Motif ID: PKNOX2

Z-value: 0.945


Transcription factors associated with PKNOX2:

Gene SymbolEntrez IDGene Name
PKNOX2 ENSG00000165495.11 PKNOX2



Activity profile for motif PKNOX2.

activity profile for motif PKNOX2


Sorted Z-values histogram for motif PKNOX2

Sorted Z-values for motif PKNOX2



Network of associatons between targets according to the STRING database.



First level regulatory network of PKNOX2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr15_+_33010175 2.023 ENST00000300177.4
ENST00000560677.1
ENST00000560830.1
 GREM1


gremlin 1, DAN family BMP antagonist


chr4_+_169418195 2.014 ENST00000261509.6
ENST00000335742.7
 PALLD

palladin, cytoskeletal associated protein

chr5_+_125758813 1.878 ENST00000285689.3
ENST00000515200.1
 GRAMD3

GRAM domain containing 3

chr3_-_127541679 1.875 ENST00000265052.5
 MGLL
monoglyceride lipase
chr5_+_125758865 1.847 ENST00000542322.1
ENST00000544396.1
 GRAMD3

GRAM domain containing 3

chr4_-_157892498 1.724 ENST00000502773.1
 PDGFC
platelet derived growth factor C
chr3_-_127541194 1.600 ENST00000453507.2
 MGLL
monoglyceride lipase
chr4_+_169418255 1.489 ENST00000505667.1
ENST00000511948.1
 PALLD

palladin, cytoskeletal associated protein

chr5_-_81046841 1.482 ENST00000509013.2
ENST00000505980.1
ENST00000509053.1
 SSBP2


single-stranded DNA binding protein 2


chr5_-_81046922 1.355 ENST00000514493.1
ENST00000320672.4
 SSBP2

single-stranded DNA binding protein 2

chr5_-_81046904 1.212 ENST00000515395.1
 SSBP2
single-stranded DNA binding protein 2
chr1_+_181057638 0.932 ENST00000367577.4
 IER5
immediate early response 5
chr18_+_54318616 0.930 ENST00000254442.3
 WDR7
WD repeat domain 7
chr18_+_54318566 0.913 ENST00000589935.1
ENST00000357574.3
 WDR7

WD repeat domain 7

chr7_-_137028534 0.877 ENST00000348225.2
 PTN
pleiotrophin
chr7_-_137028498 0.854 ENST00000393083.2
 PTN
pleiotrophin
chr2_+_219081817 0.752 ENST00000315717.5
ENST00000420104.1
ENST00000295685.10
 ARPC2


actin related protein 2/3 complex, subunit 2, 34kDa


chr2_-_211179883 0.751 ENST00000352451.3
 MYL1
myosin, light chain 1, alkali; skeletal, fast
chr2_-_179672142 0.722 ENST00000342992.6
ENST00000360870.5
ENST00000460472.2
ENST00000589042.1
ENST00000591111.1
ENST00000342175.6
ENST00000359218.5
 TTN






titin






chr17_-_26220366 0.624 ENST00000460380.2
ENST00000508862.1
ENST00000379102.3
ENST00000582441.1
 LYRM9


RP1-66C13.4
LYR motif containing 9


Uncharacterized protein
chr10_-_101945771 0.575 ENST00000370408.2
ENST00000407654.3
 ERLIN1

ER lipid raft associated 1

chr6_-_101329191 0.572 ENST00000324723.6
ENST00000369162.2
ENST00000522650.1
 ASCC3


activating signal cointegrator 1 complex subunit 3


chr16_+_50776021 0.544 ENST00000566679.2
ENST00000564634.1
ENST00000398568.2
 CYLD


cylindromatosis (turban tumor syndrome)


chr11_+_12132117 0.526 ENST00000256194.4
 MICAL2
microtubule associated monooxygenase, calponin and LIM domain containing 2
chr9_-_79307096 0.510 ENST00000376717.2
ENST00000223609.6
ENST00000443509.2
 PRUNE2


prune homolog 2 (Drosophila)


