Motif ID: PAX6
Z-value: 1.667
Transcription factors associated with PAX6:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| PAX6 | ENSG00000007372.16 | PAX6 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 0.9 | GO:0043366 | beta selection(GO:0043366) |
| 0.3 | 0.8 | GO:0042501 | serine phosphorylation of STAT protein(GO:0042501) |
| 0.2 | 1.0 | GO:0021506 | anterior neuropore closure(GO:0021506) neuropore closure(GO:0021995) |
| 0.2 | 8.1 | GO:0006309 | DNA catabolic process, endonucleolytic(GO:0000737) apoptotic DNA fragmentation(GO:0006309) |
| 0.2 | 1.1 | GO:0015803 | branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820) proline transport(GO:0015824) |
| 0.2 | 0.5 | GO:0006348 | chromatin silencing at telomere(GO:0006348) |
| 0.2 | 1.0 | GO:0015871 | choline transport(GO:0015871) |
| 0.2 | 1.7 | GO:0033327 | Leydig cell differentiation(GO:0033327) |
| 0.1 | 0.9 | GO:0016584 | nucleosome positioning(GO:0016584) |
| 0.1 | 0.6 | GO:0006529 | asparagine biosynthetic process(GO:0006529) |
| 0.1 | 0.2 | GO:0060896 | commitment of multipotent stem cells to neuronal lineage in forebrain(GO:0021898) neural plate anterior/posterior regionalization(GO:0021999) otic placode formation(GO:0043049) neural plate pattern specification(GO:0060896) neural plate regionalization(GO:0060897) |
| 0.1 | 0.3 | GO:0030488 | tRNA methylation(GO:0030488) |
| 0.1 | 0.4 | GO:0030259 | lipid glycosylation(GO:0030259) |
| 0.1 | 1.3 | GO:0051016 | barbed-end actin filament capping(GO:0051016) |
| 0.1 | 0.5 | GO:0071699 | olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699) |
| 0.1 | 0.5 | GO:0060676 | ureteric bud formation(GO:0060676) mesonephric tubule formation(GO:0072172) |
| 0.1 | 0.9 | GO:0007080 | mitotic metaphase plate congression(GO:0007080) |
| 0.1 | 0.2 | GO:0006542 | glutamine biosynthetic process(GO:0006542) |
| 0.1 | 0.3 | GO:0001507 | acetylcholine catabolic process in synaptic cleft(GO:0001507) acetylcholine catabolic process(GO:0006581) |
| 0.1 | 0.2 | GO:0060677 | ureteric bud elongation(GO:0060677) renal vesicle formation(GO:0072033) |
| 0.1 | 0.2 | GO:0000491 | small nucleolar ribonucleoprotein complex assembly(GO:0000491) box C/D snoRNP assembly(GO:0000492) |
| 0.1 | 0.6 | GO:0043011 | myeloid dendritic cell differentiation(GO:0043011) dendritic cell differentiation(GO:0097028) |
| 0.1 | 0.2 | GO:0006999 | nuclear pore organization(GO:0006999) |
| 0.0 | 0.1 | GO:0002541 | activation of plasma proteins involved in acute inflammatory response(GO:0002541) |
| 0.0 | 0.2 | GO:0009298 | GDP-mannose biosynthetic process(GO:0009298) |
| 0.0 | 0.2 | GO:1901798 | positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517) positive regulation of signal transduction by p53 class mediator(GO:1901798) |
| 0.0 | 0.9 | GO:0000291 | nuclear-transcribed mRNA catabolic process, exonucleolytic(GO:0000291) exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928) |
| 0.0 | 0.5 | GO:0006657 | CDP-choline pathway(GO:0006657) |
| 0.0 | 1.5 | GO:0007131 | reciprocal meiotic recombination(GO:0007131) reciprocal DNA recombination(GO:0035825) |
| 0.0 | 0.1 | GO:0001574 | ganglioside biosynthetic process(GO:0001574) |
| 0.0 | 0.2 | GO:0032754 | positive regulation of interleukin-5 production(GO:0032754) |
| 0.0 | 0.2 | GO:0010447 | response to acidic pH(GO:0010447) |
| 0.0 | 0.2 | GO:0015693 | magnesium ion transport(GO:0015693) |
| 0.0 | 0.2 | GO:0007258 | JUN phosphorylation(GO:0007258) |
| 0.0 | 0.6 | GO:0050732 | negative regulation of peptidyl-tyrosine phosphorylation(GO:0050732) |
| 0.0 | 3.5 | GO:0010951 | negative regulation of endopeptidase activity(GO:0010951) |
| 0.0 | 0.9 | GO:0006611 | protein export from nucleus(GO:0006611) |
| 0.0 | 0.1 | GO:1903301 | regulation of glucokinase activity(GO:0033131) positive regulation of glucokinase activity(GO:0033133) regulation of hexokinase activity(GO:1903299) positive regulation of hexokinase activity(GO:1903301) |
