Motif ID: PRDM1
Z-value: 1.942
Transcription factors associated with PRDM1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| PRDM1 | ENSG00000057657.10 | PRDM1 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 3.9 | GO:0070886 | positive regulation of calcineurin-NFAT signaling cascade(GO:0070886) |
| 0.8 | 2.4 | GO:0045062 | extrathymic T cell differentiation(GO:0033078) extrathymic T cell selection(GO:0045062) |
| 0.5 | 1.9 | GO:0045112 | integrin biosynthetic process(GO:0045112) |
| 0.3 | 11.9 | GO:0050873 | brown fat cell differentiation(GO:0050873) |
| 0.3 | 0.8 | GO:0061302 | smooth muscle cell-matrix adhesion(GO:0061302) |
| 0.2 | 1.7 | GO:0090025 | regulation of monocyte chemotaxis(GO:0090025) positive regulation of monocyte chemotaxis(GO:0090026) |
| 0.2 | 0.9 | GO:0070842 | aggresome assembly(GO:0070842) |
| 0.2 | 8.0 | GO:0030325 | adrenal gland development(GO:0030325) |
| 0.2 | 0.9 | GO:0032020 | ISG15-protein conjugation(GO:0032020) |
| 0.2 | 1.6 | GO:0006069 | ethanol metabolic process(GO:0006067) ethanol oxidation(GO:0006069) |
| 0.1 | 0.5 | GO:0042519 | tyrosine phosphorylation of Stat4 protein(GO:0042504) regulation of tyrosine phosphorylation of Stat4 protein(GO:0042519) positive regulation of tyrosine phosphorylation of Stat4 protein(GO:0042520) |
| 0.1 | 1.9 | GO:0031000 | response to caffeine(GO:0031000) |
| 0.1 | 0.3 | GO:0002678 | positive regulation of chronic inflammatory response(GO:0002678) regulation of chronic inflammatory response to antigenic stimulus(GO:0002874) |
| 0.1 | 0.2 | GO:0001780 | neutrophil homeostasis(GO:0001780) |
| 0.1 | 0.1 | GO:0002538 | arachidonic acid metabolite production involved in inflammatory response(GO:0002538) leukotriene production involved in inflammatory response(GO:0002540) |
| 0.1 | 0.3 | GO:0008588 | release of cytoplasmic sequestered NF-kappaB(GO:0008588) |
| 0.1 | 0.3 | GO:0019471 | peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) 4-hydroxyproline metabolic process(GO:0019471) peptidyl-proline hydroxylation(GO:0019511) |
| 0.1 | 0.2 | GO:0006269 | DNA replication, synthesis of RNA primer(GO:0006269) |
| 0.1 | 0.3 | GO:0002051 | osteoblast fate commitment(GO:0002051) |
| 0.0 | 0.2 | GO:0006556 | S-adenosylmethionine biosynthetic process(GO:0006556) |
| 0.0 | 4.2 | GO:0006521 | regulation of cellular amino acid metabolic process(GO:0006521) |
| 0.0 | 0.7 | GO:0046415 | urate metabolic process(GO:0046415) |
| 0.0 | 0.8 | GO:0021846 | cell proliferation in forebrain(GO:0021846) |
| 0.0 | 2.3 | GO:0001764 | neuron migration(GO:0001764) |
| 0.0 | 1.2 | GO:0006509 | membrane protein ectodomain proteolysis(GO:0006509) |
| 0.0 | 0.1 | GO:0018076 | N-terminal peptidyl-lysine acetylation(GO:0018076) |
| 0.0 | 0.1 | GO:0006531 | aspartate metabolic process(GO:0006531) aspartate catabolic process(GO:0006533) |
| 0.0 | 0.2 | GO:0032897 | negative regulation of viral transcription(GO:0032897) |
| 0.0 | 0.3 | GO:1901224 | activation of NF-kappaB-inducing kinase activity(GO:0007250) NIK/NF-kappaB signaling(GO:0038061) regulation of NIK/NF-kappaB signaling(GO:1901222) positive regulation of NIK/NF-kappaB signaling(GO:1901224) |
| 0.0 | 0.1 | GO:0030037 | actin filament reorganization involved in cell cycle(GO:0030037) actin filament reorganization(GO:0090527) |
| 0.0 | 0.1 | GO:0035414 | negative regulation of catenin import into nucleus(GO:0035414) |
| 0.0 | 1.7 | GO:0006094 | gluconeogenesis(GO:0006094) |
| 0.0 | 0.4 | GO:0033344 | cholesterol efflux(GO:0033344) |
| 0.0 | 0.1 | GO:0070309 | lens fiber cell morphogenesis(GO:0070309) |
| 0.0 | 0.7 | GO:0050931 | melanocyte differentiation(GO:0030318) pigment cell differentiation(GO:0050931) |
| 0.0 | 1.6 | GO:0034130 | toll-like receptor 1 signaling pathway(GO:0034130) |
| 0.0 | 1.2 | GO:0007229 | integrin-mediated signaling pathway(GO:0007229) |
| 0.0 | 0.8 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.0 | 0.4 | GO:0007257 | activation of JUN kinase activity(GO:0007257) |
| 0.0 | 1.2 | GO:0042157 | lipoprotein metabolic process(GO:0042157) |
| 0.0 | 0.3 | GO:0042147 | retrograde transport, endosome to Golgi(GO:0042147) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 12.5 | GO:0005606 | laminin-1 complex(GO:0005606) |
