Motif ID: PTF1A

Z-value: 1.041


Transcription factors associated with PTF1A:

Gene SymbolEntrez IDGene Name
PTF1A ENSG00000168267.5 PTF1A



Activity profile for motif PTF1A.

activity profile for motif PTF1A


Sorted Z-values histogram for motif PTF1A

Sorted Z-values for motif PTF1A



Network of associatons between targets according to the STRING database.



First level regulatory network of PTF1A

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_+_40198527 1.913 ENST00000381799.5
 RHOH
ras homolog family member H
chr22_+_23101182 1.738 ENST00000390312.2
 IGLV2-14
immunoglobulin lambda variable 2-14
chr1_-_9129735 1.626 ENST00000377424.4
 SLC2A5
solute carrier family 2 (facilitated glucose/fructose transporter), member 5
chr8_+_11351494 1.527 ENST00000259089.4
 BLK
B lymphoid tyrosine kinase
chr1_-_9129598 1.397 ENST00000535586.1
 SLC2A5
solute carrier family 2 (facilitated glucose/fructose transporter), member 5
chr2_-_160761179 1.243 ENST00000554112.1
ENST00000553424.1
ENST00000263636.4
ENST00000504764.1
ENST00000505052.1
 LY75


LY75-CD302

lymphocyte antigen 75


LY75-CD302 readthrough

chr8_+_11351876 1.210 ENST00000529894.1
 BLK
B lymphoid tyrosine kinase
chr1_-_9129895 1.134 ENST00000473209.1
 SLC2A5
solute carrier family 2 (facilitated glucose/fructose transporter), member 5
chr11_+_7597639 1.131 ENST00000533792.1
 PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr1_-_9129631 1.072 ENST00000377414.3
 SLC2A5
solute carrier family 2 (facilitated glucose/fructose transporter), member 5
chr6_-_24877490 1.031 ENST00000540914.1
ENST00000378023.4
 FAM65B

family with sequence similarity 65, member B

chr17_+_67498538 0.976 ENST00000589647.1
 MAP2K6
mitogen-activated protein kinase kinase 6
chr10_-_74856608 0.927 ENST00000307116.2
ENST00000373008.2
ENST00000412021.2
ENST00000394890.2
ENST00000263556.3
ENST00000440381.1
 P4HA1





prolyl 4-hydroxylase, alpha polypeptide I





chr7_+_7606497 0.539 ENST00000340080.4
ENST00000405785.1
ENST00000433635.1
 MIOS


missing oocyte, meiosis regulator, homolog (Drosophila)


chr1_+_12185949 0.523 ENST00000413146.2
 TNFRSF8
tumor necrosis factor receptor superfamily, member 8
chr3_+_49027308 0.476 ENST00000383729.4
ENST00000343546.4
 P4HTM

prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)

chr3_+_35721106 0.435 ENST00000474696.1
ENST00000412048.1
ENST00000396482.2
ENST00000432682.1
 ARPP21



cAMP-regulated phosphoprotein, 21kDa



chr3_+_167453493 0.419 ENST00000295777.5
ENST00000472747.2
 SERPINI1

serpin peptidase inhibitor, clade I (neuroserpin), member 1

chr12_-_90102594 0.413 ENST00000428670.3
 ATP2B1
ATPase, Ca++ transporting, plasma membrane 1
chr1_-_231114542 0.404 ENST00000522821.1
ENST00000366661.4
ENST00000366662.4
ENST00000414259.1
ENST00000522399.1
 TTC13




tetratricopeptide repeat domain 13




chr12_+_113344755 0.399 ENST00000550883.1
 OAS1
2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr3_+_35681081 0.383 ENST00000428373.1
 ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr17_+_12692774 0.381 ENST00000379672.5
ENST00000340825.3
 ARHGAP44

Rho GTPase activating protein 44

chr11_+_96123158 0.375 ENST00000332349.4
ENST00000458427.1
 JRKL

jerky homolog-like (mouse)

chr18_-_53177984 0.374 ENST00000543082.1
 TCF4
transcription factor 4
chr20_+_44441215 0.366 ENST00000356455.4
ENST00000405520.1
 UBE2C

ubiquitin-conjugating enzyme E2C

chr2_-_89513402 0.358 ENST00000498435.1
 IGKV1-27
immunoglobulin kappa variable 1-27
chr19_-_48389651 0.348 ENST00000222002.3
 SULT2A1
sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
chr17_+_53342311 0.345 ENST00000226067.5
 HLF
hepatic leukemia factor
chr20_+_44441304 0.328 ENST00000352551.5
 UBE2C
ubiquitin-conjugating enzyme E2C
chrX_-_107019181 0.310 ENST00000315660.4
ENST00000372384.2
ENST00000502650.1
ENST00000506724.1
 TSC22D3



