Motif ID: PKNOX1_TGIF2

Z-value: 2.107

Transcription factors associated with PKNOX1_TGIF2:

Gene SymbolEntrez IDGene Name
PKNOX1 ENSG00000160199.10 PKNOX1
TGIF2 ENSG00000118707.5 TGIF2






Network of associatons between targets according to the STRING database.



First level regulatory network of PKNOX1_TGIF2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_+_52828805 5.560 ENST00000416872.2
ENST00000449956.2
ITIH3

inter-alpha-trypsin inhibitor heavy chain 3

chr1_+_207262540 3.960 ENST00000452902.2
C4BPB
complement component 4 binding protein, beta
chr1_+_207262881 3.926 ENST00000451804.2
C4BPB
complement component 4 binding protein, beta
chr1_+_207262170 3.589 ENST00000367078.3
C4BPB
complement component 4 binding protein, beta
chr4_+_166300084 3.522 ENST00000402744.4
CPE
carboxypeptidase E
chr1_+_207262578 3.522 ENST00000243611.5
ENST00000367076.3
C4BPB

complement component 4 binding protein, beta

chr1_+_207262627 3.485 ENST00000391923.1
C4BPB
complement component 4 binding protein, beta
chr2_+_118846008 3.417 ENST00000245787.4
INSIG2
insulin induced gene 2
chr6_+_138188551 3.068 ENST00000237289.4
ENST00000433680.1
TNFAIP3

tumor necrosis factor, alpha-induced protein 3

chr14_-_94856987 2.887 ENST00000449399.3
ENST00000404814.4
SERPINA1

serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1

chr14_-_94857004 2.792 ENST00000557492.1
ENST00000448921.1
ENST00000437397.1
ENST00000355814.4
ENST00000393088.4
SERPINA1




serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1




chr14_-_94856951 2.787 ENST00000553327.1
ENST00000556955.1
ENST00000557118.1
ENST00000440909.1
SERPINA1



serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1



chr17_-_64225508 2.432 ENST00000205948.6
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr21_-_34186006 2.277 ENST00000490358.1
C21orf62
chromosome 21 open reading frame 62
chr9_-_33447584 2.152 ENST00000297991.4
AQP3
aquaporin 3 (Gill blood group)
chr10_-_118764862 2.082 ENST00000260777.10
KIAA1598
KIAA1598
chr21_-_34185944 2.081 ENST00000479548.1
C21orf62
chromosome 21 open reading frame 62
chr15_-_61521495 2.026 ENST00000335670.6
RORA
RAR-related orphan receptor A
chr21_-_34185989 1.959 ENST00000487113.1
ENST00000382373.4
C21orf62

chromosome 21 open reading frame 62

chr6_+_111195973 1.955 ENST00000368885.3
ENST00000368882.3
ENST00000451850.2
ENST00000368877.5
AMD1



adenosylmethionine decarboxylase 1



chr7_+_29234028 1.809 ENST00000222792.6
CHN2
chimerin 2
chr6_+_26124373 1.809 ENST00000377791.2
ENST00000602637.1
HIST1H2AC

histone cluster 1, H2ac

chr16_-_30457048 1.791 ENST00000500504.2
ENST00000542752.1
SEPHS2

selenophosphate synthetase 2

chr16_+_2588012 1.750 ENST00000354836.5
ENST00000389224.3
PDPK1

3-phosphoinositide dependent protein kinase-1

chr8_-_17752912 1.709 ENST00000398054.1
ENST00000381840.2
FGL1

fibrinogen-like 1

chr6_-_32140886 1.681 ENST00000395496.1
AGPAT1
1-acylglycerol-3-phosphate O-acyltransferase 1
chr7_+_29234101 1.606 ENST00000435288.2
CHN2
chimerin 2
chr9_-_111696340 1.605 ENST00000374647.5
IKBKAP
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
chr16_+_30212378 1.578 ENST00000569485.1
SULT1A3
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3
chr7_-_148580563 1.532 ENST00000476773.1
EZH2
enhancer of zeste homolog 2 (Drosophila)
chr10_-_73848531 1.503 ENST00000373109.2
SPOCK2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
chr22_+_17082732 1.497 ENST00000558085.2
ENST00000592918.1
ENST00000400593.2
ENST00000592107.1
ENST00000426585.1
ENST00000591299.1
TPTEP1





transmembrane phosphatase with tensin homology pseudogene 1





chr11_-_107729887 1.467 ENST00000525815.1
SLC35F2
solute carrier family 35, member F2
chr7_-_156803329 1.444 ENST00000252971.6
MNX1
motor neuron and pancreas homeobox 1
chr13_-_41837620 1.324 ENST00000379477.1
ENST00000452359.1
ENST00000379480.4
ENST00000430347.2
MTRF1



mitochondrial translational release factor 1



chr10_-_11574274 1.300 ENST00000277575.5
USP6NL
USP6 N-terminal like
chr1_-_63988846 1.288 ENST00000283568.8
ENST00000371092.3
ENST00000271002.10
ITGB3BP


integrin beta 3 binding protein (beta3-endonexin)


chr1_+_2036149 1.272 ENST00000482686.1
ENST00000400920.1
ENST00000486681.1
PRKCZ


protein kinase C, zeta


chr3_-_142166904 1.248 ENST00000264951.4
XRN1
5'-3' exoribonuclease 1
chr1_-_54872059 1.225 ENST00000371320.3
SSBP3
single stranded DNA binding protein 3
chr3_-_49726486 1.219 ENST00000449682.2
MST1
macrophage stimulating 1 (hepatocyte growth factor-like)
chr3_+_52719936 1.173 ENST00000418458.1
ENST00000394799.2
GNL3

