Motif ID: RAD21_SMC3
Z-value: 1.198
Transcription factors associated with RAD21_SMC3:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
RAD21 | ENSG00000164754.8 | RAD21 |
SMC3 | ENSG00000108055.9 | SMC3 |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.6 | 4.6 | GO:0031444 | slow-twitch skeletal muscle fiber contraction(GO:0031444) |
0.5 | 4.0 | GO:0003065 | regulation of heart rate by chemical signal(GO:0003062) positive regulation of heart rate by epinephrine(GO:0003065) |
0.5 | 4.3 | GO:0048387 | negative regulation of retinoic acid receptor signaling pathway(GO:0048387) |
0.4 | 1.1 | GO:0046586 | regulation of calcium-dependent cell-cell adhesion(GO:0046586) |
0.4 | 1.9 | GO:0007095 | blastocyst growth(GO:0001832) mitotic G2 DNA damage checkpoint(GO:0007095) |
0.2 | 3.6 | GO:0034446 | substrate adhesion-dependent cell spreading(GO:0034446) |
0.2 | 0.9 | GO:0051409 | response to nitrosative stress(GO:0051409) |
0.2 | 0.4 | GO:0097709 | connective tissue replacement involved in inflammatory response wound healing(GO:0002248) connective tissue replacement(GO:0097709) |
0.2 | 0.5 | GO:0071529 | cementum mineralization(GO:0071529) |
0.2 | 0.3 | GO:0044818 | mitotic G2/M transition checkpoint(GO:0044818) |
0.2 | 0.5 | GO:0019886 | antigen processing and presentation of exogenous peptide antigen via MHC class II(GO:0019886) |
0.2 | 1.1 | GO:0045079 | negative regulation of chemokine biosynthetic process(GO:0045079) |
0.1 | 0.6 | GO:0051541 | elastin metabolic process(GO:0051541) |
0.1 | 0.8 | GO:0016080 | synaptic vesicle targeting(GO:0016080) |
0.1 | 0.5 | GO:0030259 | lipid glycosylation(GO:0030259) |
0.1 | 0.8 | GO:0034501 | protein localization to kinetochore(GO:0034501) |
0.1 | 0.4 | GO:0019521 | aldonic acid metabolic process(GO:0019520) D-gluconate metabolic process(GO:0019521) |
0.1 | 2.0 | GO:0051927 | obsolete negative regulation of calcium ion transport via voltage-gated calcium channel activity(GO:0051927) |
0.1 | 0.9 | GO:0015671 | oxygen transport(GO:0015671) |
0.1 | 0.6 | GO:0030538 | embryonic genitalia morphogenesis(GO:0030538) |
0.1 | 3.1 | GO:0045103 | intermediate filament-based process(GO:0045103) |
0.1 | 1.2 | GO:0006776 | vitamin A metabolic process(GO:0006776) |
0.1 | 1.1 | GO:0000460 | maturation of 5.8S rRNA(GO:0000460) |
0.1 | 0.9 | GO:0035162 | embryonic hemopoiesis(GO:0035162) |
0.1 | 0.3 | GO:0010701 | positive regulation of norepinephrine secretion(GO:0010701) |
0.1 | 0.5 | GO:0002005 | angiotensin catabolic process in blood(GO:0002005) |
0.1 | 1.1 | GO:0043984 | histone H4-K16 acetylation(GO:0043984) |
0.1 | 1.1 | GO:0032008 | positive regulation of TOR signaling(GO:0032008) |
0.1 | 0.5 | GO:0009143 | nucleoside triphosphate catabolic process(GO:0009143) |
0.1 | 1.0 | GO:1902749 | regulation of G2/M transition of mitotic cell cycle(GO:0010389) regulation of cell cycle G2/M phase transition(GO:1902749) |
0.1 | 0.3 | GO:0042769 | DNA damage response, detection of DNA damage(GO:0042769) |
0.1 | 0.8 | GO:0033523 | histone monoubiquitination(GO:0010390) histone H2B ubiquitination(GO:0033523) |
0.1 | 1.1 | GO:0043968 | histone H2A acetylation(GO:0043968) |
0.1 | 0.3 | GO:0032203 | telomere formation via telomerase(GO:0032203) |
0.1 | 0.8 | GO:0032456 | endocytic recycling(GO:0032456) |
0.1 | 0.7 | GO:0008631 | intrinsic apoptotic signaling pathway in response to oxidative stress(GO:0008631) cell death in response to oxidative stress(GO:0036473) |
