Motif ID: PBX2

Z-value: 0.865


Transcription factors associated with PBX2:

Gene SymbolEntrez IDGene Name
PBX2 ENSG00000204304.7 PBX2



Activity profile for motif PBX2.

activity profile for motif PBX2


Sorted Z-values histogram for motif PBX2

Sorted Z-values for motif PBX2



Network of associatons between targets according to the STRING database.



First level regulatory network of PBX2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr8_-_6420930 1.490 ENST00000325203.5
ANGPT2
angiopoietin 2
chr2_-_190044480 1.478 ENST00000374866.3
COL5A2
collagen, type V, alpha 2
chr12_-_28124903 1.324 ENST00000395872.1
ENST00000354417.3
ENST00000201015.4
PTHLH


parathyroid hormone-like hormone


chr2_+_234601512 0.884 ENST00000305139.6
UGT1A6
UDP glucuronosyltransferase 1 family, polypeptide A6
chr1_+_101702417 0.873 ENST00000305352.6
S1PR1
sphingosine-1-phosphate receptor 1
chr2_+_234602305 0.723 ENST00000406651.1
UGT1A6
UDP glucuronosyltransferase 1 family, polypeptide A6
chr7_+_134528635 0.689 ENST00000445569.2
CALD1
caldesmon 1
chrX_+_119737806 0.650 ENST00000371317.5
MCTS1
malignant T cell amplified sequence 1
chr12_-_28125638 0.535 ENST00000545234.1
PTHLH
parathyroid hormone-like hormone
chr2_+_20646824 0.476 ENST00000272233.4
RHOB
ras homolog family member B
chr13_-_107220455 0.439 ENST00000400198.3
ARGLU1
arginine and glutamate rich 1
chr2_+_33661382 0.363 ENST00000402538.3
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr3_+_129158926 0.358 ENST00000347300.2
ENST00000296266.3
IFT122

intraflagellar transport 122 homolog (Chlamydomonas)

chr3_+_129159039 0.343 ENST00000507564.1
ENST00000431818.2
ENST00000504021.1
ENST00000349441.2
ENST00000348417.2
ENST00000440957.2
IFT122





intraflagellar transport 122 homolog (Chlamydomonas)





chr14_-_55658323 0.321 ENST00000554067.1
ENST00000247191.2
DLGAP5

discs, large (Drosophila) homolog-associated protein 5

chr3_-_129158676 0.315 ENST00000393278.2
MBD4
methyl-CpG binding domain protein 4
chr2_+_113033164 0.310 ENST00000409871.1
ENST00000343936.4
ZC3H6

zinc finger CCCH-type containing 6

chr15_+_67418047 0.283 ENST00000540846.2
SMAD3
SMAD family member 3
chrX_+_46696372 0.269 ENST00000218340.3
RP2
retinitis pigmentosa 2 (X-linked recessive)
chr2_+_12857043 0.242 ENST00000381465.2
TRIB2
tribbles pseudokinase 2
chrX_+_56590002 0.240 ENST00000338222.5
UBQLN2
ubiquilin 2
chr3_-_129158850 0.226 ENST00000503197.1
ENST00000249910.1
ENST00000429544.2
ENST00000507208.1
MBD4



methyl-CpG binding domain protein 4



chr14_-_55658252 0.211 ENST00000395425.2
DLGAP5
discs, large (Drosophila) homolog-associated protein 5
chr12_+_53835383 0.211 ENST00000429243.2
PRR13
proline rich 13
chr10_+_124320156 0.210 ENST00000338354.3
ENST00000344338.3
ENST00000330163.4
ENST00000368909.3
ENST00000368955.3
ENST00000368956.2
DMBT1





deleted in malignant brain tumors 1





chr11_+_69455855 0.199 ENST00000227507.2
ENST00000536559.1
CCND1

cyclin D1

chr10_+_124320195 0.198 ENST00000359586.6
DMBT1
deleted in malignant brain tumors 1
chr11_-_111794446 0.194 ENST00000527950.1
CRYAB
crystallin, alpha B
chr17_-_29624343 0.175 ENST00000247271.4
OMG
oligodendrocyte myelin glycoprotein
chr10_+_47894572 0.155 ENST00000355876.5
FAM21B
family with sequence similarity 21, member B
chr2_+_12857015 0.153 ENST00000155926.4
TRIB2
tribbles pseudokinase 2
chr9_-_128246769 0.149 ENST00000444226.1
MAPKAP1
mitogen-activated protein kinase associated protein 1
chr12_+_53835539 0.137 ENST00000547368.1
ENST00000379786.4
ENST00000551945.1
PRR13


