Motif ID: NR4A2
Z-value: 1.185
Transcription factors associated with NR4A2:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| NR4A2 | ENSG00000153234.9 | NR4A2 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 2.1 | GO:0043316 | natural killer cell activation involved in immune response(GO:0002323) cytotoxic T cell degranulation(GO:0043316) natural killer cell degranulation(GO:0043320) |
| 0.3 | 1.0 | GO:0051083 | 'de novo' cotranslational protein folding(GO:0051083) |
| 0.3 | 1.0 | GO:0006106 | fumarate metabolic process(GO:0006106) |
| 0.3 | 0.8 | GO:1904036 | negative regulation of epithelial cell apoptotic process(GO:1904036) negative regulation of endothelial cell apoptotic process(GO:2000352) |
| 0.2 | 1.0 | GO:0006789 | bilirubin conjugation(GO:0006789) biphenyl metabolic process(GO:0018879) biphenyl catabolic process(GO:0070980) |
| 0.2 | 1.9 | GO:0006105 | succinate metabolic process(GO:0006105) |
| 0.2 | 1.0 | GO:0014820 | tonic smooth muscle contraction(GO:0014820) artery smooth muscle contraction(GO:0014824) |
| 0.2 | 0.5 | GO:0015854 | guanine transport(GO:0015854) hypoxanthine transport(GO:0035344) thymine transport(GO:0035364) |
| 0.2 | 1.7 | GO:0006600 | creatine metabolic process(GO:0006600) |
| 0.1 | 0.4 | GO:0021836 | chemorepulsion involved in postnatal olfactory bulb interneuron migration(GO:0021836) regulation of negative chemotaxis(GO:0050923) response to heparin(GO:0071503) cellular response to heparin(GO:0071504) |
| 0.1 | 0.4 | GO:0034205 | beta-amyloid formation(GO:0034205) |
| 0.1 | 0.4 | GO:0061198 | fungiform papilla development(GO:0061196) fungiform papilla morphogenesis(GO:0061197) fungiform papilla formation(GO:0061198) |
| 0.1 | 2.1 | GO:0046902 | regulation of mitochondrial membrane permeability(GO:0046902) regulation of membrane permeability(GO:0090559) |
| 0.1 | 0.3 | GO:0048311 | mitochondrion distribution(GO:0048311) |
| 0.1 | 0.6 | GO:0006102 | isocitrate metabolic process(GO:0006102) |
| 0.1 | 0.3 | GO:1904396 | regulation of synaptic growth at neuromuscular junction(GO:0008582) regulation of neuromuscular junction development(GO:1904396) |
| 0.1 | 0.7 | GO:0006474 | N-terminal protein amino acid acetylation(GO:0006474) |
| 0.1 | 3.5 | GO:0006626 | protein targeting to mitochondrion(GO:0006626) |
| 0.1 | 1.2 | GO:0071378 | growth hormone receptor signaling pathway(GO:0060396) cellular response to growth hormone stimulus(GO:0071378) |
| 0.1 | 0.7 | GO:0015937 | coenzyme A biosynthetic process(GO:0015937) |
| 0.1 | 0.5 | GO:0000959 | mitochondrial RNA metabolic process(GO:0000959) transcription from mitochondrial promoter(GO:0006390) |
| 0.0 | 0.4 | GO:0045542 | positive regulation of cholesterol biosynthetic process(GO:0045542) |
| 0.0 | 0.2 | GO:0034723 | DNA replication-dependent nucleosome organization(GO:0034723) |
| 0.0 | 0.2 | GO:0007389 | pattern specification process(GO:0007389) |
| 0.0 | 0.5 | GO:0033137 | negative regulation of peptidyl-serine phosphorylation(GO:0033137) |
| 0.0 | 1.1 | GO:0006378 | mRNA polyadenylation(GO:0006378) |
| 0.0 | 0.2 | GO:0006122 | mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122) |
| 0.0 | 0.5 | GO:0010799 | regulation of peptidyl-threonine phosphorylation(GO:0010799) positive regulation of peptidyl-threonine phosphorylation(GO:0010800) |
