Motif ID: OLIG2_NEUROD1_ATOH1
Z-value: 1.679
Transcription factors associated with OLIG2_NEUROD1_ATOH1:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
ATOH1 | ENSG00000172238.3 | ATOH1 |
NEUROD1 | ENSG00000162992.3 | NEUROD1 |
OLIG2 | ENSG00000205927.4 | OLIG2 |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.8 | 7.4 | GO:0030913 | paranodal junction assembly(GO:0030913) |
1.4 | 8.4 | GO:0007499 | ectoderm and mesoderm interaction(GO:0007499) |
1.3 | 4.0 | GO:1903115 | regulation of muscle filament sliding(GO:0032971) regulation of actin filament-based movement(GO:1903115) |
0.8 | 3.0 | GO:0010716 | regulation of extracellular matrix disassembly(GO:0010715) negative regulation of extracellular matrix disassembly(GO:0010716) regulation of extracellular matrix organization(GO:1903053) negative regulation of extracellular matrix organization(GO:1903054) |
0.5 | 2.9 | GO:0007525 | somatic muscle development(GO:0007525) |
0.5 | 3.8 | GO:0003065 | regulation of heart rate by chemical signal(GO:0003062) positive regulation of heart rate by epinephrine(GO:0003065) |
0.5 | 2.3 | GO:0032780 | negative regulation of ATPase activity(GO:0032780) |
0.4 | 2.5 | GO:0014819 | regulation of skeletal muscle contraction(GO:0014819) |
0.3 | 0.5 | GO:0051602 | response to electrical stimulus(GO:0051602) |
0.2 | 0.7 | GO:0060279 | progesterone secretion(GO:0042701) regulation of ovulation(GO:0060278) positive regulation of ovulation(GO:0060279) |
0.2 | 0.7 | GO:0071277 | cellular response to calcium ion(GO:0071277) |
0.2 | 0.7 | GO:0031034 | skeletal muscle myosin thick filament assembly(GO:0030241) myosin filament assembly(GO:0031034) striated muscle myosin thick filament assembly(GO:0071688) |
0.2 | 1.7 | GO:0040037 | negative regulation of fibroblast growth factor receptor signaling pathway(GO:0040037) |
0.2 | 1.8 | GO:0046628 | positive regulation of insulin receptor signaling pathway(GO:0046628) positive regulation of cellular response to insulin stimulus(GO:1900078) |
0.2 | 0.5 | GO:0021570 | rhombomere 4 development(GO:0021570) |
0.1 | 1.0 | GO:0043249 | erythrocyte maturation(GO:0043249) |
0.1 | 1.2 | GO:0010799 | regulation of peptidyl-threonine phosphorylation(GO:0010799) positive regulation of peptidyl-threonine phosphorylation(GO:0010800) |
0.1 | 0.7 | GO:0032224 | positive regulation of synaptic transmission, cholinergic(GO:0032224) |
0.1 | 0.7 | GO:0071569 | protein ufmylation(GO:0071569) |
0.1 | 1.1 | GO:0032288 | myelin assembly(GO:0032288) |
0.1 | 1.2 | GO:0006600 | creatine metabolic process(GO:0006600) |
0.1 | 0.4 | GO:0060291 | long-term synaptic potentiation(GO:0060291) |
0.1 | 0.7 | GO:0007216 | G-protein coupled glutamate receptor signaling pathway(GO:0007216) |
0.1 | 0.6 | GO:0006610 | ribosomal protein import into nucleus(GO:0006610) |
0.1 | 1.7 | GO:0043462 | regulation of ATPase activity(GO:0043462) |
0.1 | 0.1 | GO:2000794 | positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501) epithelial cell proliferation involved in lung morphogenesis(GO:0060502) regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000794) |
0.1 | 0.6 | GO:0021952 | central nervous system projection neuron axonogenesis(GO:0021952) |
0.1 | 1.4 | GO:0045749 | obsolete negative regulation of S phase of mitotic cell cycle(GO:0045749) |
0.1 | 0.4 | GO:0090343 | positive regulation of cell aging(GO:0090343) |
0.1 | 0.2 | GO:1904358 | positive regulation of telomere maintenance via telomerase(GO:0032212) positive regulation of telomere maintenance via telomere lengthening(GO:1904358) |
