Motif ID: OTX2_CRX
Z-value: 0.641
Transcription factors associated with OTX2_CRX:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
CRX | ENSG00000105392.11 | CRX |
OTX2 | ENSG00000165588.12 | OTX2 |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.7 | 2.8 | GO:0060025 | regulation of synaptic activity(GO:0060025) |
0.1 | 1.3 | GO:0019800 | peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800) |
0.1 | 1.0 | GO:0040037 | negative regulation of fibroblast growth factor receptor signaling pathway(GO:0040037) |
0.1 | 0.3 | GO:0002035 | brain renin-angiotensin system(GO:0002035) |
0.0 | 0.4 | GO:0042693 | muscle cell fate commitment(GO:0042693) |
0.0 | 0.3 | GO:0042989 | sequestering of actin monomers(GO:0042989) |
0.0 | 0.1 | GO:0006591 | ornithine metabolic process(GO:0006591) |
0.0 | 0.2 | GO:0006189 | 'de novo' IMP biosynthetic process(GO:0006189) |
0.0 | 0.1 | GO:2000105 | positive regulation of DNA-dependent DNA replication initiation(GO:0032298) positive regulation of DNA-dependent DNA replication(GO:2000105) |
0.0 | 0.1 | GO:0070171 | negative regulation of tooth mineralization(GO:0070171) |
0.0 | 0.2 | GO:0072205 | collecting duct development(GO:0072044) metanephric tubule development(GO:0072170) metanephric collecting duct development(GO:0072205) metanephric epithelium development(GO:0072207) metanephric nephron tubule development(GO:0072234) metanephric nephron epithelium development(GO:0072243) |
0.0 | 0.1 | GO:0071380 | cellular response to prostaglandin E stimulus(GO:0071380) |
0.0 | 0.1 | GO:0009296 | obsolete flagellum assembly(GO:0009296) |
0.0 | 0.2 | GO:0015722 | canalicular bile acid transport(GO:0015722) |
0.0 | 0.2 | GO:0043982 | histone H4-K5 acetylation(GO:0043981) histone H4-K8 acetylation(GO:0043982) |
0.0 | 0.4 | GO:0000052 | citrulline metabolic process(GO:0000052) arginine catabolic process(GO:0006527) |
0.0 | 0.1 | GO:0001831 | trophectodermal cellular morphogenesis(GO:0001831) |
0.0 | 0.1 | GO:0007207 | phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207) |
0.0 | 0.1 | GO:0006651 | diacylglycerol biosynthetic process(GO:0006651) |
0.0 | 0.1 | GO:0035025 | positive regulation of Rho protein signal transduction(GO:0035025) |
0.0 | 0.3 | GO:0046827 | positive regulation of protein export from nucleus(GO:0046827) |
0.0 | 0.1 | GO:0090267 | positive regulation of spindle checkpoint(GO:0090232) regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) positive regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090267) positive regulation of cell cycle checkpoint(GO:1901978) regulation of mitotic spindle checkpoint(GO:1903504) |
0.0 | 0.1 | GO:0030917 | midbrain-hindbrain boundary development(GO:0030917) |
0.0 | 0.2 | GO:0035162 | embryonic hemopoiesis(GO:0035162) |
0.0 | 0.4 | GO:0045730 | respiratory burst(GO:0045730) |
0.0 | 0.1 | GO:0032528 | microvillus assembly(GO:0030033) microvillus organization(GO:0032528) |
0.0 | 0.1 | GO:0007386 | compartment pattern specification(GO:0007386) |
0.0 | 0.1 | GO:0000185 | activation of MAPKKK activity(GO:0000185) |
0.0 | 0.1 | GO:0060666 | dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666) |
0.0 | 0.1 | GO:0019934 | cGMP-mediated signaling(GO:0019934) regulation of phagocytosis, engulfment(GO:0060099) positive regulation of phagocytosis, engulfment(GO:0060100) regulation of membrane invagination(GO:1905153) positive regulation of membrane invagination(GO:1905155) |