TSC22 domain family, member 3



chr7_-_99097863 0.309 ENST00000426306.2
ENST00000337673.6
 ZNF394

zinc finger protein 394

chr12_+_113344582 0.308 ENST00000202917.5
ENST00000445409.2
ENST00000452357.2
 OAS1


2'-5'-oligoadenylate synthetase 1, 40/46kDa


chr13_+_113633620 0.291 ENST00000421756.1
ENST00000375601.3
 MCF2L

MCF.2 cell line derived transforming sequence-like

chr7_-_29186008 0.277 ENST00000396276.3
ENST00000265394.5
 CPVL

carboxypeptidase, vitellogenic-like

chr5_-_118324200 0.270 ENST00000515439.3
ENST00000510708.1
 DTWD2

DTW domain containing 2

chr12_-_48398104 0.270 ENST00000337299.6
ENST00000380518.3
 COL2A1

collagen, type II, alpha 1

chr7_-_152373216 0.254 ENST00000359321.1
 XRCC2
X-ray repair complementing defective repair in Chinese hamster cells 2
chr6_+_57182400 0.248 ENST00000607273.1
 PRIM2
primase, DNA, polypeptide 2 (58kDa)
chr22_+_24999114 0.241 ENST00000412658.1
ENST00000445029.1
ENST00000419133.1
ENST00000400382.1
ENST00000438643.2
ENST00000452551.1
ENST00000400383.1
ENST00000412898.1
ENST00000400380.1
ENST00000455483.1
ENST00000430289.1
 GGT1










gamma-glutamyltransferase 1










chr10_-_101841588 0.239 ENST00000370418.3
 CPN1
carboxypeptidase N, polypeptide 1
chr10_-_1779663 0.225 ENST00000381312.1
 ADARB2
adenosine deaminase, RNA-specific, B2 (non-functional)
chr5_+_169532896 0.224 ENST00000306268.6
ENST00000449804.2
 FOXI1

forkhead box I1

chr6_-_41715128 0.219 ENST00000356667.4
ENST00000373025.3
ENST00000425343.2
 PGC


progastricsin (pepsinogen C)


chr2_-_27435125 0.214 ENST00000414408.1
ENST00000310574.3
 SLC5A6

solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6

chr2_+_97426631 0.210 ENST00000377075.2
 CNNM4
cyclin M4
chr17_-_73892992 0.207 ENST00000540128.1
ENST00000269383.3
 TRIM65

tripartite motif containing 65

chr1_-_45956822 0.204 ENST00000372086.3
ENST00000341771.6
 TESK2

testis-specific kinase 2

chr7_-_100844193 0.200 ENST00000440203.2
ENST00000379423.3
ENST00000223114.4
 MOGAT3


monoacylglycerol O-acyltransferase 3


chr11_-_111794446 0.200 ENST00000527950.1
 CRYAB
crystallin, alpha B
chr15_-_89764929 0.198 ENST00000268125.5
 RLBP1
retinaldehyde binding protein 1
chr12_+_53689309 0.195 ENST00000351500.3
ENST00000550846.1
ENST00000334478.4
ENST00000549759.1
 PFDN5



prefoldin subunit 5



chr9_+_4985228 0.168 ENST00000381652.3
 JAK2
Janus kinase 2
chr12_+_113344811 0.166 ENST00000551241.1
ENST00000553185.1
ENST00000550689.1
 OAS1


