNA FLJ60124, highly similar to Mitochondrial dicarboxylate carrier
mitochondrial ribosomal protein L12
chr19_-_11639931 0.113 ENST00000592312.1
ENST00000590480.1
ENST00000585318.1
ENST00000252440.7
ENST00000417981.2
ENST00000270517.7
 ECSIT





ECSIT signalling integrator





chr2_+_207024306 0.106 ENST00000236957.5
ENST00000392221.1
ENST00000392222.2
ENST00000445505.1
 EEF1B2



eukaryotic translation elongation factor 1 beta 2



chr10_+_104005272 0.085 ENST00000369983.3
 GBF1
golgi brefeldin A resistant guanine nucleotide exchange factor 1
chr7_-_107443652 0.080 ENST00000340010.5
ENST00000422236.2
ENST00000453332.1
 SLC26A3


solute carrier family 26 (anion exchanger), member 3


chr7_-_81399411 0.079 ENST00000423064.2
 HGF
hepatocyte growth factor (hepapoietin A; scatter factor)
chr6_+_44126545 0.061 ENST00000532171.1
ENST00000398776.1
ENST00000542245.1
 CAPN11


calpain 11


chr12_+_49687425 0.059 ENST00000257860.4
 PRPH
peripherin
chr10_-_61666267 0.056 ENST00000263102.6
 CCDC6
coiled-coil domain containing 6
chr1_-_33815486 0.051 ENST00000373418.3
 PHC2
polyhomeotic homolog 2 (Drosophila)
chr7_-_81399438 0.046 ENST00000222390.5
 HGF
hepatocyte growth factor (hepapoietin A; scatter factor)
chr12_+_96252706 0.045 ENST00000266735.5
ENST00000553192.1
ENST00000552085.1
 SNRPF


small nuclear ribonucleoprotein polypeptide F


chr7_-_105517021 0.043 ENST00000318724.4
ENST00000419735.3
 ATXN7L1

ataxin 7-like 1

chr10_+_35484793 0.043 ENST00000488741.1
ENST00000474931.1
ENST00000468236.1
ENST00000344351.5
ENST00000490511.1
 CREM




cAMP responsive element modulator




chr15_-_42783303 0.042 ENST00000565380.1
ENST00000564754.1
 ZNF106

zinc finger protein 106

chr4_+_71108300 0.039 ENST00000304954.3
 CSN3
casein kappa
chr19_-_11639910 0.036 ENST00000588998.1
ENST00000586149.1
 ECSIT

ECSIT signalling integrator

chr17_-_7123021 0.029 ENST00000399510.2
 DLG4
discs, large homolog 4 (Drosophila)
chr19_+_17416457 0.027 ENST00000252602.1
 MRPL34
mitochondrial ribosomal protein L34
chr18_+_43753974 0.026 ENST00000282059.6
ENST00000321319.6
 C18orf25

chromosome 18 open reading frame 25

chr14_-_24711470 0.025 ENST00000559969.1
 TINF2
TERF1 (TRF1)-interacting nuclear factor 2
chr11_-_8680383 0.024 ENST00000299550.6
 TRIM66
tripartite motif containing 66
chrX_+_2746818 0.024 ENST00000398806.3
 GYG2
glycogenin 2
chr15_+_75335604 0.011 ENST00000563393.1
 PPCDC
phosphopantothenoylcysteine decarboxylase
chr7_+_99933730 0.008 ENST00000610247.1
 PILRB
paired immunoglobin-like type 2 receptor beta
chr1_+_50569575 0.007 ENST00000371827.1
 ELAVL4
ELAV like neuron-specific RNA binding protein 4
chr11_-_113577014 0.007 ENST00000544634.1
ENST00000539732.1
ENST00000538770.1
ENST00000536856.1
ENST00000544476.1
 TMPRSS5