0.0 | 0.1 | GO:0021797 | forebrain anterior/posterior pattern specification(GO:0021797) |
0.0 | 0.1 | GO:0018283 | metal incorporation into metallo-sulfur cluster(GO:0018282) iron incorporation into metallo-sulfur cluster(GO:0018283) |
0.0 | 0.2 | GO:0009296 | obsolete flagellum assembly(GO:0009296) |
0.0 | 0.5 | GO:0007216 | G-protein coupled glutamate receptor signaling pathway(GO:0007216) |
0.0 | 0.3 | GO:0046898 | response to cycloheximide(GO:0046898) |
0.0 | 0.1 | GO:0007499 | ectoderm and mesoderm interaction(GO:0007499) |
0.0 | 0.2 | GO:0090231 | regulation of spindle checkpoint(GO:0090231) |
0.0 | 0.5 | GO:0045540 | regulation of cholesterol biosynthetic process(GO:0045540) |
0.0 | 1.0 | GO:0050766 | positive regulation of phagocytosis(GO:0050766) |
0.0 | 0.1 | GO:0006273 | DNA replication, synthesis of RNA primer(GO:0006269) lagging strand elongation(GO:0006273) |
0.0 | 0.6 | GO:0032784 | regulation of DNA-templated transcription, elongation(GO:0032784) |
0.0 | 0.7 | GO:0016254 | preassembly of GPI anchor in ER membrane(GO:0016254) |
0.0 | 0.9 | GO:0009954 | proximal/distal pattern formation(GO:0009954) |
0.0 | 1.3 | GO:0001756 | somitogenesis(GO:0001756) |
0.0 | 0.3 | GO:0050771 | negative regulation of axonogenesis(GO:0050771) |
0.0 | 0.1 | GO:0051973 | positive regulation of telomerase activity(GO:0051973) |
0.0 | 0.2 | GO:0021854 | hypothalamus development(GO:0021854) |
0.0 | 0.2 | GO:0007090 | obsolete regulation of S phase of mitotic cell cycle(GO:0007090) |
0.0 | 0.3 | GO:0000090 | mitotic anaphase(GO:0000090) |
0.0 | 0.2 | GO:0007021 | tubulin complex assembly(GO:0007021) acetylcholine transport(GO:0015870) acetate ester transport(GO:1901374) |
0.0 | 1.2 | GO:0006888 | ER to Golgi vesicle-mediated transport(GO:0006888) |
0.0 | 0.7 | GO:0046580 | negative regulation of Ras protein signal transduction(GO:0046580) |
0.0 | 0.1 | GO:0043247 | telomere capping(GO:0016233) protection from non-homologous end joining at telomere(GO:0031848) telomere maintenance in response to DNA damage(GO:0043247) |
0.0 | 0.4 | GO:0001954 | positive regulation of cell-matrix adhesion(GO:0001954) |
0.0 | 0.6 | GO:0017158 | regulation of calcium ion-dependent exocytosis(GO:0017158) |
0.0 | 0.1 | GO:0060662 | tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662) |
0.0 | 0.4 | GO:0007029 | endoplasmic reticulum organization(GO:0007029) |
0.0 | 0.4 | GO:0001502 | cartilage condensation(GO:0001502) cell aggregation(GO:0098743) |
0.0 | 0.4 | GO:0016572 | histone phosphorylation(GO:0016572) |
0.0 | 0.1 | GO:0071374 | cellular response to parathyroid hormone stimulus(GO:0071374) |
0.0 | 0.1 | GO:0043248 | proteasome assembly(GO:0043248) |
0.0 | 0.1 | GO:0060023 | soft palate development(GO:0060023) |
0.0 | 0.1 | GO:0006369 | termination of RNA polymerase II transcription(GO:0006369) |
0.0 | 0.3 | GO:0007628 | adult walking behavior(GO:0007628) walking behavior(GO:0090659) |
0.0 | 0.2 | GO:0001539 | cilium or flagellum-dependent cell motility(GO:0001539) |
0.0 | 0.0 | GO:0010881 | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion(GO:0010881) |
0.0 | 0.1 | GO:0035246 | peptidyl-arginine N-methylation(GO:0035246) |
0.0 | 0.7 | GO:0030520 | intracellular estrogen receptor signaling pathway(GO:0030520) |
0.0 | 0.1 | GO:0000042 | protein targeting to Golgi(GO:0000042) establishment of protein localization to Golgi(GO:0072600) |