guanine nucleotide binding protein-like 3 (nucleolar)

chr10_-_73848764 1.153 ENST00000317376.4
ENST00000412663.1
SPOCK2

sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2

chr4_-_175443943 1.149 ENST00000296522.6
HPGD
hydroxyprostaglandin dehydrogenase 15-(NAD)
chr1_+_22778337 1.119 ENST00000404138.1
ENST00000400239.2
ENST00000375647.4
ENST00000374651.4
ZBTB40



zinc finger and BTB domain containing 40



chr1_+_154966058 1.089 ENST00000392487.1
LENEP
lens epithelial protein
chr16_-_3030407 1.055 ENST00000431515.2
ENST00000574385.1
ENST00000576268.1
ENST00000574730.1
ENST00000575632.1
ENST00000573944.1
ENST00000262300.8
PKMYT1






protein kinase, membrane associated tyrosine/threonine 1






chr19_-_12512062 1.052 ENST00000595766.1
ENST00000430385.3
ZNF799

zinc finger protein 799

chr14_-_21493123 1.048 ENST00000556147.1
ENST00000554489.1
ENST00000555657.1
ENST00000557274.1
ENST00000555158.1
ENST00000554833.1
ENST00000555384.1
ENST00000556420.1
ENST00000554893.1
ENST00000553503.1
ENST00000555733.1
ENST00000553867.1
ENST00000397856.3
ENST00000397855.3
ENST00000556008.1
ENST00000557182.1
ENST00000554483.1
ENST00000556688.1
ENST00000397853.3
ENST00000556329.2
ENST00000554143.1
ENST00000397851.2
ENST00000555142.1
ENST00000557676.1
ENST00000556924.1
NDRG2
























NDRG family member 2
























chr2_+_85804614 1.042 ENST00000263864.5
ENST00000409760.1
VAMP8

vesicle-associated membrane protein 8

chr5_-_169725231 1.029 ENST00000046794.5
LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr13_+_33160553 1.022 ENST00000315596.10
PDS5B
PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)
chr6_+_31865552 1.016 ENST00000469372.1
ENST00000497706.1
C2

complement component 2

chr7_+_94536898 1.004 ENST00000433360.1
ENST00000340694.4
ENST00000424654.1
PPP1R9A


protein phosphatase 1, regulatory subunit 9A


chr14_-_94759408 0.990 ENST00000554723.1
SERPINA10
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr2_+_242127924 0.986 ENST00000402530.3
ENST00000274979.8
ENST00000402430.3
ANO7


anoctamin 7


chr2_+_233925064 0.977 ENST00000359570.5
ENST00000538935.1
INPP5D

inositol polyphosphate-5-phosphatase, 145kDa

chr10_-_118765081 0.976 ENST00000392903.2
ENST00000355371.4
KIAA1598

KIAA1598

chr18_-_52626622 0.975 ENST00000591504.1
CCDC68
coiled-coil domain containing 68
chr14_-_94759361 0.958 ENST00000393096.1
SERPINA10
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr19_-_39322299 0.958 ENST00000601094.1
ENST00000595567.1
ENST00000602115.1
ENST00000601778.1
ENST00000597205.1
ENST00000595470.1
ECH1





enoyl CoA hydratase 1, peroxisomal





chr2_+_113885138 0.939 ENST00000409930.3
IL1RN
interleukin 1 receptor antagonist
chr1_-_247335269 0.920 ENST00000543802.2
ENST00000491356.1
ENST00000472531.1
ENST00000340684.6
ZNF124



zinc finger protein 124



chr17_+_38296576 0.886 ENST00000264645.7
CASC3
cancer susceptibility candidate 3
chr10_+_28966271 0.883 ENST00000375533.3
BAMBI
BMP and activin membrane-bound inhibitor
chr8_+_11666649 0.877 ENST00000528643.1
ENST00000525777.1
FDFT1

farnesyl-diphosphate farnesyltransferase 1

chr12_-_31479045 0.862 ENST00000539409.1
ENST00000395766.1
FAM60A

family with sequence similarity 60, member A

chr1_+_28844648 0.860 ENST00000373832.1
ENST00000373831.3
RCC1

regulator of chromosome condensation 1

chr13_-_46716969 0.846 ENST00000435666.2
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr4_-_105416039 0.825 ENST00000394767.2
CXXC4
CXXC finger protein 4
chr19_-_12551849 0.820 ENST00000301547.5
ENST00000595562.1
ZNF443
CTD-3105H18.16
zinc finger protein 443
Uncharacterized protein
chr3_-_3221358 0.787 ENST00000424814.1
ENST00000450014.1
ENST00000231948.4
ENST00000432408.2
CRBN



cereblon



chr10_+_28822636 0.780 ENST00000442148.1
ENST00000448193.1
WAC

WW domain containing adaptor with coiled-coil

chr8_-_141774467 0.751 ENST00000520151.1
ENST00000519024.1
ENST00000519465.1
PTK2


protein tyrosine kinase 2


chr5_-_58882219 0.750 ENST00000505453.1
ENST00000360047.5
PDE4D

phosphodiesterase 4D, cAMP-specific

chr15_-_37392086 0.739 ENST00000561208.1
MEIS2
Meis homeobox 2
chr4_+_3076388 0.724 ENST00000355072.5
HTT
huntingtin
chr2_+_62900986 0.713 ENST00000405015.3
ENST00000413434.1
ENST00000426940.1
ENST00000449820.1
EHBP1