chr11_+_6411636 0.505 ENST00000299397.3
ENST00000356761.2
ENST00000342245.4
 SMPD1


sphingomyelin phosphodiesterase 1, acid lysosomal


chr5_+_118407053 0.500 ENST00000311085.8
ENST00000539542.1
 DMXL1

Dmx-like 1

chrX_-_153775426 0.393 ENST00000393562.2
 G6PD
glucose-6-phosphate dehydrogenase
chr19_+_41281416 0.387 ENST00000597140.1
 MIA
melanoma inhibitory activity
chr6_+_29910301 0.385 ENST00000376809.5
ENST00000376802.2
 HLA-A

major histocompatibility complex, class I, A

chr11_+_842928 0.383 ENST00000397408.1
 TSPAN4
tetraspanin 4
chr7_-_42276612 0.382 ENST00000395925.3
ENST00000437480.1
 GLI3

GLI family zinc finger 3

chr12_+_62654155 0.372 ENST00000312635.6
ENST00000393654.3
ENST00000549237.1
 USP15


ubiquitin specific peptidase 15


chr11_-_842509 0.371 ENST00000322028.4
 POLR2L
polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
chr5_-_52405564 0.304 ENST00000510818.2
ENST00000396954.3
ENST00000508922.1
ENST00000361377.4
ENST00000582677.1
ENST00000584946.1
ENST00000450852.3
 MOCS2






molybdenum cofactor synthesis 2






chr11_+_842808 0.298 ENST00000397397.2
ENST00000397411.2
ENST00000397396.1
 TSPAN4


tetraspanin 4


chr19_+_41281060 0.293 ENST00000594436.1
ENST00000597784.1
 MIA

melanoma inhibitory activity

chr2_-_202316260 0.288 ENST00000332624.3
 TRAK2
trafficking protein, kinesin binding 2
chr18_-_54318353 0.286 ENST00000590954.1
ENST00000540155.1
 TXNL1

thioredoxin-like 1

chr14_+_61995722 0.264 ENST00000556347.1
 RP11-47I22.4
RP11-47I22.4
chr19_+_41281282 0.239 ENST00000263369.3
 MIA
melanoma inhibitory activity
chr2_+_191208196 0.238 ENST00000392329.2
ENST00000322522.4
ENST00000430311.1
ENST00000541441.1
 INPP1



inositol polyphosphate-1-phosphatase



chr9_-_132805430 0.236 ENST00000446176.2
ENST00000355681.3
ENST00000420781.1
 FNBP1


formin binding protein 1


chr8_+_31496809 0.228 ENST00000518104.1
ENST00000519301.1
 NRG1

neuregulin 1

chr6_-_116575226 0.227 ENST00000420283.1
 TSPYL4
TSPY-like 4
chr11_+_6411670 0.219 ENST00000530395.1
ENST00000527275.1
 SMPD1

sphingomyelin phosphodiesterase 1, acid lysosomal

chr12_+_62654119 0.215 ENST00000353364.3
ENST00000549523.1
ENST00000280377.5
 USP15


ubiquitin specific peptidase 15


chr11_-_64013288 0.204 ENST00000542235.1
 PPP1R14B
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chrX_-_77225135 0.201 ENST00000458128.1
 PGAM4
phosphoglycerate mutase family member 4
chr21_-_32931290 0.197 ENST00000286827.3
 TIAM1
T-cell lymphoma invasion and metastasis 1
chr10_+_49514698 0.193 ENST00000432379.1
ENST00000429041.1
ENST00000374189.1
 MAPK8


mitogen-activated protein kinase 8


chr10_+_70661014 0.191 ENST00000373585.3
 DDX50
DEAD (Asp-Glu-Ala-Asp) box polypeptide 50
chr8_+_133787586 0.181 ENST00000395379.1
ENST00000395386.2
ENST00000337920.4
 PHF20L1


