Motif ID: POU5F1_POU2F3
Z-value: 2.579
Transcription factors associated with POU5F1_POU2F3:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| POU2F3 | ENSG00000137709.5 | POU2F3 |
| POU5F1 | ENSG00000204531.11 | POU5F1 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.6 | 10.9 | GO:0035408 | histone H3-T6 phosphorylation(GO:0035408) |
| 2.0 | 6.1 | GO:0070445 | Fc receptor mediated stimulatory signaling pathway(GO:0002431) regulation of Fc receptor mediated stimulatory signaling pathway(GO:0060368) positive regulation of Fc receptor mediated stimulatory signaling pathway(GO:0060369) oligodendrocyte progenitor proliferation(GO:0070444) regulation of oligodendrocyte progenitor proliferation(GO:0070445) positive regulation of oligodendrocyte progenitor proliferation(GO:0070447) |
| 1.0 | 7.7 | GO:0000185 | activation of MAPKKK activity(GO:0000185) |
| 0.8 | 4.6 | GO:0002313 | mature B cell differentiation involved in immune response(GO:0002313) |
| 0.8 | 4.5 | GO:0009441 | glycolate metabolic process(GO:0009441) |
| 0.7 | 2.0 | GO:0007412 | axon target recognition(GO:0007412) |
| 0.6 | 1.7 | GO:0070527 | platelet aggregation(GO:0070527) |
| 0.5 | 1.6 | GO:0070340 | detection of bacterial lipoprotein(GO:0042494) detection of triacyl bacterial lipopeptide(GO:0042495) detection of bacterial lipopeptide(GO:0070340) response to triacyl bacterial lipopeptide(GO:0071725) cellular response to triacyl bacterial lipopeptide(GO:0071727) |
| 0.5 | 3.6 | GO:0042989 | sequestering of actin monomers(GO:0042989) |
| 0.5 | 2.0 | GO:0035283 | rhombomere 3 development(GO:0021569) rhombomere 5 development(GO:0021571) cranial nerve structural organization(GO:0021604) facial nerve morphogenesis(GO:0021610) facial nerve structural organization(GO:0021612) central nervous system segmentation(GO:0035283) brain segmentation(GO:0035284) |
| 0.4 | 1.3 | GO:0001552 | ovarian follicle atresia(GO:0001552) |
| 0.4 | 4.3 | GO:0019800 | peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800) |
| 0.3 | 2.1 | GO:0006880 | intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577) |
| 0.3 | 1.0 | GO:0019242 | methylglyoxal biosynthetic process(GO:0019242) |
| 0.3 | 1.7 | GO:0010508 | positive regulation of autophagy(GO:0010508) |
| 0.3 | 1.0 | GO:2000121 | regulation of removal of superoxide radicals(GO:2000121) |
| 0.3 | 7.8 | GO:0002504 | antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002504) |
| 0.3 | 1.9 | GO:2000124 | cannabinoid signaling pathway(GO:0038171) endocannabinoid signaling pathway(GO:0071926) regulation of endocannabinoid signaling pathway(GO:2000124) |
| 0.3 | 0.9 | GO:0016554 | cytidine to uridine editing(GO:0016554) |
| 0.3 | 0.9 | GO:0046080 | dUTP metabolic process(GO:0046080) |
| 0.3 | 1.3 | GO:0007221 | positive regulation of transcription of Notch receptor target(GO:0007221) |
| 0.3 | 0.5 | GO:0045603 | positive regulation of endothelial cell differentiation(GO:0045603) |
| 0.3 | 2.8 | GO:0006975 | DNA damage induced protein phosphorylation(GO:0006975) |
| 0.2 | 4.5 | GO:0006906 | vesicle fusion(GO:0006906) |
| 0.2 | 0.8 | GO:0070842 | aggresome assembly(GO:0070842) |
| 0.2 | 0.6 | GO:0031118 | rRNA pseudouridine synthesis(GO:0031118) |
| 0.2 | 0.7 | GO:0021631 | optic nerve morphogenesis(GO:0021631) |
| 0.2 | 0.9 | GO:0043402 | glucocorticoid mediated signaling pathway(GO:0043402) |
| 0.2 | 3.1 | GO:0016601 | Rac protein signal transduction(GO:0016601) |
| 0.2 | 1.0 | GO:0006772 | thiamine metabolic process(GO:0006772) |
| 0.2 | 1.4 | GO:0051973 | positive regulation of telomerase activity(GO:0051973) |
| 0.2 | 0.8 | GO:0051852 | disruption by host of symbiont cells(GO:0051852) killing by host of symbiont cells(GO:0051873) |
| 0.2 | 0.5 | GO:0002887 | negative regulation of myeloid leukocyte mediated immunity(GO:0002887) negative regulation of leukocyte degranulation(GO:0043301) |
| 0.2 | 1.4 | GO:0045898 | regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898) |
| 0.1 | 10.5 | GO:0030183 | B cell differentiation(GO:0030183) |
| 0.1 | 1.4 | GO:0009404 | toxin metabolic process(GO:0009404) |
