Motif ID: PBX1
Z-value: 1.694
Transcription factors associated with PBX1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| PBX1 | ENSG00000185630.14 | PBX1 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 1.8 | GO:0019731 | antibacterial humoral response(GO:0019731) |
| 0.5 | 4.2 | GO:0051918 | negative regulation of fibrinolysis(GO:0051918) |
| 0.4 | 1.3 | GO:0071380 | cellular response to prostaglandin E stimulus(GO:0071380) |
| 0.4 | 1.7 | GO:0061302 | smooth muscle cell-matrix adhesion(GO:0061302) |
| 0.4 | 1.9 | GO:0007614 | short-term memory(GO:0007614) |
| 0.3 | 1.0 | GO:0097237 | autophagic cell death(GO:0048102) cellular response to antibiotic(GO:0071236) cellular response to toxic substance(GO:0097237) |
| 0.3 | 1.5 | GO:0030210 | heparin biosynthetic process(GO:0030210) negative regulation of vascular permeability(GO:0043116) Tie signaling pathway(GO:0048014) |
| 0.3 | 2.5 | GO:0031017 | exocrine pancreas development(GO:0031017) |
| 0.2 | 0.9 | GO:0006531 | aspartate metabolic process(GO:0006531) aspartate catabolic process(GO:0006533) |
| 0.2 | 1.3 | GO:0072205 | collecting duct development(GO:0072044) metanephric collecting duct development(GO:0072205) |
| 0.2 | 1.6 | GO:0071267 | amino acid salvage(GO:0043102) L-methionine biosynthetic process(GO:0071265) L-methionine salvage(GO:0071267) |
| 0.2 | 0.7 | GO:0000354 | cis assembly of pre-catalytic spliceosome(GO:0000354) |
| 0.2 | 0.6 | GO:0006478 | peptidyl-tyrosine sulfation(GO:0006478) |
| 0.2 | 1.4 | GO:0070584 | mitochondrion morphogenesis(GO:0070584) |
| 0.2 | 0.8 | GO:0007095 | mitotic G2 DNA damage checkpoint(GO:0007095) |
| 0.2 | 1.5 | GO:0032000 | positive regulation of fatty acid beta-oxidation(GO:0032000) |
| 0.1 | 0.6 | GO:0000491 | small nucleolar ribonucleoprotein complex assembly(GO:0000491) box C/D snoRNP assembly(GO:0000492) |
| 0.1 | 0.3 | GO:0006419 | alanyl-tRNA aminoacylation(GO:0006419) |
| 0.1 | 0.3 | GO:0007231 | osmosensory signaling pathway(GO:0007231) |
| 0.1 | 0.3 | GO:0010172 | embryonic body morphogenesis(GO:0010172) |
| 0.1 | 0.5 | GO:0006927 | obsolete transformed cell apoptotic process(GO:0006927) |
| 0.1 | 2.5 | GO:0002076 | osteoblast development(GO:0002076) |
| 0.1 | 1.3 | GO:0090399 | replicative senescence(GO:0090399) |
| 0.1 | 0.2 | GO:0060662 | tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662) |
| 0.1 | 0.2 | GO:0032071 | obsolete cleavage of lamin involved in execution phase of apoptosis(GO:0006922) regulation of endodeoxyribonuclease activity(GO:0032071) negative regulation of nuclease activity(GO:0032074) |
| 0.1 | 1.2 | GO:0008210 | estrogen metabolic process(GO:0008210) |
| 0.1 | 0.3 | GO:0006538 | glutamate catabolic process(GO:0006538) |
| 0.1 | 0.6 | GO:0006268 | DNA unwinding involved in DNA replication(GO:0006268) |
| 0.1 | 4.7 | GO:0006334 | nucleosome assembly(GO:0006334) |
| 0.0 | 1.2 | GO:0006099 | tricarboxylic acid cycle(GO:0006099) |
| 0.0 | 0.1 | GO:0060120 | auditory receptor cell fate commitment(GO:0009912) inner ear receptor cell fate commitment(GO:0060120) |
| 0.0 | 0.2 | GO:0048619 | embryonic hindgut morphogenesis(GO:0048619) |
| 0.0 | 0.2 | GO:0015811 | sulfur amino acid transport(GO:0000101) L-cystine transport(GO:0015811) |
| 0.0 | 0.3 | GO:0010507 | negative regulation of autophagy(GO:0010507) |
| 0.0 | 0.2 | GO:0042905 | 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905) |
| 0.0 | 0.2 | GO:0045074 | interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074) |
| 0.0 | 0.2 | GO:0045003 | DNA recombinase assembly(GO:0000730) double-strand break repair via synthesis-dependent strand annealing(GO:0045003) |
| 0.0 | 0.2 | GO:0035058 | nonmotile primary cilium assembly(GO:0035058) |
| 0.0 | 0.8 | GO:0051457 | maintenance of protein location in nucleus(GO:0051457) |