0.0 | 1.0 | GO:0032387 | negative regulation of intracellular transport(GO:0032387) |
0.0 | 0.2 | GO:0097031 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
0.0 | 0.1 | GO:0019985 | translesion synthesis(GO:0019985) |
0.0 | 0.1 | GO:0006452 | translational frameshifting(GO:0006452) positive regulation of translational elongation(GO:0045901) positive regulation of translational termination(GO:0045905) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 1.3 | GO:0098647 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
0.1 | 0.2 | GO:0005588 | collagen type V trimer(GO:0005588) |
0.0 | 0.1 | GO:0000308 | cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308) |
0.0 | 0.2 | GO:0005642 | annulate lamellae(GO:0005642) |
0.0 | 0.1 | GO:0031512 | motile primary cilium(GO:0031512) |
0.0 | 2.8 | GO:0016607 | nuclear speck(GO:0016607) |
0.0 | 0.1 | GO:0005827 | polar microtubule(GO:0005827) |
0.0 | 0.2 | GO:0031095 | platelet dense tubular network membrane(GO:0031095) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 0.3 | GO:0001618 | virus receptor activity(GO:0001618) |
0.1 | 0.4 | GO:0016403 | dimethylargininase activity(GO:0016403) |
0.1 | 1.0 | GO:0004065 | arylsulfatase activity(GO:0004065) |
0.1 | 0.4 | GO:0031404 | chloride ion binding(GO:0031404) |
0.1 | 0.2 | GO:0016882 | cyclo-ligase activity(GO:0016882) |
0.1 | 0.2 | GO:0004947 | bradykinin receptor activity(GO:0004947) |
0.0 | 0.2 | GO:0004692 | cGMP-dependent protein kinase activity(GO:0004692) |
0.0 | 0.2 | GO:0015254 | glycerol channel activity(GO:0015254) |
0.0 | 1.0 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
0.0 | 0.2 | GO:0005499 | vitamin D binding(GO:0005499) |
0.0 | 0.2 | GO:0005220 | inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220) |
0.0 | 1.3 | GO:0050840 | extracellular matrix binding(GO:0050840) |
0.0 | 0.4 | GO:0005522 | profilin binding(GO:0005522) |
0.0 | 0.1 | GO:0045499 | chemorepellent activity(GO:0045499) |
0.0 | 0.1 | GO:0004663 | Rab geranylgeranyltransferase activity(GO:0004663) |
0.0 | 0.5 | GO:0005388 | calcium-transporting ATPase activity(GO:0005388) |
0.0 | 1.9 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
0.0 | 0.1 | GO:0070892 | lipoteichoic acid receptor activity(GO:0070892) |
0.0 | 0.0 | GO:0005223 | intracellular cGMP activated cation channel activity(GO:0005223) |
0.0 | 0.1 | GO:0070290 | N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290) |
0.0 | 0.2 | GO:0015643 | toxic substance binding(GO:0015643) |
0.0 | 0.1 | GO:0005112 | Notch binding(GO:0005112) |
0.0 | 0.1 | GO:0016907 | G-protein coupled acetylcholine receptor activity(GO:0016907) |
0.0 | 2.4 | GO:0003702 | obsolete RNA polymerase II transcription factor activity(GO:0003702) |
0.0 | 0.4 | GO:0070888 | E-box binding(GO:0070888) |
0.0 | 0.0 | GO:0002046 | opsin binding(GO:0002046) |
0.0 | 0.2 | GO:0030332 | cyclin binding(GO:0030332) |
0.0 | 0.2 | GO:0070063 | RNA polymerase binding(GO:0070063) |
0.0 | 0.1 | GO:0001228 | transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0000982) transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
0.0 | 0.1 | GO:0031701 | angiotensin receptor binding(GO:0031701) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.0 | 0.2 | ST_JAK_STAT_PATHWAY | Jak-STAT Pathway |