| 0.1 | 0.8 | GO:0032472 | cellular manganese ion homeostasis(GO:0030026) Golgi calcium ion homeostasis(GO:0032468) Golgi calcium ion transport(GO:0032472) manganese ion homeostasis(GO:0055071) |
| 0.1 | 0.7 | GO:0060292 | phosphorylated carbohydrate dephosphorylation(GO:0046838) inositol phosphate dephosphorylation(GO:0046855) long term synaptic depression(GO:0060292) |
| 0.1 | 0.6 | GO:0035455 | response to interferon-alpha(GO:0035455) |
| 0.1 | 0.5 | GO:0019805 | quinolinate biosynthetic process(GO:0019805) |
| 0.1 | 0.8 | GO:0045059 | positive thymic T cell selection(GO:0045059) |
| 0.1 | 0.6 | GO:0070935 | 3'-UTR-mediated mRNA stabilization(GO:0070935) |
| 0.1 | 0.5 | GO:0032933 | response to sterol depletion(GO:0006991) SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501) |
| 0.1 | 13.1 | GO:0065004 | protein-DNA complex assembly(GO:0065004) |
| 0.1 | 0.3 | GO:0046292 | formaldehyde metabolic process(GO:0046292) |
| 0.1 | 0.4 | GO:0032506 | cytokinetic process(GO:0032506) |
| 0.1 | 0.2 | GO:0090047 | obsolete positive regulation of transcription regulator activity(GO:0090047) |
| 0.1 | 0.8 | GO:0030903 | notochord development(GO:0030903) |
| 0.1 | 0.3 | GO:0019046 | release from viral latency(GO:0019046) |
| 0.1 | 0.7 | GO:0045084 | positive regulation of interleukin-12 biosynthetic process(GO:0045084) |
| 0.1 | 1.7 | GO:0000303 | response to superoxide(GO:0000303) |
| 0.1 | 0.2 | GO:0042501 | serine phosphorylation of STAT protein(GO:0042501) |
| 0.1 | 0.2 | GO:0042320 | regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) |
| 0.1 | 0.3 | GO:0043116 | negative regulation of vascular permeability(GO:0043116) |
| 0.1 | 0.2 | GO:0009162 | deoxyribonucleoside monophosphate metabolic process(GO:0009162) pyrimidine deoxyribonucleoside monophosphate metabolic process(GO:0009176) transformation of host cell by virus(GO:0019087) dUMP metabolic process(GO:0046078) intestinal epithelial cell maturation(GO:0060574) intestinal epithelial cell development(GO:0060576) |
| 0.1 | 0.5 | GO:0044245 | polysaccharide digestion(GO:0044245) |
| 0.1 | 0.2 | GO:0048861 | leukemia inhibitory factor signaling pathway(GO:0048861) |
| 0.1 | 0.8 | GO:0097435 | extracellular fibril organization(GO:0043206) fibril organization(GO:0097435) |
| 0.1 | 0.3 | GO:0006391 | transcription initiation from mitochondrial promoter(GO:0006391) |
| 0.1 | 0.3 | GO:0034587 | piRNA metabolic process(GO:0034587) |
| 0.1 | 1.0 | GO:0050858 | negative regulation of antigen receptor-mediated signaling pathway(GO:0050858) negative regulation of T cell receptor signaling pathway(GO:0050860) |
| 0.1 | 0.6 | GO:0035162 | embryonic hemopoiesis(GO:0035162) |
| 0.1 | 0.4 | GO:0048388 | endosomal lumen acidification(GO:0048388) |
| 0.1 | 6.8 | GO:0071357 | response to type I interferon(GO:0034340) type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357) |
| 0.1 | 0.6 | GO:0097061 | dendritic spine morphogenesis(GO:0060997) regulation of dendritic spine morphogenesis(GO:0061001) dendritic spine organization(GO:0097061) |
| 0.1 | 0.2 | GO:0002125 | maternal aggressive behavior(GO:0002125) obsolete negative regulation of diuresis(GO:0003077) positive regulation of norepinephrine secretion(GO:0010701) |
| 0.1 | 0.2 | GO:0014049 | positive regulation of glutamate secretion(GO:0014049) |
| 0.1 | 0.2 | GO:0034310 | primary alcohol catabolic process(GO:0034310) |
| 0.1 | 0.3 | GO:0007100 | mitotic centrosome separation(GO:0007100) |
| 0.1 | 0.7 | GO:0051497 | negative regulation of stress fiber assembly(GO:0051497) |
| 0.1 | 0.1 | GO:0090009 | primitive streak formation(GO:0090009) |
| 0.1 | 0.8 | GO:0060828 | regulation of canonical Wnt signaling pathway(GO:0060828) |
| 0.1 | 0.8 | GO:0019228 | neuronal action potential(GO:0019228) |
| 0.1 | 0.8 | GO:0032876 | regulation of DNA endoreduplication(GO:0032875) negative regulation of DNA endoreduplication(GO:0032876) DNA endoreduplication(GO:0042023) |
| 0.1 | 0.8 | GO:0010042 | response to manganese ion(GO:0010042) |