| 0.0 | 0.5 | GO:0050812 | acetyl-CoA biosynthetic process from pyruvate(GO:0006086) regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510) regulation of acyl-CoA biosynthetic process(GO:0050812) |
| 0.0 | 1.0 | GO:0000060 | protein import into nucleus, translocation(GO:0000060) |
| 0.0 | 0.4 | GO:0042255 | ribosome assembly(GO:0042255) |
| 0.0 | 0.4 | GO:0015884 | folic acid transport(GO:0015884) |
| 0.0 | 0.1 | GO:0015722 | canalicular bile acid transport(GO:0015722) |
| 0.0 | 0.6 | GO:0030199 | collagen fibril organization(GO:0030199) |
| 0.0 | 1.0 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 0.0 | 0.3 | GO:0008209 | androgen metabolic process(GO:0008209) |
| 0.0 | 0.3 | GO:0000380 | alternative mRNA splicing, via spliceosome(GO:0000380) |
| 0.0 | 0.4 | GO:0044349 | nucleotide-excision repair, DNA damage removal(GO:0000718) DNA excision(GO:0044349) |
| 0.0 | 0.6 | GO:0043484 | regulation of RNA splicing(GO:0043484) |
| 0.0 | 0.1 | GO:0071400 | cellular response to oleic acid(GO:0071400) |
| 0.0 | 0.2 | GO:0030321 | transepithelial chloride transport(GO:0030321) |
| 0.0 | 0.1 | GO:0008628 | hormone-mediated apoptotic signaling pathway(GO:0008628) |
| 0.0 | 0.2 | GO:0009812 | flavonoid metabolic process(GO:0009812) |
| 0.0 | 0.4 | GO:0007194 | negative regulation of adenylate cyclase activity(GO:0007194) negative regulation of cyclase activity(GO:0031280) negative regulation of lyase activity(GO:0051350) |
| 0.0 | 0.1 | GO:0010739 | positive regulation of protein kinase A signaling(GO:0010739) |
| 0.0 | 0.9 | GO:0008360 | regulation of cell shape(GO:0008360) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 1.7 | GO:0071062 | alphav-beta3 integrin-vitronectin complex(GO:0071062) |
| 0.3 | 1.5 | GO:0045179 | apical cortex(GO:0045179) |
| 0.2 | 1.8 | GO:0042589 | phagocytic vesicle membrane(GO:0030670) zymogen granule membrane(GO:0042589) |
| 0.1 | 1.4 | GO:0031265 | CD95 death-inducing signaling complex(GO:0031265) |
| 0.1 | 0.7 | GO:0005682 | U5 snRNP(GO:0005682) |
| 0.1 | 4.1 | GO:0000786 | nucleosome(GO:0000786) |
| 0.1 | 0.6 | GO:0070761 | pre-snoRNP complex(GO:0070761) |
| 0.1 | 0.9 | GO:0030914 | STAGA complex(GO:0030914) |
| 0.1 | 0.4 | GO:0019907 | cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907) |
| 0.1 | 0.6 | GO:0005678 | obsolete chromatin assembly complex(GO:0005678) |
| 0.0 | 3.3 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 0.0 | 0.8 | GO:0005763 | organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763) |
| 0.0 | 0.2 | GO:0070369 | beta-catenin-TCF7L2 complex(GO:0070369) beta-catenin-TCF complex(GO:1990907) |
| 0.0 | 1.5 | GO:0005902 | microvillus(GO:0005902) |
| 0.0 | 0.2 | GO:0005662 | DNA replication factor A complex(GO:0005662) |
| 0.0 | 1.9 | GO:0005746 | mitochondrial respiratory chain(GO:0005746) |
| 0.0 | 0.3 | GO:0005671 | Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671) |
| 0.0 | 0.3 | GO:0032391 | photoreceptor connecting cilium(GO:0032391) |
| 0.0 | 0.5 | GO:0080008 | Cul4-RING E3 ubiquitin ligase complex(GO:0080008) |
| 0.0 | 1.0 | GO:0005884 | actin filament(GO:0005884) |
| 0.0 | 1.2 | GO:0000781 | chromosome, telomeric region(GO:0000781) |
| 0.0 | 0.6 | GO:0030175 | filopodium(GO:0030175) |
| 0.0 | 4.2 | GO:0005792 | obsolete microsome(GO:0005792) |
| 0.0 | 0.6 | GO:0030018 | Z disc(GO:0030018) |
| 0.0 | 0.3 | GO:0042579 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.0 | 0.7 | GO:0008287 | protein serine/threonine phosphatase complex(GO:0008287) phosphatase complex(GO:1903293) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 1.5 | GO:0005324 | long-chain fatty acid transporter activity(GO:0005324) |
| 0.2 | 0.6 | GO:0008476 | protein-tyrosine sulfotransferase activity(GO:0008476) |
| 0.2 | 0.6 | GO:0004609 | phosphatidylserine decarboxylase activity(GO:0004609) |
| 0.2 | 4.2 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
| 0.1 | 1.7 | GO:0030247 | pattern binding(GO:0001871) polysaccharide binding(GO:0030247) |