2'-5'-oligoadenylate synthetase 1, 40/46kDa


chr13_-_79979919 0.151 ENST00000267229.7
 RBM26
RNA binding motif protein 26
chr2_-_89417335 0.149 ENST00000490686.1
 IGKV1-17
immunoglobulin kappa variable 1-17
chr1_-_76076759 0.148 ENST00000370855.5
 SLC44A5
solute carrier family 44, member 5
chr1_-_78149041 0.144 ENST00000414381.1
ENST00000370798.1
 ZZZ3

zinc finger, ZZ-type containing 3

chrX_+_154299690 0.135 ENST00000340647.4
ENST00000330045.7
 BRCC3

BRCA1/BRCA2-containing complex, subunit 3

chr19_-_10491234 0.133 ENST00000524462.1
ENST00000531836.1
ENST00000525621.1
 TYK2


tyrosine kinase 2


chr17_-_33416231 0.131 ENST00000584655.1
ENST00000447669.2
ENST00000315249.7
 RFFL


ring finger and FYVE-like domain containing E3 ubiquitin protein ligase


chr16_+_89696692 0.128 ENST00000261615.4
 DPEP1
dipeptidase 1 (renal)
chr13_-_79979952 0.127 ENST00000438724.1
 RBM26
RNA binding motif protein 26
chr17_-_3461092 0.126 ENST00000301365.4
ENST00000572519.1
 TRPV3

transient receptor potential cation channel, subfamily V, member 3

chr16_-_75569068 0.124 ENST00000336257.3
ENST00000565039.1
 CHST5

carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5

chr1_-_45956800 0.121 ENST00000538496.1
 TESK2
testis-specific kinase 2
chr10_-_5855350 0.119 ENST00000456041.1
ENST00000380181.3
ENST00000418688.1
ENST00000380132.4
ENST00000609712.1
ENST00000380191.4
 GDI2





GDP dissociation inhibitor 2





chr11_-_207221 0.117 ENST00000486280.1
ENST00000332865.6
ENST00000529614.2
ENST00000325147.9
ENST00000410108.1
ENST00000382762.3
 BET1L





Bet1 golgi vesicular membrane trafficking protein-like





chr10_+_76871454 0.115 ENST00000372687.4
 SAMD8
sterile alpha motif domain containing 8
chr2_-_89278535 0.114 ENST00000390247.2
 IGKV3-7
immunoglobulin kappa variable 3-7 (non-functional)
chr6_-_62996066 0.104 ENST00000281156.4
 KHDRBS2
KH domain containing, RNA binding, signal transduction associated 2
chr17_-_42143963 0.103 ENST00000585388.1
ENST00000293406.3
 LSM12

LSM12 homolog (S. cerevisiae)

chr2_-_136288113 0.103 ENST00000401392.1
 ZRANB3
zinc finger, RAN-binding domain containing 3
chrX_+_154299753 0.097 ENST00000369459.2
ENST00000369462.1
ENST00000411985.1
ENST00000399042.1
 BRCC3



BRCA1/BRCA2-containing complex, subunit 3



chr20_+_30697298 0.094 ENST00000398022.2
 TM9SF4
transmembrane 9 superfamily protein member 4
chr5_+_140557371 0.085 ENST00000239444.2
 PCDHB8
protocadherin beta 8
chr12_+_50451331 0.081 ENST00000228468.4
 ASIC1
acid-sensing (proton-gated) ion channel 1
chr10_+_99332198 0.076 ENST00000307518.5
ENST00000298808.5
ENST00000370655.1
 ANKRD2


ankyrin repeat domain 2 (stretch responsive muscle)


chr6_-_56258892 0.076 ENST00000370819.1
 COL21A1
collagen, type XXI, alpha 1
chr18_+_5238549 0.073 ENST00000580684.1
 LINC00667
long intergenic non-protein coding RNA 667
chr14_-_77737543 0.069 ENST00000298352.4
 NGB
neuroglobin
chr12_+_112451120 0.066 ENST00000261735.3
ENST00000455836.1
 ERP29

endoplasmic reticulum protein 29

chr17_+_40996590 0.065 ENST00000253799.3
ENST00000452774.2
 AOC2

amine oxidase, copper containing 2 (retina-specific)

chr13_+_113812956 0.062 ENST00000375547.2
ENST00000342783.4
 PROZ

protein Z, vitamin K-dependent plasma glycoprotein

chr13_+_49794474 0.057 ENST00000218721.1
ENST00000398307.1
 MLNR

motilin receptor

chrX_+_155110956 0.054 ENST00000286448.6
ENST00000262640.6
ENST00000460621.1
 VAMP7


vesicle-associated membrane protein 7


chr3_+_51663407 0.053 ENST00000432863.1
ENST00000296477.3
 RAD54L2

RAD54-like 2 (S. cerevisiae)