| 0.1 | 0.4 | GO:0044413 | evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834) |
| 0.1 | 0.3 | GO:0043615 | astrocyte cell migration(GO:0043615) |
| 0.1 | 0.2 | GO:0071168 | protein localization to chromatin(GO:0071168) |
| 0.1 | 0.5 | GO:0045824 | negative regulation of innate immune response(GO:0045824) |
| 0.1 | 0.2 | GO:0048295 | positive regulation of isotype switching to IgE isotypes(GO:0048295) |
| 0.0 | 0.0 | GO:0048852 | diencephalon morphogenesis(GO:0048852) |
| 0.0 | 0.1 | GO:0002384 | hepatic immune response(GO:0002384) positive regulation of transmission of nerve impulse(GO:0051971) |
| 0.0 | 0.4 | GO:0045671 | negative regulation of osteoclast differentiation(GO:0045671) |
| 0.0 | 0.5 | GO:0048873 | homeostasis of number of cells within a tissue(GO:0048873) |
| 0.0 | 0.4 | GO:0070327 | thyroid hormone transport(GO:0070327) |
| 0.0 | 3.7 | GO:0007229 | integrin-mediated signaling pathway(GO:0007229) |
| 0.0 | 0.2 | GO:0060049 | short-term memory(GO:0007614) regulation of protein ADP-ribosylation(GO:0010835) nitric oxide homeostasis(GO:0033484) regulation of protein glycosylation(GO:0060049) |
| 0.0 | 0.3 | GO:0001867 | complement activation, lectin pathway(GO:0001867) |
| 0.0 | 0.6 | GO:0006986 | response to unfolded protein(GO:0006986) response to topologically incorrect protein(GO:0035966) |
| 0.0 | 0.2 | GO:0021520 | spinal cord motor neuron cell fate specification(GO:0021520) |
| 0.0 | 0.4 | GO:0030097 | hemopoiesis(GO:0030097) |
| 0.0 | 0.2 | GO:0060750 | epithelial cell proliferation involved in mammary gland duct elongation(GO:0060750) branch elongation involved in mammary gland duct branching(GO:0060751) |
| 0.0 | 0.6 | GO:1901661 | quinone metabolic process(GO:1901661) |
| 0.0 | 0.4 | GO:0090292 | nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292) |
| 0.0 | 0.7 | GO:0007158 | neuron cell-cell adhesion(GO:0007158) |
| 0.0 | 0.5 | GO:0015939 | pantothenate metabolic process(GO:0015939) |
| 0.0 | 0.2 | GO:0048147 | negative regulation of fibroblast proliferation(GO:0048147) |
| 0.0 | 0.1 | GO:0043619 | regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0043619) |
| 0.0 | 0.2 | GO:0045744 | negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744) |
| 0.0 | 1.1 | GO:0006309 | DNA catabolic process, endonucleolytic(GO:0000737) apoptotic DNA fragmentation(GO:0006309) |
| 0.0 | 0.1 | GO:0002328 | pro-B cell differentiation(GO:0002328) |
| 0.0 | 0.2 | GO:0051323 | metaphase(GO:0051323) |
| 0.0 | 3.7 | GO:0006959 | humoral immune response(GO:0006959) |
| 0.0 | 0.7 | GO:0000291 | nuclear-transcribed mRNA catabolic process, exonucleolytic(GO:0000291) exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928) |
| 0.0 | 0.1 | GO:0016045 | detection of bacterium(GO:0016045) |
| 0.0 | 0.1 | GO:0045716 | positive regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045716) |
| 0.0 | 0.4 | GO:0009408 | response to heat(GO:0009408) |
| 0.0 | 2.1 | GO:0051291 | protein heterooligomerization(GO:0051291) |
| 0.0 | 0.1 | GO:0032486 | Rap protein signal transduction(GO:0032486) |
| 0.0 | 0.1 | GO:0070295 | renal water absorption(GO:0070295) |
| 0.0 | 0.2 | GO:0002507 | tolerance induction(GO:0002507) |
| 0.0 | 0.2 | GO:0045040 | outer mitochondrial membrane organization(GO:0007008) protein import into mitochondrial outer membrane(GO:0045040) |
| 0.0 | 0.1 | GO:0006597 | spermine biosynthetic process(GO:0006597) |
| 0.0 | 0.2 | GO:0070059 | intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress(GO:0070059) |
| 0.0 | 0.1 | GO:0005984 | disaccharide metabolic process(GO:0005984) |
| 0.0 | 0.1 | GO:0019695 | choline metabolic process(GO:0019695) |
| 0.0 | 0.1 | GO:0006562 | proline catabolic process(GO:0006562) |
| 0.0 | 0.5 | GO:0050892 | intestinal absorption(GO:0050892) |
| 0.0 | 0.1 | GO:0001574 | ganglioside biosynthetic process(GO:0001574) |
| 0.0 | 0.3 | GO:0006111 | regulation of gluconeogenesis(GO:0006111) |
| 0.0 | 0.1 | GO:0006196 | AMP catabolic process(GO:0006196) |