PHD finger protein 20-like 1


chr18_-_54305658 0.171 ENST00000586262.1
ENST00000217515.6
 TXNL1

thioredoxin-like 1

chr4_-_149365827 0.168 ENST00000344721.4
 NR3C2
nuclear receptor subfamily 3, group C, member 2
chr3_-_52001448 0.164 ENST00000461554.1
ENST00000395013.3
ENST00000428823.2
ENST00000483411.1
ENST00000461544.1
ENST00000355852.2
 PCBP4





poly(rC) binding protein 4





chr1_+_109756523 0.162 ENST00000234677.2
ENST00000369923.4
 SARS

seryl-tRNA synthetase

chr17_+_68071389 0.161 ENST00000283936.1
ENST00000392671.1
 KCNJ16

potassium inwardly-rectifying channel, subfamily J, member 16

chr17_+_68071458 0.155 ENST00000589377.1
 KCNJ16
potassium inwardly-rectifying channel, subfamily J, member 16
chr5_-_94620239 0.154 ENST00000515393.1
 MCTP1
multiple C2 domains, transmembrane 1
chr8_+_57124245 0.146 ENST00000521831.1
ENST00000355315.3
ENST00000303759.3
ENST00000517636.1
ENST00000517933.1
ENST00000518801.1
ENST00000523975.1
ENST00000396723.5
ENST00000523061.1
ENST00000521524.1
 CHCHD7









coiled-coil-helix-coiled-coil-helix domain containing 7









chr11_-_59383617 0.143 ENST00000263847.1
 OSBP
oxysterol binding protein
chr16_-_1275257 0.142 ENST00000234798.4
 TPSG1
tryptase gamma 1
chr3_-_33481835 0.135 ENST00000283629.3
 UBP1
upstream binding protein 1 (LBP-1a)
chr17_-_29151794 0.131 ENST00000324238.6
 CRLF3
cytokine receptor-like factor 3
chr12_+_103981044 0.125 ENST00000388887.2
 STAB2
stabilin 2
chr1_-_201081579 0.120 ENST00000367338.3
ENST00000362061.3
 CACNA1S

calcium channel, voltage-dependent, L type, alpha 1S subunit

chr11_+_74660278 0.109 ENST00000263672.6
ENST00000530257.1
ENST00000526361.1
ENST00000532972.1
 SPCS2



signal peptidase complex subunit 2 homolog (S. cerevisiae)



chr6_+_42123141 0.108 ENST00000418175.1
ENST00000541991.1
ENST00000053469.4
ENST00000394237.1
ENST00000372963.1
 GUCA1A



RP1-139D8.6
guanylate cyclase activator 1A (retina)



RP1-139D8.6
chr6_-_84418860 0.101 ENST00000521743.1
 SNAP91
synaptosomal-associated protein, 91kDa
chr1_-_35658736 0.094 ENST00000357214.5
 SFPQ
splicing factor proline/glutamine-rich
chr6_-_84418841 0.090 ENST00000369694.2
ENST00000195649.6
 SNAP91

synaptosomal-associated protein, 91kDa

chr6_+_31674639 0.089 ENST00000556581.1
ENST00000375832.4
ENST00000503322.1
 LY6G6F

MEGT1
lymphocyte antigen 6 complex, locus G6F

HCG43720, isoform CRA_a; Lymphocyte antigen 6 complex locus protein G6f; Megakaryocyte-enhanced gene transcript 1 protein; Uncharacterized protein
chr8_-_20161466 0.088 ENST00000381569.1
 LZTS1
leucine zipper, putative tumor suppressor 1
chr6_+_150070831 0.083 ENST00000367380.5
 PCMT1
protein-L-isoaspartate (D-aspartate) O-methyltransferase
chr1_-_179198702 0.083 ENST00000502732.1
 ABL2
c-abl oncogene 2, non-receptor tyrosine kinase
chrX_+_16804544 0.075 ENST00000380122.5
ENST00000398155.4
 TXLNG

