Motif ID: OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4
Z-value: 1.139
Transcription factors associated with OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
HOXC4 | ENSG00000198353.6 | HOXC4 |
HOXC4 | ENSG00000273266.1 | HOXC4 |
LHX1 | ENSG00000132130.7 | LHX1 |
LHX5 | ENSG00000089116.3 | LHX5 |
LMX1A | ENSG00000162761.10 | LMX1A |
OTP | ENSG00000171540.6 | OTP |
PHOX2B | ENSG00000109132.5 | PHOX2B |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.2 | 5.8 | GO:0007614 | short-term memory(GO:0007614) |
0.4 | 1.3 | GO:1901419 | regulation of response to alcohol(GO:1901419) |
0.4 | 1.5 | GO:0010944 | negative regulation of transcription by competitive promoter binding(GO:0010944) |
0.3 | 2.1 | GO:0008228 | opsonization(GO:0008228) |
0.3 | 1.0 | GO:0060318 | definitive erythrocyte differentiation(GO:0060318) |
0.2 | 0.5 | GO:0014889 | muscle atrophy(GO:0014889) regulation of skeletal muscle tissue growth(GO:0048631) |
0.2 | 1.3 | GO:0034392 | negative regulation of smooth muscle cell apoptotic process(GO:0034392) |
0.2 | 0.9 | GO:0035414 | negative regulation of catenin import into nucleus(GO:0035414) |
0.1 | 2.9 | GO:0009812 | flavonoid metabolic process(GO:0009812) |
0.1 | 0.6 | GO:0055098 | response to low-density lipoprotein particle(GO:0055098) regulation of cholesterol transporter activity(GO:0060694) |
0.1 | 1.0 | GO:0034638 | phosphatidylcholine catabolic process(GO:0034638) |
0.1 | 2.3 | GO:0042147 | retrograde transport, endosome to Golgi(GO:0042147) |
0.1 | 1.4 | GO:0006071 | glycerol metabolic process(GO:0006071) |
0.1 | 0.7 | GO:0008354 | germ cell migration(GO:0008354) |
0.1 | 0.4 | GO:0032509 | endosome transport via multivesicular body sorting pathway(GO:0032509) plasma membrane to endosome transport(GO:0048227) negative regulation of lipoprotein lipase activity(GO:0051005) negative regulation of lipase activity(GO:0060192) |
0.1 | 5.6 | GO:0019882 | antigen processing and presentation(GO:0019882) |
0.1 | 0.2 | GO:0045715 | negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715) |
0.1 | 0.9 | GO:0033687 | osteoblast proliferation(GO:0033687) |
0.1 | 0.2 | GO:0019276 | UDP-N-acetylgalactosamine metabolic process(GO:0019276) |
0.0 | 0.1 | GO:0010273 | regulation of oxidative phosphorylation(GO:0002082) detoxification of copper ion(GO:0010273) stress response to copper ion(GO:1990169) |
0.0 | 0.1 | GO:0010107 | potassium ion import(GO:0010107) |
0.0 | 0.6 | GO:0034446 | substrate adhesion-dependent cell spreading(GO:0034446) |
0.0 | 0.2 | GO:0002726 | positive regulation of T cell cytokine production(GO:0002726) |
0.0 | 0.2 | GO:0006264 | mitochondrial DNA replication(GO:0006264) |
0.0 | 0.1 | GO:0071318 | cellular response to ATP(GO:0071318) |
0.0 | 0.1 | GO:0050955 | thermoception(GO:0050955) |
0.0 | 0.2 | GO:0033089 | positive regulation of T cell differentiation in thymus(GO:0033089) positive regulation of thymocyte aggregation(GO:2000400) |
0.0 | 0.1 | GO:0006562 | proline catabolic process(GO:0006562) |
0.0 | 0.1 | GO:0060164 | regulation of timing of neuron differentiation(GO:0060164) |
0.0 | 0.1 | GO:0071168 | protein localization to chromatin(GO:0071168) |
0.0 | 0.1 | GO:0070842 | aggresome assembly(GO:0070842) |
0.0 | 1.2 | GO:0006986 | response to unfolded protein(GO:0006986) |
0.0 | 0.0 | GO:0060744 | thelarche(GO:0042695) mammary gland branching involved in thelarche(GO:0060744) |
0.0 | 0.1 | GO:0045116 | protein neddylation(GO:0045116) |
0.0 | 1.1 | GO:0051592 | response to calcium ion(GO:0051592) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.4 | 1.3 | GO:0005726 | perichromatin fibrils(GO:0005726) |
0.3 | 1.0 | GO:0034673 | inhibin-betaglycan-ActRII complex(GO:0034673) |
0.2 | 5.8 | GO:0042612 | MHC class I protein complex(GO:0042612) |
0.2 | 0.6 | GO:0005607 | laminin-2 complex(GO:0005607) |
0.2 | 1.3 | GO:0046581 | intercellular canaliculus(GO:0046581) |
0.1 | 3.5 | GO:0016010 | dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665) |
