Motif ID: PRDM14

Z-value: 0.556


Transcription factors associated with PRDM14:

Gene SymbolEntrez IDGene Name
PRDM14 ENSG00000147596.3 PRDM14



Activity profile for motif PRDM14.

activity profile for motif PRDM14


Sorted Z-values histogram for motif PRDM14

Sorted Z-values for motif PRDM14



Network of associatons between targets according to the STRING database.



First level regulatory network of PRDM14

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr22_+_23241661 0.958 ENST00000390322.2
 IGLJ2
immunoglobulin lambda joining 2
chr18_+_57567180 0.862 ENST00000316660.6
ENST00000269518.9
 PMAIP1

phorbol-12-myristate-13-acetate-induced protein 1

chr19_-_49314169 0.849 ENST00000597011.1
ENST00000601681.1
 BCAT2

branched chain amino-acid transaminase 2, mitochondrial

chr4_-_103266626 0.826 ENST00000356736.4
 SLC39A8
solute carrier family 39 (zinc transporter), member 8
chr19_-_49314269 0.800 ENST00000545387.2
ENST00000316273.6
ENST00000402551.1
ENST00000598162.1
ENST00000599246.1
 BCAT2




branched chain amino-acid transaminase 2, mitochondrial




chrX_+_15525426 0.591 ENST00000342014.6
 BMX
BMX non-receptor tyrosine kinase
chr11_-_62474803 0.590 ENST00000533982.1
ENST00000360796.5
 BSCL2

Berardinelli-Seip congenital lipodystrophy 2 (seipin)

chr3_+_16926441 0.509 ENST00000418129.2
ENST00000396755.2
 PLCL2

phospholipase C-like 2

chr1_+_36621529 0.424 ENST00000316156.4
 MAP7D1
MAP7 domain containing 1
chr2_-_145278475 0.380 ENST00000558170.2
 ZEB2
zinc finger E-box binding homeobox 2
chr9_+_132597722 0.356 ENST00000372429.3
ENST00000315480.4
ENST00000358355.1
 USP20


ubiquitin specific peptidase 20


chr3_+_37035289 0.318 ENST00000455445.2
ENST00000441265.1
ENST00000435176.1
ENST00000429117.1
ENST00000536378.1
 MLH1




mutL homolog 1




chr12_+_121647868 0.304 ENST00000359949.7
ENST00000541532.1
ENST00000543171.1
ENST00000538701.1
 P2RX4



purinergic receptor P2X, ligand-gated ion channel, 4



chr19_+_39109735 0.301 ENST00000593149.1
ENST00000248342.4
ENST00000538434.1
ENST00000588934.1
ENST00000545173.2
ENST00000589307.1
ENST00000586513.1
ENST00000591409.1
ENST00000592558.1
 EIF3K








eukaryotic translation initiation factor 3, subunit K








chr1_-_27216729 0.298 ENST00000431781.2
ENST00000374135.4
 GPN2

GPN-loop GTPase 2

chr3_+_37035263 0.296 ENST00000458205.2
ENST00000539477.1
 MLH1

mutL homolog 1

chr12_+_121647962 0.294 ENST00000542067.1
 P2RX4
purinergic receptor P2X, ligand-gated ion channel, 4
chr19_+_49838653 0.292 ENST00000598095.1
ENST00000426897.2
ENST00000323906.4
ENST00000535669.2
ENST00000597602.1
ENST00000595660.1
 CD37





CD37 molecule





chr11_+_85956182 0.255 ENST00000327320.4
ENST00000351625.6
ENST00000534595.1
 EED


embryonic ectoderm development


chrX_+_41193407 0.249 ENST00000457138.2
ENST00000441189.2
 DDX3X

DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked

chr12_-_49351228 0.248 ENST00000541959.1
ENST00000447318.2
 ARF3

ADP-ribosylation factor 3

chr14_-_21492251 0.229 ENST00000554398.1
 NDRG2
NDRG family member 2
chr12_-_49351148 0.222 ENST00000539611.1
ENST00000398092.4
 ARF3
RP11-302B13.5
ADP-ribosylation factor 3
ADP-ribosylation factor 3
chr14_-_21492113 0.207 ENST00000554094.1
 NDRG2
NDRG family member 2
chr2_-_192711968 0.202 ENST00000304141.4
 SDPR
serum deprivation response
chr8_-_102216925 0.196 ENST00000517844.1
 ZNF706
zinc finger protein 706
chr12_-_49351303 0.177 ENST00000256682.4
 ARF3
ADP-ribosylation factor 3
chr19_+_3572758 0.172 ENST00000416526.1
 HMG20B
high mobility group 20B
chr1_+_65730385 0.150 ENST00000263441.7
ENST00000395325.3
 DNAJC6