| 0.0 | 0.1 | GO:0071220 | response to bacterial lipoprotein(GO:0032493) response to bacterial lipopeptide(GO:0070339) cellular response to bacterial lipoprotein(GO:0071220) cellular response to bacterial lipopeptide(GO:0071221) |
| 0.0 | 0.7 | GO:0016079 | synaptic vesicle exocytosis(GO:0016079) |
| 0.0 | 0.2 | GO:0042693 | muscle cell fate commitment(GO:0042693) |
| 0.0 | 0.1 | GO:0010898 | positive regulation of triglyceride catabolic process(GO:0010898) |
| 0.0 | 0.1 | GO:2000831 | renin-angiotensin regulation of aldosterone production(GO:0002018) regulation of blood vessel size by renin-angiotensin(GO:0002034) renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure(GO:0003072) obsolete regulation of natriuresis(GO:0003078) regulation of NAD(P)H oxidase activity(GO:0033860) positive regulation of NAD(P)H oxidase activity(GO:0033864) corticosteroid hormone secretion(GO:0035930) mineralocorticoid secretion(GO:0035931) aldosterone secretion(GO:0035932) regulation of steroid hormone secretion(GO:2000831) regulation of corticosteroid hormone secretion(GO:2000846) regulation of mineralocorticoid secretion(GO:2000855) regulation of aldosterone secretion(GO:2000858) |
| 0.0 | 0.3 | GO:0045742 | positive regulation of epidermal growth factor receptor signaling pathway(GO:0045742) positive regulation of ERBB signaling pathway(GO:1901186) |
| 0.0 | 0.1 | GO:0014850 | response to muscle activity(GO:0014850) |
| 0.0 | 1.1 | GO:0006338 | chromatin remodeling(GO:0006338) |
| 0.0 | 0.0 | GO:0010454 | negative regulation of cell fate commitment(GO:0010454) |
| 0.0 | 0.0 | GO:0006333 | chromatin assembly or disassembly(GO:0006333) |
| 0.0 | 0.0 | GO:0032416 | negative regulation of sodium:proton antiporter activity(GO:0032416) musculoskeletal movement, spinal reflex action(GO:0050883) positive regulation of dopamine receptor signaling pathway(GO:0060161) negative regulation of sodium ion transmembrane transport(GO:1902306) negative regulation of sodium ion transmembrane transporter activity(GO:2000650) |
| 0.0 | 0.0 | GO:0060180 | female courtship behavior(GO:0008050) regulation of female receptivity(GO:0045924) female mating behavior(GO:0060180) |
| 0.0 | 0.7 | GO:0007167 | enzyme linked receptor protein signaling pathway(GO:0007167) |
| 0.0 | 0.3 | GO:0006297 | nucleotide-excision repair, DNA gap filling(GO:0006297) |
| 0.0 | 0.2 | GO:0042436 | tryptophan metabolic process(GO:0006568) tryptophan catabolic process(GO:0006569) indolalkylamine metabolic process(GO:0006586) indole-containing compound catabolic process(GO:0042436) indolalkylamine catabolic process(GO:0046218) |
| 0.0 | 0.1 | GO:0031274 | pseudopodium assembly(GO:0031269) regulation of pseudopodium assembly(GO:0031272) positive regulation of pseudopodium assembly(GO:0031274) |
| 0.0 | 0.1 | GO:0060666 | dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666) |
| 0.0 | 0.8 | GO:0006369 | termination of RNA polymerase II transcription(GO:0006369) |
| 0.0 | 0.4 | GO:0000725 | double-strand break repair via homologous recombination(GO:0000724) recombinational repair(GO:0000725) |
| 0.0 | 0.2 | GO:0016578 | histone deubiquitination(GO:0016578) |
| 0.0 | 0.3 | GO:0045576 | mast cell activation(GO:0045576) |
| 0.0 | 0.3 | GO:0009083 | branched-chain amino acid catabolic process(GO:0009083) |
| 0.0 | 0.5 | GO:0001541 | ovarian follicle development(GO:0001541) |
| 0.0 | 0.2 | GO:0043252 | sodium-independent organic anion transport(GO:0043252) |
| 0.0 | 0.4 | GO:0006937 | regulation of muscle contraction(GO:0006937) |
| 0.0 | 0.1 | GO:0021903 | rostrocaudal neural tube patterning(GO:0021903) midbrain-hindbrain boundary development(GO:0030917) |
| 0.0 | 0.2 | GO:0030838 | positive regulation of actin filament polymerization(GO:0030838) |
| 0.0 | 0.6 | GO:0008016 | regulation of heart contraction(GO:0008016) |
| 0.0 | 0.1 | GO:0014003 | oligodendrocyte development(GO:0014003) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 1.6 | GO:0035354 | Toll-like receptor 1-Toll-like receptor 2 protein complex(GO:0035354) |
| 0.5 | 6.1 | GO:0030061 | mitochondrial crista(GO:0030061) |
| 0.4 | 3.6 | GO:0016942 | insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454) |