| 0.0 | 0.1 | GO:0042769 | DNA damage response, detection of DNA damage(GO:0042769) |
| 0.0 | 0.1 | GO:0045039 | protein import into mitochondrial inner membrane(GO:0045039) |
| 0.0 | 0.2 | GO:0032703 | negative regulation of interleukin-2 production(GO:0032703) |
| 0.0 | 1.6 | GO:0007162 | negative regulation of cell adhesion(GO:0007162) |
| 0.0 | 2.3 | GO:0002576 | platelet degranulation(GO:0002576) |
| 0.0 | 0.7 | GO:0045576 | mast cell activation(GO:0045576) |
| 0.0 | 2.3 | GO:0042113 | B cell activation(GO:0042113) |
| 0.0 | 0.4 | GO:0002088 | lens development in camera-type eye(GO:0002088) |
| 0.0 | 0.1 | GO:0032099 | negative regulation of appetite(GO:0032099) |
| 0.0 | 3.2 | GO:0006184 | obsolete GTP catabolic process(GO:0006184) |
| 0.0 | 0.9 | GO:0016579 | protein deubiquitination(GO:0016579) |
| 0.0 | 1.1 | GO:0007229 | integrin-mediated signaling pathway(GO:0007229) |
| 0.0 | 1.2 | GO:0007498 | mesoderm development(GO:0007498) |
| 0.0 | 0.2 | GO:0071479 | cellular response to ionizing radiation(GO:0071479) |
| 0.0 | 0.4 | GO:0072659 | protein localization to plasma membrane(GO:0072659) protein localization to cell periphery(GO:1990778) |
| 0.0 | 0.5 | GO:0007422 | peripheral nervous system development(GO:0007422) |
| 0.0 | 1.0 | GO:0034599 | cellular response to oxidative stress(GO:0034599) |
| 0.0 | 0.2 | GO:0033598 | mammary gland epithelial cell proliferation(GO:0033598) |
| 0.0 | 0.8 | GO:0007608 | sensory perception of smell(GO:0007608) |
| 0.0 | 1.5 | GO:0006865 | amino acid transport(GO:0006865) |
| 0.0 | 0.1 | GO:0032438 | melanosome organization(GO:0032438) pigment granule organization(GO:0048753) |
| 0.0 | 2.0 | GO:0006813 | potassium ion transport(GO:0006813) |
| 0.0 | 0.9 | GO:0071357 | response to type I interferon(GO:0034340) type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 0.9 | GO:0035327 | transcriptionally active chromatin(GO:0035327) |
| 0.2 | 0.8 | GO:0016533 | cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533) |
| 0.1 | 0.9 | GO:0019815 | immunoglobulin complex(GO:0019814) B cell receptor complex(GO:0019815) |
| 0.1 | 1.3 | GO:0008290 | F-actin capping protein complex(GO:0008290) |
| 0.1 | 0.9 | GO:0005828 | kinetochore microtubule(GO:0005828) |
| 0.1 | 0.9 | GO:0005762 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.1 | 0.5 | GO:0042587 | glycogen granule(GO:0042587) |
| 0.0 | 0.6 | GO:0031080 | nuclear pore outer ring(GO:0031080) |
| 0.0 | 0.2 | GO:0001741 | XY body(GO:0001741) |
| 0.0 | 0.1 | GO:0032585 | multivesicular body membrane(GO:0032585) |
| 0.0 | 0.2 | GO:0070761 | pre-snoRNP complex(GO:0070761) |
| 0.0 | 0.4 | GO:0005922 | connexon complex(GO:0005922) |
| 0.0 | 0.7 | GO:0090568 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) nuclear transcriptional repressor complex(GO:0090568) |
| 0.0 | 1.1 | GO:0098636 | integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636) |
| 0.0 | 0.3 | GO:0000808 | origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664) |
| 0.0 | 0.4 | GO:0001772 | immunological synapse(GO:0001772) |
| 0.0 | 2.8 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.0 | 0.1 | GO:0042719 | mitochondrial intermembrane space protein transporter complex(GO:0042719) |
| 0.0 | 1.6 | GO:0005643 | nuclear pore(GO:0005643) |
| 0.0 | 1.5 | GO:0005604 | basement membrane(GO:0005604) |
| 0.0 | 2.5 | GO:0005769 | early endosome(GO:0005769) |
| 0.0 | 0.8 | GO:0000786 | nucleosome(GO:0000786) |
| 0.0 | 8.1 | GO:0048471 | perinuclear region of cytoplasm(GO:0048471) |
| 0.0 | 2.3 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.0 | 0.3 | GO:0032982 | myosin filament(GO:0032982) |
| 0.0 | 0.6 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 7.9 | GO:0008656 | cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656) |