DnaJ (Hsp40) homolog, subfamily C, member 6

chr7_-_124405681 0.147 ENST00000303921.2
 GPR37
G protein-coupled receptor 37 (endothelin receptor type B-like)
chr2_+_113033164 0.138 ENST00000409871.1
ENST00000343936.4
 ZC3H6

zinc finger CCCH-type containing 6

chr7_-_140714430 0.126 ENST00000393008.3
 MRPS33
mitochondrial ribosomal protein S33
chr4_+_81187753 0.115 ENST00000312465.7
ENST00000456523.3
 FGF5

fibroblast growth factor 5

chr5_+_32711419 0.115 ENST00000265074.8
 NPR3
natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)
chr7_-_140714739 0.105 ENST00000467334.1
ENST00000324787.5
 MRPS33

mitochondrial ribosomal protein S33

chr6_-_46048116 0.105 ENST00000185206.6
 CLIC5
chloride intracellular channel 5
chr2_-_69098566 0.103 ENST00000295379.1
 BMP10
bone morphogenetic protein 10
chr3_+_10289707 0.099 ENST00000287652.4
 TATDN2
TatD DNase domain containing 2
chr19_-_6279932 0.098 ENST00000252674.7
 MLLT1
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1
chr7_+_39989611 0.094 ENST00000181839.4
 CDK13
cyclin-dependent kinase 13
chr1_+_50571949 0.093 ENST00000357083.4
 ELAVL4
ELAV like neuron-specific RNA binding protein 4
chr8_+_110346546 0.087 ENST00000521662.1
ENST00000521688.1
ENST00000520147.1
 ENY2


enhancer of yellow 2 homolog (Drosophila)


chr17_-_46691990 0.077 ENST00000576562.1
 HOXB8
homeobox B8
chr7_-_139763521 0.070 ENST00000263549.3
 PARP12
poly (ADP-ribose) polymerase family, member 12
chr11_+_62475130 0.065 ENST00000294117.5
 GNG3
guanine nucleotide binding protein (G protein), gamma 3
chr2_-_228244013 0.063 ENST00000304568.3
 TM4SF20
transmembrane 4 L six family member 20
chr6_-_109777128 0.061 ENST00000358807.3
ENST00000358577.3
 MICAL1

microtubule associated monooxygenase, calponin and LIM domain containing 1

chr5_+_32710736 0.059 ENST00000415685.2
 NPR3
natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)
chr17_-_46692287 0.056 ENST00000239144.4
 HOXB8
homeobox B8
chr1_-_116383322 0.033 ENST00000429731.1
 NHLH2
nescient helix loop helix 2
chr1_-_42384343 0.032 ENST00000372584.1
 HIVEP3
human immunodeficiency virus type I enhancer binding protein 3
chr1_+_153963227 0.028 ENST00000368567.4
ENST00000392558.4
 RPS27

ribosomal protein S27

chr15_+_45694523 0.021 ENST00000305560.6
 SPATA5L1
spermatogenesis associated 5-like 1
chr11_-_65624415 0.021 ENST00000524553.1
ENST00000527344.1
 CFL1

cofilin 1 (non-muscle)

chr20_-_48770174 0.009 ENST00000341698.2
 TMEM189-UBE2V1
TMEM189-UBE2V1 readthrough
chr12_+_3600356 0.008 ENST00000382622.3
 PRMT8
protein arginine methyltransferase 8
chr12_+_56325812 0.006 ENST00000394147.1
ENST00000551156.1
ENST00000553783.1
ENST00000557080.1
ENST00000432422.3
ENST00000556001.1
 DGKA





diacylglycerol kinase, alpha 80kDa





chr2_-_37193606 0.000 ENST00000379213.2
ENST00000263918.4
 STRN

striatin, calmodulin binding protein


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.6 GO:0006549 isoleucine metabolic process(GO:0006549)
0.2 0.6 GO:0051255 spindle midzone assembly(GO:0051255) meiotic spindle midzone assembly(GO:0051257)
0.1 0.6 GO:0042118 endothelial cell activation(GO:0042118)
0.1 0.9 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.0 0.2 GO:0002158 osteoclast proliferation(GO:0002158)
0.0 0.8 GO:0071577 zinc II ion transmembrane transport(GO:0071577)
0.0 0.4 GO:0071108 protein K48-linked deubiquitination(GO:0071108)
0.0 0.1 GO:0070816 phosphorylation of RNA polymerase II C-terminal domain(GO:0070816)
0.0 0.1 GO:0014742 positive regulation of cardiac muscle hypertrophy(GO:0010613) positive regulation of muscle hypertrophy(GO:0014742)
0.0 0.4 GO:0021846 cell proliferation in forebrain(GO:0021846)
0.0 0.3 GO:0002920 regulation of humoral immune response(GO:0002920)
0.0 0.1 GO:0021516 dorsal spinal cord development(GO:0021516)
0.0 0.1 GO:0060122 auditory receptor cell morphogenesis(GO:0002093) auditory receptor cell stereocilium organization(GO:0060088) inner ear receptor stereocilium organization(GO:0060122)
0.0 0.3 GO:0006349 regulation of gene expression by genetic imprinting(GO:0006349)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0005712 chiasma(GO:0005712) MutLbeta complex(GO:0032390)
0.0 0.3 GO:0001739 sex chromatin(GO:0001739)
0.0 0.1 GO:0000124 SAGA complex(GO:0000124)
0.0 0.6 GO:0043195 terminal bouton(GO:0043195)
0.0 0.3 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0 0.2 GO:0005763 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.6 GO:0052654 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.1 0.6 GO:0032137 guanine/thymine mispair binding(GO:0032137)
0.1 0.6 GO:0035381 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.0 0.8 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.2 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.0 0.2 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 0.1 GO:0031702 type 1 angiotensin receptor binding(GO:0031702)
0.0 0.2 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004)
0.0 0.3 GO:0043022 ribosome binding(GO:0043022)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.