| 0.4 | 7.8 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.3 | 1.0 | GO:0071953 | elastic fiber(GO:0071953) |
| 0.3 | 4.3 | GO:0098647 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 0.3 | 0.8 | GO:0000308 | cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308) |
| 0.2 | 0.7 | GO:0035327 | transcriptionally active chromatin(GO:0035327) |
| 0.1 | 0.3 | GO:0002102 | podosome(GO:0002102) |
| 0.1 | 0.3 | GO:0032009 | early phagosome(GO:0032009) |
| 0.1 | 0.3 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.1 | 0.5 | GO:0045179 | apical cortex(GO:0045179) |
| 0.1 | 2.1 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
| 0.1 | 0.3 | GO:0071546 | pi-body(GO:0071546) |
| 0.1 | 1.0 | GO:0071778 | obsolete WINAC complex(GO:0071778) |
| 0.1 | 0.8 | GO:1903561 | extracellular exosome(GO:0070062) extracellular vesicle(GO:1903561) |
| 0.1 | 1.0 | GO:0030130 | clathrin coat of trans-Golgi network vesicle(GO:0030130) |
| 0.1 | 0.3 | GO:0005947 | mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947) |
| 0.1 | 0.2 | GO:0016533 | cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533) |
| 0.1 | 2.9 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
| 0.1 | 2.6 | GO:0000786 | nucleosome(GO:0000786) |
| 0.0 | 0.7 | GO:0031088 | platelet dense granule membrane(GO:0031088) |
| 0.0 | 0.8 | GO:0016235 | aggresome(GO:0016235) |
| 0.0 | 0.7 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.0 | 0.2 | GO:0000778 | condensed nuclear chromosome kinetochore(GO:0000778) condensed nuclear chromosome outer kinetochore(GO:0000942) |
| 0.0 | 0.1 | GO:0036477 | somatodendritic compartment(GO:0036477) |
| 0.0 | 0.5 | GO:0098643 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
| 0.0 | 0.6 | GO:0016585 | obsolete chromatin remodeling complex(GO:0016585) |
| 0.0 | 0.3 | GO:0005663 | DNA replication factor C complex(GO:0005663) |
| 0.0 | 0.2 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.0 | 0.4 | GO:0034993 | microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993) |
| 0.0 | 0.1 | GO:0005896 | interleukin-6 receptor complex(GO:0005896) |
| 0.0 | 0.6 | GO:0005732 | small nucleolar ribonucleoprotein complex(GO:0005732) |
| 0.0 | 2.5 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.0 | 0.5 | GO:0044224 | juxtaparanode region of axon(GO:0044224) |
| 0.0 | 1.9 | GO:0005884 | actin filament(GO:0005884) |
| 0.0 | 0.3 | GO:0030897 | HOPS complex(GO:0030897) |
| 0.0 | 0.1 | GO:0060201 | clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201) |
| 0.0 | 0.5 | GO:0030867 | rough endoplasmic reticulum membrane(GO:0030867) |
| 0.0 | 0.4 | GO:0000808 | origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664) |
| 0.0 | 0.8 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.0 | 0.2 | GO:0000125 | PCAF complex(GO:0000125) |
| 0.0 | 0.1 | GO:0017071 | intracellular cyclic nucleotide activated cation channel complex(GO:0017071) |
| 0.0 | 0.2 | GO:0016272 | prefoldin complex(GO:0016272) |
| 0.0 | 0.9 | GO:0030530 | obsolete heterogeneous nuclear ribonucleoprotein complex(GO:0030530) |
| 0.0 | 0.4 | GO:0045335 | phagocytic vesicle(GO:0045335) |
| 0.0 | 0.1 | GO:0032585 | multivesicular body membrane(GO:0032585) |
| 0.0 | 0.4 | GO:0005859 | muscle myosin complex(GO:0005859) |
| 0.0 | 1.1 | GO:0030175 | filopodium(GO:0030175) |
| 0.0 | 0.2 | GO:0098799 | outer mitochondrial membrane protein complex(GO:0098799) |
| 0.0 | 2.5 | GO:0005770 | late endosome(GO:0005770) |
| 0.0 | 0.4 | GO:0032982 | myosin filament(GO:0032982) |
| 0.0 | 0.9 | GO:0005782 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.0 | 0.1 | GO:0060205 | cytoplasmic membrane-bounded vesicle lumen(GO:0060205) |
| 0.0 | 0.2 | GO:0005885 | Arp2/3 protein complex(GO:0005885) |
| 0.0 | 0.3 | GO:0071203 | WASH complex(GO:0071203) |
| 0.0 | 0.5 | GO:0016592 | mediator complex(GO:0016592) |
| 0.0 | 0.1 | GO:0005641 | nuclear envelope lumen(GO:0005641) |
| 0.0 | 1.4 | GO:0005765 | lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852) |
| 0.0 | 0.6 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
| 0.0 | 3.4 | GO:0098857 | membrane raft(GO:0045121) membrane microdomain(GO:0098857) |
| 0.0 | 5.7 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.0 | 0.8 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.0 | 0.1 | GO:0042382 | paraspeckles(GO:0042382) |
| 0.0 | 0.6 | GO:0055037 | recycling endosome(GO:0055037) |
| 0.0 | 0.4 | GO:0043195 | terminal bouton(GO:0043195) |
| 0.0 | 0.9 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 0.0 | 1.0 | GO:0071013 | catalytic step 2 spliceosome(GO:0071013) |
| 0.0 | 3.9 | GO:0005792 | obsolete microsome(GO:0005792) |
| 0.0 | 0.1 | GO:0031201 | SNARE complex(GO:0031201) |
| 0.0 | 1.8 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.0 | 0.1 | GO:0030681 | nucleolar ribonuclease P complex(GO:0005655) ribonuclease P complex(GO:0030677) multimeric ribonuclease P complex(GO:0030681) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.6 | 10.9 | GO:0035403 | histone kinase activity (H3-T6 specific)(GO:0035403) |
| 2.6 | 7.9 | GO:0008349 | MAP kinase kinase kinase kinase activity(GO:0008349) |
| 1.0 | 12.3 | GO:0005068 | transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068) |
| 1.0 | 3.0 | GO:0003835 | beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835) |
| 0.8 | 10.4 | GO:0001011 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, RNA polymerase II basal transcription factor binding(GO:0001083) transcription factor activity, TFIIB-class binding(GO:0001087) RNA polymerase II basal transcription factor binding(GO:0001091) TFIIB-class transcription factor binding(GO:0001093) |
| 0.6 | 5.9 | GO:0043208 | glycosphingolipid binding(GO:0043208) |
| 0.6 | 7.8 | GO:0032395 | MHC class II receptor activity(GO:0032395) |
| 0.5 | 2.2 | GO:0016286 | small conductance calcium-activated potassium channel activity(GO:0016286) |
| 0.4 | 1.3 | GO:0000150 | recombinase activity(GO:0000150) |
| 0.4 | 2.4 | GO:0001102 | RNA polymerase II activating transcription factor binding(GO:0001102) |
| 0.4 | 2.0 | GO:0031694 | alpha-2A adrenergic receptor binding(GO:0031694) |
| 0.4 | 3.8 | GO:0070053 | thrombospondin receptor activity(GO:0070053) |
| 0.4 | 9.1 | GO:0045028 | G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028) |
| 0.3 | 1.0 | GO:0004347 | glucose-6-phosphate isomerase activity(GO:0004347) |
| 0.3 | 0.9 | GO:0004170 | dUTP diphosphatase activity(GO:0004170) |
| 0.3 | 1.3 | GO:0031957 | very long-chain fatty acid-CoA ligase activity(GO:0031957) |
| 0.2 | 0.5 | GO:0004771 | sterol esterase activity(GO:0004771) |
| 0.2 | 1.1 | GO:0016623 | oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor(GO:0016623) |
| 0.2 | 0.7 | GO:0016314 | phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314) |
| 0.2 | 0.8 | GO:0004998 | transferrin receptor activity(GO:0004998) |
| 0.2 | 0.8 | GO:0048020 | CCR chemokine receptor binding(GO:0048020) |
| 0.2 | 1.9 | GO:0043325 | phosphatidylinositol-3,4-bisphosphate binding(GO:0043325) |
| 0.2 | 0.7 | GO:0046625 | sphingolipid binding(GO:0046625) |
| 0.2 | 0.9 | GO:0004126 | cytidine deaminase activity(GO:0004126) |
| 0.2 | 0.9 | GO:0004883 | glucocorticoid receptor activity(GO:0004883) |
| 0.2 | 1.9 | GO:0047372 | acylglycerol lipase activity(GO:0047372) |
| 0.1 | 0.8 | GO:0003960 | NADPH:quinone reductase activity(GO:0003960) |
| 0.1 | 2.1 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
| 0.1 | 0.5 | GO:0032450 | maltose alpha-glucosidase activity(GO:0032450) |
| 0.1 | 0.5 | GO:0000247 | C-8 sterol isomerase activity(GO:0000247) |
| 0.1 | 0.8 | GO:0015410 | manganese-transporting ATPase activity(GO:0015410) |
| 0.1 | 0.8 | GO:0051766 | inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440) inositol trisphosphate kinase activity(GO:0051766) |
| 0.1 | 0.5 | GO:0005324 | long-chain fatty acid transporter activity(GO:0005324) |
| 0.1 | 0.4 | GO:0070064 | proline-rich region binding(GO:0070064) |
| 0.1 | 3.6 | GO:0005159 | insulin-like growth factor receptor binding(GO:0005159) |
| 0.1 | 1.0 | GO:0016778 | diphosphotransferase activity(GO:0016778) |