0.0 | 3.0 | GO:0006470 | protein dephosphorylation(GO:0006470) |
0.0 | 0.1 | GO:0014820 | tonic smooth muscle contraction(GO:0014820) artery smooth muscle contraction(GO:0014824) |
0.0 | 1.2 | GO:0006521 | regulation of cellular amino acid metabolic process(GO:0006521) |
0.0 | 0.5 | GO:0000387 | spliceosomal snRNP assembly(GO:0000387) |
0.0 | 0.1 | GO:0002268 | follicular dendritic cell activation(GO:0002266) follicular dendritic cell differentiation(GO:0002268) |
0.0 | 1.2 | GO:0007229 | integrin-mediated signaling pathway(GO:0007229) |
0.0 | 0.4 | GO:0030239 | myofibril assembly(GO:0030239) |
0.0 | 0.2 | GO:0045444 | fat cell differentiation(GO:0045444) |
0.0 | 0.4 | GO:0006490 | dolichol-linked oligosaccharide biosynthetic process(GO:0006488) oligosaccharide-lipid intermediate biosynthetic process(GO:0006490) |
0.0 | 0.3 | GO:0048168 | regulation of neuronal synaptic plasticity(GO:0048168) |
0.0 | 0.0 | GO:0043923 | positive regulation by host of viral transcription(GO:0043923) |
0.0 | 0.7 | GO:0008033 | tRNA processing(GO:0008033) |
0.0 | 0.6 | GO:0051084 | 'de novo' posttranslational protein folding(GO:0051084) |
0.0 | 0.3 | GO:0016486 | peptide hormone processing(GO:0016486) |
0.0 | 0.4 | GO:0001570 | vasculogenesis(GO:0001570) |
0.0 | 0.5 | GO:0006636 | unsaturated fatty acid biosynthetic process(GO:0006636) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.4 | 1.8 | GO:0043240 | Fanconi anaemia nuclear complex(GO:0043240) |
0.4 | 1.9 | GO:0042405 | nuclear inclusion body(GO:0042405) |
0.3 | 4.0 | GO:0032059 | bleb(GO:0032059) |
0.3 | 1.1 | GO:0016939 | kinesin II complex(GO:0016939) |
0.3 | 3.6 | GO:0031527 | filopodium membrane(GO:0031527) |
0.2 | 4.6 | GO:0005861 | troponin complex(GO:0005861) |
0.2 | 0.8 | GO:0016593 | Cdc73/Paf1 complex(GO:0016593) |
0.2 | 0.9 | GO:0042599 | lamellar body(GO:0042599) |
0.2 | 1.1 | GO:0072487 | MSL complex(GO:0072487) |
0.1 | 0.8 | GO:0005828 | kinetochore microtubule(GO:0005828) |
0.1 | 1.7 | GO:0035267 | NuA4 histone acetyltransferase complex(GO:0035267) |
0.1 | 0.1 | GO:0030137 | COPI-coated vesicle(GO:0030137) |
0.1 | 0.9 | GO:0005833 | hemoglobin complex(GO:0005833) |
0.1 | 0.4 | GO:0051233 | spindle midzone(GO:0051233) |
0.1 | 1.4 | GO:0001772 | immunological synapse(GO:0001772) |
0.0 | 0.6 | GO:0005838 | proteasome regulatory particle(GO:0005838) |
0.0 | 0.1 | GO:0000806 | Y chromosome(GO:0000806) |
0.0 | 0.6 | GO:0035631 | CD40 receptor complex(GO:0035631) |
0.0 | 0.3 | GO:0033179 | proton-transporting V-type ATPase, V0 domain(GO:0033179) |
0.0 | 2.6 | GO:0008287 | protein serine/threonine phosphatase complex(GO:0008287) phosphatase complex(GO:1903293) |
0.0 | 0.8 | GO:0031105 | septin complex(GO:0031105) septin cytoskeleton(GO:0032156) |
0.0 | 1.6 | GO:0030175 | filopodium(GO:0030175) |
0.0 | 0.1 | GO:0000308 | cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308) |
0.0 | 0.8 | GO:0071564 | npBAF complex(GO:0071564) |
0.0 | 0.2 | GO:0031235 | intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235) |
0.0 | 0.2 | GO:0031512 | motile primary cilium(GO:0031512) |
0.0 | 0.7 | GO:0031231 | integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231) |
0.0 | 2.7 | GO:0005882 | intermediate filament(GO:0005882) |
0.0 | 0.8 | GO:0055038 | recycling endosome membrane(GO:0055038) |
0.0 | 1.2 | GO:0098636 | integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636) |
