Motif ID: PAX8
Z-value: 1.554
Transcription factors associated with PAX8:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| PAX8 | ENSG00000125618.12 | PAX8 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 2.9 | GO:0033364 | mast cell secretory granule organization(GO:0033364) |
| 0.5 | 3.2 | GO:0030240 | skeletal muscle thin filament assembly(GO:0030240) |
| 0.4 | 1.5 | GO:0051712 | positive regulation of killing of cells of other organism(GO:0051712) |
| 0.3 | 1.0 | GO:0010701 | positive regulation of norepinephrine secretion(GO:0010701) |
| 0.3 | 1.6 | GO:0006436 | tryptophanyl-tRNA aminoacylation(GO:0006436) |
| 0.3 | 1.3 | GO:0047484 | regulation of response to osmotic stress(GO:0047484) |
| 0.3 | 0.8 | GO:0002538 | arachidonic acid metabolite production involved in inflammatory response(GO:0002538) leukotriene production involved in inflammatory response(GO:0002540) |
| 0.2 | 0.6 | GO:0042097 | lymphotoxin A production(GO:0032641) interleukin-4 biosynthetic process(GO:0042097) lymphotoxin A biosynthetic process(GO:0042109) regulation of interleukin-4 biosynthetic process(GO:0045402) positive regulation of interleukin-4 biosynthetic process(GO:0045404) |
| 0.2 | 0.9 | GO:0032329 | serine transport(GO:0032329) |
| 0.2 | 1.0 | GO:0006772 | thiamine metabolic process(GO:0006772) |
| 0.2 | 0.7 | GO:0009106 | lipoate metabolic process(GO:0009106) |
| 0.2 | 1.6 | GO:0015074 | DNA integration(GO:0015074) |
| 0.2 | 0.8 | GO:0006529 | asparagine biosynthetic process(GO:0006529) |
| 0.1 | 0.9 | GO:0007525 | somatic muscle development(GO:0007525) |
| 0.1 | 1.0 | GO:0032713 | negative regulation of interleukin-4 production(GO:0032713) |
| 0.1 | 0.6 | GO:0007614 | short-term memory(GO:0007614) |
| 0.1 | 0.3 | GO:0060128 | corticotropin hormone secreting cell differentiation(GO:0060128) |
| 0.1 | 0.7 | GO:0006883 | cellular sodium ion homeostasis(GO:0006883) |
| 0.1 | 0.3 | GO:0006104 | succinyl-CoA metabolic process(GO:0006104) |
| 0.1 | 0.2 | GO:0071380 | cellular response to prostaglandin E stimulus(GO:0071380) |
| 0.1 | 0.5 | GO:0001554 | luteolysis(GO:0001554) |
| 0.1 | 1.0 | GO:0032814 | regulation of natural killer cell activation(GO:0032814) |
| 0.1 | 1.3 | GO:0006099 | tricarboxylic acid cycle(GO:0006099) |
| 0.0 | 0.1 | GO:0034551 | respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033) |
| 0.0 | 0.2 | GO:0046968 | peptide antigen transport(GO:0046968) |
| 0.0 | 0.2 | GO:0010157 | response to chlorate(GO:0010157) |
| 0.0 | 1.7 | GO:0050830 | defense response to Gram-positive bacterium(GO:0050830) |
| 0.0 | 0.2 | GO:0070995 | NADPH oxidation(GO:0070995) |
| 0.0 | 0.2 | GO:0015693 | magnesium ion transport(GO:0015693) |
| 0.0 | 0.5 | GO:0030146 | obsolete diuresis(GO:0030146) |
| 0.0 | 0.3 | GO:0031017 | exocrine pancreas development(GO:0031017) |
| 0.0 | 0.2 | GO:0007217 | tachykinin receptor signaling pathway(GO:0007217) |
| 0.0 | 0.6 | GO:0031055 | DNA replication-independent nucleosome assembly(GO:0006336) chromatin remodeling at centromere(GO:0031055) CENP-A containing nucleosome assembly(GO:0034080) DNA replication-independent nucleosome organization(GO:0034724) CENP-A containing chromatin organization(GO:0061641) |
| 0.0 | 0.6 | GO:0002504 | antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002504) |
| 0.0 | 1.1 | GO:0060048 | cardiac muscle contraction(GO:0060048) |