| 0.3 | 1.0 | GO:0015220 | choline transmembrane transporter activity(GO:0015220) |
| 0.2 | 0.9 | GO:0008574 | ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) ATP-dependent microtubule motor activity(GO:1990939) |
| 0.2 | 0.8 | GO:0004727 | prenylated protein tyrosine phosphatase activity(GO:0004727) |
| 0.2 | 0.5 | GO:0008489 | UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity(GO:0008489) |
| 0.2 | 0.8 | GO:0005176 | ErbB-2 class receptor binding(GO:0005176) tau-protein kinase activity(GO:0050321) |
| 0.2 | 1.6 | GO:0005094 | Rho GDP-dissociation inhibitor activity(GO:0005094) |
| 0.1 | 1.0 | GO:0017056 | structural constituent of nuclear pore(GO:0017056) |
| 0.1 | 0.6 | GO:0004066 | asparagine synthase (glutamine-hydrolyzing) activity(GO:0004066) |
| 0.1 | 0.6 | GO:0004090 | carbonyl reductase (NADPH) activity(GO:0004090) |
| 0.1 | 0.3 | GO:0016429 | tRNA (adenine) methyltransferase activity(GO:0016426) tRNA (adenine-N1-)-methyltransferase activity(GO:0016429) |
| 0.1 | 0.5 | GO:0004105 | choline-phosphate cytidylyltransferase activity(GO:0004105) |
| 0.1 | 1.7 | GO:0003857 | 3-hydroxyacyl-CoA dehydrogenase activity(GO:0003857) |
| 0.1 | 0.2 | GO:0016211 | glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880) |
| 0.1 | 0.9 | GO:0000175 | 3'-5'-exoribonuclease activity(GO:0000175) |
| 0.1 | 0.7 | GO:0005068 | transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068) |
| 0.1 | 1.1 | GO:0005328 | neurotransmitter:sodium symporter activity(GO:0005328) |
| 0.0 | 1.3 | GO:0005242 | inward rectifier potassium channel activity(GO:0005242) |
| 0.0 | 1.2 | GO:0005487 | nucleocytoplasmic transporter activity(GO:0005487) |
| 0.0 | 1.3 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 0.0 | 0.2 | GO:0019870 | potassium channel inhibitor activity(GO:0019870) |
| 0.0 | 1.5 | GO:0003724 | RNA helicase activity(GO:0003724) |
| 0.0 | 0.8 | GO:0043560 | insulin receptor substrate binding(GO:0043560) |
| 0.0 | 0.1 | GO:0046403 | polynucleotide 3'-phosphatase activity(GO:0046403) |
| 0.0 | 0.9 | GO:0004716 | receptor signaling protein tyrosine kinase activity(GO:0004716) |
| 0.0 | 0.2 | GO:0070568 | guanylyltransferase activity(GO:0070568) |
| 0.0 | 0.4 | GO:0008499 | UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity(GO:0008499) |
| 0.0 | 0.2 | GO:0016909 | JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909) |
| 0.0 | 0.5 | GO:0034483 | heparan sulfate sulfotransferase activity(GO:0034483) |
| 0.0 | 3.5 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 0.3 | GO:0003688 | DNA replication origin binding(GO:0003688) |
| 0.0 | 0.1 | GO:0005534 | galactose binding(GO:0005534) |
| 0.0 | 0.7 | GO:0004129 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.0 | 0.4 | GO:0010181 | FMN binding(GO:0010181) |
| 0.0 | 0.6 | GO:0008373 | sialyltransferase activity(GO:0008373) |
| 0.0 | 0.8 | GO:0004003 | ATP-dependent DNA helicase activity(GO:0004003) |
| 0.0 | 0.9 | GO:0036459 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005) |
| 0.0 | 0.1 | GO:0003873 | 6-phosphofructo-2-kinase activity(GO:0003873) |
| 0.0 | 0.6 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 0.0 | 0.2 | GO:0032407 | MutSalpha complex binding(GO:0032407) |
| 0.0 | 0.8 | GO:0004984 | olfactory receptor activity(GO:0004984) |
| 0.0 | 0.2 | GO:0032395 | MHC class II receptor activity(GO:0032395) |
| 0.0 | 0.4 | GO:0004385 | guanylate kinase activity(GO:0004385) |
| 0.0 | 0.1 | GO:0003956 | NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956) |
| 0.0 | 0.2 | GO:0004407 | histone deacetylase activity(GO:0004407) |
| 0.0 | 3.2 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.0 | 1.1 | GO:0005178 | integrin binding(GO:0005178) |
| 0.0 | 0.4 | GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.8 | SA_B_CELL_RECEPTOR_COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
| 0.0 | 0.6 | ST_JNK_MAPK_PATHWAY | JNK MAPK Pathway |