proline rich 13


chr17_+_8191815 0.131 ENST00000226105.6
ENST00000407006.4
ENST00000580434.1
ENST00000439238.3
RANGRF



RAN guanine nucleotide release factor



chr17_-_29151794 0.072 ENST00000324238.6
CRLF3
cytokine receptor-like factor 3
chr8_+_110098850 0.068 ENST00000518632.1
TRHR
thyrotropin-releasing hormone receptor
chr1_-_39339777 0.054 ENST00000397572.2
MYCBP
MYC binding protein
chr6_+_26045603 0.024 ENST00000540144.1
HIST1H3C
histone cluster 1, H3c
chr11_+_68228186 0.023 ENST00000393799.2
ENST00000393800.2
ENST00000528635.1
ENST00000533127.1
ENST00000529907.1
ENST00000529344.1
ENST00000534534.1
ENST00000524845.1
ENST00000265637.4
ENST00000524904.1
ENST00000393801.3
ENST00000265636.5
ENST00000529710.1
PPP6R3












protein phosphatase 6, regulatory subunit 3












chr22_+_42017987 0.022 ENST00000405506.1
XRCC6
X-ray repair complementing defective repair in Chinese hamster cells 6
chr16_+_1128781 0.018 ENST00000293897.4
ENST00000562758.1
SSTR5

somatostatin receptor 5

chr10_-_45474237 0.015 ENST00000448778.1
ENST00000298295.3
C10orf10

chromosome 10 open reading frame 10

chr12_+_53835508 0.015 ENST00000541275.1
ENST00000551003.1
ENST00000549068.1
ENST00000549740.1
ENST00000546581.1
ENST00000549581.1
PCBP2
PRR13




poly(rC) binding protein 2
proline rich 13




chr3_-_52864680 0.011 ENST00000406595.1
ENST00000485816.1
ENST00000434759.3
ENST00000346281.5
ENST00000266041.4
ITIH4




inter-alpha-trypsin inhibitor heavy chain family, member 4




chr14_-_23624511 0.009 ENST00000529705.2
SLC7A8
solute carrier family 7 (amino acid transporter light chain, L system), member 8
chr16_+_1832902 0.004 ENST00000262302.9
ENST00000563136.1
ENST00000565987.1
ENST00000543305.1
ENST00000568287.1
ENST00000565134.1
NUBP2





nucleotide binding protein 2





chr4_+_37962018 0.002 ENST00000504686.1
PTTG2
pituitary tumor-transforming 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.9 GO:0060649 nipple development(GO:0060618) mammary gland bud elongation(GO:0060649) nipple morphogenesis(GO:0060658) nipple sheath formation(GO:0060659)
0.4 1.5 GO:0050928 negative regulation of positive chemotaxis(GO:0050928)
0.2 0.7 GO:0010172 embryonic body morphogenesis(GO:0010172)
0.2 0.5 GO:0007079 mitotic chromosome movement towards spindle pole(GO:0007079) chromosome movement towards spindle pole(GO:0051305)
0.1 0.4 GO:0019731 antibacterial humoral response(GO:0019731)
0.1 0.5 GO:0006927 obsolete transformed cell apoptotic process(GO:0006927)
0.1 0.9 GO:0051497 negative regulation of stress fiber assembly(GO:0051497)
0.1 0.4 GO:0045074 interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.1 0.5 GO:0045008 depyrimidination(GO:0045008)
0.1 0.2 GO:0048670 regulation of collateral sprouting(GO:0048670)
0.1 1.5 GO:0030199 collagen fibril organization(GO:0030199)
0.0 0.2 GO:0033197 response to vitamin E(GO:0033197)
0.0 0.3 GO:0007023 post-chaperonin tubulin folding pathway(GO:0007023)
0.0 0.3 GO:0044413 evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.0 0.1 GO:0090073 positive regulation of protein homodimerization activity(GO:0090073)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.5 GO:0005588 collagen type V trimer(GO:0005588)
0.1 0.5 GO:0031616 spindle pole centrosome(GO:0031616)
0.1 0.7 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 0.4 GO:0042589 phagocytic vesicle membrane(GO:0030670) zymogen granule membrane(GO:0042589)
0.0 0.2 GO:0071203 WASH complex(GO:0071203)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0003696 satellite DNA binding(GO:0003696)
0.1 0.9 GO:0046625 obsolete lysosphingolipid and lysophosphatidic acid receptor activity(GO:0001619) sphingolipid binding(GO:0046625)
0.1 1.6 GO:0001972 retinoic acid binding(GO:0001972)
0.0 0.3 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.0 0.4 GO:0051637 obsolete Gram-positive bacterial cell surface binding(GO:0051637)
0.0 0.4 GO:0055103 ligase regulator activity(GO:0055103) ubiquitin-protein transferase regulator activity(GO:0055106)
0.0 1.5 GO:1990782 receptor tyrosine kinase binding(GO:0030971) protein tyrosine kinase binding(GO:1990782)
0.0 0.3 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.0 0.7 GO:0005523 tropomyosin binding(GO:0005523)
0.0 0.4 GO:0019992 diacylglycerol binding(GO:0019992)
0.0 1.5 GO:0046332 SMAD binding(GO:0046332)
0.0 0.5 GO:0019003 GDP binding(GO:0019003)
0.0 0.2 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)