| 0.1 | 1.5 | GO:0051637 | obsolete Gram-positive bacterial cell surface binding(GO:0051637) |
| 0.1 | 1.7 | GO:0016405 | CoA-ligase activity(GO:0016405) |
| 0.1 | 0.4 | GO:0004965 | G-protein coupled GABA receptor activity(GO:0004965) |
| 0.1 | 0.7 | GO:0005499 | vitamin D binding(GO:0005499) |
| 0.1 | 0.3 | GO:0004813 | alanine-tRNA ligase activity(GO:0004813) |
| 0.1 | 0.6 | GO:0003917 | DNA topoisomerase type I activity(GO:0003917) |
| 0.1 | 0.3 | GO:0047042 | androsterone dehydrogenase (B-specific) activity(GO:0047042) |
| 0.1 | 0.9 | GO:0004726 | non-membrane spanning protein tyrosine phosphatase activity(GO:0004726) |
| 0.1 | 2.5 | GO:0005159 | insulin-like growth factor receptor binding(GO:0005159) |
| 0.1 | 1.8 | GO:0008430 | selenium binding(GO:0008430) |
| 0.1 | 0.2 | GO:0050051 | leukotriene-B4 20-monooxygenase activity(GO:0050051) |
| 0.1 | 2.2 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 0.1 | 1.0 | GO:0004861 | cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861) |
| 0.1 | 0.2 | GO:0003951 | NAD+ kinase activity(GO:0003951) |
| 0.0 | 1.0 | GO:0017134 | fibroblast growth factor binding(GO:0017134) |
| 0.0 | 1.3 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 0.0 | 0.2 | GO:0055103 | ligase regulator activity(GO:0055103) ubiquitin-protein transferase regulator activity(GO:0055106) |
| 0.0 | 0.6 | GO:0030346 | protein phosphatase 2B binding(GO:0030346) |
| 0.0 | 0.6 | GO:0016638 | oxidoreductase activity, acting on the CH-NH2 group of donors(GO:0016638) |
| 0.0 | 1.5 | GO:1990782 | receptor tyrosine kinase binding(GO:0030971) protein tyrosine kinase binding(GO:1990782) |
| 0.0 | 0.2 | GO:0015184 | L-cystine transmembrane transporter activity(GO:0015184) |
| 0.0 | 0.5 | GO:0004190 | aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001) |
| 0.0 | 0.1 | GO:0043398 | HLH domain binding(GO:0043398) |
| 0.0 | 0.3 | GO:0008266 | poly(U) RNA binding(GO:0008266) |
| 0.0 | 0.3 | GO:0070513 | death domain binding(GO:0070513) |
| 0.0 | 0.1 | GO:0004826 | phenylalanine-tRNA ligase activity(GO:0004826) |
| 0.0 | 1.6 | GO:0016836 | hydro-lyase activity(GO:0016836) |
| 0.0 | 1.8 | GO:0042562 | hormone binding(GO:0042562) |
| 0.0 | 0.2 | GO:0004022 | alcohol dehydrogenase (NAD) activity(GO:0004022) |
| 0.0 | 1.1 | GO:0004402 | histone acetyltransferase activity(GO:0004402) |
| 0.0 | 0.2 | GO:0031432 | titin binding(GO:0031432) |
| 0.0 | 0.4 | GO:0005542 | folic acid binding(GO:0005542) |
| 0.0 | 0.4 | GO:0008353 | RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353) |
| 0.0 | 1.0 | GO:0050136 | NADH dehydrogenase activity(GO:0003954) NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.0 | 1.2 | GO:0051287 | NAD binding(GO:0051287) |
| 0.0 | 1.9 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 0.5 | GO:0019003 | GDP binding(GO:0019003) |
| 0.0 | 0.6 | GO:0097472 | cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472) |
| 0.0 | 1.2 | GO:0008026 | ATP-dependent helicase activity(GO:0008026) purine NTP-dependent helicase activity(GO:0070035) |
| 0.0 | 3.7 | GO:0003682 | chromatin binding(GO:0003682) |
| 0.0 | 0.1 | GO:0008179 | adenylate cyclase binding(GO:0008179) |
| 0.0 | 1.4 | GO:0004197 | cysteine-type endopeptidase activity(GO:0004197) |
| 0.0 | 0.2 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.0 | 0.7 | GO:0030145 | manganese ion binding(GO:0030145) |
| 0.0 | 0.2 | GO:0004062 | aryl sulfotransferase activity(GO:0004062) |
| 0.0 | 0.5 | GO:0003725 | double-stranded RNA binding(GO:0003725) |
| 0.0 | 0.2 | GO:0070016 | armadillo repeat domain binding(GO:0070016) |
| 0.0 | 1.4 | GO:0008201 | heparin binding(GO:0008201) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.4 | SA_FAS_SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
| 0.0 | 1.0 | SA_REG_CASCADE_OF_CYCLIN_EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