| 0.0 | 0.9 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 0.0 | 0.2 | GO:2001259 | positive regulation of calcium ion transmembrane transporter activity(GO:1901021) positive regulation of cation channel activity(GO:2001259) |
| 0.0 | 0.3 | GO:0006477 | protein sulfation(GO:0006477) |
| 0.0 | 0.3 | GO:0006642 | triglyceride mobilization(GO:0006642) |
| 0.0 | 0.1 | GO:0002679 | respiratory burst involved in defense response(GO:0002679) |
| 0.0 | 0.1 | GO:0048670 | regulation of collateral sprouting(GO:0048670) |
| 0.0 | 0.6 | GO:0000380 | alternative mRNA splicing, via spliceosome(GO:0000380) |
| 0.0 | 0.8 | GO:0019370 | leukotriene biosynthetic process(GO:0019370) |
| 0.0 | 0.1 | GO:0060013 | righting reflex(GO:0060013) |
| 0.0 | 0.1 | GO:0006922 | obsolete cleavage of lamin involved in execution phase of apoptosis(GO:0006922) |
| 0.0 | 0.1 | GO:0001507 | acetylcholine catabolic process in synaptic cleft(GO:0001507) acetylcholine catabolic process(GO:0006581) |
| 0.0 | 0.8 | GO:0015985 | energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986) |
| 0.0 | 0.3 | GO:0097031 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
| 0.0 | 0.1 | GO:0030913 | paranodal junction assembly(GO:0030913) |
| 0.0 | 0.1 | GO:0048488 | synaptic vesicle recycling(GO:0036465) synaptic vesicle endocytosis(GO:0048488) clathrin-mediated endocytosis(GO:0072583) |
| 0.0 | 0.3 | GO:0001662 | behavioral fear response(GO:0001662) |
| 0.0 | 0.4 | GO:0019674 | NAD metabolic process(GO:0019674) |
| 0.0 | 0.5 | GO:0033138 | regulation of peptidyl-serine phosphorylation(GO:0033135) positive regulation of peptidyl-serine phosphorylation(GO:0033138) |
| 0.0 | 0.1 | GO:0002860 | natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002420) natural killer cell mediated immune response to tumor cell(GO:0002423) regulation of natural killer cell mediated immune response to tumor cell(GO:0002855) positive regulation of natural killer cell mediated immune response to tumor cell(GO:0002857) regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002858) positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002860) |
| 0.0 | 0.1 | GO:0060666 | dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666) |
| 0.0 | 0.2 | GO:0007616 | long-term memory(GO:0007616) |
| 0.0 | 0.3 | GO:0051568 | histone H3-K4 methylation(GO:0051568) |
| 0.0 | 0.1 | GO:0016056 | rhodopsin mediated signaling pathway(GO:0016056) |
| 0.0 | 0.4 | GO:0072659 | protein localization to plasma membrane(GO:0072659) protein localization to cell periphery(GO:1990778) |
| 0.0 | 0.5 | GO:0033572 | ferric iron transport(GO:0015682) transferrin transport(GO:0033572) trivalent inorganic cation transport(GO:0072512) |
| 0.0 | 0.1 | GO:0015824 | proline transport(GO:0015824) |
| 0.0 | 0.4 | GO:0006839 | mitochondrial transport(GO:0006839) |
| 0.0 | 0.3 | GO:0001974 | blood vessel remodeling(GO:0001974) |
| 0.0 | 0.8 | GO:0006892 | post-Golgi vesicle-mediated transport(GO:0006892) |
| 0.0 | 0.2 | GO:0071479 | cellular response to ionizing radiation(GO:0071479) |
| 0.0 | 0.2 | GO:0043278 | response to isoquinoline alkaloid(GO:0014072) response to morphine(GO:0043278) |
| 0.0 | 0.2 | GO:0045823 | positive regulation of heart contraction(GO:0045823) |
| 0.0 | 0.9 | GO:0022904 | respiratory electron transport chain(GO:0022904) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 1.9 | GO:0045257 | mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283) |