chr10_+_43572475 0.053 ENST00000355710.3
ENST00000498820.1
ENST00000340058.5
 RET


ret proto-oncogene


chr16_-_15950868 0.052 ENST00000396324.3
ENST00000452625.2
ENST00000576790.2
ENST00000300036.5
 MYH11



myosin, heavy chain 11, smooth muscle



chr16_+_2802316 0.052 ENST00000301740.8
 SRRM2
serine/arginine repetitive matrix 2
chr3_+_40518599 0.051 ENST00000314686.5
ENST00000447116.2
ENST00000429348.2
ENST00000456778.1
 ZNF619



zinc finger protein 619



chrX_+_15808569 0.049 ENST00000380308.3
ENST00000307771.7
 ZRSR2

zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2

chr20_-_48732472 0.044 ENST00000340309.3
ENST00000415862.2
ENST00000371677.3
ENST00000420027.2
 UBE2V1



ubiquitin-conjugating enzyme E2 variant 1



chr12_+_75784850 0.043 ENST00000550916.1
ENST00000435775.1
ENST00000378689.2
ENST00000378692.3
ENST00000320460.4
ENST00000547164.1
 GLIPR1L2





GLI pathogenesis-related 1 like 2





chr6_+_27107053 0.041 ENST00000354348.2
 HIST1H4I
histone cluster 1, H4i
chr18_+_33877654 0.039 ENST00000257209.4
ENST00000445677.1
ENST00000590592.1
ENST00000359247.4
 FHOD3



formin homology 2 domain containing 3



chr8_-_22089533 0.036 ENST00000321613.3
 PHYHIP
phytanoyl-CoA 2-hydroxylase interacting protein
chr15_+_68924327 0.036 ENST00000543950.1
 CORO2B
coronin, actin binding protein, 2B
chr22_-_17640110 0.036 ENST00000399852.3
ENST00000336737.4
 CECR5

cat eye syndrome chromosome region, candidate 5

chr4_+_156588115 0.036 ENST00000455639.2
 GUCY1A3
guanylate cyclase 1, soluble, alpha 3
chr22_-_50523760 0.036 ENST00000395876.2
 MLC1
megalencephalic leukoencephalopathy with subcortical cysts 1
chr12_+_12966250 0.034 ENST00000352940.4
ENST00000358007.3
ENST00000544400.1
 DDX47


DEAD (Asp-Glu-Ala-Asp) box polypeptide 47


chr4_-_83719884 0.032 ENST00000282709.4
ENST00000273908.4
 SCD5

stearoyl-CoA desaturase 5

chr4_-_89744314 0.032 ENST00000508369.1
 FAM13A
family with sequence similarity 13, member A
chr19_-_40331345 0.028 ENST00000597224.1
 FBL
fibrillarin
chr4_-_89744365 0.028 ENST00000513837.1
ENST00000503556.1
 FAM13A

family with sequence similarity 13, member A

chr12_+_120884222 0.028 ENST00000551765.1
ENST00000229384.5
 GATC

glutamyl-tRNA(Gln) amidotransferase, subunit C

chr21_+_44073916 0.026 ENST00000349112.3
ENST00000398224.3
 PDE9A

phosphodiesterase 9A

chr21_+_44073860 0.025 ENST00000335512.4
ENST00000539837.1
ENST00000291539.6
ENST00000380328.2
ENST00000398232.3
ENST00000398234.3
ENST00000398236.3
ENST00000328862.6
ENST00000335440.6
ENST00000398225.3
ENST00000398229.3
ENST00000398227.3
 PDE9A











phosphodiesterase 9A











chr16_-_46723066 0.024 ENST00000299138.7
 VPS35
vacuolar protein sorting 35 homolog (S. cerevisiae)
chr4_-_175750364 0.020 ENST00000340217.5
ENST00000274093.3
 GLRA3

glycine receptor, alpha 3

chr11_+_71238313 0.020 ENST00000398536.4
 KRTAP5-7
keratin associated protein 5-7
chr13_+_49280951 0.007 ENST00000282018.3
 CYSLTR2
cysteinyl leukotriene receptor 2
chr19_+_45254529 0.004 ENST00000444487.1
 BCL3
B-cell CLL/lymphoma 3
chr4_-_123843597 0.003 ENST00000510735.1
ENST00000304430.5
 NUDT6