EH domain binding protein 1



chr10_+_114710516 0.709 ENST00000542695.1
ENST00000346198.4
TCF7L2

transcription factor 7-like 2 (T-cell specific, HMG-box)

chr19_+_2867325 0.700 ENST00000307635.2
ENST00000586426.1
ZNF556

zinc finger protein 556

chr16_+_2587998 0.698 ENST00000441549.3
ENST00000268673.7
PDPK1

3-phosphoinositide dependent protein kinase-1

chr15_+_68346501 0.681 ENST00000249636.6
PIAS1
protein inhibitor of activated STAT, 1
chr1_+_74701062 0.676 ENST00000326637.3
TNNI3K
TNNI3 interacting kinase
chr19_-_39322497 0.661 ENST00000221418.4
ECH1
enoyl CoA hydratase 1, peroxisomal
chr14_-_21492113 0.659 ENST00000554094.1
NDRG2
NDRG family member 2
chr8_-_99837856 0.652 ENST00000518165.1
ENST00000419617.2
STK3

serine/threonine kinase 3

chr19_+_49496705 0.648 ENST00000595090.1
RUVBL2
RuvB-like AAA ATPase 2
chr9_-_132805430 0.645 ENST00000446176.2
ENST00000355681.3
ENST00000420781.1
FNBP1


formin binding protein 1


chrX_+_135730373 0.643 ENST00000370628.2
CD40LG
CD40 ligand
chr10_+_51565188 0.638 ENST00000430396.2
ENST00000374087.4
ENST00000414907.2
NCOA4


nuclear receptor coactivator 4


chr21_-_34143971 0.623 ENST00000290178.4
PAXBP1
PAX3 and PAX7 binding protein 1
chrX_+_135730297 0.617 ENST00000370629.2
CD40LG
CD40 ligand
chr2_-_24149977 0.606 ENST00000238789.5
ATAD2B
ATPase family, AAA domain containing 2B
chr7_+_29234375 0.604 ENST00000409350.1
ENST00000495789.2
ENST00000539389.1
CHN2


chimerin 2


chr12_+_72148614 0.598 ENST00000261263.3
RAB21
RAB21, member RAS oncogene family
chr12_-_91451758 0.593 ENST00000266719.3
KERA
keratocan
chr2_+_128848881 0.563 ENST00000259253.6
UGGT1
UDP-glucose glycoprotein glucosyltransferase 1
chr9_-_124989804 0.559 ENST00000373755.2
ENST00000373754.2
LHX6

LIM homeobox 6

chr1_+_205473720 0.557 ENST00000429964.2
ENST00000506784.1
ENST00000360066.2
CDK18


cyclin-dependent kinase 18


chr14_-_21492251 0.552 ENST00000554398.1
NDRG2
NDRG family member 2
chr2_-_183106641 0.547 ENST00000346717.4
PDE1A
phosphodiesterase 1A, calmodulin-dependent
chr3_+_111260954 0.546 ENST00000283285.5
CD96
CD96 molecule
chr3_+_185080908 0.544 ENST00000265026.3
MAP3K13
mitogen-activated protein kinase kinase kinase 13
chr9_+_133454943 0.544 ENST00000319725.9
FUBP3
far upstream element (FUSE) binding protein 3
chr1_-_225615599 0.532 ENST00000421383.1
ENST00000272163.4
LBR

lamin B receptor

chr4_-_46391805 0.531 ENST00000540012.1
GABRA2
gamma-aminobutyric acid (GABA) A receptor, alpha 2
chr1_-_53163992 0.528 ENST00000371538.3
SELRC1
cytochrome c oxidase assembly factor 7
chr3_-_52569023 0.524 ENST00000307076.4
NT5DC2
5'-nucleotidase domain containing 2
chr19_-_10764509 0.510 ENST00000591501.1
ILF3-AS1
ILF3 antisense RNA 1 (head to head)
chr2_+_128848740 0.507 ENST00000375990.3
UGGT1
UDP-glucose glycoprotein glucosyltransferase 1
chr4_-_83483395 0.490 ENST00000515780.2
TMEM150C
transmembrane protein 150C
chr19_-_45663408 0.488 ENST00000317951.4
NKPD1
NTPase, KAP family P-loop domain containing 1
chr19_-_13044494 0.488 ENST00000593021.1
ENST00000587981.1
ENST00000423140.2
ENST00000314606.4
FARSA



phenylalanyl-tRNA synthetase, alpha subunit



chr3_+_63897605 0.485 ENST00000487717.1
ATXN7
ataxin 7
chr1_-_51425902 0.478 ENST00000396153.2
FAF1
Fas (TNFRSF6) associated factor 1
chr20_-_33872518 0.472 ENST00000374436.3
EIF6
eukaryotic translation initiation factor 6
chr7_+_95115210 0.471 ENST00000428113.1
ENST00000325885.5
ASB4

ankyrin repeat and SOCS box containing 4

chr12_-_91398796 0.469 ENST00000261172.3
ENST00000551767.1
EPYC

epiphycan

chr2_+_99953816 0.459 ENST00000289371.6
EIF5B
eukaryotic translation initiation factor 5B
chr17_+_13972807 0.458 ENST00000429152.2
ENST00000261643.3
ENST00000536205.1
ENST00000537334.1
COX10



cytochrome c oxidase assembly homolog 10 (yeast)



chr6_-_131949200 0.444 ENST00000539158.1
ENST00000368058.1
MED23

mediator complex subunit 23

chr7_-_104909435 0.437 ENST00000357311.3
SRPK2
SRSF protein kinase 2
chr18_+_3449821 0.433 ENST00000407501.2
ENST00000405385.3
ENST00000546979.1
TGIF1