| 0.2 | 2.9 | GO:0005744 | mitochondrial inner membrane presequence translocase complex(GO:0005744) |
| 0.2 | 1.1 | GO:0005742 | mitochondrial outer membrane translocase complex(GO:0005742) |
| 0.1 | 1.0 | GO:0045239 | tricarboxylic acid cycle enzyme complex(GO:0045239) |
| 0.1 | 0.4 | GO:0014802 | terminal cisterna(GO:0014802) endoplasmic reticulum subcompartment(GO:0098827) |
| 0.1 | 0.6 | GO:0042382 | paraspeckles(GO:0042382) |
| 0.0 | 0.5 | GO:0019773 | proteasome core complex, alpha-subunit complex(GO:0019773) |
| 0.0 | 0.5 | GO:0031588 | nucleotide-activated protein kinase complex(GO:0031588) |
| 0.0 | 2.8 | GO:0030667 | secretory granule membrane(GO:0030667) |
| 0.0 | 0.8 | GO:0045263 | proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263) |
| 0.0 | 0.5 | GO:0005762 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.0 | 0.1 | GO:0042622 | photoreceptor outer segment membrane(GO:0042622) |
| 0.0 | 0.4 | GO:0033180 | proton-transporting V-type ATPase, V1 domain(GO:0033180) |
| 0.0 | 0.8 | GO:0043198 | dendritic shaft(GO:0043198) |
| 0.0 | 0.6 | GO:0045334 | clathrin-coated endocytic vesicle(GO:0045334) |
| 0.0 | 0.4 | GO:0070822 | Sin3 complex(GO:0016580) Sin3-type complex(GO:0070822) |
| 0.0 | 6.4 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.0 | 0.5 | GO:0001772 | immunological synapse(GO:0001772) |
| 0.0 | 0.1 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.0 | 0.1 | GO:0045202 | synapse(GO:0045202) |
| 0.0 | 0.9 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.0 | 0.2 | GO:0005862 | muscle thin filament tropomyosin(GO:0005862) |
| 0.0 | 0.2 | GO:0005721 | pericentric heterochromatin(GO:0005721) obsolete WINAC complex(GO:0071778) |
| 0.0 | 0.1 | GO:0033018 | sarcoplasmic reticulum lumen(GO:0033018) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 1.9 | GO:0016635 | succinate dehydrogenase activity(GO:0000104) oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor(GO:0016635) |
| 0.3 | 1.7 | GO:0004111 | creatine kinase activity(GO:0004111) |
| 0.3 | 0.9 | GO:0015141 | thiosulfate transmembrane transporter activity(GO:0015117) succinate transmembrane transporter activity(GO:0015141) |
| 0.2 | 2.1 | GO:0031489 | myosin V binding(GO:0031489) |
| 0.2 | 2.1 | GO:0016018 | cyclosporin A binding(GO:0016018) |
| 0.2 | 2.9 | GO:0015450 | P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450) |
| 0.2 | 1.2 | GO:0008269 | JAK pathway signal transduction adaptor activity(GO:0008269) |
| 0.2 | 1.0 | GO:0031708 | bombesin receptor binding(GO:0031705) endothelin B receptor binding(GO:0031708) |
| 0.2 | 0.5 | GO:0045155 | electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity(GO:0045155) |
| 0.2 | 1.4 | GO:0015288 | porin activity(GO:0015288) |
| 0.2 | 0.6 | GO:0004449 | isocitrate dehydrogenase (NAD+) activity(GO:0004449) |
| 0.1 | 0.4 | GO:0008431 | vitamin E binding(GO:0008431) |
| 0.1 | 0.4 | GO:0003951 | NAD+ kinase activity(GO:0003951) |
| 0.1 | 0.3 | GO:0033867 | Fas-activated serine/threonine kinase activity(GO:0033867) |
| 0.1 | 0.5 | GO:0034594 | phosphatidylinositol trisphosphate phosphatase activity(GO:0034594) |
| 0.1 | 0.4 | GO:0050508 | glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508) |
| 0.1 | 0.2 | GO:0070260 | 5'-tyrosyl-DNA phosphodiesterase activity(GO:0070260) |