0.1 | 6.9 | GO:0007519 | skeletal muscle tissue development(GO:0007519) |
0.1 | 0.2 | GO:0007175 | negative regulation of epidermal growth factor-activated receptor activity(GO:0007175) |
0.1 | 1.1 | GO:0009312 | oligosaccharide biosynthetic process(GO:0009312) |
0.1 | 0.3 | GO:0021869 | forebrain ventricular zone progenitor cell division(GO:0021869) |
0.1 | 3.7 | GO:0007585 | respiratory gaseous exchange(GO:0007585) |
0.1 | 0.2 | GO:0032060 | bleb assembly(GO:0032060) |
0.1 | 0.2 | GO:0010982 | regulation of high-density lipoprotein particle clearance(GO:0010982) |
0.1 | 1.6 | GO:0051925 | obsolete regulation of calcium ion transport via voltage-gated calcium channel activity(GO:0051925) |
0.1 | 0.3 | GO:0097352 | autophagosome maturation(GO:0097352) |
0.1 | 11.2 | GO:0007517 | muscle organ development(GO:0007517) |
0.1 | 0.2 | GO:1903332 | regulation of protein folding(GO:1903332) |
0.0 | 1.5 | GO:0030049 | muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275) |
0.0 | 1.4 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
0.0 | 3.8 | GO:0007229 | integrin-mediated signaling pathway(GO:0007229) |
0.0 | 0.4 | GO:0000185 | activation of MAPKKK activity(GO:0000185) |
0.0 | 0.7 | GO:0021772 | olfactory bulb development(GO:0021772) |
0.0 | 0.6 | GO:0060749 | mammary gland alveolus development(GO:0060749) mammary gland lobule development(GO:0061377) |
0.0 | 1.1 | GO:0018208 | peptidyl-proline modification(GO:0018208) |
0.0 | 0.4 | GO:0035590 | purinergic nucleotide receptor signaling pathway(GO:0035590) |
0.0 | 1.7 | GO:0007026 | negative regulation of microtubule depolymerization(GO:0007026) |
0.0 | 1.8 | GO:0030520 | intracellular estrogen receptor signaling pathway(GO:0030520) |
0.0 | 0.3 | GO:0045071 | negative regulation of viral genome replication(GO:0045071) |
0.0 | 0.4 | GO:0006310 | DNA recombination(GO:0006310) |
0.0 | 0.3 | GO:0006561 | proline biosynthetic process(GO:0006561) |
0.0 | 0.2 | GO:0007144 | female meiosis I(GO:0007144) |
0.0 | 0.5 | GO:1904031 | positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737) positive regulation of cyclin-dependent protein kinase activity(GO:1904031) |
0.0 | 0.4 | GO:0002076 | osteoblast development(GO:0002076) |
0.0 | 1.2 | GO:0000188 | inactivation of MAPK activity(GO:0000188) |
0.0 | 1.1 | GO:0001837 | epithelial to mesenchymal transition(GO:0001837) |
0.0 | 0.5 | GO:0045103 | intermediate filament-based process(GO:0045103) |
0.0 | 0.1 | GO:0007403 | glial cell fate determination(GO:0007403) |
0.0 | 0.1 | GO:0006200 | obsolete ATP catabolic process(GO:0006200) |
0.0 | 0.1 | GO:0000394 | RNA splicing, via endonucleolytic cleavage and ligation(GO:0000394) tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388) |
0.0 | 0.1 | GO:0070295 | renal water absorption(GO:0070295) |
0.0 | 0.1 | GO:0008628 | hormone-mediated apoptotic signaling pathway(GO:0008628) |
0.0 | 0.2 | GO:0042753 | positive regulation of circadian rhythm(GO:0042753) |
0.0 | 0.1 | GO:0060028 | convergent extension involved in axis elongation(GO:0060028) negative regulation of non-canonical Wnt signaling pathway(GO:2000051) |
0.0 | 0.1 | GO:0001553 | luteinization(GO:0001553) |
0.0 | 0.1 | GO:0001552 | ovarian follicle atresia(GO:0001552) |
0.0 | 0.2 | GO:0045898 | regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898) |
0.0 | 0.1 | GO:0033327 | Leydig cell differentiation(GO:0033327) |
0.0 | 0.1 | GO:1902414 | protein localization to adherens junction(GO:0071896) protein localization to cell junction(GO:1902414) |