taxilin gamma

chr22_+_30279144 0.074 ENST00000401950.2
ENST00000333027.3
ENST00000445401.1
ENST00000323630.5
ENST00000351488.3
 MTMR3




myotubularin related protein 3




chr4_+_140222609 0.067 ENST00000296543.5
ENST00000398947.1
 NAA15

N(alpha)-acetyltransferase 15, NatA auxiliary subunit

chr9_+_87285539 0.064 ENST00000359847.3
 NTRK2
neurotrophic tyrosine kinase, receptor, type 2
chr12_+_49621658 0.064 ENST00000541364.1
 TUBA1C
tubulin, alpha 1c
chr6_+_37225540 0.054 ENST00000373491.3
 TBC1D22B
TBC1 domain family, member 22B
chr22_+_50946645 0.052 ENST00000420993.2
ENST00000395698.3
ENST00000395701.3
ENST00000523045.1
ENST00000299821.11
 NCAPH2




non-SMC condensin II complex, subunit H2




chr12_-_121734489 0.051 ENST00000412367.2
ENST00000402834.4
ENST00000404169.3
 CAMKK2


calcium/calmodulin-dependent protein kinase kinase 2, beta


chr17_-_4046257 0.050 ENST00000381638.2
 ZZEF1
zinc finger, ZZ-type with EF-hand domain 1
chr9_+_137772652 0.042 ENST00000350339.2
ENST00000291744.6
 FCN2

ficolin (collagen/fibrinogen domain containing lectin) 2

chr5_-_132073111 0.042 ENST00000403231.1
 KIF3A
kinesin family member 3A
chr11_+_129245796 0.042 ENST00000281437.4
 BARX2
BARX homeobox 2
chr17_+_39868577 0.041 ENST00000329402.3
 GAST
gastrin
chr20_+_43514320 0.036 ENST00000372839.3
ENST00000428262.1
ENST00000445830.1
 YWHAB


tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta


chr6_+_150070857 0.034 ENST00000544496.1
 PCMT1
protein-L-isoaspartate (D-aspartate) O-methyltransferase
chr4_-_100871506 0.031 ENST00000296417.5
 H2AFZ
H2A histone family, member Z
chr1_+_170904612 0.030 ENST00000367759.4
ENST00000367758.3
 MROH9

maestro heat-like repeat family member 9

chr16_+_57481382 0.029 ENST00000564655.1
ENST00000567072.1
ENST00000567933.1
ENST00000563166.1
 COQ9



coenzyme Q9



chr20_-_3065362 0.020 ENST00000380293.3
 AVP
arginine vasopressin
chr8_-_99837856 0.017 ENST00000518165.1
ENST00000419617.2
 STK3