| 0.0 | 0.6 | GO:0006370 | 7-methylguanosine mRNA capping(GO:0006370) |
| 0.0 | 1.8 | GO:0000236 | mitotic prometaphase(GO:0000236) |
| 0.0 | 0.6 | GO:0006362 | transcription elongation from RNA polymerase I promoter(GO:0006362) |
| 0.0 | 0.9 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 0.0 | 0.2 | GO:0006953 | acute-phase response(GO:0006953) |
| 0.0 | 0.6 | GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436) positive regulation of proteasomal protein catabolic process(GO:1901800) |
| 0.0 | 0.2 | GO:0042976 | activation of Janus kinase activity(GO:0042976) |
| 0.0 | 2.2 | GO:0042113 | B cell activation(GO:0042113) |
| 0.0 | 0.2 | GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146) |
| 0.0 | 0.2 | GO:0006359 | regulation of transcription from RNA polymerase III promoter(GO:0006359) |
| 0.0 | 0.5 | GO:0060338 | regulation of type I interferon-mediated signaling pathway(GO:0060338) |
| 0.0 | 0.9 | GO:0006367 | transcription initiation from RNA polymerase II promoter(GO:0006367) |
| 0.0 | 0.3 | GO:0006493 | protein O-linked glycosylation(GO:0006493) |
| 0.0 | 4.8 | GO:0000122 | negative regulation of transcription from RNA polymerase II promoter(GO:0000122) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 2.9 | GO:0042629 | mast cell granule(GO:0042629) |
| 0.2 | 0.7 | GO:0043159 | acrosomal matrix(GO:0043159) |
| 0.2 | 0.6 | GO:0000120 | RNA polymerase I transcription factor complex(GO:0000120) |
| 0.1 | 0.6 | GO:0005954 | calcium- and calmodulin-dependent protein kinase complex(GO:0005954) |
| 0.1 | 1.4 | GO:0031080 | nuclear pore outer ring(GO:0031080) |
| 0.1 | 0.6 | GO:0031618 | nuclear pericentric heterochromatin(GO:0031618) |
| 0.1 | 5.7 | GO:0016363 | nuclear matrix(GO:0016363) |
| 0.1 | 0.3 | GO:0030062 | mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062) |
| 0.0 | 0.3 | GO:0016272 | prefoldin complex(GO:0016272) |
| 0.0 | 1.0 | GO:0005859 | muscle myosin complex(GO:0005859) |
| 0.0 | 2.7 | GO:0031674 | I band(GO:0031674) |
| 0.0 | 0.6 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.0 | 5.8 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.0 | 2.1 | GO:0005746 | mitochondrial respiratory chain(GO:0005746) |
| 0.0 | 0.5 | GO:0034362 | low-density lipoprotein particle(GO:0034362) |
| 0.0 | 0.6 | GO:0005665 | DNA-directed RNA polymerase II, core complex(GO:0005665) |
| 0.0 | 0.6 | GO:0016010 | dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665) |
| 0.0 | 0.2 | GO:0005797 | Golgi medial cisterna(GO:0005797) |
| 0.0 | 1.0 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.0 | 1.1 | GO:0000777 | condensed chromosome kinetochore(GO:0000777) |
| 0.0 | 0.2 | GO:0016324 | apical plasma membrane(GO:0016324) |
| 0.0 | 0.4 | GO:0030530 | obsolete heterogeneous nuclear ribonucleoprotein complex(GO:0030530) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 1.6 | GO:0008907 | integrase activity(GO:0008907) |
| 0.3 | 1.6 | GO:0004830 | tryptophan-tRNA ligase activity(GO:0004830) |
| 0.3 | 1.5 | GO:0019863 | IgE binding(GO:0019863) |
| 0.2 | 0.6 | GO:0008489 | UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity(GO:0008489) |
| 0.2 | 1.0 | GO:0005000 | vasopressin receptor activity(GO:0005000) |
| 0.2 | 0.8 | GO:0004066 | asparagine synthase (glutamine-hydrolyzing) activity(GO:0004066) |
| 0.1 | 0.6 | GO:0030060 | L-malate dehydrogenase activity(GO:0030060) |