0.0 | 0.5 | GO:0007398 | ectoderm development(GO:0007398) |
0.0 | 1.1 | GO:0006749 | glutathione metabolic process(GO:0006749) |
0.0 | 0.3 | GO:0043388 | positive regulation of DNA binding(GO:0043388) |
0.0 | 0.3 | GO:0006974 | cellular response to DNA damage stimulus(GO:0006974) |
0.0 | 3.1 | GO:0007179 | transforming growth factor beta receptor signaling pathway(GO:0007179) |
0.0 | 0.3 | GO:0046415 | urate metabolic process(GO:0046415) |
0.0 | 1.6 | GO:0006986 | response to unfolded protein(GO:0006986) |
0.0 | 0.7 | GO:0042771 | intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771) |
0.0 | 0.1 | GO:0007059 | chromosome segregation(GO:0007059) |
0.0 | 0.1 | GO:0042074 | cell migration involved in gastrulation(GO:0042074) |
0.0 | 1.0 | GO:0030521 | androgen receptor signaling pathway(GO:0030521) |
0.0 | 0.1 | GO:0015670 | carbon dioxide transport(GO:0015670) |
0.0 | 0.4 | GO:0010043 | response to zinc ion(GO:0010043) |
0.0 | 0.1 | GO:0071108 | protein K48-linked deubiquitination(GO:0071108) |
0.0 | 3.4 | GO:0007601 | visual perception(GO:0007601) |
0.0 | 0.1 | GO:0071354 | response to interleukin-6(GO:0070741) cellular response to interleukin-6(GO:0071354) |
0.0 | 0.1 | GO:0016540 | protein autoprocessing(GO:0016540) |
0.0 | 1.1 | GO:0006367 | transcription initiation from RNA polymerase II promoter(GO:0006367) |
0.0 | 0.3 | GO:0007257 | activation of JUN kinase activity(GO:0007257) |
0.0 | 0.2 | GO:0090174 | organelle membrane fusion(GO:0090174) |
0.0 | 0.3 | GO:0008633 | obsolete activation of pro-apoptotic gene products(GO:0008633) |
0.0 | 6.4 | GO:0006518 | peptide metabolic process(GO:0006518) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.6 | 3.0 | GO:0071438 | invadopodium membrane(GO:0071438) |
0.4 | 7.3 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
0.4 | 6.7 | GO:0005862 | muscle thin filament tropomyosin(GO:0005862) |
0.3 | 7.0 | GO:0005865 | striated muscle thin filament(GO:0005865) |
0.3 | 7.6 | GO:0005859 | muscle myosin complex(GO:0005859) |
0.2 | 0.7 | GO:0043512 | inhibin complex(GO:0043511) inhibin A complex(GO:0043512) |
0.1 | 0.4 | GO:0031904 | endosome lumen(GO:0031904) |
0.1 | 0.5 | GO:0044298 | neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298) |
0.1 | 1.1 | GO:0043218 | compact myelin(GO:0043218) |
0.1 | 5.9 | GO:0030018 | Z disc(GO:0030018) |
0.1 | 0.3 | GO:0035032 | phosphatidylinositol 3-kinase complex, class III(GO:0035032) PAS complex(GO:0070772) |
0.1 | 1.2 | GO:0031588 | nucleotide-activated protein kinase complex(GO:0031588) |
0.1 | 4.3 | GO:0098636 | integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636) |
0.1 | 2.4 | GO:0005811 | lipid particle(GO:0005811) |
0.1 | 1.2 | GO:0008180 | COP9 signalosome(GO:0008180) |
0.1 | 5.1 | GO:0016459 | myosin complex(GO:0016459) |
0.1 | 1.9 | GO:0016010 | dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665) |
0.1 | 2.6 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
0.1 | 1.7 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
0.0 | 0.7 | GO:0005606 | laminin-1 complex(GO:0005606) |
0.0 | 0.4 | GO:0005638 | lamin filament(GO:0005638) |
0.0 | 0.2 | GO:0005602 | complement component C1 complex(GO:0005602) |
0.0 | 0.6 | GO:0001527 | microfibril(GO:0001527) |
0.0 | 1.7 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
0.0 | 9.9 | GO:0030141 | secretory granule(GO:0030141) |
0.0 | 0.1 | GO:0005577 | fibrinogen complex(GO:0005577) |
0.0 | 0.1 | GO:0034750 | Scrib-APC-beta-catenin complex(GO:0034750) |