TGFB-induced factor homeobox 1


chr6_-_35656685 0.432 ENST00000539068.1
ENST00000540787.1
FKBP5

FK506 binding protein 5

chr19_+_49496782 0.430 ENST00000601968.1
ENST00000596837.1
RUVBL2

RuvB-like AAA ATPase 2

chr11_+_129245796 0.408 ENST00000281437.4
BARX2
BARX homeobox 2
chr20_-_33872548 0.402 ENST00000374443.3
EIF6
eukaryotic translation initiation factor 6
chr21_-_34144157 0.396 ENST00000331923.4
PAXBP1
PAX3 and PAX7 binding protein 1
chr21_-_43735446 0.378 ENST00000398431.2
TFF3
trefoil factor 3 (intestinal)
chr6_-_86099898 0.376 ENST00000455071.1
RP11-30P6.6
RP11-30P6.6
chr17_-_39661849 0.373 ENST00000246635.3
ENST00000336861.3
ENST00000587544.1
ENST00000587435.1
KRT13



keratin 13



chr19_-_51538148 0.367 ENST00000319590.4
ENST00000250351.4
KLK12

kallikrein-related peptidase 12

chr2_-_61765315 0.360 ENST00000406957.1
ENST00000401558.2
XPO1

exportin 1 (CRM1 homolog, yeast)

chr8_-_17555164 0.348 ENST00000297488.6
MTUS1
microtubule associated tumor suppressor 1
chr5_-_132073111 0.343 ENST00000403231.1
KIF3A
kinesin family member 3A
chr14_-_21994525 0.341 ENST00000538754.1
SALL2
spalt-like transcription factor 2
chr19_-_51538118 0.337 ENST00000529888.1
KLK12
kallikrein-related peptidase 12
chr12_+_69201923 0.336 ENST00000462284.1
ENST00000258149.5
ENST00000356290.4
ENST00000540827.1
ENST00000428863.2
ENST00000393412.3
MDM2





MDM2 oncogene, E3 ubiquitin protein ligase





chr16_+_16484691 0.336 ENST00000344087.4
NPIPA7
nuclear pore complex interacting protein family, member A7
chr17_+_76374714 0.328 ENST00000262764.6
ENST00000589689.1
ENST00000329897.7
ENST00000592043.1
ENST00000587356.1
PGS1




phosphatidylglycerophosphate synthase 1




chr19_-_12267524 0.323 ENST00000455799.1
ENST00000355738.1
ENST00000439556.2
ENST00000542938.1
ZNF625



zinc finger protein 625



chr16_+_2587965 0.322 ENST00000342085.4
ENST00000566659.1
PDPK1

3-phosphoinositide dependent protein kinase-1

chr2_-_152589670 0.315 ENST00000604864.1
ENST00000603639.1
NEB

nebulin

chr6_+_41021027 0.309 ENST00000244669.2
APOBEC2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2
chr6_-_131949305 0.302 ENST00000368053.4
ENST00000354577.4
ENST00000403834.3
ENST00000540546.1
ENST00000368068.3
ENST00000368060.3
MED23





mediator complex subunit 23





chr5_+_71014990 0.301 ENST00000296777.4
CARTPT
CART prepropeptide
chr6_-_28220002 0.299 ENST00000377294.2
ZKSCAN4
zinc finger with KRAB and SCAN domains 4
chr6_-_163148780 0.298 ENST00000366892.1
ENST00000366898.1
ENST00000366897.1
ENST00000366896.1
PARK2



parkin RBR E3 ubiquitin protein ligase



chr15_+_51200871 0.297 ENST00000560508.1
AP4E1
adaptor-related protein complex 4, epsilon 1 subunit
chr22_+_50946645 0.293 ENST00000420993.2
ENST00000395698.3
ENST00000395701.3
ENST00000523045.1
ENST00000299821.11
NCAPH2




non-SMC condensin II complex, subunit H2




chr5_+_173763250 0.289 ENST00000515513.1
ENST00000507361.1
ENST00000510234.1
RP11-267A15.1


RP11-267A15.1


chr3_+_111260856 0.288 ENST00000352690.4
CD96
CD96 molecule
chr4_+_57774042 0.286 ENST00000309042.7
REST
RE1-silencing transcription factor
chr16_-_30569584 0.280 ENST00000252797.2
ENST00000568114.1
ZNF764
AC002310.13
zinc finger protein 764
Uncharacterized protein
chr4_-_46391367 0.279 ENST00000503806.1
ENST00000356504.1
ENST00000514090.1
ENST00000506961.1
GABRA2



gamma-aminobutyric acid (GABA) A receptor, alpha 2



chr7_+_76139833 0.274 ENST00000257632.5
UPK3B
uroplakin 3B
chr11_-_111741994 0.273 ENST00000398006.2
ALG9
ALG9, alpha-1,2-mannosyltransferase
chr13_+_24844819 0.273 ENST00000399949.2
SPATA13
spermatogenesis associated 13
chr6_+_112375462 0.270 ENST00000361714.1
WISP3
WNT1 inducible signaling pathway protein 3
chr3_+_38017264 0.270 ENST00000436654.1
CTDSPL
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
chr1_+_24286287 0.269 ENST00000334351.7
ENST00000374468.1
PNRC2