0.1 | 1.1 | GO:0005577 | fibrinogen complex(GO:0005577) |
0.1 | 1.3 | GO:0042627 | chylomicron(GO:0042627) |
0.0 | 5.9 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
0.0 | 1.0 | GO:0034364 | high-density lipoprotein particle(GO:0034364) |
0.0 | 0.1 | GO:0005873 | plus-end kinesin complex(GO:0005873) |
0.0 | 0.1 | GO:0000444 | MIS12/MIND type complex(GO:0000444) |
0.0 | 0.5 | GO:0030140 | trans-Golgi network transport vesicle(GO:0030140) |
0.0 | 0.2 | GO:0008385 | IkappaB kinase complex(GO:0008385) |
0.0 | 1.4 | GO:0032993 | protein-DNA complex(GO:0032993) |
0.0 | 0.2 | GO:0030914 | STAGA complex(GO:0030914) |
0.0 | 1.2 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.4 | 5.6 | GO:0030881 | beta-2-microglobulin binding(GO:0030881) |
0.4 | 2.9 | GO:0047894 | flavonol 3-sulfotransferase activity(GO:0047894) |
0.4 | 1.5 | GO:0008190 | eukaryotic initiation factor 4E binding(GO:0008190) |
0.3 | 1.1 | GO:0042910 | xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910) |
0.3 | 1.3 | GO:0060230 | lipoprotein lipase activator activity(GO:0060230) |
0.2 | 1.0 | GO:0008112 | nicotinamide N-methyltransferase activity(GO:0008112) pyridine N-methyltransferase activity(GO:0030760) |
0.2 | 1.2 | GO:0008889 | glycerophosphodiester phosphodiesterase activity(GO:0008889) |
0.2 | 2.1 | GO:0030247 | pattern binding(GO:0001871) polysaccharide binding(GO:0030247) |
0.1 | 1.3 | GO:0034056 | estrogen response element binding(GO:0034056) |
0.1 | 0.7 | GO:0042577 | lipid phosphatase activity(GO:0042577) |
0.1 | 1.2 | GO:0004571 | mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571) |
0.1 | 1.0 | GO:0005114 | type II transforming growth factor beta receptor binding(GO:0005114) |
0.1 | 1.0 | GO:0034185 | apolipoprotein binding(GO:0034185) |
0.1 | 0.2 | GO:0004797 | thymidine kinase activity(GO:0004797) |
0.1 | 0.5 | GO:0048027 | mRNA 5'-UTR binding(GO:0048027) |
0.1 | 0.6 | GO:1901567 | icosanoid binding(GO:0050542) arachidonic acid binding(GO:0050544) fatty acid derivative binding(GO:1901567) |
0.1 | 0.4 | GO:0048406 | nerve growth factor binding(GO:0048406) |
0.1 | 1.6 | GO:0004623 | phospholipase A2 activity(GO:0004623) |
0.1 | 0.2 | GO:0004613 | phosphoenolpyruvate carboxykinase activity(GO:0004611) phosphoenolpyruvate carboxykinase (GTP) activity(GO:0004613) |
0.1 | 0.7 | GO:0016812 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812) |
0.1 | 1.7 | GO:0005523 | tropomyosin binding(GO:0005523) |
0.1 | 5.5 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
0.1 | 1.1 | GO:0043499 | obsolete eukaryotic cell surface binding(GO:0043499) |
0.0 | 2.3 | GO:0017137 | Rab GTPase binding(GO:0017137) |
0.0 | 0.2 | GO:0017159 | pantetheine hydrolase activity(GO:0017159) GPI anchor binding(GO:0034235) |
0.0 | 0.1 | GO:0004657 | proline dehydrogenase activity(GO:0004657) |
0.0 | 0.1 | GO:0016531 | copper chaperone activity(GO:0016531) |
0.0 | 0.1 | GO:0019166 | trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166) |
0.0 | 0.1 | GO:0008907 | integrase activity(GO:0008907) |
0.0 | 0.3 | GO:0050786 | RAGE receptor binding(GO:0050786) |
0.0 | 0.5 | GO:0000049 | tRNA binding(GO:0000049) |
0.0 | 0.6 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
0.0 | 0.1 | GO:0019788 | NEDD8 transferase activity(GO:0019788) |
0.0 | 0.3 | GO:0005522 | profilin binding(GO:0005522) |
0.0 | 0.1 | GO:0046790 | virion binding(GO:0046790) |
0.0 | 0.2 | GO:0001011 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, RNA polymerase II basal transcription factor binding(GO:0001083) transcription factor activity, TFIIB-class binding(GO:0001087) RNA polymerase II basal transcription factor binding(GO:0001091) TFIIB-class transcription factor binding(GO:0001093) |
0.0 | 0.0 | GO:0070996 | type 1 melanocortin receptor binding(GO:0070996) |
0.0 | 0.3 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 2.1 | ST_MYOCYTE_AD_PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |