Motif ID: POU3F3_POU3F4
Z-value: 1.790
Transcription factors associated with POU3F3_POU3F4:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
POU3F3 | ENSG00000198914.2 | POU3F3 |
POU3F4 | ENSG00000196767.4 | POU3F4 |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.9 | 5.6 | GO:0007499 | ectoderm and mesoderm interaction(GO:0007499) |
0.6 | 6.1 | GO:0019800 | peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800) |
0.5 | 1.4 | GO:0051451 | myoblast migration(GO:0051451) |
0.5 | 4.7 | GO:0097435 | extracellular fibril organization(GO:0043206) fibril organization(GO:0097435) |
0.4 | 1.7 | GO:0043128 | regulation of 1-phosphatidylinositol 4-kinase activity(GO:0043126) positive regulation of 1-phosphatidylinositol 4-kinase activity(GO:0043128) |
0.4 | 2.5 | GO:0016255 | attachment of GPI anchor to protein(GO:0016255) |
0.3 | 1.7 | GO:0033148 | positive regulation of intracellular estrogen receptor signaling pathway(GO:0033148) |
0.2 | 0.2 | GO:0014029 | neural crest formation(GO:0014029) neural crest cell fate commitment(GO:0014034) |
0.2 | 0.8 | GO:0034337 | RNA folding(GO:0034337) DNA hypomethylation(GO:0044028) hypomethylation of CpG island(GO:0044029) regulation of DNA methylation(GO:0044030) |
0.2 | 2.8 | GO:0009312 | oligosaccharide biosynthetic process(GO:0009312) |
0.2 | 0.9 | GO:2000124 | cannabinoid signaling pathway(GO:0038171) endocannabinoid signaling pathway(GO:0071926) regulation of endocannabinoid signaling pathway(GO:2000124) |
0.2 | 0.6 | GO:0031223 | auditory behavior(GO:0031223) malate-aspartate shuttle(GO:0043490) |
0.1 | 0.9 | GO:0072205 | collecting duct development(GO:0072044) metanephric tubule development(GO:0072170) metanephric collecting duct development(GO:0072205) metanephric epithelium development(GO:0072207) metanephric nephron tubule development(GO:0072234) metanephric nephron epithelium development(GO:0072243) |
0.1 | 3.1 | GO:0006825 | copper ion transport(GO:0006825) |
0.1 | 0.4 | GO:0048549 | positive regulation of pinocytosis(GO:0048549) |
0.1 | 0.7 | GO:0070050 | neuron cellular homeostasis(GO:0070050) |
0.1 | 3.2 | GO:0030199 | collagen fibril organization(GO:0030199) |
0.1 | 1.4 | GO:0035590 | purinergic nucleotide receptor signaling pathway(GO:0035590) |
0.1 | 0.7 | GO:0090005 | negative regulation of establishment of protein localization to plasma membrane(GO:0090005) negative regulation of protein localization to plasma membrane(GO:1903077) negative regulation of protein localization to cell periphery(GO:1904376) |
0.1 | 2.0 | GO:0034605 | cellular response to heat(GO:0034605) |
0.1 | 0.3 | GO:0070171 | negative regulation of tooth mineralization(GO:0070171) |
0.1 | 0.8 | GO:0071692 | sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116) |
0.1 | 1.5 | GO:0031293 | membrane protein intracellular domain proteolysis(GO:0031293) |
0.1 | 1.8 | GO:0030511 | positive regulation of transforming growth factor beta receptor signaling pathway(GO:0030511) positive regulation of cellular response to transforming growth factor beta stimulus(GO:1903846) |
0.1 | 0.3 | GO:0006848 | pyruvate transport(GO:0006848) |
0.1 | 0.2 | GO:0044314 | protein K27-linked ubiquitination(GO:0044314) |
0.1 | 0.2 | GO:0002890 | negative regulation of B cell mediated immunity(GO:0002713) negative regulation of immunoglobulin mediated immune response(GO:0002890) |
0.1 | 0.4 | GO:2000172 | regulation of branching morphogenesis of a nerve(GO:2000172) |
0.1 | 1.3 | GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146) |
0.1 | 0.3 | GO:0051563 | smooth endoplasmic reticulum calcium ion homeostasis(GO:0051563) |
0.1 | 5.5 | GO:0007229 | integrin-mediated signaling pathway(GO:0007229) |
0.1 | 0.2 | GO:0001780 | neutrophil homeostasis(GO:0001780) |
0.1 | 1.2 | GO:0031529 | ruffle organization(GO:0031529) |
0.1 | 0.2 | GO:0000394 | RNA splicing, via endonucleolytic cleavage and ligation(GO:0000394) tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388) |
0.0 | 0.4 | GO:0034638 | phosphatidylcholine catabolic process(GO:0034638) |
0.0 | 0.3 | GO:0001514 | selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451) |
0.0 | 0.5 | GO:0006600 | creatine metabolic process(GO:0006600) |
0.0 | 0.4 | GO:0000460 | maturation of 5.8S rRNA(GO:0000460) |
0.0 | 0.3 | GO:0046487 | glyoxylate metabolic process(GO:0046487) |
0.0 | 0.4 | GO:0046835 | carbohydrate phosphorylation(GO:0046835) |
0.0 | 0.4 | GO:0010658 | striated muscle cell apoptotic process(GO:0010658) cardiac muscle cell apoptotic process(GO:0010659) regulation of striated muscle cell apoptotic process(GO:0010662) negative regulation of striated muscle cell apoptotic process(GO:0010664) regulation of cardiac muscle cell apoptotic process(GO:0010665) negative regulation of cardiac muscle cell apoptotic process(GO:0010667) |
0.0 | 0.2 | GO:0045356 | positive regulation of interferon-alpha biosynthetic process(GO:0045356) |
0.0 | 0.7 | GO:0060765 | regulation of androgen receptor signaling pathway(GO:0060765) |
0.0 | 0.2 | GO:0044245 | polysaccharide digestion(GO:0044245) |
0.0 | 0.6 | GO:0006700 | C21-steroid hormone biosynthetic process(GO:0006700) |
0.0 | 0.2 | GO:0043116 | negative regulation of vascular permeability(GO:0043116) |
0.0 | 2.5 | GO:0019722 | calcium-mediated signaling(GO:0019722) |
0.0 | 0.2 | GO:0060100 | regulation of phagocytosis, engulfment(GO:0060099) positive regulation of phagocytosis, engulfment(GO:0060100) regulation of membrane invagination(GO:1905153) positive regulation of membrane invagination(GO:1905155) |
0.0 | 0.2 | GO:0051482 | positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482) |
0.0 | 1.0 | GO:0051693 | actin filament capping(GO:0051693) |
0.0 | 0.1 | GO:0032509 | endosome transport via multivesicular body sorting pathway(GO:0032509) plasma membrane to endosome transport(GO:0048227) negative regulation of lipoprotein lipase activity(GO:0051005) |
0.0 | 2.9 | GO:0006367 | transcription initiation from RNA polymerase II promoter(GO:0006367) |
0.0 | 3.3 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
0.0 | 0.7 | GO:0030866 | cortical actin cytoskeleton organization(GO:0030866) |
0.0 | 0.1 | GO:0034063 | stress granule assembly(GO:0034063) |
0.0 | 0.1 | GO:0070857 | regulation of bile acid biosynthetic process(GO:0070857) regulation of bile acid metabolic process(GO:1904251) |
0.0 | 0.2 | GO:0007635 | chemosensory behavior(GO:0007635) |
0.0 | 0.1 | GO:0002092 | positive regulation of receptor internalization(GO:0002092) |
0.0 | 0.0 | GO:0009162 | deoxyribonucleoside monophosphate metabolic process(GO:0009162) pyrimidine deoxyribonucleoside monophosphate metabolic process(GO:0009176) dUMP metabolic process(GO:0046078) |
0.0 | 0.5 | GO:0051353 | positive regulation of oxidoreductase activity(GO:0051353) |
0.0 | 0.0 | GO:0002887 | negative regulation of myeloid leukocyte mediated immunity(GO:0002887) negative regulation of leukocyte degranulation(GO:0043301) |
0.0 | 1.2 | GO:0030049 | muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275) actin-mediated cell contraction(GO:0070252) |
