Motif ID: PAX3

Z-value: 1.070


Transcription factors associated with PAX3:

Gene SymbolEntrez IDGene Name
PAX3 ENSG00000135903.14 PAX3



Activity profile for motif PAX3.

activity profile for motif PAX3


Sorted Z-values histogram for motif PAX3

Sorted Z-values for motif PAX3



Network of associatons between targets according to the STRING database.



First level regulatory network of PAX3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_+_7060432 2.426 ENST00000318974.9
ENST00000456013.1
PTPN6

protein tyrosine phosphatase, non-receptor type 6

chr11_-_73694346 2.317 ENST00000310473.3
UCP2
uncoupling protein 2 (mitochondrial, proton carrier)
chr11_+_313503 2.137 ENST00000528780.1
ENST00000328221.5
IFITM1

interferon induced transmembrane protein 1

chr16_+_23847339 1.320 ENST00000303531.7
PRKCB
protein kinase C, beta
chr6_-_32908792 1.311 ENST00000418107.2
HLA-DMB
major histocompatibility complex, class II, DM beta
chr6_+_14117872 1.283 ENST00000379153.3
CD83
CD83 molecule
chr12_-_53594227 1.229 ENST00000550743.2
ITGB7
integrin, beta 7
chr7_+_99816859 1.164 ENST00000317271.2
PVRIG
poliovirus receptor related immunoglobulin domain containing
chr15_-_80263506 1.141 ENST00000335661.6
BCL2A1
BCL2-related protein A1
chr17_-_34417479 1.024 ENST00000225245.5
CCL3
chemokine (C-C motif) ligand 3
chr1_+_101185290 0.969 ENST00000370119.4
ENST00000347652.2
ENST00000294728.2
ENST00000370115.1
VCAM1



vascular cell adhesion molecule 1



chr11_-_615570 0.932 ENST00000525445.1
ENST00000348655.6
ENST00000397566.1
IRF7


interferon regulatory factor 7


chrX_-_53461288 0.866 ENST00000375298.4
ENST00000375304.5
HSD17B10

hydroxysteroid (17-beta) dehydrogenase 10

chrX_-_53461305 0.859 ENST00000168216.6
HSD17B10
hydroxysteroid (17-beta) dehydrogenase 10
chr6_-_109804412 0.794 ENST00000230122.3
ZBTB24
zinc finger and BTB domain containing 24
chr15_-_43622736 0.760 ENST00000544735.1
ENST00000567039.1
ENST00000305641.5
LCMT2


leucine carboxyl methyltransferase 2


chrX_-_15872914 0.748 ENST00000380291.1
ENST00000545766.1
ENST00000421527.2
ENST00000329235.2
AP1S2



adaptor-related protein complex 1, sigma 2 subunit



chr11_-_615942 0.742 ENST00000397562.3
ENST00000330243.5
ENST00000397570.1
ENST00000397574.2
IRF7



interferon regulatory factor 7



chr15_+_81591757 0.710 ENST00000558332.1
IL16
interleukin 16
chr5_+_49961727 0.700 ENST00000505697.2
ENST00000503750.2
ENST00000514342.2
PARP8


poly (ADP-ribose) polymerase family, member 8


chr9_-_35650900 0.690 ENST00000259608.3
SIT1
signaling threshold regulating transmembrane adaptor 1
chr6_-_32908765 0.513 ENST00000416244.2
HLA-DMB
major histocompatibility complex, class II, DM beta
chr2_+_152214098 0.500 ENST00000243347.3
TNFAIP6
tumor necrosis factor, alpha-induced protein 6
chr7_-_148580563 0.463 ENST00000476773.1
EZH2
enhancer of zeste homolog 2 (Drosophila)
chr4_+_156680153 0.439 ENST00000502959.1
ENST00000505764.1
ENST00000507146.1
ENST00000264424.8
ENST00000503520.1
GUCY1B3




guanylate cyclase 1, soluble, beta 3




chr10_-_75226166 0.415 ENST00000544628.1
PPP3CB
protein phosphatase 3, catalytic subunit, beta isozyme
chr19_+_35168567 0.400 ENST00000457781.2
ENST00000505163.1
ENST00000505242.1
ENST00000423823.2
ENST00000507959.1
ENST00000446502.2
ZNF302





zinc finger protein 302





chr1_+_99729813 0.399 ENST00000457765.1
LPPR4
Lipid phosphate phosphatase-related protein type 4
chr7_+_116502605 0.393 ENST00000458284.2
ENST00000490693.1
CAPZA2