| 0.1 | 1.0 | GO:0016778 | diphosphotransferase activity(GO:0016778) |
| 0.1 | 0.3 | GO:0003878 | ATP citrate synthase activity(GO:0003878) |
| 0.1 | 0.8 | GO:1901567 | icosanoid binding(GO:0050542) arachidonic acid binding(GO:0050544) fatty acid derivative binding(GO:1901567) |
| 0.1 | 1.0 | GO:0051393 | alpha-actinin binding(GO:0051393) |
| 0.1 | 0.5 | GO:0004957 | prostaglandin E receptor activity(GO:0004957) |
| 0.1 | 0.6 | GO:0003701 | obsolete RNA polymerase I transcription factor activity(GO:0003701) |
| 0.1 | 0.7 | GO:0016668 | oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668) |
| 0.1 | 0.2 | GO:0015095 | magnesium ion transmembrane transporter activity(GO:0015095) |
| 0.1 | 2.3 | GO:0017022 | myosin binding(GO:0017022) |
| 0.1 | 5.9 | GO:0016566 | obsolete specific transcriptional repressor activity(GO:0016566) |
| 0.1 | 0.7 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.1 | 2.9 | GO:0005518 | collagen binding(GO:0005518) |
| 0.1 | 1.4 | GO:0005487 | nucleocytoplasmic transporter activity(GO:0005487) |
| 0.0 | 0.2 | GO:0043423 | 3-phosphoinositide-dependent protein kinase binding(GO:0043423) |
| 0.0 | 0.6 | GO:0032395 | MHC class II receptor activity(GO:0032395) |
| 0.0 | 0.6 | GO:0008140 | cAMP response element binding protein binding(GO:0008140) |
| 0.0 | 0.6 | GO:0001011 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, RNA polymerase II basal transcription factor binding(GO:0001083) transcription factor activity, TFIIB-class binding(GO:0001087) RNA polymerase II basal transcription factor binding(GO:0001091) TFIIB-class transcription factor binding(GO:0001093) |
| 0.0 | 0.6 | GO:0004190 | aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001) |
| 0.0 | 0.6 | GO:0016565 | obsolete general transcriptional repressor activity(GO:0016565) |
| 0.0 | 0.2 | GO:0005113 | patched binding(GO:0005113) |
| 0.0 | 0.2 | GO:0005132 | type I interferon receptor binding(GO:0005132) |
| 0.0 | 0.2 | GO:0046790 | virion binding(GO:0046790) |
| 0.0 | 0.4 | GO:0017025 | TBP-class protein binding(GO:0017025) |
| 0.0 | 1.7 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 0.0 | 1.9 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.0 | 0.5 | GO:0004683 | calmodulin-dependent protein kinase activity(GO:0004683) |
| 0.0 | 1.1 | GO:0003823 | antigen binding(GO:0003823) |
| 0.0 | 0.6 | GO:0015026 | coreceptor activity(GO:0015026) |
| 0.0 | 0.9 | GO:0050136 | NADH dehydrogenase activity(GO:0003954) NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.0 | 0.4 | GO:0004129 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.0 | 0.2 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.0 | 0.3 | GO:0017134 | fibroblast growth factor binding(GO:0017134) |
| 0.0 | 0.1 | GO:0043176 | amine binding(GO:0043176) |
| 0.0 | 0.2 | GO:0003709 | obsolete RNA polymerase III transcription factor activity(GO:0003709) |
| 0.0 | 0.6 | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity(GO:0008138) |
| 0.0 | 0.6 | GO:0003899 | DNA-directed RNA polymerase activity(GO:0003899) RNA polymerase activity(GO:0034062) |
| 0.0 | 0.1 | GO:0003678 | DNA helicase activity(GO:0003678) |
| 0.0 | 0.7 | GO:0016651 | oxidoreductase activity, acting on NAD(P)H(GO:0016651) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.9 | ST_GAQ_PATHWAY | G alpha q Pathway |