0.0 | 0.4 | GO:0031258 | lamellipodium membrane(GO:0031258) |
0.0 | 0.1 | GO:0000214 | tRNA-intron endonuclease complex(GO:0000214) |
0.0 | 0.1 | GO:0019718 | obsolete rough microsome(GO:0019718) |
0.0 | 0.7 | GO:0043195 | terminal bouton(GO:0043195) |
0.0 | 0.5 | GO:0030175 | filopodium(GO:0030175) |
0.0 | 0.7 | GO:0005902 | microvillus(GO:0005902) |
0.0 | 1.4 | GO:0042383 | sarcolemma(GO:0042383) |
0.0 | 0.3 | GO:0005868 | cytoplasmic dynein complex(GO:0005868) |
0.0 | 6.0 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
0.0 | 0.3 | GO:0000421 | autophagosome membrane(GO:0000421) |
0.0 | 0.5 | GO:0005669 | transcription factor TFIID complex(GO:0005669) |
0.0 | 0.5 | GO:0031526 | brush border membrane(GO:0031526) |
0.0 | 0.5 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
0.0 | 1.2 | GO:0005802 | trans-Golgi network(GO:0005802) |
0.0 | 0.1 | GO:0042788 | polysomal ribosome(GO:0042788) |
0.0 | 0.2 | GO:0030914 | STAGA complex(GO:0030914) |
0.0 | 2.6 | GO:0031965 | nuclear membrane(GO:0031965) |
0.0 | 0.2 | GO:0005852 | eukaryotic translation initiation factor 3 complex(GO:0005852) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
2.4 | 9.8 | GO:0004504 | peptidylglycine monooxygenase activity(GO:0004504) peptidylamidoglycolate lyase activity(GO:0004598) |
0.6 | 3.9 | GO:0097493 | extracellular matrix constituent conferring elasticity(GO:0030023) structural molecule activity conferring elasticity(GO:0097493) |
0.6 | 6.1 | GO:0031013 | troponin I binding(GO:0031013) |
0.3 | 1.5 | GO:0031995 | insulin-like growth factor II binding(GO:0031995) |
0.2 | 21.5 | GO:0008307 | structural constituent of muscle(GO:0008307) |
0.2 | 0.7 | GO:0048184 | obsolete follistatin binding(GO:0048184) |
0.2 | 1.1 | GO:0004111 | creatine kinase activity(GO:0004111) |
0.2 | 2.7 | GO:0016805 | dipeptidase activity(GO:0016805) |
0.2 | 3.0 | GO:0008239 | dipeptidyl-peptidase activity(GO:0008239) |
0.1 | 1.7 | GO:0004065 | arylsulfatase activity(GO:0004065) |
0.1 | 0.5 | GO:0016972 | thiol oxidase activity(GO:0016972) |
0.1 | 1.1 | GO:0008499 | UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity(GO:0008499) |
0.1 | 0.4 | GO:0005105 | type 1 fibroblast growth factor receptor binding(GO:0005105) |
0.1 | 0.5 | GO:0015467 | G-protein activated inward rectifier potassium channel activity(GO:0015467) |
0.1 | 1.0 | GO:0008607 | phosphorylase kinase regulator activity(GO:0008607) |
0.1 | 11.0 | GO:0005178 | integrin binding(GO:0005178) |
0.1 | 0.5 | GO:0004991 | parathyroid hormone receptor activity(GO:0004991) |
0.1 | 0.1 | GO:0005111 | type 2 fibroblast growth factor receptor binding(GO:0005111) |
0.1 | 1.0 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
0.1 | 0.7 | GO:0004157 | dihydropyrimidinase activity(GO:0004157) |
0.1 | 0.9 | GO:0001011 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, RNA polymerase II basal transcription factor binding(GO:0001083) transcription factor activity, TFIIB-class binding(GO:0001087) RNA polymerase II basal transcription factor binding(GO:0001091) TFIIB-class transcription factor binding(GO:0001093) |
0.1 | 0.5 | GO:0008331 | high voltage-gated calcium channel activity(GO:0008331) |
0.1 | 1.1 | GO:0050786 | RAGE receptor binding(GO:0050786) |
0.1 | 0.2 | GO:0008970 | phosphatidylcholine 1-acylhydrolase activity(GO:0008970) |
0.1 | 0.3 | GO:0004735 | pyrroline-5-carboxylate reductase activity(GO:0004735) |
0.1 | 0.8 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