nudix (nucleoside diphosphate linked moiety X)-type motif 6


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 5.2 GO:0015755 fructose transport(GO:0015755)
0.2 0.9 GO:0019471 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) 4-hydroxyproline metabolic process(GO:0019471) peptidyl-proline hydroxylation(GO:0019511)
0.1 0.7 GO:0010993 ubiquitin homeostasis(GO:0010992) regulation of ubiquitin homeostasis(GO:0010993) free ubiquitin chain polymerization(GO:0010994)
0.1 1.1 GO:0015074 DNA integration(GO:0015074)
0.1 1.0 GO:0006975 DNA damage induced protein phosphorylation(GO:0006975)
0.1 0.2 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
0.1 2.9 GO:0032024 positive regulation of insulin secretion(GO:0032024)
0.1 0.2 GO:0035461 vitamin transmembrane transport(GO:0035461)
0.1 0.2 GO:0043049 otic placode formation(GO:0043049)
0.0 0.2 GO:0070537 histone H2A K63-linked deubiquitination(GO:0070537)
0.0 1.9 GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.0 0.5 GO:0042535 positive regulation of tumor necrosis factor biosynthetic process(GO:0042535)
0.0 0.8 GO:0034605 cellular response to heat(GO:0034605)
0.0 0.3 GO:0060272 embryonic skeletal joint morphogenesis(GO:0060272) embryonic skeletal joint development(GO:0072498)
0.0 0.1 GO:0015871 choline transport(GO:0015871)
0.0 0.1 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.0 0.2 GO:0006776 vitamin A metabolic process(GO:0006776)
0.0 0.5 GO:0051923 sulfation(GO:0051923)
0.0 0.1 GO:0031034 skeletal muscle myosin thick filament assembly(GO:0030241) myosin filament assembly(GO:0031034) striated muscle myosin thick filament assembly(GO:0071688)
0.0 0.2 GO:0006750 glutathione biosynthetic process(GO:0006750)
0.0 0.1 GO:0048484 enteric nervous system development(GO:0048484)
0.0 0.2 GO:0006071 glycerol metabolic process(GO:0006071)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.0 0.2 GO:0070552 BRISC complex(GO:0070552)
0.0 0.3 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 0.2 GO:0016272 prefoldin complex(GO:0016272)
0.0 0.7 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 1.0 GO:0030175 filopodium(GO:0030175)
0.0 0.1 GO:0031528 microvillus membrane(GO:0031528)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 5.2 GO:0005353 fructose transmembrane transporter activity(GO:0005353)
0.3 1.1 GO:0008907 integrase activity(GO:0008907)
0.2 0.9 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656) peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.1 1.9 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.1 0.2 GO:0003896 DNA primase activity(GO:0003896)
0.1 0.2 GO:0008523 sodium-dependent multivitamin transmembrane transporter activity(GO:0008523)
0.1 0.2 GO:0003846 2-acylglycerol O-acyltransferase activity(GO:0003846)
0.0 3.0 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.3 GO:0030020 extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.0 1.0 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.0 0.1 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.0 0.3 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.0 0.5 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031)
0.0 0.4 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, RNA polymerase II basal transcription factor binding(GO:0001083) transcription factor activity, TFIIB-class binding(GO:0001087) RNA polymerase II basal transcription factor binding(GO:0001091) TFIIB-class transcription factor binding(GO:0001093)
0.0 0.1 GO:0001517 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517)
0.0 0.2 GO:0004000 adenosine deaminase activity(GO:0004000)
0.0 0.1 GO:0052593 tryptamine:oxygen oxidoreductase (deaminating) activity(GO:0052593) aminoacetone:oxygen oxidoreductase(deaminating) activity(GO:0052594) aliphatic-amine oxidase activity(GO:0052595) phenethylamine:oxygen oxidoreductase (deaminating) activity(GO:0052596)
0.0 0.5 GO:0031418 L-ascorbic acid binding(GO:0031418)
0.0 0.2 GO:0003840 gamma-glutamyltransferase activity(GO:0003840)
0.0 0.4 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 0.2 GO:0019841 retinol binding(GO:0019841)
0.0 0.0 GO:0036002 pre-mRNA binding(GO:0036002)
0.0 0.2 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0 0.1 GO:0016520 growth hormone-releasing hormone receptor activity(GO:0016520)
0.0 0.2 GO:0031593 polyubiquitin binding(GO:0031593)
0.0 0.2 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.0 GO:0004768 stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 ST_IL_13_PATHWAY Interleukin 13 (IL-13) Pathway
0.0 0.5 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 1.0 ST_P38_MAPK_PATHWAY p38 MAPK Pathway