| 0.1 | 0.5 | GO:0016822 | hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823) |
| 0.1 | 0.3 | GO:0004618 | phosphoglycerate kinase activity(GO:0004618) |
| 0.1 | 0.5 | GO:0019956 | chemokine binding(GO:0019956) |
| 0.1 | 0.5 | GO:0017159 | pantetheine hydrolase activity(GO:0017159) |
| 0.1 | 0.6 | GO:0016167 | glial cell-derived neurotrophic factor receptor activity(GO:0016167) |
| 0.1 | 0.3 | GO:0004809 | tRNA (guanine-N2-)-methyltransferase activity(GO:0004809) |
| 0.1 | 3.2 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
| 0.1 | 1.7 | GO:0005522 | profilin binding(GO:0005522) |
| 0.1 | 4.0 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.1 | 5.3 | GO:0003823 | antigen binding(GO:0003823) |
| 0.1 | 2.2 | GO:0004708 | MAP kinase kinase activity(GO:0004708) |
| 0.1 | 0.5 | GO:0004430 | 1-phosphatidylinositol 4-kinase activity(GO:0004430) |
| 0.1 | 0.5 | GO:0017162 | aryl hydrocarbon receptor binding(GO:0017162) |
| 0.1 | 0.8 | GO:0004571 | mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571) |
| 0.1 | 0.1 | GO:0003990 | acetylcholinesterase activity(GO:0003990) |
| 0.1 | 0.1 | GO:0004024 | alcohol dehydrogenase activity, zinc-dependent(GO:0004024) |
| 0.1 | 1.1 | GO:0016888 | endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888) |
| 0.1 | 0.8 | GO:0048407 | platelet-derived growth factor binding(GO:0048407) |
| 0.1 | 0.3 | GO:0070363 | mitochondrial light strand promoter sense binding(GO:0070363) |
| 0.1 | 1.7 | GO:0005246 | calcium channel regulator activity(GO:0005246) |
| 0.1 | 0.6 | GO:0030515 | snoRNA binding(GO:0030515) |
| 0.1 | 0.2 | GO:0004833 | tryptophan 2,3-dioxygenase activity(GO:0004833) |
| 0.1 | 0.4 | GO:0031432 | titin binding(GO:0031432) |
| 0.1 | 0.3 | GO:0003689 | DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170) |
| 0.1 | 0.2 | GO:0003951 | NAD+ kinase activity(GO:0003951) |
| 0.1 | 0.3 | GO:0032454 | histone demethylase activity (H3-K9 specific)(GO:0032454) |
| 0.1 | 0.2 | GO:0004924 | oncostatin-M receptor activity(GO:0004924) ciliary neurotrophic factor receptor binding(GO:0005127) |
| 0.0 | 0.3 | GO:0015016 | [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016) |
| 0.0 | 0.2 | GO:0005176 | ErbB-2 class receptor binding(GO:0005176) tau-protein kinase activity(GO:0050321) |
| 0.0 | 0.8 | GO:0015269 | calcium-activated potassium channel activity(GO:0015269) |
| 0.0 | 1.0 | GO:0070330 | aromatase activity(GO:0070330) |
| 0.0 | 0.7 | GO:0000175 | 3'-5'-exoribonuclease activity(GO:0000175) |
| 0.0 | 0.7 | GO:0030276 | clathrin binding(GO:0030276) |
| 0.0 | 0.7 | GO:0005003 | ephrin receptor activity(GO:0005003) |
| 0.0 | 0.8 | GO:0030332 | cyclin binding(GO:0030332) |
| 0.0 | 0.4 | GO:0043015 | gamma-tubulin binding(GO:0043015) |
| 0.0 | 0.2 | GO:0030528 | obsolete transcription regulator activity(GO:0030528) |
| 0.0 | 0.1 | GO:0047057 | oxidoreductase activity, acting on the CH-OH group of donors, disulfide as acceptor(GO:0016900) vitamin-K-epoxide reductase (warfarin-sensitive) activity(GO:0047057) |
| 0.0 | 0.5 | GO:0070628 | proteasome binding(GO:0070628) |
| 0.0 | 0.3 | GO:0032266 | phosphatidylinositol-3-phosphate binding(GO:0032266) |
| 0.0 | 5.3 | GO:0016779 | nucleotidyltransferase activity(GO:0016779) |
| 0.0 | 0.5 | GO:0016493 | C-C chemokine receptor activity(GO:0016493) |
| 0.0 | 0.2 | GO:0005499 | vitamin D binding(GO:0005499) |
| 0.0 | 0.4 | GO:0008266 | poly(U) RNA binding(GO:0008266) |
| 0.0 | 0.4 | GO:0003688 | DNA replication origin binding(GO:0003688) |
| 0.0 | 0.5 | GO:0004065 | arylsulfatase activity(GO:0004065) |
| 0.0 | 0.1 | GO:0004657 | proline dehydrogenase activity(GO:0004657) |
| 0.0 | 0.1 | GO:0004132 | dCMP deaminase activity(GO:0004132) |
| 0.0 | 0.2 | GO:0008331 | high voltage-gated calcium channel activity(GO:0008331) |
| 0.0 | 0.1 | GO:0004461 | lactose synthase activity(GO:0004461) |
| 0.0 | 0.1 | GO:0005138 | interleukin-6 receptor binding(GO:0005138) |
| 0.0 | 0.3 | GO:0035251 | UDP-glucosyltransferase activity(GO:0035251) |
| 0.0 | 0.4 | GO:0005521 | lamin binding(GO:0005521) |
