Motif ID: PRRX1_ALX4_PHOX2A
Z-value: 1.286
Transcription factors associated with PRRX1_ALX4_PHOX2A:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| ALX4 | ENSG00000052850.5 | ALX4 |
| PHOX2A | ENSG00000165462.5 | PHOX2A |
| PRRX1 | ENSG00000116132.7 | PRRX1 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 4.3 | GO:0060318 | definitive erythrocyte differentiation(GO:0060318) |
| 0.8 | 8.8 | GO:0019800 | peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800) |
| 0.4 | 1.3 | GO:0034036 | purine ribonucleoside bisphosphate biosynthetic process(GO:0034036) 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process(GO:0050428) |
| 0.3 | 1.1 | GO:0090161 | Golgi ribbon formation(GO:0090161) |
| 0.3 | 1.3 | GO:0070050 | neuron cellular homeostasis(GO:0070050) |
| 0.2 | 0.7 | GO:0035987 | endodermal cell fate commitment(GO:0001711) endodermal cell differentiation(GO:0035987) |
| 0.2 | 0.5 | GO:0045760 | positive regulation of action potential(GO:0045760) |
| 0.2 | 0.6 | GO:0051503 | purine ribonucleotide transport(GO:0015868) adenine nucleotide transport(GO:0051503) |
| 0.2 | 1.4 | GO:0030277 | epithelial structure maintenance(GO:0010669) maintenance of gastrointestinal epithelium(GO:0030277) |
| 0.1 | 2.7 | GO:0021846 | cell proliferation in forebrain(GO:0021846) |
| 0.1 | 0.3 | GO:0035120 | post-embryonic appendage morphogenesis(GO:0035120) |
| 0.1 | 0.5 | GO:0055098 | response to low-density lipoprotein particle(GO:0055098) regulation of cholesterol transporter activity(GO:0060694) |
| 0.1 | 0.4 | GO:0060743 | epithelial cell maturation involved in prostate gland development(GO:0060743) |
| 0.1 | 0.4 | GO:0006434 | seryl-tRNA aminoacylation(GO:0006434) |
| 0.1 | 0.5 | GO:0035414 | negative regulation of catenin import into nucleus(GO:0035414) |
| 0.1 | 0.5 | GO:0016255 | attachment of GPI anchor to protein(GO:0016255) |
| 0.1 | 0.2 | GO:0021859 | pyramidal neuron differentiation(GO:0021859) pyramidal neuron development(GO:0021860) |
| 0.1 | 0.4 | GO:0048669 | collateral sprouting in absence of injury(GO:0048669) |
| 0.1 | 0.6 | GO:0060586 | multicellular organismal iron ion homeostasis(GO:0060586) |
| 0.1 | 1.0 | GO:0007128 | meiotic prophase I(GO:0007128) |
| 0.1 | 0.2 | GO:0050928 | negative regulation of positive chemotaxis(GO:0050928) |
| 0.1 | 2.6 | GO:0090263 | positive regulation of canonical Wnt signaling pathway(GO:0090263) |
| 0.1 | 0.2 | GO:0070171 | negative regulation of tooth mineralization(GO:0070171) |
| 0.1 | 0.3 | GO:0043267 | negative regulation of potassium ion transport(GO:0043267) |
| 0.1 | 0.3 | GO:0007182 | common-partner SMAD protein phosphorylation(GO:0007182) |
| 0.1 | 0.8 | GO:0048207 | vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208) COPII-coated vesicle budding(GO:0090114) |
| 0.0 | 0.2 | GO:0040034 | regulation of development, heterochronic(GO:0040034) regulation of timing of cell differentiation(GO:0048505) regulation of timing of neuron differentiation(GO:0060164) |
| 0.0 | 0.2 | GO:0007500 | mesodermal cell fate determination(GO:0007500) |
| 0.0 | 0.1 | GO:0044314 | protein K27-linked ubiquitination(GO:0044314) |
| 0.0 | 0.6 | GO:0035329 | hippo signaling(GO:0035329) |
| 0.0 | 0.2 | GO:0048486 | parasympathetic nervous system development(GO:0048486) |
| 0.0 | 0.1 | GO:0070172 | positive regulation of tooth mineralization(GO:0070172) |
| 0.0 | 0.1 | GO:0007181 | transforming growth factor beta receptor complex assembly(GO:0007181) |
| 0.0 | 0.3 | GO:0043011 | myeloid dendritic cell differentiation(GO:0043011) dendritic cell differentiation(GO:0097028) |
| 0.0 | 0.7 | GO:0035338 | long-chain fatty-acyl-CoA metabolic process(GO:0035336) long-chain fatty-acyl-CoA biosynthetic process(GO:0035338) |
| 0.0 | 1.5 | GO:0060828 | regulation of canonical Wnt signaling pathway(GO:0060828) |
| 0.0 | 0.2 | GO:0002221 | activation of innate immune response(GO:0002218) pattern recognition receptor signaling pathway(GO:0002221) innate immune response-activating signal transduction(GO:0002758) positive regulation of innate immune response(GO:0045089) |