| 0.1 | 0.5 | GO:0031434 | mitogen-activated protein kinase kinase binding(GO:0031434) |
| 0.1 | 0.4 | GO:0043237 | laminin-1 binding(GO:0043237) |
| 0.1 | 0.9 | GO:0019992 | diacylglycerol binding(GO:0019992) |
| 0.1 | 0.4 | GO:0005219 | ryanodine-sensitive calcium-release channel activity(GO:0005219) |
| 0.0 | 1.5 | GO:0001972 | retinoic acid binding(GO:0001972) |
| 0.0 | 0.2 | GO:0033829 | O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829) |
| 0.0 | 0.5 | GO:0008607 | phosphorylase kinase regulator activity(GO:0008607) |
| 0.0 | 0.1 | GO:0004045 | aminoacyl-tRNA hydrolase activity(GO:0004045) |
| 0.0 | 0.6 | GO:0017070 | U6 snRNA binding(GO:0017070) |
| 0.0 | 1.5 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) |
| 0.0 | 1.0 | GO:0045028 | G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028) |
| 0.0 | 0.3 | GO:0042975 | peroxisome proliferator activated receptor binding(GO:0042975) |
| 0.0 | 0.4 | GO:0016884 | carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884) |
| 0.0 | 0.1 | GO:0001641 | group II metabotropic glutamate receptor activity(GO:0001641) |
| 0.0 | 0.5 | GO:0005337 | nucleoside transmembrane transporter activity(GO:0005337) |
| 0.0 | 0.4 | GO:0031078 | histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) histone deacetylase activity (H4-K16 specific)(GO:0034739) NAD-dependent histone deacetylase activity (H4-K16 specific)(GO:0046970) |
| 0.0 | 0.2 | GO:0008294 | calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294) |
| 0.0 | 0.1 | GO:0003747 | translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079) |
| 0.0 | 0.1 | GO:0015193 | L-proline transmembrane transporter activity(GO:0015193) |
| 0.0 | 0.2 | GO:0016681 | ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681) |
| 0.0 | 0.6 | GO:0004129 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.0 | 0.1 | GO:0016499 | orexin receptor activity(GO:0016499) |
| 0.0 | 0.6 | GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding(GO:0005546) |
| 0.0 | 0.1 | GO:0000293 | ferric-chelate reductase activity(GO:0000293) |
| 0.0 | 0.6 | GO:0004385 | guanylate kinase activity(GO:0004385) |
| 0.0 | 0.1 | GO:0004630 | phospholipase D activity(GO:0004630) |
| 0.0 | 0.5 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.0 | 0.1 | GO:0003960 | NADPH:quinone reductase activity(GO:0003960) |
| 0.0 | 0.4 | GO:0003746 | translation elongation factor activity(GO:0003746) |
| 0.0 | 0.3 | GO:0046933 | proton-transporting ATP synthase activity, rotational mechanism(GO:0046933) |
| 0.0 | 0.7 | GO:0016831 | carboxy-lyase activity(GO:0016831) |
| 0.0 | 0.2 | GO:0035173 | histone kinase activity(GO:0035173) |
| 0.0 | 1.6 | GO:0047485 | protein N-terminus binding(GO:0047485) |
| 0.0 | 0.8 | GO:0016836 | hydro-lyase activity(GO:0016836) |
| 0.0 | 0.8 | GO:0015078 | hydrogen ion transmembrane transporter activity(GO:0015078) |
| 0.0 | 0.8 | GO:0008080 | N-acetyltransferase activity(GO:0008080) |
| 0.0 | 0.3 | GO:0005520 | insulin-like growth factor binding(GO:0005520) |
| 0.0 | 0.1 | GO:0017154 | semaphorin receptor activity(GO:0017154) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.5 | ST_G_ALPHA_S_PATHWAY | G alpha s Pathway |
| 0.0 | 1.7 | ST_P38_MAPK_PATHWAY | p38 MAPK Pathway |
| 0.0 | 0.9 | ST_T_CELL_SIGNAL_TRANSDUCTION | T Cell Signal Transduction |
