Motif ID: POU2F2_POU3F1
Z-value: 4.001
Transcription factors associated with POU2F2_POU3F1:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
POU2F2 | ENSG00000028277.16 | POU2F2 |
POU3F1 | ENSG00000185668.5 | POU3F1 |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
16.8 | 50.4 | GO:0035408 | histone H3-T6 phosphorylation(GO:0035408) |
6.5 | 19.4 | GO:0070445 | Fc receptor mediated stimulatory signaling pathway(GO:0002431) regulation of Fc receptor mediated stimulatory signaling pathway(GO:0060368) positive regulation of Fc receptor mediated stimulatory signaling pathway(GO:0060369) oligodendrocyte progenitor proliferation(GO:0070444) regulation of oligodendrocyte progenitor proliferation(GO:0070445) positive regulation of oligodendrocyte progenitor proliferation(GO:0070447) |
1.8 | 9.0 | GO:0010508 | positive regulation of autophagy(GO:0010508) |
1.0 | 7.0 | GO:0042989 | sequestering of actin monomers(GO:0042989) |
0.8 | 4.1 | GO:0034371 | positive regulation of sequestering of triglyceride(GO:0010890) chylomicron remodeling(GO:0034371) |
0.8 | 75.8 | GO:0006334 | nucleosome assembly(GO:0006334) |
0.6 | 1.7 | GO:0008050 | female courtship behavior(GO:0008050) |
0.5 | 3.1 | GO:0071699 | olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699) |
0.4 | 3.1 | GO:0031657 | regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle(GO:0031657) positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle(GO:0031659) |
0.4 | 4.6 | GO:0006776 | vitamin A metabolic process(GO:0006776) |
0.4 | 1.6 | GO:0031936 | negative regulation of chromatin silencing(GO:0031936) |
0.4 | 2.7 | GO:0021830 | interneuron migration from the subpallium to the cortex(GO:0021830) cerebral cortex GABAergic interneuron migration(GO:0021853) cerebral cortex GABAergic interneuron development(GO:0021894) interneuron migration(GO:1904936) |
0.4 | 1.1 | GO:0046984 | regulation of hemoglobin biosynthetic process(GO:0046984) |
0.3 | 1.2 | GO:0033262 | regulation of nuclear cell cycle DNA replication(GO:0033262) replication fork protection(GO:0048478) |
0.3 | 1.7 | GO:0006422 | aspartyl-tRNA aminoacylation(GO:0006422) |
0.2 | 1.5 | GO:0006658 | phosphatidylserine metabolic process(GO:0006658) |
0.2 | 1.6 | GO:0045627 | regulation of granulocyte macrophage colony-stimulating factor biosynthetic process(GO:0045423) positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process(GO:0045425) positive regulation of T-helper 1 cell differentiation(GO:0045627) |
0.2 | 0.7 | GO:0019858 | cytosine metabolic process(GO:0019858) |
0.2 | 0.9 | GO:0060261 | positive regulation of transcription initiation from RNA polymerase II promoter(GO:0060261) positive regulation of DNA-templated transcription, initiation(GO:2000144) |
0.2 | 8.3 | GO:0065004 | protein-DNA complex assembly(GO:0065004) |
0.2 | 1.2 | GO:0030185 | nitric oxide transport(GO:0030185) |
0.2 | 2.5 | GO:0043330 | response to exogenous dsRNA(GO:0043330) type I interferon biosynthetic process(GO:0045351) |
0.1 | 0.7 | GO:0007288 | sperm axoneme assembly(GO:0007288) |
0.1 | 1.3 | GO:0016180 | snRNA processing(GO:0016180) |
0.1 | 0.4 | GO:0021913 | regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913) |
0.1 | 0.9 | GO:0005984 | disaccharide metabolic process(GO:0005984) |
0.1 | 0.5 | GO:0034310 | primary alcohol catabolic process(GO:0034310) |
0.1 | 0.6 | GO:0007100 | mitotic centrosome separation(GO:0007100) |
0.1 | 0.4 | GO:2000001 | regulation of DNA damage checkpoint(GO:2000001) |
0.1 | 16.9 | GO:0006959 | humoral immune response(GO:0006959) |
0.1 | 1.0 | GO:0006983 | ER overload response(GO:0006983) |
0.1 | 0.4 | GO:0031580 | membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580) |
0.1 | 0.5 | GO:0007221 | positive regulation of transcription of Notch receptor target(GO:0007221) |
0.1 | 0.6 | GO:0060670 | branching involved in labyrinthine layer morphogenesis(GO:0060670) |