proline-rich nuclear receptor coactivator 2

chr18_+_3451646 0.267 ENST00000345133.5
ENST00000330513.5
ENST00000549546.1
TGIF1


TGFB-induced factor homeobox 1


chr3_-_192445289 0.261 ENST00000430714.1
ENST00000418610.1
ENST00000448795.1
ENST00000445105.2
FGF12



fibroblast growth factor 12



chr16_-_20817753 0.259 ENST00000389345.5
ENST00000300005.3
ENST00000357967.4
ENST00000569729.1
ERI2



ERI1 exoribonuclease family member 2



chr19_+_49497121 0.256 ENST00000413176.2
RUVBL2
RuvB-like AAA ATPase 2
chr21_-_10990830 0.253 ENST00000361285.4
ENST00000342420.5
ENST00000328758.5
TPTE


transmembrane phosphatase with tensin homology


chr20_+_60878005 0.251 ENST00000253003.2
ADRM1
adhesion regulating molecule 1
chr6_+_110299501 0.250 ENST00000414000.2
GPR6
G protein-coupled receptor 6
chr12_+_10658489 0.245 ENST00000538173.1
EIF2S3L
Putative eukaryotic translation initiation factor 2 subunit 3-like protein
chr2_+_233271546 0.240 ENST00000295453.3
ALPPL2
alkaline phosphatase, placental-like 2
chr22_-_50219548 0.239 ENST00000404034.1
BRD1
bromodomain containing 1
chr2_+_16080659 0.236 ENST00000281043.3
MYCN
v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
chr17_-_29151794 0.235 ENST00000324238.6
CRLF3
cytokine receptor-like factor 3
chr8_+_97506033 0.234 ENST00000518385.1
SDC2
syndecan 2
chr21_-_10990888 0.232 ENST00000298232.7
TPTE
transmembrane phosphatase with tensin homology
chr1_-_32384693 0.232 ENST00000602683.1
ENST00000470404.1
PTP4A2

protein tyrosine phosphatase type IVA, member 2

chr17_-_3499125 0.230 ENST00000399759.3
TRPV1
transient receptor potential cation channel, subfamily V, member 1
chr17_-_40337470 0.229 ENST00000293330.1
HCRT
hypocretin (orexin) neuropeptide precursor
chr5_-_154230130 0.228 ENST00000519501.1
ENST00000518651.1
ENST00000517938.1
ENST00000520461.1
FAXDC2



fatty acid hydroxylase domain containing 2



chr3_+_49726932 0.225 ENST00000327697.6
ENST00000432042.1
ENST00000454491.1
RNF123


ring finger protein 123


chr12_-_30887948 0.224 ENST00000433722.2
CAPRIN2
caprin family member 2
chr19_-_6424783 0.223 ENST00000398148.3
KHSRP
KH-type splicing regulatory protein
chr1_+_171217677 0.222 ENST00000402921.2
FMO1
flavin containing monooxygenase 1
chr6_-_26027480 0.222 ENST00000377364.3
HIST1H4B
histone cluster 1, H4b
chr12_-_104531785 0.220 ENST00000551727.1
NFYB
nuclear transcription factor Y, beta
chr10_-_124768300 0.219 ENST00000368886.5
IKZF5
IKAROS family zinc finger 5 (Pegasus)
chr22_-_30234218 0.218 ENST00000307790.3
ENST00000542393.1
ENST00000397771.2
ASCC2


activating signal cointegrator 1 complex subunit 2


chr4_+_128886532 0.217 ENST00000444616.1
ENST00000388795.5
C4orf29

chromosome 4 open reading frame 29

chr1_+_26348259 0.216 ENST00000374280.3
EXTL1
exostosin-like glycosyltransferase 1
chr11_-_84028180 0.212 ENST00000280241.8
DLG2
discs, large homolog 2 (Drosophila)
chr3_-_183273477 0.211 ENST00000341319.3
KLHL6
kelch-like family member 6
chr15_-_43559055 0.211 ENST00000220420.5
ENST00000349114.4
TGM5

transglutaminase 5

chr15_-_37391614 0.206 ENST00000219869.9
MEIS2
Meis homeobox 2
chr8_-_144241664 0.205 ENST00000342752.4
LY6H
lymphocyte antigen 6 complex, locus H
chrX_+_101380642 0.203 ENST00000372780.1
ENST00000329035.2
TCEAL2

transcription elongation factor A (SII)-like 2

chr7_-_99332719 0.202 ENST00000336374.2
CYP3A7
cytochrome P450, family 3, subfamily A, polypeptide 7
chr2_-_37068530 0.199 ENST00000593798.1
AC007382.1
Uncharacterized protein
chr1_-_33502528 0.198 ENST00000354858.6
AK2
adenylate kinase 2
chr13_+_73302047 0.198 ENST00000377814.2
ENST00000377815.3
ENST00000390667.5
BORA


bora, aurora kinase A activator


chr5_-_58571935 0.197 ENST00000503258.1
PDE4D
phosphodiesterase 4D, cAMP-specific