0.0 | 0.1 | GO:0032472 | cellular manganese ion homeostasis(GO:0030026) Golgi calcium ion homeostasis(GO:0032468) Golgi calcium ion transport(GO:0032472) manganese ion homeostasis(GO:0055071) |
0.0 | 0.3 | GO:0042036 | negative regulation of cytokine biosynthetic process(GO:0042036) |
0.0 | 0.2 | GO:0043508 | negative regulation of JUN kinase activity(GO:0043508) |
0.0 | 0.1 | GO:0015985 | energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.7 | 7.9 | GO:0098643 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
0.4 | 6.1 | GO:0098647 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
0.1 | 3.0 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
0.1 | 3.6 | GO:0098636 | integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636) |
0.1 | 1.5 | GO:0032982 | myosin filament(GO:0032982) |
0.1 | 0.8 | GO:0030897 | HOPS complex(GO:0030897) |
0.1 | 1.0 | GO:0008290 | F-actin capping protein complex(GO:0008290) |
0.1 | 0.2 | GO:0000214 | tRNA-intron endonuclease complex(GO:0000214) |
0.0 | 0.8 | GO:0042581 | specific granule(GO:0042581) |
0.0 | 0.3 | GO:0051233 | spindle midzone(GO:0051233) |
0.0 | 0.4 | GO:0031143 | pseudopodium(GO:0031143) |
0.0 | 0.6 | GO:0043205 | fibril(GO:0043205) |
0.0 | 2.9 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
0.0 | 0.5 | GO:0001772 | immunological synapse(GO:0001772) |
0.0 | 1.3 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
0.0 | 0.3 | GO:0000808 | origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664) |
0.0 | 0.1 | GO:0030061 | mitochondrial crista(GO:0030061) |
0.0 | 0.8 | GO:0005884 | actin filament(GO:0005884) |
0.0 | 0.2 | GO:0005797 | Golgi medial cisterna(GO:0005797) |
0.0 | 1.0 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
0.0 | 0.2 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
0.0 | 0.2 | GO:0008091 | spectrin(GO:0008091) |
0.0 | 0.1 | GO:0000276 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) |
0.0 | 0.1 | GO:0045179 | apical cortex(GO:0045179) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.8 | 2.5 | GO:0030377 | urokinase plasminogen activator receptor activity(GO:0030377) |
0.4 | 4.7 | GO:0048407 | platelet-derived growth factor binding(GO:0048407) |
0.3 | 2.8 | GO:0008499 | UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity(GO:0008499) |
0.2 | 3.1 | GO:0001011 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, RNA polymerase II basal transcription factor binding(GO:0001083) transcription factor activity, TFIIB-class binding(GO:0001087) RNA polymerase II basal transcription factor binding(GO:0001091) TFIIB-class transcription factor binding(GO:0001093) |
0.2 | 2.0 | GO:0070053 | thrombospondin receptor activity(GO:0070053) |
0.2 | 2.6 | GO:0030346 | protein phosphatase 2B binding(GO:0030346) |
0.2 | 9.2 | GO:0005518 | collagen binding(GO:0005518) |
0.1 | 0.9 | GO:0005499 | vitamin D binding(GO:0005499) |
0.1 | 0.4 | GO:0047391 | alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391) |
0.1 | 1.4 | GO:0035381 | extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381) |
0.1 | 1.8 | GO:0004861 | cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861) |
0.1 | 0.4 | GO:0051731 | polynucleotide 5'-hydroxyl-kinase activity(GO:0051731) |
0.1 | 0.3 | GO:0050833 | pyruvate secondary active transmembrane transporter activity(GO:0005477) pyruvate transmembrane transporter activity(GO:0050833) |
0.1 | 0.9 | GO:0047372 | acylglycerol lipase activity(GO:0047372) |