capping protein (actin filament) muscle Z-line, alpha 2

chr6_-_169654139 0.387 ENST00000366787.3
THBS2
thrombospondin 2
chr5_-_180688105 0.380 ENST00000327767.4
TRIM52
tripartite motif containing 52
chr6_+_127588020 0.346 ENST00000309649.3
ENST00000610162.1
ENST00000610153.1
ENST00000608991.1
ENST00000480444.1
RNF146




ring finger protein 146




chr4_+_156680143 0.341 ENST00000505154.1
GUCY1B3
guanylate cyclase 1, soluble, beta 3
chr19_+_35168633 0.336 ENST00000505365.2
ZNF302
zinc finger protein 302
chr8_+_107670064 0.320 ENST00000312046.6
OXR1
oxidation resistance 1
chr12_+_112563335 0.315 ENST00000549358.1
ENST00000257604.5
ENST00000548092.1
ENST00000552896.1
TRAFD1



TRAF-type zinc finger domain containing 1



chr3_-_119379427 0.314 ENST00000264231.3
ENST00000468801.1
ENST00000538678.1
POPDC2


popeye domain containing 2


chr1_-_205180664 0.302 ENST00000367161.3
ENST00000367162.3
ENST00000367160.4
DSTYK


dual serine/threonine and tyrosine protein kinase


chr12_+_112563303 0.299 ENST00000412615.2
TRAFD1
TRAF-type zinc finger domain containing 1
chr3_-_119379719 0.295 ENST00000493094.1
POPDC2
popeye domain containing 2
chr6_+_127587755 0.286 ENST00000368314.1
ENST00000476956.1
ENST00000609447.1
ENST00000356799.2
ENST00000477776.1
ENST00000609944.1
RNF146





ring finger protein 146





chr10_+_91087651 0.282 ENST00000371818.4
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chrX_+_30265256 0.274 ENST00000397548.2
MAGEB1
melanoma antigen family B, 1
chr11_-_104972158 0.262 ENST00000598974.1
ENST00000593315.1
ENST00000594519.1
ENST00000415981.2
ENST00000525374.1
ENST00000375707.1
CASP1



CARD16
CARD17
caspase 1, apoptosis-related cysteine peptidase



caspase recruitment domain family, member 16
caspase recruitment domain family, member 17
chr3_+_183892635 0.257 ENST00000427072.1
ENST00000411763.2
ENST00000292807.5
ENST00000448139.1
ENST00000455925.1
AP2M1




adaptor-related protein complex 2, mu 1 subunit




chr5_+_178977546 0.254 ENST00000319449.4
ENST00000377001.2
RUFY1

RUN and FYVE domain containing 1

chr14_+_19553365 0.251 ENST00000409832.3
POTEG
POTE ankyrin domain family, member G
chr2_-_68479614 0.248 ENST00000234310.3
PPP3R1
protein phosphatase 3, regulatory subunit B, alpha
chr15_-_52861157 0.247 ENST00000564163.1
ARPP19
cAMP-regulated phosphoprotein, 19kDa
chr1_+_203444887 0.235 ENST00000343110.2
PRELP
proline/arginine-rich end leucine-rich repeat protein
chrX_+_102883620 0.223 ENST00000372626.3
TCEAL1
transcription elongation factor A (SII)-like 1
chr9_+_100395891 0.216 ENST00000375147.3
NCBP1
nuclear cap binding protein subunit 1, 80kDa
chr19_-_41903161 0.211 ENST00000602129.1
ENST00000593771.1
ENST00000596905.1
ENST00000221233.4
EXOSC5



exosome component 5



chr2_-_44588893 0.198 ENST00000409272.1
ENST00000410081.1
ENST00000541738.1
PREPL


prolyl endopeptidase-like


chr5_+_70220768 0.197 ENST00000351205.4
ENST00000503079.2
ENST00000380707.4
ENST00000514951.1
ENST00000506163.1
SMN1




survival of motor neuron 1, telomeric




chr3_+_160117418 0.190 ENST00000465903.1
ENST00000485645.1
ENST00000360111.2
ENST00000472991.1
ENST00000467468.1
ENST00000469762.1
ENST00000489573.1
ENST00000462787.1
ENST00000490207.1
ENST00000485867.1
SMC4