0.1 | 0.5 | GO:0045767 | obsolete regulation of anti-apoptosis(GO:0045767) |
0.1 | 1.3 | GO:0060736 | prostate gland growth(GO:0060736) |
0.1 | 0.8 | GO:0016045 | detection of bacterium(GO:0016045) |
0.1 | 0.4 | GO:0072369 | positive regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045716) regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter(GO:0072369) |
0.1 | 0.2 | GO:0072201 | negative regulation of mesenchymal cell proliferation(GO:0072201) |
0.1 | 0.4 | GO:0009642 | response to light intensity(GO:0009642) |
0.1 | 0.8 | GO:0070327 | thyroid hormone transport(GO:0070327) |
0.1 | 1.1 | GO:0030539 | male genitalia development(GO:0030539) |
0.1 | 0.9 | GO:0009223 | pyrimidine deoxyribonucleotide catabolic process(GO:0009223) |
0.1 | 0.3 | GO:0045872 | regulation of rhodopsin gene expression(GO:0007468) positive regulation of rhodopsin gene expression(GO:0045872) |
0.1 | 0.3 | GO:0070933 | histone H3 deacetylation(GO:0070932) histone H4 deacetylation(GO:0070933) |
0.1 | 0.5 | GO:0046835 | carbohydrate phosphorylation(GO:0046835) |
0.1 | 1.0 | GO:0032438 | melanosome organization(GO:0032438) pigment granule organization(GO:0048753) |
0.1 | 6.1 | GO:0071357 | response to type I interferon(GO:0034340) type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357) |
0.1 | 0.3 | GO:0032736 | positive regulation of interleukin-13 production(GO:0032736) |
0.1 | 1.3 | GO:0090399 | replicative senescence(GO:0090399) |
0.1 | 0.3 | GO:0040016 | embryonic cleavage(GO:0040016) |
0.1 | 0.2 | GO:0043276 | anoikis(GO:0043276) |
0.1 | 0.3 | GO:0032878 | regulation of establishment or maintenance of cell polarity(GO:0032878) |
0.1 | 1.0 | GO:0007020 | microtubule nucleation(GO:0007020) |
0.1 | 1.1 | GO:0000380 | alternative mRNA splicing, via spliceosome(GO:0000380) |
0.1 | 1.3 | GO:0000291 | nuclear-transcribed mRNA catabolic process, exonucleolytic(GO:0000291) exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928) |
0.1 | 0.3 | GO:0006003 | fructose 2,6-bisphosphate metabolic process(GO:0006003) |
0.0 | 1.4 | GO:0018208 | peptidyl-proline modification(GO:0018208) |
0.0 | 0.1 | GO:0048865 | stem cell fate commitment(GO:0048865) stem cell fate determination(GO:0048867) |
0.0 | 0.5 | GO:0048488 | synaptic vesicle recycling(GO:0036465) synaptic vesicle endocytosis(GO:0048488) clathrin-mediated endocytosis(GO:0072583) |
0.0 | 0.6 | GO:0046827 | positive regulation of protein export from nucleus(GO:0046827) |
0.0 | 0.2 | GO:0070050 | neuron cellular homeostasis(GO:0070050) |
0.0 | 0.2 | GO:0006556 | S-adenosylmethionine biosynthetic process(GO:0006556) |
0.0 | 0.6 | GO:0002076 | osteoblast development(GO:0002076) |
0.0 | 0.1 | GO:0045591 | positive regulation of regulatory T cell differentiation(GO:0045591) |
0.0 | 0.8 | GO:0060113 | inner ear receptor cell differentiation(GO:0060113) |
0.0 | 1.1 | GO:0007214 | gamma-aminobutyric acid signaling pathway(GO:0007214) |
0.0 | 0.2 | GO:0015889 | cobalamin transport(GO:0015889) |
0.0 | 0.7 | GO:0071804 | cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805) |
0.0 | 1.8 | GO:0016579 | protein deubiquitination(GO:0016579) |
0.0 | 0.8 | GO:0030520 | intracellular estrogen receptor signaling pathway(GO:0030520) |
0.0 | 0.4 | GO:0008635 | activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c(GO:0008635) |
0.0 | 0.5 | GO:0030097 | hemopoiesis(GO:0030097) |
0.0 | 0.1 | GO:0010842 | retina layer formation(GO:0010842) |
0.0 | 0.4 | GO:0060711 | labyrinthine layer development(GO:0060711) |
0.0 | 0.1 | GO:0007352 | zygotic specification of dorsal/ventral axis(GO:0007352) |
0.0 | 0.4 | GO:0021846 | cell proliferation in forebrain(GO:0021846) |
0.0 | 1.8 | GO:0006094 | gluconeogenesis(GO:0006094) |
0.0 | 0.8 | GO:0043484 | regulation of RNA splicing(GO:0043484) |
0.0 | 0.1 | GO:0007196 | adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway(GO:0007196) |