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 8.5 GO:0033986 response to methanol(GO:0033986) response to chromate(GO:0046687)
1.2 3.5 GO:1901142 insulin processing(GO:0030070) insulin metabolic process(GO:1901142)
1.0 3.1 GO:0034139 regulation of toll-like receptor 2 signaling pathway(GO:0034135) regulation of toll-like receptor 3 signaling pathway(GO:0034139) negative regulation of epithelial cell apoptotic process(GO:1904036) negative regulation of endothelial cell apoptotic process(GO:2000352)
0.7 3.4 GO:0032933 SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)
0.7 2.0 GO:0006597 spermine biosynthetic process(GO:0006597)
0.5 1.4 GO:0060539 diaphragm development(GO:0060539)
0.4 2.2 GO:0070295 renal water absorption(GO:0070295)
0.4 5.6 GO:0030212 hyaluronan metabolic process(GO:0030212)
0.3 19.5 GO:0006958 complement activation, classical pathway(GO:0006958)
0.3 1.0 GO:0045656 negative regulation of monocyte differentiation(GO:0045656)
0.3 1.3 GO:1904035 endothelial cell apoptotic process(GO:0072577) epithelial cell apoptotic process(GO:1904019) regulation of epithelial cell apoptotic process(GO:1904035) positive regulation of epithelial cell apoptotic process(GO:1904037) regulation of endothelial cell apoptotic process(GO:2000351) positive regulation of endothelial cell apoptotic process(GO:2000353)
0.3 1.2 GO:0071025 RNA surveillance(GO:0071025) nuclear RNA surveillance(GO:0071027) nuclear mRNA surveillance(GO:0071028)
0.3 2.4 GO:0034392 negative regulation of smooth muscle cell apoptotic process(GO:0034392)
0.3 0.9 GO:0008298 intracellular mRNA localization(GO:0008298)
0.2 0.9 GO:0045338 farnesyl diphosphate metabolic process(GO:0045338)
0.2 1.3 GO:0019372 lipoxygenase pathway(GO:0019372)
0.2 0.8 GO:0071894 histone H2B conserved C-terminal lysine ubiquitination(GO:0071894)
0.2 1.9 GO:0060046 regulation of acrosome reaction(GO:0060046)
0.2 1.7 GO:0006654 phosphatidic acid biosynthetic process(GO:0006654)
0.2 2.8 GO:0032148 activation of protein kinase B activity(GO:0032148)
0.2 0.7 GO:0019805 lactate metabolic process(GO:0006089) quinolinate biosynthetic process(GO:0019805)
0.2 0.7 GO:0048619 embryonic hindgut morphogenesis(GO:0048619)
0.2 0.5 GO:0051971 positive regulation of transmission of nerve impulse(GO:0051971)
0.2 1.5 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.2 0.5 GO:0006432 phenylalanyl-tRNA aminoacylation(GO:0006432)
0.1 0.8 GO:0007352 zygotic specification of dorsal/ventral axis(GO:0007352)
0.1 1.0 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
0.1 0.6 GO:0042637 catagen(GO:0042637)
0.1 1.6 GO:0007252 I-kappaB phosphorylation(GO:0007252)
0.1 0.9 GO:0007090 obsolete regulation of S phase of mitotic cell cycle(GO:0007090)
0.1 1.3 GO:0006449 regulation of translational termination(GO:0006449)
0.1 0.4 GO:0070995 NADPH oxidation(GO:0070995)
0.1 0.3 GO:0072383 plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.1 0.6 GO:0021830 interneuron migration from the subpallium to the cortex(GO:0021830) cerebral cortex GABAergic interneuron migration(GO:0021853) cerebral cortex GABAergic interneuron development(GO:0021894) interneuron migration(GO:1904936)
0.1 1.8 GO:0009070 serine family amino acid biosynthetic process(GO:0009070)
0.1 0.3 GO:0070842 aggresome assembly(GO:0070842)
0.1 1.5 GO:0009812 flavonoid metabolic process(GO:0009812)
0.1 1.3 GO:0043968 histone H2A acetylation(GO:0043968)
0.1 0.9 GO:0035413 positive regulation of catenin import into nucleus(GO:0035413)
0.1 0.3 GO:0006216 cytidine catabolic process(GO:0006216) cytidine deamination(GO:0009972) cytidine metabolic process(GO:0046087)
0.1 1.3 GO:0031055 DNA replication-independent nucleosome assembly(GO:0006336) chromatin remodeling at centromere(GO:0031055) CENP-A containing nucleosome assembly(GO:0034080) DNA replication-independent nucleosome organization(GO:0034724) CENP-A containing chromatin organization(GO:0061641)
0.1 0.5 GO:0000266 mitochondrial fission(GO:0000266)
0.1 0.1 GO:0051970 regulation of transmission of nerve impulse(GO:0051969) negative regulation of transmission of nerve impulse(GO:0051970)
0.1 0.9 GO:0042255 ribosome assembly(GO:0042255)
0.1 1.3 GO:0050732 negative regulation of peptidyl-tyrosine phosphorylation(GO:0050732)
0.1 0.3 GO:0007525 somatic muscle development(GO:0007525)
0.0 0.2 GO:0060236 regulation of mitotic spindle organization(GO:0060236)
0.0 0.1 GO:0030091 protein repair(GO:0030091)
0.0 0.7 GO:0033235 positive regulation of protein sumoylation(GO:0033235)
0.0 0.2 GO:0061003 positive regulation of dendritic spine morphogenesis(GO:0061003)
0.0 2.7 GO:0007416 synapse assembly(GO:0007416)
0.0 0.2 GO:0045218 zonula adherens maintenance(GO:0045218)
0.0 0.9 GO:0001960 negative regulation of cytokine-mediated signaling pathway(GO:0001960)
0.0 0.2 GO:0055098 response to low-density lipoprotein particle(GO:0055098) regulation of cholesterol transporter activity(GO:0060694)
0.0 0.3 GO:1900087 traversing start control point of mitotic cell cycle(GO:0007089) positive regulation of G1/S transition of mitotic cell cycle(GO:1900087) positive regulation of cell cycle G1/S phase transition(GO:1902808)