0.1 | 0.2 | GO:0000213 | tRNA-intron endonuclease activity(GO:0000213) |
0.1 | 0.2 | GO:0033858 | N-acetylgalactosamine kinase activity(GO:0033858) |
0.1 | 1.5 | GO:0000146 | microfilament motor activity(GO:0000146) |
0.1 | 1.1 | GO:0003785 | actin monomer binding(GO:0003785) |
0.1 | 0.6 | GO:0005314 | high-affinity glutamate transmembrane transporter activity(GO:0005314) glutamate binding(GO:0016595) |
0.1 | 0.2 | GO:0061133 | endopeptidase activator activity(GO:0061133) |
0.1 | 0.8 | GO:0016566 | obsolete specific transcriptional repressor activity(GO:0016566) |
0.0 | 3.1 | GO:0005507 | copper ion binding(GO:0005507) |
0.0 | 0.3 | GO:0030280 | structural constituent of epidermis(GO:0030280) |
0.0 | 0.3 | GO:0004800 | thyroxine 5'-deiodinase activity(GO:0004800) |
0.0 | 0.1 | GO:0008386 | cholesterol monooxygenase (side-chain-cleaving) activity(GO:0008386) |
0.0 | 0.2 | GO:0017040 | ceramidase activity(GO:0017040) |
0.0 | 0.4 | GO:0030297 | transmembrane receptor protein tyrosine kinase activator activity(GO:0030297) |
0.0 | 0.5 | GO:0008641 | small protein activating enzyme activity(GO:0008641) |
0.0 | 0.6 | GO:0005522 | profilin binding(GO:0005522) |
0.0 | 0.2 | GO:0031404 | chloride ion binding(GO:0031404) |
0.0 | 0.5 | GO:0017127 | cholesterol transporter activity(GO:0017127) |
0.0 | 0.9 | GO:0005001 | transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) |
0.0 | 0.2 | GO:0042731 | PH domain binding(GO:0042731) |
0.0 | 0.2 | GO:0000293 | ferric-chelate reductase activity(GO:0000293) |
0.0 | 0.6 | GO:0008430 | selenium binding(GO:0008430) |
0.0 | 0.3 | GO:0033130 | acetylcholine receptor binding(GO:0033130) |
0.0 | 0.2 | GO:0008379 | thioredoxin peroxidase activity(GO:0008379) |
0.0 | 0.8 | GO:0005024 | transforming growth factor beta-activated receptor activity(GO:0005024) |
0.0 | 0.3 | GO:0010181 | FMN binding(GO:0010181) |
0.0 | 0.1 | GO:0005148 | prolactin receptor binding(GO:0005148) |
0.0 | 0.1 | GO:0048406 | nerve growth factor binding(GO:0048406) |
0.0 | 0.1 | GO:0008574 | ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) ATP-dependent microtubule motor activity(GO:1990939) |
0.0 | 0.9 | GO:0050681 | androgen receptor binding(GO:0050681) |
0.0 | 0.2 | GO:0046625 | sphingolipid binding(GO:0046625) |
0.0 | 0.5 | GO:0004385 | guanylate kinase activity(GO:0004385) |
0.0 | 1.6 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
0.0 | 0.1 | GO:0015410 | manganese-transporting ATPase activity(GO:0015410) |
0.0 | 0.1 | GO:0005324 | long-chain fatty acid transporter activity(GO:0005324) |
0.0 | 0.2 | GO:0016922 | ligand-dependent nuclear receptor binding(GO:0016922) |
0.0 | 0.5 | GO:0016769 | transferase activity, transferring nitrogenous groups(GO:0016769) |
0.0 | 0.2 | GO:0004437 | obsolete inositol or phosphatidylinositol phosphatase activity(GO:0004437) |
0.0 | 0.0 | GO:0048020 | CCR chemokine receptor binding(GO:0048020) |
0.0 | 0.1 | GO:0005041 | low-density lipoprotein receptor activity(GO:0005041) |
0.0 | 0.1 | GO:0008140 | cAMP response element binding protein binding(GO:0008140) |
0.0 | 0.3 | GO:0005523 | tropomyosin binding(GO:0005523) |
0.0 | 0.5 | GO:0030145 | manganese ion binding(GO:0030145) |
0.0 | 2.7 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 5.1 | SIG_BCR_SIGNALING_PATHWAY | Members of the BCR signaling pathway |
0.0 | 1.5 | SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES | Genes related to regulation of the actin cytoskeleton |
0.0 | 0.2 | ST_PAC1_RECEPTOR_PATHWAY | PAC1 Receptor Pathway |