Motif ID: PLAG1
Z-value: 1.601
Transcription factors associated with PLAG1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| PLAG1 | ENSG00000181690.3 | PLAG1 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 2.6 | GO:0071379 | cellular response to prostaglandin stimulus(GO:0071379) |
| 0.4 | 3.1 | GO:0030579 | ubiquitin-dependent SMAD protein catabolic process(GO:0030579) |
| 0.4 | 4.3 | GO:0031017 | exocrine pancreas development(GO:0031017) |
| 0.3 | 0.9 | GO:0048861 | serine phosphorylation of STAT protein(GO:0042501) leukemia inhibitory factor signaling pathway(GO:0048861) |
| 0.3 | 0.8 | GO:0032571 | response to vitamin K(GO:0032571) |
| 0.2 | 0.7 | GO:0045198 | establishment of epithelial cell apical/basal polarity(GO:0045198) |
| 0.2 | 0.8 | GO:0019471 | peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) 4-hydroxyproline metabolic process(GO:0019471) peptidyl-proline hydroxylation(GO:0019511) |
| 0.2 | 1.7 | GO:0032429 | regulation of phospholipase A2 activity(GO:0032429) |
| 0.1 | 1.1 | GO:0030903 | notochord development(GO:0030903) |
| 0.1 | 1.0 | GO:0060325 | face morphogenesis(GO:0060325) |
| 0.1 | 0.4 | GO:0050758 | thymidylate synthase biosynthetic process(GO:0050757) regulation of thymidylate synthase biosynthetic process(GO:0050758) negative regulation of thymidylate synthase biosynthetic process(GO:0050760) |
| 0.1 | 1.1 | GO:0034260 | negative regulation of GTPase activity(GO:0034260) |
| 0.1 | 0.3 | GO:0003056 | regulation of vascular smooth muscle contraction(GO:0003056) |
| 0.1 | 0.4 | GO:0071428 | rRNA-containing ribonucleoprotein complex export from nucleus(GO:0071428) |
| 0.1 | 1.9 | GO:0042749 | regulation of circadian sleep/wake cycle(GO:0042749) regulation of circadian sleep/wake cycle, sleep(GO:0045187) |
| 0.1 | 1.9 | GO:0006656 | phosphatidylcholine biosynthetic process(GO:0006656) |
| 0.1 | 0.7 | GO:0046473 | low-density lipoprotein particle remodeling(GO:0034374) phosphatidic acid metabolic process(GO:0046473) |
| 0.1 | 0.6 | GO:0035590 | purinergic nucleotide receptor signaling pathway(GO:0035590) |
| 0.0 | 0.7 | GO:0001885 | endothelial cell development(GO:0001885) |
| 0.0 | 1.0 | GO:0018208 | peptidyl-proline modification(GO:0018208) |
| 0.0 | 0.8 | GO:0036503 | ER-associated ubiquitin-dependent protein catabolic process(GO:0030433) ERAD pathway(GO:0036503) |
| 0.0 | 2.1 | GO:0031668 | cellular response to extracellular stimulus(GO:0031668) |
| 0.0 | 0.1 | GO:0060023 | soft palate development(GO:0060023) |
| 0.0 | 0.8 | GO:0006612 | protein targeting to membrane(GO:0006612) |
| 0.0 | 0.8 | GO:0007528 | neuromuscular junction development(GO:0007528) |
| 0.0 | 0.9 | GO:0000188 | inactivation of MAPK activity(GO:0000188) |
| 0.0 | 1.5 | GO:0030071 | regulation of mitotic metaphase/anaphase transition(GO:0030071) regulation of metaphase/anaphase transition of cell cycle(GO:1902099) |
| 0.0 | 2.3 | GO:0006937 | regulation of muscle contraction(GO:0006937) |
| 0.0 | 0.4 | GO:0050812 | acetyl-CoA biosynthetic process from pyruvate(GO:0006086) regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510) regulation of acyl-CoA biosynthetic process(GO:0050812) |
| 0.0 | 0.8 | GO:0006361 | transcription initiation from RNA polymerase I promoter(GO:0006361) |
| 0.0 | 0.5 | GO:0007566 | embryo implantation(GO:0007566) |
| 0.0 | 0.8 | GO:0030049 | muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275) |
| 0.0 | 0.3 | GO:0035329 | hippo signaling(GO:0035329) |
| 0.0 | 0.2 | GO:0050872 | white fat cell differentiation(GO:0050872) |
| 0.0 | 1.1 | GO:0006986 | response to unfolded protein(GO:0006986) |
| 0.0 | 1.0 | GO:0034332 | adherens junction organization(GO:0034332) |
| 0.0 | 1.1 | GO:0051592 | response to calcium ion(GO:0051592) |
| 0.0 | 0.3 | GO:0015804 | neutral amino acid transport(GO:0015804) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 2.6 | GO:0031904 | endosome lumen(GO:0031904) |
| 0.1 | 1.6 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.1 | 0.3 | GO:0009279 | cell outer membrane(GO:0009279) |
| 0.1 | 0.4 | GO:0033596 | TSC1-TSC2 complex(GO:0033596) |
| 0.1 | 2.5 | GO:0005859 | muscle myosin complex(GO:0005859) |
| 0.1 | 0.4 | GO:0045254 | pyruvate dehydrogenase complex(GO:0045254) |
| 0.1 | 0.3 | GO:0071256 | Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256) |
| 0.1 | 1.5 | GO:0033116 | endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116) |