| 0.0 | 1.1 | GO:0051101 | regulation of DNA binding(GO:0051101) |
| 0.0 | 0.2 | GO:0045898 | regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898) |
| 0.0 | 3.2 | GO:0046328 | regulation of JNK cascade(GO:0046328) |
| 0.0 | 0.1 | GO:0006848 | pyruvate transport(GO:0006848) |
| 0.0 | 2.8 | GO:0006814 | sodium ion transport(GO:0006814) |
| 0.0 | 0.1 | GO:0071318 | cellular response to ATP(GO:0071318) |
| 0.0 | 0.1 | GO:0046051 | GTP biosynthetic process(GO:0006183) UTP biosynthetic process(GO:0006228) CTP biosynthetic process(GO:0006241) pyrimidine ribonucleoside triphosphate metabolic process(GO:0009208) pyrimidine ribonucleoside triphosphate biosynthetic process(GO:0009209) CTP metabolic process(GO:0046036) UTP metabolic process(GO:0046051) |
| 0.0 | 0.1 | GO:0042693 | muscle cell fate commitment(GO:0042693) |
| 0.0 | 0.1 | GO:0008628 | hormone-mediated apoptotic signaling pathway(GO:0008628) |
| 0.0 | 1.3 | GO:0051592 | response to calcium ion(GO:0051592) |
| 0.0 | 0.1 | GO:0015824 | proline transport(GO:0015824) |
| 0.0 | 0.1 | GO:0006610 | ribosomal protein import into nucleus(GO:0006610) |
| 0.0 | 0.1 | GO:0090292 | nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292) |
| 0.0 | 2.1 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.0 | 2.1 | GO:0008203 | cholesterol metabolic process(GO:0008203) |
| 0.0 | 1.1 | GO:0007229 | integrin-mediated signaling pathway(GO:0007229) |
| 0.0 | 0.1 | GO:0045091 | regulation of single stranded viral RNA replication via double stranded DNA intermediate(GO:0045091) |
| 0.0 | 0.3 | GO:0034199 | activation of protein kinase A activity(GO:0034199) |
| 0.0 | 0.7 | GO:0048704 | embryonic skeletal system morphogenesis(GO:0048704) |
| 0.0 | 0.2 | GO:0051281 | positive regulation of release of sequestered calcium ion into cytosol(GO:0051281) |
| 0.0 | 0.2 | GO:0060765 | regulation of androgen receptor signaling pathway(GO:0060765) |
| 0.0 | 0.5 | GO:0006954 | inflammatory response(GO:0006954) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 4.3 | GO:0034673 | inhibin-betaglycan-ActRII complex(GO:0034673) |
| 0.6 | 8.8 | GO:0098647 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 0.5 | 1.5 | GO:0000308 | cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308) |
| 0.2 | 2.5 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.1 | 0.4 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.1 | 0.6 | GO:0005916 | fascia adherens(GO:0005916) |
| 0.1 | 1.3 | GO:0005892 | acetylcholine-gated channel complex(GO:0005892) |
| 0.1 | 0.8 | GO:0030127 | COPII vesicle coat(GO:0030127) |
| 0.1 | 0.4 | GO:0051233 | spindle midzone(GO:0051233) |
| 0.1 | 1.4 | GO:0042612 | MHC class I protein complex(GO:0042612) |
| 0.0 | 1.0 | GO:0016281 | eukaryotic translation initiation factor 4F complex(GO:0016281) |
| 0.0 | 0.2 | GO:0035189 | Rb-E2F complex(GO:0035189) |
| 0.0 | 1.0 | GO:0016010 | dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665) |
| 0.0 | 1.1 | GO:0098636 | integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636) |
| 0.0 | 0.2 | GO:0005579 | membrane attack complex(GO:0005579) |
| 0.0 | 0.1 | GO:0033268 | node of Ranvier(GO:0033268) |
| 0.0 | 0.3 | GO:0008091 | spectrin(GO:0008091) |
| 0.0 | 0.3 | GO:0000421 | autophagosome membrane(GO:0000421) |
| 0.0 | 0.3 | GO:0043198 | dendritic shaft(GO:0043198) |
| 0.0 | 0.6 | GO:0045095 | keratin filament(GO:0045095) |
| 0.0 | 0.1 | GO:0034993 | microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993) |
| 0.0 | 0.7 | GO:0005778 | peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903) |
| 0.0 | 1.0 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 0.0 | 0.3 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.0 | 0.1 | GO:0043202 | lysosomal lumen(GO:0043202) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 1.3 | GO:0004781 | adenylylsulfate kinase activity(GO:0004020) sulfate adenylyltransferase activity(GO:0004779) sulfate adenylyltransferase (ATP) activity(GO:0004781) |
| 0.4 | 4.3 | GO:0005114 | type II transforming growth factor beta receptor binding(GO:0005114) |
| 0.4 | 0.4 | GO:0070052 | collagen V binding(GO:0070052) |