serine/threonine kinase 3

chr11_-_132813566 0.012 ENST00000331898.7
 OPCML
opioid binding protein/cell adhesion molecule-like
chr22_-_31885514 0.002 ENST00000397525.1
 EIF4ENIF1
eukaryotic translation initiation factor 4E nuclear import factor 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 3.5 GO:2000124 cannabinoid signaling pathway(GO:0038171) endocannabinoid signaling pathway(GO:0071926) regulation of endocannabinoid signaling pathway(GO:2000124)
0.5 2.0 GO:0002689 negative regulation of leukocyte chemotaxis(GO:0002689)
0.2 0.7 GO:0031034 skeletal muscle myosin thick filament assembly(GO:0030241) myosin filament assembly(GO:0031034) striated muscle myosin thick filament assembly(GO:0071688)
0.2 1.7 GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.1 0.4 GO:0006740 NADPH regeneration(GO:0006740)
0.1 0.4 GO:0060831 smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:0060831)
0.1 0.7 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.1 0.2 GO:0031558 obsolete induction of apoptosis in response to chemical stimulus(GO:0031558) determination of dorsal identity(GO:0048263)
0.1 1.7 GO:0048008 platelet-derived growth factor receptor signaling pathway(GO:0048008)
0.0 0.2 GO:0006434 seryl-tRNA aminoacylation(GO:0006434)
0.0 0.1 GO:0030091 protein repair(GO:0030091)
0.0 0.4 GO:0006356 regulation of transcription from RNA polymerase I promoter(GO:0006356)
0.0 0.3 GO:0043545 Mo-molybdopterin cofactor biosynthetic process(GO:0006777) Mo-molybdopterin cofactor metabolic process(GO:0019720) molybdopterin cofactor biosynthetic process(GO:0032324) molybdopterin cofactor metabolic process(GO:0043545) prosthetic group metabolic process(GO:0051189)
0.0 0.1 GO:0043501 skeletal muscle adaptation(GO:0043501)
0.0 0.8 GO:0030838 positive regulation of actin filament polymerization(GO:0030838)
0.0 0.5 GO:0042347 negative regulation of NF-kappaB import into nucleus(GO:0042347)
0.0 0.6 GO:0036503 ER-associated ubiquitin-dependent protein catabolic process(GO:0030433) ERAD pathway(GO:0036503)
0.0 0.5 GO:0006662 glycerol ether metabolic process(GO:0006662) ether metabolic process(GO:0018904)
0.0 0.2 GO:0010658 striated muscle cell apoptotic process(GO:0010658) cardiac muscle cell apoptotic process(GO:0010659) regulation of striated muscle cell apoptotic process(GO:0010662) negative regulation of striated muscle cell apoptotic process(GO:0010664) regulation of cardiac muscle cell apoptotic process(GO:0010665) negative regulation of cardiac muscle cell apoptotic process(GO:0010667)
0.0 0.1 GO:0031282 regulation of guanylate cyclase activity(GO:0031282)
0.0 0.2 GO:0048013 ephrin receptor signaling pathway(GO:0048013)
0.0 0.8 GO:0060048 cardiac muscle contraction(GO:0060048)
0.0 0.4 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
0.0 0.2 GO:0048268 clathrin coat assembly(GO:0048268)
0.0 0.3 GO:0006493 protein O-linked glycosylation(GO:0006493)
0.0 0.0 GO:0072383 plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0019008 molybdopterin synthase complex(GO:0019008)
0.1 0.7 GO:0031430 M band(GO:0031430)
0.1 3.5 GO:0005884 actin filament(GO:0005884)
0.1 0.8 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 0.1 GO:0005787 signal peptidase complex(GO:0005787)
0.0 0.8 GO:0005859 muscle myosin complex(GO:0005859)
0.0 0.4 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0 0.4 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 0.4 GO:0016592 mediator complex(GO:0016592)
0.0 0.1 GO:0042382 paraspeckles(GO:0042382)
0.0 0.5 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 0.0 GO:0016939 kinesin II complex(GO:0016939)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 3.5 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.3 3.5 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.1 0.7 GO:0051393 alpha-actinin binding(GO:0051393)
0.1 0.4 GO:0004345 glucose-6-phosphate dehydrogenase activity(GO:0004345)
0.1 1.7 GO:0043498 obsolete cell surface binding(GO:0043498)
0.1 0.7 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.1 1.9 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.1 3.9 GO:0003697 single-stranded DNA binding(GO:0003697)
0.1 0.2 GO:0004083 bisphosphoglycerate mutase activity(GO:0004082) bisphosphoglycerate 2-phosphatase activity(GO:0004083) phosphoglycerate mutase activity(GO:0004619)
0.0 0.2 GO:0004828 serine-tRNA ligase activity(GO:0004828)
0.0 0.1 GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.0 0.2 GO:0016312 inositol bisphosphate phosphatase activity(GO:0016312)
0.0 0.2 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0 0.3 GO:0050811 GABA receptor binding(GO:0050811)
0.0 0.4 GO:0032393 MHC class I receptor activity(GO:0032393)
0.0 0.4 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 0.2 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.0 0.5 GO:0070064 proline-rich region binding(GO:0070064)
0.0 0.3 GO:0016783 sulfurtransferase activity(GO:0016783)
0.0 0.1 GO:0008048 calcium sensitive guanylate cyclase activator activity(GO:0008048)
0.0 0.1 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.0 0.2 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.6 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035)
0.0 0.2 GO:0030276 clathrin binding(GO:0030276)
0.0 0.3 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.0 0.0 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) ATP-dependent microtubule motor activity(GO:1990939)