| 0.6 | 1.9 | GO:0005588 | collagen type V trimer(GO:0005588) |
| 0.3 | 1.9 | GO:0008537 | proteasome activator complex(GO:0008537) |
| 0.2 | 0.8 | GO:0071062 | alphav-beta3 integrin-vitronectin complex(GO:0071062) |
| 0.1 | 0.8 | GO:0031465 | Cul4B-RING E3 ubiquitin ligase complex(GO:0031465) |
| 0.1 | 2.3 | GO:0005839 | proteasome core complex(GO:0005839) |
| 0.1 | 0.9 | GO:0016235 | aggresome(GO:0016235) |
| 0.1 | 0.4 | GO:0031618 | nuclear pericentric heterochromatin(GO:0031618) |
| 0.0 | 1.1 | GO:0031105 | septin complex(GO:0031105) septin cytoskeleton(GO:0032156) |
| 0.0 | 0.9 | GO:0005811 | lipid particle(GO:0005811) |
| 0.0 | 0.2 | GO:0005658 | alpha DNA polymerase:primase complex(GO:0005658) |
| 0.0 | 0.5 | GO:0033116 | endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116) |
| 0.0 | 1.0 | GO:0098636 | integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636) |
| 0.0 | 0.4 | GO:0045335 | phagocytic vesicle(GO:0045335) |
| 0.0 | 0.5 | GO:0031519 | PcG protein complex(GO:0031519) |
| 0.0 | 0.2 | GO:0034464 | BBSome(GO:0034464) |
| 0.0 | 0.2 | GO:0031941 | filamentous actin(GO:0031941) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 1.2 | GO:0004024 | alcohol dehydrogenase activity, zinc-dependent(GO:0004024) |
| 0.2 | 1.9 | GO:0048407 | platelet-derived growth factor binding(GO:0048407) |
| 0.2 | 2.3 | GO:0003706 | obsolete ligand-regulated transcription factor activity(GO:0003706) |
| 0.2 | 1.3 | GO:0005138 | interleukin-6 receptor binding(GO:0005138) |
| 0.1 | 12.5 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.1 | 0.8 | GO:0030247 | pattern binding(GO:0001871) polysaccharide binding(GO:0030247) |
| 0.1 | 2.3 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.1 | 1.0 | GO:0001011 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, RNA polymerase II basal transcription factor binding(GO:0001083) transcription factor activity, TFIIB-class binding(GO:0001087) RNA polymerase II basal transcription factor binding(GO:0001091) TFIIB-class transcription factor binding(GO:0001093) |
| 0.1 | 0.4 | GO:0004022 | alcohol dehydrogenase (NAD) activity(GO:0004022) |
| 0.1 | 0.9 | GO:0008641 | small protein activating enzyme activity(GO:0008641) |
| 0.1 | 0.5 | GO:0005143 | interleukin-12 receptor binding(GO:0005143) |
| 0.1 | 0.9 | GO:0070628 | proteasome binding(GO:0070628) |
| 0.1 | 8.2 | GO:0008201 | heparin binding(GO:0008201) |
| 0.1 | 0.3 | GO:0004656 | procollagen-proline 4-dioxygenase activity(GO:0004656) peptidyl-proline 4-dioxygenase activity(GO:0031545) |
| 0.1 | 0.2 | GO:0003896 | DNA primase activity(GO:0003896) |
| 0.0 | 9.6 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.0 | 0.7 | GO:0015347 | sodium-independent organic anion transmembrane transporter activity(GO:0015347) |
| 0.0 | 1.1 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 0.0 | 1.4 | GO:0008009 | chemokine activity(GO:0008009) |
| 0.0 | 1.0 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
| 0.0 | 0.1 | GO:0043426 | MRF binding(GO:0043426) |
| 0.0 | 0.4 | GO:0016565 | obsolete general transcriptional repressor activity(GO:0016565) |
| 0.0 | 0.6 | GO:0005247 | voltage-gated chloride channel activity(GO:0005247) |
| 0.0 | 1.9 | GO:0030165 | PDZ domain binding(GO:0030165) |
| 0.0 | 0.1 | GO:0008267 | poly-glutamine tract binding(GO:0008267) |
| 0.0 | 0.3 | GO:0030618 | transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618) |
| 0.0 | 0.1 | GO:0004046 | aminoacylase activity(GO:0004046) |
| 0.0 | 0.4 | GO:0005001 | transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) |
| 0.0 | 0.1 | GO:0008035 | high-density lipoprotein particle binding(GO:0008035) |
| 0.0 | 0.3 | GO:0005484 | SNAP receptor activity(GO:0005484) |
| 0.0 | 0.3 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
| 0.0 | 0.1 | GO:1901567 | icosanoid binding(GO:0050542) arachidonic acid binding(GO:0050544) fatty acid derivative binding(GO:1901567) |
| 0.0 | 1.1 | GO:0005319 | lipid transporter activity(GO:0005319) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.8 | ST_ERK1_ERK2_MAPK_PATHWAY | ERK1/ERK2 MAPK Pathway |
| 0.0 | 0.2 | SA_TRKA_RECEPTOR | The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. |
