Motif ID: PAX1_PAX9

Z-value: 0.667

Transcription factors associated with PAX1_PAX9:

Gene SymbolEntrez IDGene Name
PAX1 ENSG00000125813.9 PAX1
PAX9 ENSG00000198807.8 PAX9



Activity profile for motif PAX1_PAX9.

activity profile for motif PAX1_PAX9


Sorted Z-values histogram for motif PAX1_PAX9

Sorted Z-values for motif PAX1_PAX9



Network of associatons between targets according to the STRING database.



First level regulatory network of PAX1_PAX9

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr8_-_23261589 1.330 ENST00000524168.1
ENST00000523833.2
ENST00000519243.1
ENST00000389131.3
 LOXL2



lysyl oxidase-like 2



chr4_+_123747834 0.850 ENST00000264498.3
 FGF2
fibroblast growth factor 2 (basic)
chr2_-_175712270 0.785 ENST00000295497.7
ENST00000444394.1
 CHN1

chimerin 1

chr8_-_101965559 0.785 ENST00000353245.3
 YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
chr4_+_75230853 0.770 ENST00000244869.2
 EREG
epiregulin
chr4_+_123747979 0.664 ENST00000608478.1
 FGF2
fibroblast growth factor 2 (basic)
chr18_+_39766626 0.657 ENST00000593234.1
ENST00000585627.1
ENST00000591199.1
ENST00000586990.1
ENST00000593051.1
ENST00000593316.1
ENST00000591381.1
ENST00000585639.1
ENST00000589068.1
 LINC00907








long intergenic non-protein coding RNA 907








chrX_-_153707545 0.632 ENST00000357360.4
 LAGE3
L antigen family, member 3
chr9_+_33750515 0.576 ENST00000361005.5
 PRSS3
protease, serine, 3
chr9_+_33750667 0.560 ENST00000457896.1
ENST00000342836.4
ENST00000429677.3
 PRSS3


protease, serine, 3


chrX_-_153707246 0.553 ENST00000407062.1
 LAGE3
L antigen family, member 3
chr8_-_101965146 0.488 ENST00000395957.2
ENST00000395948.2
ENST00000457309.1
 YWHAZ


tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta


chr9_+_33795533 0.426 ENST00000379405.3
 PRSS3
protease, serine, 3
chr7_-_19157248 0.403 ENST00000242261.5
 TWIST1
twist family bHLH transcription factor 1
chr17_+_15848231 0.385 ENST00000304222.2
 ADORA2B
adenosine A2b receptor
chr9_-_104249400 0.292 ENST00000374848.3
 TMEM246
transmembrane protein 246
chr8_+_84824920 0.278 ENST00000523678.1
 RP11-120I21.2
RP11-120I21.2
chr6_+_34857019 0.259 ENST00000360359.3
ENST00000535627.1
 ANKS1A

ankyrin repeat and sterile alpha motif domain containing 1A

chr15_+_63569731 0.209 ENST00000261879.5
 APH1B
APH1B gamma secretase subunit
chr11_+_6947720 0.194 ENST00000414517.2
 ZNF215
zinc finger protein 215
chr15_+_63569785 0.173 ENST00000380343.4
ENST00000560353.1
 APH1B

APH1B gamma secretase subunit

chrX_-_148669116 0.172 ENST00000243314.5
 MAGEA9B
melanoma antigen family A, 9B
chr1_-_213031418 0.171 ENST00000356684.3
ENST00000426161.1
ENST00000424044.1
 FLVCR1-AS1


FLVCR1 antisense RNA 1 (head to head)


chr13_+_21141270 0.163 ENST00000319980.6
ENST00000537103.1
ENST00000389373.3
 IFT88


intraflagellar transport 88 homolog (Chlamydomonas)


chr6_+_74104471 0.159 ENST00000370336.4
 DDX43
DEAD (Asp-Glu-Ala-Asp) box polypeptide 43
chr17_-_39968406 0.145 ENST00000393928.1
 LEPREL4
leprecan-like 4
chr14_+_24540046 0.126 ENST00000397016.2
ENST00000537691.1
ENST00000560356.1
ENST00000558450.1
 CPNE6



copine VI (neuronal)



chr6_-_132945414 0.123 ENST00000367931.1
ENST00000537809.1
 TAAR2

trace amine associated receptor 2

chr9_-_21142144 0.123 ENST00000380229.2
 IFNW1
interferon, omega 1
chr13_+_21141208 0.122 ENST00000351808.5
 IFT88
intraflagellar transport 88 homolog (Chlamydomonas)
chrX_+_148622513 0.115 ENST00000393985.3
ENST00000423421.1
ENST00000423540.2
ENST00000434353.2
ENST00000514208.1
 CXorf40A