structural maintenance of chromosomes 4









chr1_-_24151903 0.183 ENST00000436439.2
ENST00000374490.3
HMGCL

3-hydroxymethyl-3-methylglutaryl-CoA lyase

chr2_-_11810284 0.183 ENST00000306928.5
NTSR2
neurotensin receptor 2
chr10_-_104178857 0.180 ENST00000020673.5
PSD
pleckstrin and Sec7 domain containing
chr17_+_4855053 0.179 ENST00000518175.1
ENO3
enolase 3 (beta, muscle)
chr18_+_23806437 0.177 ENST00000578121.1
TAF4B
TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
chr10_+_118305435 0.176 ENST00000369221.2
PNLIP
pancreatic lipase
chr10_+_104178946 0.173 ENST00000432590.1
FBXL15
F-box and leucine-rich repeat protein 15
chr12_-_57400227 0.172 ENST00000300101.2
ZBTB39
zinc finger and BTB domain containing 39
chr2_-_44588694 0.167 ENST00000409957.1
PREPL
prolyl endopeptidase-like
chr1_-_155214475 0.165 ENST00000428024.3
GBA
glucosidase, beta, acid
chr2_-_44588679 0.159 ENST00000409411.1
PREPL
prolyl endopeptidase-like
chr8_+_125463048 0.152 ENST00000328599.3
TRMT12
tRNA methyltransferase 12 homolog (S. cerevisiae)
chr5_+_69345350 0.149 ENST00000380741.4
ENST00000380743.4
ENST00000511812.1
ENST00000380742.4
SMN2



survival of motor neuron 2, centromeric



chr6_-_24721054 0.149 ENST00000378119.4
C6orf62
chromosome 6 open reading frame 62
chr16_+_27214802 0.142 ENST00000380948.2
ENST00000286096.4
KDM8

lysine (K)-specific demethylase 8

chr19_+_2841433 0.141 ENST00000334241.4
ENST00000585966.1
ENST00000591539.1
ZNF555


zinc finger protein 555


chr2_-_44588624 0.140 ENST00000438314.1
ENST00000409936.1
PREPL

prolyl endopeptidase-like

chr9_+_104161123 0.138 ENST00000374861.3
ENST00000339664.2
ENST00000259395.4
ZNF189


zinc finger protein 189


chr2_-_183106641 0.135 ENST00000346717.4
PDE1A
phosphodiesterase 1A, calmodulin-dependent
chr7_+_116502527 0.134 ENST00000361183.3
CAPZA2
capping protein (actin filament) muscle Z-line, alpha 2
chr1_-_24151892 0.131 ENST00000235958.4
HMGCL
3-hydroxymethyl-3-methylglutaryl-CoA lyase
chr15_+_51973680 0.129 ENST00000542355.2
SCG3
secretogranin III
chr9_-_88897426 0.118 ENST00000375991.4
ENST00000326094.4
ISCA1

iron-sulfur cluster assembly 1

chr22_+_18593507 0.114 ENST00000330423.3
TUBA8
tubulin, alpha 8
chr3_+_160117087 0.113 ENST00000357388.3
SMC4
structural maintenance of chromosomes 4
chr1_-_205091115 0.110 ENST00000264515.6
ENST00000367164.1
RBBP5

retinoblastoma binding protein 5

chr22_-_44258360 0.106 ENST00000330884.4
ENST00000249130.5
SULT4A1

sulfotransferase family 4A, member 1

chr8_-_81083731 0.098 ENST00000379096.5
TPD52
tumor protein D52
chr15_+_51973550 0.097 ENST00000220478.3
SCG3
secretogranin III
chr21_-_37451680 0.095 ENST00000399201.1
SETD4
SET domain containing 4
chr8_-_101718991 0.093 ENST00000517990.1
PABPC1
poly(A) binding protein, cytoplasmic 1
chr11_+_66624527 0.092 ENST00000393952.3
LRFN4
leucine rich repeat and fibronectin type III domain containing 4
chr1_+_12524965 0.089 ENST00000471923.1
VPS13D
vacuolar protein sorting 13 homolog D (S. cerevisiae)
chr19_-_41388657 0.089 ENST00000301146.4
ENST00000291764.3
CYP2A7

cytochrome P450, family 2, subfamily A, polypeptide 7

chr17_-_39538550 0.083 ENST00000394001.1
KRT34
keratin 34
chr6_+_89674246 0.076 ENST00000369474.1
AL079342.1
Uncharacterized protein; cDNA FLJ27030 fis, clone SLV07741
chr14_-_24711806 0.075 ENST00000540705.1
ENST00000538777.1
ENST00000558566.1
ENST00000559019.1
TINF2