0.0 0.7 GO:0035329 hippo signaling(GO:0035329)
0.0 0.8 GO:0007172 signal complex assembly(GO:0007172)
0.0 0.5 GO:0007253 cytoplasmic sequestering of NF-kappaB(GO:0007253)
0.0 0.1 GO:0042560 10-formyltetrahydrofolate metabolic process(GO:0009256) 10-formyltetrahydrofolate catabolic process(GO:0009258) folic acid-containing compound catabolic process(GO:0009397) pteridine-containing compound catabolic process(GO:0042560)
0.0 0.1 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.0 0.4 GO:0043587 tongue morphogenesis(GO:0043587)
0.0 0.1 GO:0001552 ovarian follicle atresia(GO:0001552)
0.0 1.8 GO:0006334 nucleosome assembly(GO:0006334)
0.0 0.3 GO:0007204 positive regulation of cytosolic calcium ion concentration(GO:0007204) regulation of cytosolic calcium ion concentration(GO:0051480)
0.0 0.1 GO:0060748 tertiary branching involved in mammary gland duct morphogenesis(GO:0060748)
0.0 0.5 GO:0016578 histone deubiquitination(GO:0016578)
0.0 1.0 GO:0050663 cytokine secretion(GO:0050663)
0.0 0.1 GO:0042754 regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) negative regulation of circadian sleep/wake cycle, sleep(GO:0042321) negative regulation of circadian rhythm(GO:0042754) negative regulation of behavior(GO:0048521)
0.0 0.8 GO:0031100 organ regeneration(GO:0031100)
0.0 0.3 GO:0048268 clathrin coat assembly(GO:0048268)
0.0 0.2 GO:0051001 negative regulation of nitric-oxide synthase activity(GO:0051001)
0.0 1.1 GO:0051084 'de novo' posttranslational protein folding(GO:0051084)
0.0 0.2 GO:0031000 response to caffeine(GO:0031000)
0.0 1.6 GO:0034339 obsolete regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor(GO:0034339)
0.0 0.1 GO:0018206 peptidyl-methionine modification(GO:0018206)
0.0 0.2 GO:0002467 germinal center formation(GO:0002467)
0.0 0.4 GO:0018208 peptidyl-proline modification(GO:0018208)
0.0 1.0 GO:0061025 membrane fusion(GO:0061025)
0.0 1.1 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029)
0.0 0.3 GO:0030032 lamellipodium assembly(GO:0030032)
0.0 0.4 GO:1902583 multi-organism transport(GO:0044766) transport of virus(GO:0046794) intracellular transport of virus(GO:0075733) multi-organism localization(GO:1902579) multi-organism intracellular transport(GO:1902583)
0.0 0.1 GO:0015824 proline transport(GO:0015824)
0.0 0.5 GO:0006505 GPI anchor metabolic process(GO:0006505)
0.0 0.3 GO:0006368 transcription elongation from RNA polymerase II promoter(GO:0006368)
0.0 0.6 GO:0000186 activation of MAPKK activity(GO:0000186)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:0098563 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.2 1.7 GO:0005577 fibrinogen complex(GO:0005577)
0.1 0.5 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.1 0.8 GO:0001891 phagocytic cup(GO:0001891)
0.1 0.7 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369) beta-catenin-TCF complex(GO:1990907)
0.1 2.4 GO:0042627 chylomicron(GO:0042627)
0.1 1.5 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.1 8.5 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.1 0.8 GO:0031464 Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.1 0.3 GO:0016939 kinesin II complex(GO:0016939)
0.1 1.6 GO:0008023 transcription elongation factor complex(GO:0008023)
0.1 1.3 GO:0035267 NuA4 histone acetyltransferase complex(GO:0035267)
0.1 0.4 GO:0005642 annulate lamellae(GO:0005642)
0.0 0.5 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 0.2 GO:0070776 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0 3.4 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 0.9 GO:0031227 intrinsic component of endoplasmic reticulum membrane(GO:0031227)
0.0 1.0 GO:0031201 SNARE complex(GO:0031201)
0.0 1.8 GO:0000786 nucleosome(GO:0000786)
0.0 0.3 GO:0030126 COPI vesicle coat(GO:0030126)
0.0 0.5 GO:0031265 CD95 death-inducing signaling complex(GO:0031265)
0.0 0.7 GO:0005776 autophagosome(GO:0005776)
0.0 0.3 GO:0030118 clathrin coat(GO:0030118)
0.0 0.2 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 0.3 GO:0016235 aggresome(GO:0016235)
0.0 1.1 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.0 0.2 GO:0005915 zonula adherens(GO:0005915)
0.0 0.6 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 31.6 GO:0005576 extracellular region(GO:0005576)
0.0 1.6 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 0.1 GO:0017119 Golgi transport complex(GO:0017119)
0.0 0.8 GO:0005626 obsolete insoluble fraction(GO:0005626)
0.0 0.9 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.0 1.0 GO:0034707 chloride channel complex(GO:0034707)
0.0 2.8 GO:0005911 cell-cell junction(GO:0005911)
0.0 1.7 GO:0045111 intermediate filament cytoskeleton(GO:0045111)
0.0 2.7 GO:0030424 axon(GO:0030424)
0.0 0.6 GO:0030426 growth cone(GO:0030426)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.8 GO:0004676 3-phosphoinositide-dependent protein kinase activity(GO:0004676)
0.6 1.8 GO:0004756 selenide, water dikinase activity(GO:0004756) phosphotransferase activity, paired acceptors(GO:0016781)
0.5 2.2 GO:0015254 glycerol channel activity(GO:0015254)
0.5 2.4 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
0.4 1.3 GO:0005174 CD40 receptor binding(GO:0005174)