chromosome X open reading frame 40A




chr1_+_26758790 0.111 ENST00000427245.2
ENST00000525682.2
ENST00000236342.7
ENST00000526219.1
ENST00000374185.3
ENST00000360009.2
 DHDDS





dehydrodolichyl diphosphate synthase





chr7_+_142457315 0.111 ENST00000486171.1
ENST00000311737.7
 PRSS1

protease, serine, 1 (trypsin 1)

chr11_+_6947647 0.104 ENST00000278319.5
 ZNF215
zinc finger protein 215
chr19_-_40791302 0.099 ENST00000392038.2
ENST00000578123.1
 AKT2

v-akt murine thymoma viral oncogene homolog 2

chr3_+_15247686 0.078 ENST00000253693.2
 CAPN7
calpain 7
chr19_-_40791211 0.070 ENST00000579047.1
 AKT2
v-akt murine thymoma viral oncogene homolog 2
chr3_+_127771212 0.062 ENST00000243253.3
ENST00000481210.1
 SEC61A1

Sec61 alpha 1 subunit (S. cerevisiae)

chr12_-_101801505 0.058 ENST00000539055.1
ENST00000551688.1
ENST00000551671.1
ENST00000261636.8
 ARL1



ADP-ribosylation factor-like 1



chr12_+_57828521 0.047 ENST00000309668.2
 INHBC
inhibin, beta C
chr10_-_99393242 0.044 ENST00000370635.3
ENST00000478953.1
ENST00000335628.3
 MORN4


MORN repeat containing 4


chr17_-_39968855 0.042 ENST00000355468.3
ENST00000590496.1
 LEPREL4

leprecan-like 4

chr2_+_119699864 0.042 ENST00000541757.1
ENST00000412481.1
 MARCO

macrophage receptor with collagenous structure

chr10_-_43904608 0.035 ENST00000337970.3
 HNRNPF
heterogeneous nuclear ribonucleoprotein F
chr22_+_39745930 0.035 ENST00000318801.4
ENST00000216155.7
ENST00000406293.3
ENST00000328933.5
 SYNGR1



synaptogyrin 1



chr19_-_5838768 0.032 ENST00000527106.1
ENST00000531199.1
ENST00000529165.1
 FUT6


fucosyltransferase 6 (alpha (1,3) fucosyltransferase)


chr14_+_39703112 0.029 ENST00000555143.1
ENST00000280082.3
 MIA2

melanoma inhibitory activity 2

chr6_-_137366163 0.029 ENST00000367748.1
 IL20RA
interleukin 20 receptor, alpha
chr10_-_99393208 0.009 ENST00000307450.6
 MORN4
MORN repeat containing 4
chr4_+_619347 0.005 ENST00000255622.6
 PDE6B
phosphodiesterase 6B, cGMP-specific, rod, beta

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.5 GO:0060128 corticotropin hormone secreting cell differentiation(GO:0060128)
0.3 0.8 GO:0051151 negative regulation of smooth muscle cell differentiation(GO:0051151)
0.1 1.3 GO:0002553 histamine production involved in inflammatory response(GO:0002349) histamine secretion involved in inflammatory response(GO:0002441) histamine secretion by mast cell(GO:0002553)
0.1 0.4 GO:0010701 positive regulation of chronic inflammatory response(GO:0002678) positive regulation of norepinephrine secretion(GO:0010701) positive regulation of guanylate cyclase activity(GO:0031284)
0.0 0.4 GO:0060363 cranial suture morphogenesis(GO:0060363) craniofacial suture morphogenesis(GO:0097094)
0.0 0.2 GO:1903960 negative regulation of plasma membrane long-chain fatty acid transport(GO:0010748) response to muscle activity(GO:0014850) negative regulation of anion transmembrane transport(GO:1903960) negative regulation of fatty acid transport(GO:2000192)
0.0 0.4 GO:0007220 Notch receptor processing(GO:0007220) membrane protein intracellular domain proteolysis(GO:0031293)
0.0 0.2 GO:0007130 synaptonemal complex assembly(GO:0007130)
0.0 1.4 GO:0043542 endothelial cell migration(GO:0043542)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 0.3 GO:0030992 intraciliary transport particle B(GO:0030992)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.3 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641)
0.1 1.5 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.1 0.4 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.0 0.8 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 0.4 GO:0070888 E-box binding(GO:0070888)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.4 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY PI3K Pathway