TERF1 (TRF1)-interacting nuclear factor 2



chr1_+_26496362 0.074 ENST00000374266.5
ENST00000270812.5
ZNF593

zinc finger protein 593

chr11_+_33563821 0.073 ENST00000321505.4
ENST00000265654.5
ENST00000389726.3
KIAA1549L


KIAA1549-like


chr6_+_35227449 0.070 ENST00000373953.3
ENST00000440666.2
ENST00000339411.5
ZNF76


zinc finger protein 76


chr9_-_91793675 0.068 ENST00000375835.4
ENST00000375830.1
SHC3

SHC (Src homology 2 domain containing) transforming protein 3

chr1_+_154244987 0.056 ENST00000328703.7
ENST00000457918.2
ENST00000483970.2
ENST00000435087.1
ENST00000532105.1
HAX1




HCLS1 associated protein X-1




chr12_+_10460549 0.055 ENST00000543420.1
ENST00000543777.1
KLRD1

killer cell lectin-like receptor subfamily D, member 1

chr22_+_20105259 0.051 ENST00000416427.1
ENST00000421656.1
ENST00000423859.1
ENST00000418705.2
RANBP1



RAN binding protein 1



chr1_-_155214436 0.042 ENST00000327247.5
GBA
glucosidase, beta, acid
chr1_-_52344471 0.041 ENST00000352171.7
ENST00000354831.7
NRD1

nardilysin (N-arginine dibasic convertase)

chr12_+_69080734 0.040 ENST00000378905.2
NUP107
nucleoporin 107kDa
chr13_+_96085847 0.034 ENST00000376873.3
CLDN10
claudin 10
chr19_-_54784353 0.032 ENST00000391746.1
LILRB2
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
chr20_-_17511962 0.029 ENST00000377873.3
BFSP1
beaded filament structural protein 1, filensin
chr2_-_219524193 0.026 ENST00000450560.1
ENST00000449707.1
ENST00000432460.1
ENST00000411696.2
ZNF142



zinc finger protein 142



chr22_+_39101728 0.026 ENST00000216044.5
ENST00000484657.1
GTPBP1

GTP binding protein 1

chr3_+_112709804 0.023 ENST00000383677.3
GTPBP8
GTP-binding protein 8 (putative)
chr3_+_112709755 0.022 ENST00000383678.2
GTPBP8
GTP-binding protein 8 (putative)
chr5_+_159343688 0.021 ENST00000306675.3
ADRA1B
adrenoceptor alpha 1B
chr15_+_99791567 0.020 ENST00000558879.1
ENST00000301981.3
ENST00000422500.2
ENST00000447360.2
ENST00000442993.2
LRRC28




leucine rich repeat containing 28




chr5_-_157079428 0.020 ENST00000265007.6
SOX30
SRY (sex determining region Y)-box 30
chr4_-_168155417 0.019 ENST00000511269.1
ENST00000506697.1
ENST00000512042.1
SPOCK3


sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3


chr2_-_217724767 0.019 ENST00000236979.2
TNP1
transition protein 1 (during histone to protamine replacement)
chrX_+_70364667 0.017 ENST00000536169.1
ENST00000395855.2
ENST00000374051.3
ENST00000358741.3
NLGN3



neuroligin 3



chr20_-_23807358 0.011 ENST00000304725.2
CST2
cystatin SA
chr17_+_3118915 0.005 ENST00000304094.1
OR1A1
olfactory receptor, family 1, subfamily A, member 1
chrX_+_1734051 0.004 ENST00000381229.4
ENST00000381233.3
ASMT

acetylserotonin O-methyltransferase

chr10_-_102289611 0.001 ENST00000535773.1
ENST00000299166.4
ENST00000370320.4
ENST00000531258.1
ENST00000370322.1
SEC31B
NDUFB8