| 0.2 | 8.6 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.2 | 1.0 | GO:0034597 | phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316) phosphatidylinositol phosphate 4-phosphatase activity(GO:0034596) phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity(GO:0034597) |
| 0.2 | 0.8 | GO:0030881 | beta-2-microglobulin binding(GO:0030881) |
| 0.2 | 0.7 | GO:0004321 | fatty-acyl-CoA synthase activity(GO:0004321) |
| 0.2 | 0.5 | GO:0030377 | urokinase plasminogen activator receptor activity(GO:0030377) |
| 0.2 | 0.5 | GO:0004937 | alpha1-adrenergic receptor activity(GO:0004937) |
| 0.2 | 0.8 | GO:0004692 | cGMP-dependent protein kinase activity(GO:0004692) |
| 0.1 | 0.9 | GO:0008321 | Ral guanyl-nucleotide exchange factor activity(GO:0008321) |
| 0.1 | 1.3 | GO:0042166 | acetylcholine binding(GO:0042166) |
| 0.1 | 0.6 | GO:0017162 | aryl hydrocarbon receptor binding(GO:0017162) |
| 0.1 | 0.4 | GO:0004828 | serine-tRNA ligase activity(GO:0004828) |
| 0.1 | 1.5 | GO:0030332 | cyclin binding(GO:0030332) |
| 0.1 | 0.8 | GO:0004117 | calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) |
| 0.1 | 1.7 | GO:0043499 | obsolete eukaryotic cell surface binding(GO:0043499) |
| 0.1 | 0.4 | GO:0004597 | peptide-aspartate beta-dioxygenase activity(GO:0004597) |
| 0.1 | 1.0 | GO:0000339 | RNA cap binding(GO:0000339) |
| 0.1 | 0.2 | GO:0004947 | bradykinin receptor activity(GO:0004947) |
| 0.1 | 0.3 | GO:0004090 | carbonyl reductase (NADPH) activity(GO:0004090) |
| 0.1 | 0.5 | GO:1901567 | icosanoid binding(GO:0050542) arachidonic acid binding(GO:0050544) fatty acid derivative binding(GO:1901567) |
| 0.1 | 0.6 | GO:0005243 | gap junction channel activity(GO:0005243) |
| 0.0 | 0.7 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
| 0.0 | 0.4 | GO:0033130 | acetylcholine receptor binding(GO:0033130) |
| 0.0 | 0.2 | GO:0016531 | copper chaperone activity(GO:0016531) |
| 0.0 | 0.3 | GO:0051378 | serotonin binding(GO:0051378) |
| 0.0 | 2.6 | GO:0003697 | single-stranded DNA binding(GO:0003697) |
| 0.0 | 2.3 | GO:0046332 | SMAD binding(GO:0046332) |
| 0.0 | 0.2 | GO:0004977 | melanocortin receptor activity(GO:0004977) |
| 0.0 | 0.9 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.0 | 0.9 | GO:0005545 | 1-phosphatidylinositol binding(GO:0005545) |
| 0.0 | 2.7 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 0.2 | GO:0030021 | extracellular matrix structural constituent conferring compression resistance(GO:0030021) structural constituent of tooth enamel(GO:0030345) |
| 0.0 | 0.2 | GO:1990782 | receptor tyrosine kinase binding(GO:0030971) protein tyrosine kinase binding(GO:1990782) |
| 0.0 | 0.3 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 0.0 | 0.1 | GO:0004457 | lactate dehydrogenase activity(GO:0004457) L-lactate dehydrogenase activity(GO:0004459) |
| 0.0 | 0.1 | GO:0050833 | pyruvate secondary active transmembrane transporter activity(GO:0005477) pyruvate transmembrane transporter activity(GO:0050833) |
| 0.0 | 0.9 | GO:0048306 | calcium-dependent protein binding(GO:0048306) |
| 0.0 | 0.2 | GO:0008469 | histone-arginine N-methyltransferase activity(GO:0008469) |
| 0.0 | 0.1 | GO:0004886 | 9-cis retinoic acid receptor activity(GO:0004886) |
| 0.0 | 0.2 | GO:0055056 | D-glucose transmembrane transporter activity(GO:0055056) |
| 0.0 | 0.1 | GO:0003998 | acylphosphatase activity(GO:0003998) |
| 0.0 | 0.1 | GO:0004550 | nucleoside diphosphate kinase activity(GO:0004550) |
| 0.0 | 0.2 | GO:0008527 | taste receptor activity(GO:0008527) |
| 0.0 | 0.1 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
| 0.0 | 0.3 | GO:0001228 | transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0000982) transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
| 0.0 | 1.7 | GO:0008194 | UDP-glycosyltransferase activity(GO:0008194) |
| 0.0 | 0.2 | GO:1905030 | voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030) |
| 0.0 | 0.2 | GO:0004887 | thyroid hormone receptor activity(GO:0004887) |
| 0.0 | 1.1 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
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