0.0 | 0.3 | GO:0042273 | ribosomal large subunit biogenesis(GO:0042273) |
0.0 | 1.7 | GO:0046777 | protein autophosphorylation(GO:0046777) |
0.0 | 0.1 | GO:0000460 | maturation of 5.8S rRNA(GO:0000460) |
0.0 | 0.5 | GO:0006665 | sphingolipid metabolic process(GO:0006665) |
0.0 | 1.2 | GO:0051591 | response to cAMP(GO:0051591) |
0.0 | 2.5 | GO:0051028 | mRNA transport(GO:0051028) |
0.0 | 0.2 | GO:0071300 | cellular response to retinoic acid(GO:0071300) |
0.0 | 0.1 | GO:0015937 | coenzyme A biosynthetic process(GO:0015937) |
0.0 | 0.5 | GO:0035272 | exocrine system development(GO:0035272) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.6 | 19.4 | GO:0030061 | mitochondrial crista(GO:0030061) |
1.5 | 75.8 | GO:0000786 | nucleosome(GO:0000786) |
0.4 | 1.3 | GO:0035327 | transcriptionally active chromatin(GO:0035327) |
0.3 | 1.2 | GO:0031838 | haptoglobin-hemoglobin complex(GO:0031838) |
0.2 | 1.0 | GO:0032585 | multivesicular body membrane(GO:0032585) |
0.2 | 4.1 | GO:0042627 | chylomicron(GO:0042627) |
0.2 | 1.8 | GO:0032039 | integrator complex(GO:0032039) |
0.1 | 1.0 | GO:0005828 | kinetochore microtubule(GO:0005828) |
0.1 | 7.0 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
0.1 | 0.4 | GO:0008537 | proteasome activator complex(GO:0008537) |
0.1 | 0.7 | GO:0032839 | dendrite cytoplasm(GO:0032839) |
0.1 | 0.2 | GO:0031232 | extrinsic component of external side of plasma membrane(GO:0031232) |
0.1 | 0.9 | GO:0005763 | organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763) |
0.1 | 7.9 | GO:0031225 | anchored component of membrane(GO:0031225) |
0.0 | 1.9 | GO:0030530 | obsolete heterogeneous nuclear ribonucleoprotein complex(GO:0030530) |
0.0 | 3.2 | GO:0031901 | early endosome membrane(GO:0031901) |
0.0 | 1.7 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
0.0 | 0.6 | GO:0016585 | obsolete chromatin remodeling complex(GO:0016585) |
0.0 | 6.9 | GO:0000785 | chromatin(GO:0000785) |
0.0 | 0.7 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
0.0 | 6.8 | GO:0005792 | obsolete microsome(GO:0005792) |
0.0 | 0.1 | GO:0032444 | activin responsive factor complex(GO:0032444) |
0.0 | 5.0 | GO:0005667 | transcription factor complex(GO:0005667) |
0.0 | 1.1 | GO:0034707 | chloride channel complex(GO:0034707) |
0.0 | 0.5 | GO:0005782 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
0.0 | 0.1 | GO:0017071 | intracellular cyclic nucleotide activated cation channel complex(GO:0017071) |
0.0 | 0.3 | GO:0001533 | cornified envelope(GO:0001533) |
0.0 | 0.6 | GO:0005884 | actin filament(GO:0005884) |
0.0 | 2.5 | GO:0010008 | endosome membrane(GO:0010008) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
16.8 | 50.4 | GO:0035403 | histone kinase activity (H3-T6 specific)(GO:0035403) |
1.9 | 19.5 | GO:0043208 | glycosphingolipid binding(GO:0043208) |
1.4 | 4.1 | GO:0017129 | triglyceride binding(GO:0017129) |
0.8 | 3.1 | GO:0016286 | small conductance calcium-activated potassium channel activity(GO:0016286) |
0.7 | 7.8 | GO:0005068 | transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068) |
0.6 | 7.7 | GO:0001011 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, RNA polymerase II basal transcription factor binding(GO:0001083) transcription factor activity, TFIIB-class binding(GO:0001087) RNA polymerase II basal transcription factor binding(GO:0001091) TFIIB-class transcription factor binding(GO:0001093) |
0.4 | 1.8 | GO:0015183 | L-aspartate transmembrane transporter activity(GO:0015183) |
0.4 | 5.9 | GO:0004028 | 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028) |
0.3 | 1.6 | GO:0003680 | AT DNA binding(GO:0003680) |
0.3 | 1.7 | GO:0004815 | aspartate-tRNA ligase activity(GO:0004815) |
0.3 | 0.8 | GO:0008970 | phosphatidylcholine 1-acylhydrolase activity(GO:0008970) |
0.2 | 0.9 | GO:0070324 | thyroid hormone binding(GO:0070324) |