| 0.0 | 0.1 | GO:0070324 | thyroid hormone binding(GO:0070324) |
| 0.0 | 4.0 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.0 | 0.3 | GO:0030274 | LIM domain binding(GO:0030274) |
| 0.0 | 0.1 | GO:0001596 | angiotensin type I receptor activity(GO:0001596) |
| 0.0 | 0.4 | GO:0019992 | diacylglycerol binding(GO:0019992) |
| 0.0 | 0.2 | GO:0016802 | adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802) |
| 0.0 | 0.2 | GO:0004176 | ATP-dependent peptidase activity(GO:0004176) |
| 0.0 | 0.2 | GO:0034056 | estrogen response element binding(GO:0034056) |
| 0.0 | 0.8 | GO:0003730 | mRNA 3'-UTR binding(GO:0003730) |
| 0.0 | 0.5 | GO:0001104 | transcription factor activity, RNA polymerase II transcription factor binding(GO:0001076) RNA polymerase II transcription cofactor activity(GO:0001104) |
| 0.0 | 0.5 | GO:0030553 | cGMP binding(GO:0030553) |
| 0.0 | 0.1 | GO:0003796 | lysozyme activity(GO:0003796) |
| 0.0 | 0.6 | GO:0004129 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.0 | 0.3 | GO:0043560 | insulin receptor substrate binding(GO:0043560) |
| 0.0 | 0.9 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 0.0 | 0.1 | GO:0031996 | thioesterase binding(GO:0031996) |
| 0.0 | 0.2 | GO:0016986 | obsolete transcription initiation factor activity(GO:0016986) |
| 0.0 | 0.1 | GO:0000978 | RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159) |
| 0.0 | 0.0 | GO:0035198 | miRNA binding(GO:0035198) |
| 0.0 | 0.1 | GO:0004766 | spermidine synthase activity(GO:0004766) |
| 0.0 | 0.2 | GO:0015125 | bile acid transmembrane transporter activity(GO:0015125) |
| 0.0 | 0.4 | GO:0005247 | voltage-gated chloride channel activity(GO:0005247) |
| 0.0 | 0.1 | GO:0050700 | CARD domain binding(GO:0050700) |
| 0.0 | 0.1 | GO:0003876 | AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623) |
| 0.0 | 0.4 | GO:0048487 | beta-tubulin binding(GO:0048487) |
| 0.0 | 0.1 | GO:0001671 | ATPase activator activity(GO:0001671) |
| 0.0 | 0.2 | GO:0070888 | E-box binding(GO:0070888) |
| 0.0 | 0.1 | GO:0003998 | acylphosphatase activity(GO:0003998) |
| 0.0 | 0.0 | GO:0004946 | bombesin receptor activity(GO:0004946) |
| 0.0 | 0.2 | GO:0071855 | neuropeptide receptor binding(GO:0071855) |
| 0.0 | 0.2 | GO:0005388 | calcium-transporting ATPase activity(GO:0005388) |
| 0.0 | 0.1 | GO:0050998 | nitric-oxide synthase binding(GO:0050998) |
| 0.0 | 0.1 | GO:0005172 | vascular endothelial growth factor receptor binding(GO:0005172) |
| 0.0 | 0.0 | GO:0004504 | peptidylglycine monooxygenase activity(GO:0004504) peptidylamidoglycolate lyase activity(GO:0004598) |
| 0.0 | 0.2 | GO:0043498 | obsolete cell surface binding(GO:0043498) |
| 0.0 | 0.3 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.0 | 0.8 | GO:0008094 | DNA-dependent ATPase activity(GO:0008094) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 18.4 | SA_B_CELL_RECEPTOR_COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
| 0.2 | 8.0 | SIG_IL4RECEPTOR_IN_B_LYPHOCYTES | Genes related to IL4 rceptor signaling in B lymphocytes |
| 0.1 | 1.2 | ST_PAC1_RECEPTOR_PATHWAY | PAC1 Receptor Pathway |
| 0.1 | 3.0 | SA_CASPASE_CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.1 | 2.7 | SIG_BCR_SIGNALING_PATHWAY | Members of the BCR signaling pathway |
| 0.1 | 0.7 | SA_PTEN_PATHWAY | PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. |
| 0.1 | 0.4 | SIG_CHEMOTAXIS | Genes related to chemotaxis |
| 0.1 | 2.4 | ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS | Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway. |
| 0.1 | 2.6 | ST_P38_MAPK_PATHWAY | p38 MAPK Pathway |
| 0.0 | 1.4 | ST_T_CELL_SIGNAL_TRANSDUCTION | T Cell Signal Transduction |
| 0.0 | 1.6 | SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES | Genes related to PIP3 signaling in cardiac myocytes |
| 0.0 | 0.2 | SA_G2_AND_M_PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.0 | 0.3 | ST_WNT_CA2_CYCLIC_GMP_PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.0 | 0.1 | ST_STAT3_PATHWAY | STAT3 Pathway |
|
|
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