transmembrane protease, serine 5





Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.4 7.3 GO:0010989 regulation of high-density lipoprotein particle clearance(GO:0010982) negative regulation of low-density lipoprotein particle clearance(GO:0010989) regulation of cholesterol import(GO:0060620) negative regulation of cholesterol import(GO:0060621) regulation of sterol import(GO:2000909) negative regulation of sterol import(GO:2000910)
0.8 2.3 GO:0014063 regulation of serotonin secretion(GO:0014062) negative regulation of serotonin secretion(GO:0014063)
0.6 2.6 GO:0031643 regulation of Schwann cell differentiation(GO:0014038) positive regulation of Schwann cell differentiation(GO:0014040) positive regulation of myelination(GO:0031643)
0.4 2.1 GO:0019255 glucose 1-phosphate metabolic process(GO:0019255)
0.2 1.8 GO:0034755 iron ion transmembrane transport(GO:0034755)
0.2 1.8 GO:0051918 negative regulation of fibrinolysis(GO:0051918)
0.2 3.5 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.2 0.6 GO:0017014 protein nitrosylation(GO:0017014) peptidyl-cysteine S-nitrosylation(GO:0018119)
0.2 1.5 GO:0015074 DNA integration(GO:0015074)
0.1 1.0 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.1 0.3 GO:0042760 very long-chain fatty acid catabolic process(GO:0042760)
0.1 1.4 GO:1902603 carnitine shuttle(GO:0006853) carnitine transmembrane transport(GO:1902603)
0.1 0.4 GO:2001259 positive regulation of calcium ion transmembrane transporter activity(GO:1901021) positive regulation of cation channel activity(GO:2001259)
0.1 0.5 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.1 0.7 GO:0034643 establishment of mitochondrion localization, microtubule-mediated(GO:0034643) mitochondrion transport along microtubule(GO:0047497)
0.1 0.2 GO:0002125 maternal aggressive behavior(GO:0002125) obsolete negative regulation of diuresis(GO:0003077) positive regulation of norepinephrine secretion(GO:0010701)
0.1 0.4 GO:0006069 ethanol metabolic process(GO:0006067) ethanol oxidation(GO:0006069)
0.0 0.3 GO:1901503 ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
0.0 4.7 GO:0042742 defense response to bacterium(GO:0042742)
0.0 1.2 GO:0043403 skeletal muscle tissue regeneration(GO:0043403)
0.0 1.8 GO:0006958 complement activation, classical pathway(GO:0006958)
0.0 1.8 GO:0006094 gluconeogenesis(GO:0006094)
0.0 0.5 GO:0005980 glycogen catabolic process(GO:0005980)
0.0 0.5 GO:0051881 regulation of mitochondrial membrane potential(GO:0051881)
0.0 1.3 GO:0051291 protein heterooligomerization(GO:0051291)
0.0 1.6 GO:0042157 lipoprotein metabolic process(GO:0042157)
0.0 0.3 GO:0006911 phagocytosis, engulfment(GO:0006911) membrane invagination(GO:0010324) Rac protein signal transduction(GO:0016601)
0.0 0.1 GO:0090292 nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.0 1.1 GO:0015718 monocarboxylic acid transport(GO:0015718)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 7.3 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
0.2 2.6 GO:0016442 RISC complex(GO:0016442) RNAi effector complex(GO:0031332)
0.2 1.8 GO:0046581 intercellular canaliculus(GO:0046581)
0.2 1.2 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.0 0.9 GO:0005640 nuclear outer membrane(GO:0005640)
0.0 3.4 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 2.1 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.0 1.8 GO:0034707 chloride channel complex(GO:0034707)
0.0 0.7 GO:0045095 keratin filament(GO:0045095)
0.0 2.0 GO:0005741 mitochondrial outer membrane(GO:0005741) organelle outer membrane(GO:0031968)
0.0 0.1 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 0.6 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 0.6 GO:0043197 dendritic spine(GO:0043197)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 7.3 GO:0070653 high-density lipoprotein particle receptor binding(GO:0070653)
0.6 2.6 GO:0004525 ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296)
0.5 2.3 GO:0008131 primary amine oxidase activity(GO:0008131)
0.4 1.5 GO:0008907 integrase activity(GO:0008907)
0.4 3.5 GO:0001848 complement binding(GO:0001848)
0.3 2.1 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.3 1.0 GO:0047391 alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391)
0.2 0.9 GO:0003989 acetyl-CoA carboxylase activity(GO:0003989)
0.2 1.8 GO:0005381 iron ion transmembrane transporter activity(GO:0005381)
0.2 1.2 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.2 0.6 GO:0043891 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
0.1 0.5 GO:0008466 glycogenin glucosyltransferase activity(GO:0008466)
0.1 0.6 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.1 0.5 GO:0004095 carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.1 4.7 GO:0008009 chemokine activity(GO:0008009)
0.1 0.3 GO:0017099 very-long-chain-acyl-CoA dehydrogenase activity(GO:0017099)
0.1 0.6 GO:0004969 histamine receptor activity(GO:0004969)
0.1 0.4 GO:0001758 retinal dehydrogenase activity(GO:0001758)
0.0 0.1 GO:0015141 thiosulfate transmembrane transporter activity(GO:0015117) succinate transmembrane transporter activity(GO:0015141)
0.0 0.6 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.0 1.7 GO:0002020 protease binding(GO:0002020)
0.0 2.3 GO:0005319 lipid transporter activity(GO:0005319)
0.0 0.1 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.0 1.1 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.0 0.7 GO:0048487 beta-tubulin binding(GO:0048487)
0.0 1.1 GO:0005080 protein kinase C binding(GO:0005080)
0.0 0.4 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 1.8 GO:0008514 organic anion transmembrane transporter activity(GO:0008514)
0.0 0.1 GO:0008271 secondary active sulfate transmembrane transporter activity(GO:0008271)
0.0 2.3 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.1 GO:0060590 ATPase regulator activity(GO:0060590)