0.2 | 0.9 | GO:0004461 | lactose synthase activity(GO:0004461) |
0.2 | 4.7 | GO:0045028 | G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028) |
0.2 | 1.3 | GO:0030492 | hemoglobin binding(GO:0030492) |
0.2 | 0.9 | GO:0019103 | pyrimidine nucleotide binding(GO:0019103) |
0.2 | 0.5 | GO:0000150 | recombinase activity(GO:0000150) |
0.2 | 0.5 | GO:0033858 | N-acetylgalactosamine kinase activity(GO:0033858) |
0.1 | 1.0 | GO:0008107 | galactoside 2-alpha-L-fucosyltransferase activity(GO:0008107) alpha-(1,2)-fucosyltransferase activity(GO:0031127) |
0.1 | 1.1 | GO:0070700 | BMP receptor binding(GO:0070700) |
0.1 | 1.5 | GO:0008266 | poly(U) RNA binding(GO:0008266) |
0.1 | 1.6 | GO:0004887 | thyroid hormone receptor activity(GO:0004887) |
0.1 | 0.5 | GO:0016623 | oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor(GO:0016623) |
0.1 | 0.7 | GO:0001784 | phosphotyrosine binding(GO:0001784) |
0.1 | 1.1 | GO:0030274 | LIM domain binding(GO:0030274) |
0.1 | 0.3 | GO:0061505 | DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505) |
0.1 | 0.8 | GO:0019826 | oxygen sensor activity(GO:0019826) |
0.1 | 1.3 | GO:0000175 | 3'-5'-exoribonuclease activity(GO:0000175) |
0.1 | 0.6 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
0.1 | 1.3 | GO:0005104 | fibroblast growth factor receptor binding(GO:0005104) |
0.1 | 0.4 | GO:0000978 | RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159) |
0.1 | 0.5 | GO:0004875 | complement receptor activity(GO:0004875) |
0.1 | 4.4 | GO:0003823 | antigen binding(GO:0003823) |
0.1 | 0.4 | GO:0004971 | AMPA glutamate receptor activity(GO:0004971) |
0.1 | 3.4 | GO:0036459 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005) |
0.1 | 0.4 | GO:0046912 | transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912) |
0.1 | 0.6 | GO:0070053 | thrombospondin receptor activity(GO:0070053) |
0.1 | 0.7 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
0.1 | 3.1 | GO:0030145 | manganese ion binding(GO:0030145) |
0.1 | 0.3 | GO:0003873 | 6-phosphofructo-2-kinase activity(GO:0003873) |
0.0 | 1.4 | GO:0005528 | macrolide binding(GO:0005527) FK506 binding(GO:0005528) |
0.0 | 0.3 | GO:0044323 | retinoic acid-responsive element binding(GO:0044323) |
0.0 | 1.6 | GO:0015026 | coreceptor activity(GO:0015026) |
0.0 | 3.5 | GO:0016779 | nucleotidyltransferase activity(GO:0016779) |
0.0 | 0.1 | GO:0004594 | pantothenate kinase activity(GO:0004594) |
0.0 | 0.6 | GO:0005522 | profilin binding(GO:0005522) |
0.0 | 0.3 | GO:0031078 | histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) histone deacetylase activity (H4-K16 specific)(GO:0034739) NAD-dependent histone deacetylase activity (H4-K16 specific)(GO:0046970) |
0.0 | 1.1 | GO:0004890 | GABA-A receptor activity(GO:0004890) |
0.0 | 0.1 | GO:0051731 | polynucleotide 5'-hydroxyl-kinase activity(GO:0051731) |
0.0 | 67.8 | GO:0003677 | DNA binding(GO:0003677) |
0.0 | 0.4 | GO:0005123 | death receptor binding(GO:0005123) |
0.0 | 0.4 | GO:0043499 | obsolete eukaryotic cell surface binding(GO:0043499) |
0.0 | 0.3 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
0.0 | 0.8 | GO:0010843 | obsolete promoter binding(GO:0010843) |
0.0 | 0.4 | GO:0008656 | cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656) |
0.0 | 0.2 | GO:0051059 | NF-kappaB binding(GO:0051059) |
0.0 | 0.5 | GO:0019209 | kinase activator activity(GO:0019209) |
0.0 | 0.3 | GO:0005523 | tropomyosin binding(GO:0005523) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.7 | 27.9 | SA_B_CELL_RECEPTOR_COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
0.0 | 1.1 | ST_GA12_PATHWAY | G alpha 12 Pathway |
0.0 | 0.9 | ST_GA13_PATHWAY | G alpha 13 Pathway |
0.0 | 0.4 | SA_PROGRAMMED_CELL_DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
0.0 | 0.8 | SIG_BCR_SIGNALING_PATHWAY | Members of the BCR signaling pathway |