Motif ID: PITX2

Z-value: 0.434


Transcription factors associated with PITX2:

Gene SymbolEntrez IDGene Name
PITX2 ENSG00000164093.11 PITX2



Activity profile for motif PITX2.

activity profile for motif PITX2


Sorted Z-values histogram for motif PITX2

Sorted Z-values for motif PITX2



Network of associatons between targets according to the STRING database.



First level regulatory network of PITX2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr13_-_36429763 0.550 ENST00000379893.1
 DCLK1
doublecortin-like kinase 1
chr12_-_90049828 0.528 ENST00000261173.2
ENST00000348959.3
 ATP2B1

ATPase, Ca++ transporting, plasma membrane 1

chr12_-_90049878 0.513 ENST00000359142.3
 ATP2B1
ATPase, Ca++ transporting, plasma membrane 1
chr1_-_31230650 0.415 ENST00000294507.3
 LAPTM5
lysosomal protein transmembrane 5
chr19_+_2476116 0.284 ENST00000215631.4
ENST00000587345.1
 GADD45B

growth arrest and DNA-damage-inducible, beta

chrX_-_6146876 0.244 ENST00000381095.3
 NLGN4X
neuroligin 4, X-linked
chr13_+_73632897 0.238 ENST00000377687.4
 KLF5
Kruppel-like factor 5 (intestinal)
chr3_+_158787041 0.193 ENST00000471575.1
ENST00000476809.1
ENST00000485419.1
 IQCJ-SCHIP1


IQCJ-SCHIP1 readthrough


chr4_+_126237554 0.151 ENST00000394329.3
 FAT4
FAT atypical cadherin 4
chr2_+_201994569 0.147 ENST00000457277.1
 CFLAR
CASP8 and FADD-like apoptosis regulator
chr16_-_5116025 0.121 ENST00000472572.3
ENST00000315997.5
ENST00000422873.1
ENST00000350219.4
 C16orf89



chromosome 16 open reading frame 89



chr14_+_75988851 0.109 ENST00000555504.1
 BATF
basic leucine zipper transcription factor, ATF-like
chrX_-_54384425 0.101 ENST00000375169.3
ENST00000354646.2
 WNK3

WNK lysine deficient protein kinase 3

chr2_+_120770645 0.094 ENST00000443902.2
 EPB41L5
erythrocyte membrane protein band 4.1 like 5
chrX_-_48931648 0.093 ENST00000376386.3
ENST00000376390.4
 PRAF2

PRA1 domain family, member 2

chr2_+_120770581 0.087 ENST00000263713.5
 EPB41L5
erythrocyte membrane protein band 4.1 like 5
chr5_+_64920543 0.086 ENST00000399438.3
ENST00000510585.2
 TRAPPC13
CTC-534A2.2
trafficking protein particle complex 13
CDNA FLJ26957 fis, clone SLV00486; Uncharacterized protein
chr6_-_111804905 0.079 ENST00000358835.3
ENST00000435970.1
 REV3L

REV3-like, polymerase (DNA directed), zeta, catalytic subunit

chr14_+_75988768 0.074 ENST00000286639.6
 BATF
basic leucine zipper transcription factor, ATF-like
chr7_+_73868220 0.060 ENST00000455841.2
 GTF2IRD1
GTF2I repeat domain containing 1
chr5_-_64920115 0.060 ENST00000381018.3
ENST00000274327.7
 TRIM23

tripartite motif containing 23

chr22_-_39096661 0.059 ENST00000216039.5
 JOSD1
Josephin domain containing 1
chr7_+_73868439 0.056 ENST00000424337.2
 GTF2IRD1
GTF2I repeat domain containing 1
chr16_+_28722684 0.046 ENST00000331666.6
ENST00000395587.1
ENST00000569690.1
ENST00000564243.1
 EIF3C



eukaryotic translation initiation factor 3, subunit C



chr4_+_70916119 0.045 ENST00000246896.3
ENST00000511674.1
 HTN1

histatin 1

chr22_-_30234218 0.041 ENST00000307790.3
ENST00000542393.1
ENST00000397771.2
 ASCC2


activating signal cointegrator 1 complex subunit 2


chr18_-_47017956 0.035 ENST00000584895.1
ENST00000332968.6
ENST00000580210.1
ENST00000579408.1
 RPL17-C18orf32

RPL17

RPL17-C18orf32 readthrough

ribosomal protein L17

chr4_-_76912070 0.019 ENST00000395711.4
ENST00000356260.5
 SDAD1

SDA1 domain containing 1

chr1_+_92417716 0.018 ENST00000402388.1
 BRDT
bromodomain, testis-specific
chr21_-_19775973 0.017 ENST00000284885.3
 TMPRSS15
transmembrane protease, serine 15
chr2_+_3622893 0.016 ENST00000407445.3
ENST00000403564.1
 RPS7

ribosomal protein S7

chr21_-_34915147 0.012 ENST00000381831.3
ENST00000381839.3
 GART

phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase

chr9_+_8858102 0.011 ENST00000447950.1
ENST00000430766.1
 RP11-75C9.1

RP11-75C9.1

chr12_-_323689 0.007 ENST00000428720.1
 SLC6A12
solute carrier family 6 (neurotransmitter transporter), member 12
chr17_+_79495397 0.007 ENST00000417245.2
ENST00000334850.7
 FSCN2

fascin homolog 2, actin-bundling protein, retinal (Strongylocentrotus purpuratus)

chr3_-_50388522 0.005 ENST00000232501.3
 NPRL2
nitrogen permease regulator-like 2 (S. cerevisiae)
chr16_-_68014732 0.003 ENST00000268793.4
 DPEP3
dipeptidase 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0002124 territorial aggressive behavior(GO:0002124) brainstem development(GO:0003360) vocalization behavior(GO:0071625)
0.1 0.6 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.0 0.2 GO:0032525 somite rostral/caudal axis specification(GO:0032525)
0.0 0.3 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.0 0.2 GO:0032528 microvillus assembly(GO:0030033) microvillus organization(GO:0032528)
0.0 0.1 GO:0019985 translesion synthesis(GO:0019985)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 1.0 GO:0005388 calcium-transporting ATPase activity(GO:0005388)