0.1 | 0.7 | GO:0008494 | translation activator activity(GO:0008494) |
0.1 | 1.8 | GO:0005159 | insulin-like growth factor receptor binding(GO:0005159) |
0.1 | 1.4 | GO:0001540 | beta-amyloid binding(GO:0001540) |
0.1 | 0.1 | GO:0008545 | JUN kinase kinase activity(GO:0008545) |
0.0 | 0.7 | GO:0004745 | retinol dehydrogenase activity(GO:0004745) |
0.0 | 1.3 | GO:0005245 | voltage-gated calcium channel activity(GO:0005245) |
0.0 | 0.3 | GO:0080025 | phosphatidylinositol-3,5-bisphosphate binding(GO:0080025) |
0.0 | 1.1 | GO:0005528 | macrolide binding(GO:0005527) FK506 binding(GO:0005528) |
0.0 | 0.1 | GO:0016524 | latrotoxin receptor activity(GO:0016524) |
0.0 | 0.2 | GO:0051766 | inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440) inositol trisphosphate kinase activity(GO:0051766) |
0.0 | 0.4 | GO:0035381 | extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381) |
0.0 | 0.1 | GO:0000213 | tRNA-intron endonuclease activity(GO:0000213) |
0.0 | 0.1 | GO:0005017 | platelet-derived growth factor-activated receptor activity(GO:0005017) |
0.0 | 0.2 | GO:0001784 | phosphotyrosine binding(GO:0001784) |
0.0 | 1.1 | GO:0050699 | WW domain binding(GO:0050699) |
0.0 | 0.1 | GO:0015254 | glycerol channel activity(GO:0015254) |
0.0 | 0.1 | GO:0005229 | intracellular calcium activated chloride channel activity(GO:0005229) |
0.0 | 1.1 | GO:0004364 | glutathione transferase activity(GO:0004364) |
0.0 | 0.1 | GO:0004176 | ATP-dependent peptidase activity(GO:0004176) |
0.0 | 0.1 | GO:0004994 | somatostatin receptor activity(GO:0004994) |
0.0 | 0.1 | GO:0051635 | obsolete bacterial cell surface binding(GO:0051635) |
0.0 | 0.3 | GO:0008140 | cAMP response element binding protein binding(GO:0008140) |
0.0 | 0.2 | GO:0004835 | tubulin-tyrosine ligase activity(GO:0004835) |
0.0 | 0.2 | GO:0017049 | GTP-Rho binding(GO:0017049) |
0.0 | 0.2 | GO:0031078 | histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) histone deacetylase activity (H4-K16 specific)(GO:0034739) NAD-dependent histone deacetylase activity (H4-K16 specific)(GO:0046970) |
0.0 | 0.5 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
0.0 | 0.1 | GO:0031957 | very long-chain fatty acid-CoA ligase activity(GO:0031957) |
0.0 | 0.1 | GO:0048406 | nerve growth factor binding(GO:0048406) |
0.0 | 0.7 | GO:0043130 | ubiquitin binding(GO:0043130) |
0.0 | 0.2 | GO:0051787 | misfolded protein binding(GO:0051787) |
0.0 | 0.1 | GO:0061133 | endopeptidase activator activity(GO:0061133) |
0.0 | 0.4 | GO:0017048 | Rho GTPase binding(GO:0017048) |
0.0 | 5.8 | GO:0003779 | actin binding(GO:0003779) |
0.0 | 1.3 | GO:0017124 | SH3 domain binding(GO:0017124) |
0.0 | 0.7 | GO:0001948 | glycoprotein binding(GO:0001948) |
0.0 | 1.3 | GO:0019838 | growth factor binding(GO:0019838) |
0.0 | 0.2 | GO:0070063 | RNA polymerase binding(GO:0070063) |
0.0 | 0.3 | GO:0008656 | cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656) |
0.0 | 0.1 | GO:0004340 | glucokinase activity(GO:0004340) |
0.0 | 0.1 | GO:0050682 | AF-2 domain binding(GO:0050682) |
0.0 | 0.4 | GO:0035257 | nuclear hormone receptor binding(GO:0035257) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.0 | 0.4 | ST_G_ALPHA_I_PATHWAY | G alpha i Pathway |
0.0 | 0.8 | ST_MYOCYTE_AD_PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
0.0 | 1.5 | ST_FAS_SIGNALING_PATHWAY | Fas Signaling Pathway |
0.0 | 0.2 | SA_G2_AND_M_PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
0.0 | 1.4 | ST_INTEGRIN_SIGNALING_PATHWAY | Integrin Signaling Pathway |