SEC31 homolog B (S. cerevisiae)
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa



chr19_+_55105085 0.001 ENST00000251372.3
ENST00000453777.1
LILRA1

leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 GO:0035408 histone H3-T6 phosphorylation(GO:0035408)
0.2 1.0 GO:0022614 membrane to membrane docking(GO:0022614) chorio-allantoic fusion(GO:0060710)
0.2 1.3 GO:0032713 negative regulation of interleukin-4 production(GO:0032713)
0.2 1.7 GO:0033327 Leydig cell differentiation(GO:0033327)
0.1 1.7 GO:0032727 positive regulation of interferon-alpha production(GO:0032727)
0.1 2.3 GO:0000303 response to superoxide(GO:0000303)
0.1 2.4 GO:0050732 negative regulation of peptidyl-tyrosine phosphorylation(GO:0050732)
0.1 0.3 GO:0043441 acetoacetic acid biosynthetic process(GO:0043441)
0.1 1.8 GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002504)
0.1 0.5 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.1 0.6 GO:0045824 negative regulation of innate immune response(GO:0045824)
0.0 0.7 GO:0050930 induction of positive chemotaxis(GO:0050930)
0.0 0.4 GO:0046839 phospholipid dephosphorylation(GO:0046839)
0.0 0.2 GO:0050685 positive regulation of mRNA 3'-end processing(GO:0031442) positive regulation of mRNA processing(GO:0050685) positive regulation of mRNA metabolic process(GO:1903313)
0.0 0.3 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.0 0.9 GO:0045069 regulation of viral genome replication(GO:0045069)
0.0 0.2 GO:0060487 lung epithelial cell differentiation(GO:0060487)
0.0 0.8 GO:0007263 nitric oxide mediated signal transduction(GO:0007263)
0.0 2.4 GO:0071357 response to type I interferon(GO:0034340) type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357)
0.0 0.1 GO:0010836 negative regulation of protein ADP-ribosylation(GO:0010836) negative regulation of protein glycosylation(GO:0060051)
0.0 0.1 GO:0045722 positive regulation of gluconeogenesis(GO:0045722)
0.0 1.0 GO:0050690 regulation of defense response to virus by virus(GO:0050690)
0.0 0.3 GO:0007076 mitotic chromosome condensation(GO:0007076)
0.0 0.1 GO:0046604 regulation of mitotic centrosome separation(GO:0046602) positive regulation of mitotic centrosome separation(GO:0046604)
0.0 0.0 GO:0000917 barrier septum assembly(GO:0000917) cell septum assembly(GO:0090529) mitotic cytokinetic process(GO:1902410)
0.0 0.5 GO:0051693 actin filament capping(GO:0051693)
0.0 0.9 GO:0008033 tRNA processing(GO:0008033)
0.0 1.2 GO:0007229 integrin-mediated signaling pathway(GO:0007229)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0071065 alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex(GO:0071065)
0.1 1.8 GO:0042613 MHC class II protein complex(GO:0042613)
0.1 0.8 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.1 0.2 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.1 0.2 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.5 GO:0008290 F-actin capping protein complex(GO:0008290)
0.0 0.3 GO:0000796 condensin complex(GO:0000796)
0.0 0.5 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 0.2 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.0 1.2 GO:0098636 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.0 0.1 GO:0010370 perinucleolar chromocenter(GO:0010370)
0.0 1.0 GO:0030119 AP-type membrane coat adaptor complex(GO:0030119)
0.0 0.2 GO:0034518 mRNA cap binding complex(GO:0005845) RNA cap binding complex(GO:0034518)
0.0 4.3 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 0.1 GO:0048188 Set1C/COMPASS complex(GO:0048188)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 GO:0035403 histone kinase activity (H3-T6 specific)(GO:0035403)
0.1 1.7 GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity(GO:0003857)
0.1 0.4 GO:0042577 lipid phosphatase activity(GO:0042577)
0.1 0.3 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.1 0.2 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723)
0.1 0.2 GO:0004348 glucosylceramidase activity(GO:0004348)
0.0 1.0 GO:0042056 chemoattractant activity(GO:0042056)
0.0 0.8 GO:0051879 guanylate cyclase activity(GO:0004383) Hsp90 protein binding(GO:0051879)
0.0 0.2 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.0 0.7 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 0.5 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 2.4 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 0.1 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0 0.2 GO:0000339 RNA cap binding(GO:0000339)
0.0 0.7 GO:0042169 SH2 domain binding(GO:0042169)
0.0 0.2 GO:0000175 3'-5'-exoribonuclease activity(GO:0000175)
0.0 0.1 GO:0004117 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117)
0.0 0.5 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.0 1.3 GO:0003704 obsolete specific RNA polymerase II transcription factor activity(GO:0003704)
0.0 1.9 GO:0005057 receptor signaling protein activity(GO:0005057)