0.4 1.1 GO:0003980 UDP-glucose:glycoprotein glucosyltransferase activity(GO:0003980)
0.3 1.3 GO:0016404 15-hydroxyprostaglandin dehydrogenase (NAD+) activity(GO:0016404)
0.3 1.0 GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.3 0.9 GO:0005152 interleukin-1 receptor antagonist activity(GO:0005152)
0.3 0.9 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.2 11.8 GO:0002020 protease binding(GO:0002020)
0.2 1.3 GO:0003747 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.2 0.9 GO:0051996 farnesyl-diphosphate farnesyltransferase activity(GO:0004310) squalene synthase activity(GO:0051996)
0.2 1.6 GO:0004300 enoyl-CoA hydratase activity(GO:0004300)
0.2 1.2 GO:0008409 5'-3' exonuclease activity(GO:0008409)
0.2 0.5 GO:0050613 delta14-sterol reductase activity(GO:0050613)
0.2 1.6 GO:0008607 phosphorylase kinase regulator activity(GO:0008607)
0.2 0.8 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.2 3.5 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 0.5 GO:0004826 phenylalanine-tRNA ligase activity(GO:0004826)
0.1 0.7 GO:0034452 dynactin binding(GO:0034452)
0.1 1.7 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) lysophosphatidic acid acyltransferase activity(GO:0042171) lysophospholipid acyltransferase activity(GO:0071617)
0.1 0.5 GO:0004311 farnesyltranstransferase activity(GO:0004311)
0.1 1.6 GO:0004062 aryl sulfotransferase activity(GO:0004062)
0.1 0.7 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.1 0.9 GO:0005114 type II transforming growth factor beta receptor binding(GO:0005114)
0.1 0.3 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) ATP-dependent microtubule motor activity(GO:1990939)
0.1 7.5 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 0.7 GO:0019789 SUMO transferase activity(GO:0019789)
0.1 0.8 GO:0004176 ATP-dependent peptidase activity(GO:0004176)
0.1 0.3 GO:0017163 obsolete basal transcription repressor activity(GO:0017163)
0.1 0.8 GO:0008503 benzodiazepine receptor activity(GO:0008503)
0.1 0.3 GO:0004126 cytidine deaminase activity(GO:0004126)
0.1 0.2 GO:0004727 prenylated protein tyrosine phosphatase activity(GO:0004727)
0.1 1.3 GO:0043560 insulin receptor substrate binding(GO:0043560)
0.1 0.5 GO:0004117 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117)
0.0 0.1 GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.0 0.7 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 0.2 GO:0050508 glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.0 0.4 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.0 2.0 GO:0016831 carboxy-lyase activity(GO:0016831)
0.0 3.9 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 0.4 GO:0031013 troponin I binding(GO:0031013)
0.0 0.2 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.0 0.9 GO:0043022 ribosome binding(GO:0043022)
0.0 1.3 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.0 0.2 GO:0004630 phospholipase D activity(GO:0004630)
0.0 0.7 GO:0030528 obsolete transcription regulator activity(GO:0030528)
0.0 0.3 GO:0017169 CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.0 0.1 GO:0031177 formyltetrahydrofolate dehydrogenase activity(GO:0016155) phosphopantetheine binding(GO:0031177)
0.0 2.2 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.0 1.2 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.0 0.3 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.2 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0 0.2 GO:0017081 chloride channel regulator activity(GO:0017081)
0.0 0.1 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0 0.7 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.5 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 0.8 GO:0042169 SH2 domain binding(GO:0042169)
0.0 1.4 GO:0030165 PDZ domain binding(GO:0030165)
0.0 0.3 GO:0001619 obsolete lysosphingolipid and lysophosphatidic acid receptor activity(GO:0001619)
0.0 0.1 GO:0004914 interleukin-5 receptor activity(GO:0004914)
0.0 0.5 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 0.5 GO:0051059 NF-kappaB binding(GO:0051059)
0.0 0.1 GO:0004985 opioid receptor activity(GO:0004985)
0.0 0.3 GO:0000030 mannosyltransferase activity(GO:0000030)
0.0 0.3 GO:0030276 clathrin binding(GO:0030276)
0.0 0.1 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0 0.4 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0 0.3 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 2.5 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.6 GO:0097472 cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472)
0.0 0.2 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 0.3 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 0.6 GO:0050681 androgen receptor binding(GO:0050681)
0.0 0.5 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.1 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor Necrosis Factor Pathway.
0.1 0.7 ST_JAK_STAT_PATHWAY Jak-STAT Pathway
0.0 0.6 ST_GA12_PATHWAY G alpha 12 Pathway
0.0 0.7 ST_INTERLEUKIN_4_PATHWAY Interleukin 4 (IL-4) Pathway
0.0 0.5 ST_JNK_MAPK_PATHWAY JNK MAPK Pathway
0.0 1.0 ST_T_CELL_SIGNAL_TRANSDUCTION T Cell Signal Transduction
0.0 1.3 ST_INTEGRIN_SIGNALING_PATHWAY Integrin Signaling Pathway