| 0.0 | 1.5 | GO:0005680 | anaphase-promoting complex(GO:0005680) |
| 0.0 | 1.9 | GO:0005791 | rough endoplasmic reticulum(GO:0005791) |
| 0.0 | 2.0 | GO:0016528 | sarcoplasm(GO:0016528) |
| 0.0 | 3.1 | GO:0016363 | nuclear matrix(GO:0016363) |
| 0.0 | 1.1 | GO:0043195 | terminal bouton(GO:0043195) |
| 0.0 | 1.7 | GO:0005905 | clathrin-coated pit(GO:0005905) |
| 0.0 | 0.8 | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment(GO:0005793) |
| 0.0 | 0.8 | GO:0031594 | neuromuscular junction(GO:0031594) |
| 0.0 | 0.4 | GO:0005861 | troponin complex(GO:0005861) |
| 0.0 | 0.7 | GO:0030286 | dynein complex(GO:0030286) |
| 0.0 | 0.1 | GO:0072487 | MSL complex(GO:0072487) |
| 0.0 | 0.1 | GO:0005602 | complement component C1 complex(GO:0005602) |
| 0.0 | 0.1 | GO:0005682 | U5 snRNP(GO:0005682) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 1.9 | GO:0005324 | long-chain fatty acid transporter activity(GO:0005324) |
| 0.5 | 1.9 | GO:0004667 | prostaglandin-D synthase activity(GO:0004667) |
| 0.4 | 3.1 | GO:0048495 | Roundabout binding(GO:0048495) |
| 0.3 | 0.9 | GO:0005017 | platelet-derived growth factor-activated receptor activity(GO:0005017) |
| 0.3 | 1.7 | GO:0034187 | obsolete apolipoprotein E binding(GO:0034187) |
| 0.2 | 2.6 | GO:0017127 | cholesterol transporter activity(GO:0017127) |
| 0.2 | 0.8 | GO:0004656 | procollagen-proline 4-dioxygenase activity(GO:0004656) peptidyl-proline 4-dioxygenase activity(GO:0031545) |
| 0.1 | 4.3 | GO:0005159 | insulin-like growth factor receptor binding(GO:0005159) |
| 0.1 | 0.4 | GO:0032794 | GTPase activating protein binding(GO:0032794) |
| 0.1 | 0.5 | GO:0017034 | Rap guanyl-nucleotide exchange factor activity(GO:0017034) |
| 0.1 | 0.4 | GO:0004738 | pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739) |
| 0.1 | 0.4 | GO:0008327 | methyl-CpG binding(GO:0008327) |
| 0.1 | 0.9 | GO:0035381 | extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381) |
| 0.1 | 0.7 | GO:0047498 | calcium-dependent phospholipase A2 activity(GO:0047498) |
| 0.1 | 1.6 | GO:0043499 | obsolete eukaryotic cell surface binding(GO:0043499) |
| 0.0 | 0.4 | GO:0030172 | troponin C binding(GO:0030172) calcium-dependent ATPase activity(GO:0030899) |
| 0.0 | 0.3 | GO:0005087 | Ran guanyl-nucleotide exchange factor activity(GO:0005087) |
| 0.0 | 1.1 | GO:0005001 | transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) |
| 0.0 | 0.5 | GO:0016641 | oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641) |
| 0.0 | 0.8 | GO:0004707 | MAP kinase activity(GO:0004707) |
| 0.0 | 1.0 | GO:0005528 | macrolide binding(GO:0005527) FK506 binding(GO:0005528) |
| 0.0 | 0.4 | GO:0004904 | interferon receptor activity(GO:0004904) |
| 0.0 | 0.2 | GO:0001965 | G-protein alpha-subunit binding(GO:0001965) |
| 0.0 | 2.5 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.0 | 2.7 | GO:0004714 | transmembrane receptor protein tyrosine kinase activity(GO:0004714) |
| 0.0 | 0.5 | GO:0005095 | GTPase inhibitor activity(GO:0005095) |
| 0.0 | 0.0 | GO:0070008 | serine-type exopeptidase activity(GO:0070008) |
| 0.0 | 0.8 | GO:0042169 | SH2 domain binding(GO:0042169) |
| 0.0 | 0.8 | GO:0016831 | carboxy-lyase activity(GO:0016831) |
| 0.0 | 0.4 | GO:0070064 | proline-rich region binding(GO:0070064) |
| 0.0 | 0.2 | GO:0034185 | apolipoprotein binding(GO:0034185) |
| 0.0 | 0.1 | GO:0015016 | [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016) |
| 0.0 | 0.6 | GO:0005080 | protein kinase C binding(GO:0005080) |
| 0.0 | 0.1 | GO:0008331 | high voltage-gated calcium channel activity(GO:0008331) |
| 0.0 | 0.6 | GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115) |
| 0.0 | 0.7 | GO:0004180 | carboxypeptidase activity(GO:0004180) |
| 0.0 | 1.5 | GO:0031625 | ubiquitin protein ligase binding(GO:0031625) ubiquitin-like protein ligase binding(GO:0044389) |
| 0.0 | 0.3 | GO:0015175 | neutral amino acid transmembrane transporter activity(GO:0015175) |
| 0.0 | 0.9 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 0.0 | 0.1 | GO:0004157 | dihydropyrimidinase activity(GO:0004157) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.7 | ST_INTERFERON_GAMMA_PATHWAY | Interferon gamma pathway. |
| 0.0 | 1.7 | ST_WNT_BETA_CATENIN_PATHWAY | Wnt/beta-catenin Pathway |
| 0.0 | 0.8 | SA_PTEN_PATHWAY | PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. |