0.0 | 0.2 | GO:0042788 | polysomal ribosome(GO:0042788) |
0.0 | 0.1 | GO:0016600 | flotillin complex(GO:0016600) |
0.0 | 0.3 | GO:0030125 | clathrin vesicle coat(GO:0030125) |
0.0 | 0.5 | GO:0005689 | U12-type spliceosomal complex(GO:0005689) |
0.0 | 0.1 | GO:0033268 | node of Ranvier(GO:0033268) |
0.0 | 0.3 | GO:0005697 | telomerase holoenzyme complex(GO:0005697) |
0.0 | 0.2 | GO:0005858 | axonemal dynein complex(GO:0005858) axoneme part(GO:0044447) |
0.0 | 3.0 | GO:0031225 | anchored component of membrane(GO:0031225) |
0.0 | 0.1 | GO:0005954 | calcium- and calmodulin-dependent protein kinase complex(GO:0005954) |
0.0 | 0.1 | GO:0005658 | alpha DNA polymerase:primase complex(GO:0005658) |
0.0 | 0.2 | GO:0000242 | pericentriolar material(GO:0000242) |
0.0 | 0.4 | GO:0030140 | trans-Golgi network transport vesicle(GO:0030140) |
0.0 | 0.7 | GO:0030426 | growth cone(GO:0030426) |
0.0 | 0.0 | GO:0036452 | ESCRT III complex(GO:0000815) ESCRT complex(GO:0036452) |
0.0 | 0.4 | GO:0005796 | Golgi lumen(GO:0005796) |
0.0 | 0.1 | GO:0033257 | Bcl3/NF-kappaB2 complex(GO:0033257) |
0.0 | 0.1 | GO:0097610 | cell division site(GO:0032153) cleavage furrow(GO:0032154) cell division site part(GO:0032155) cell surface furrow(GO:0097610) |
0.0 | 0.6 | GO:0030672 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
0.0 | 0.3 | GO:0031201 | SNARE complex(GO:0031201) |
0.0 | 0.5 | GO:0032587 | ruffle membrane(GO:0032587) |
0.0 | 3.5 | GO:0030659 | cytoplasmic vesicle membrane(GO:0030659) |
0.0 | 0.2 | GO:0016234 | inclusion body(GO:0016234) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.3 | 4.6 | GO:0031014 | troponin T binding(GO:0031014) |
0.3 | 2.1 | GO:0001758 | retinal dehydrogenase activity(GO:0001758) |
0.2 | 0.9 | GO:0019870 | potassium channel inhibitor activity(GO:0019870) |
0.2 | 1.1 | GO:0051731 | polynucleotide 5'-hydroxyl-kinase activity(GO:0051731) |
0.2 | 4.2 | GO:0042974 | retinoic acid receptor binding(GO:0042974) |
0.1 | 1.5 | GO:0008140 | cAMP response element binding protein binding(GO:0008140) |
0.1 | 0.5 | GO:0016530 | metallochaperone activity(GO:0016530) |
0.1 | 0.5 | GO:0019103 | pyrimidine nucleotide binding(GO:0019103) |
0.1 | 0.8 | GO:0019237 | centromeric DNA binding(GO:0019237) |
0.1 | 0.5 | GO:0008241 | peptidyl-dipeptidase activity(GO:0008241) |
0.1 | 4.9 | GO:0005518 | collagen binding(GO:0005518) |
0.1 | 0.5 | GO:0031435 | mitogen-activated protein kinase kinase kinase binding(GO:0031435) |
0.1 | 0.7 | GO:0019826 | oxygen sensor activity(GO:0019826) |
0.1 | 1.8 | GO:0019894 | kinesin binding(GO:0019894) |
0.1 | 0.6 | GO:0016717 | oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water(GO:0016717) |
0.1 | 0.2 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
0.1 | 0.5 | GO:0004035 | alkaline phosphatase activity(GO:0004035) |
0.1 | 1.3 | GO:0030296 | protein tyrosine kinase activator activity(GO:0030296) |
0.1 | 0.7 | GO:0004157 | dihydropyrimidinase activity(GO:0004157) |
0.1 | 0.7 | GO:0017176 | phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176) |
0.1 | 0.9 | GO:0005344 | oxygen transporter activity(GO:0005344) |
0.1 | 2.5 | GO:0004003 | ATP-dependent DNA helicase activity(GO:0004003) |
0.1 | 0.2 | GO:0042808 | obsolete neuronal Cdc2-like kinase binding(GO:0042808) |
0.1 | 0.7 | GO:0004526 | ribonuclease P activity(GO:0004526) |
0.1 | 0.3 | GO:0003960 | NADPH:quinone reductase activity(GO:0003960) |
0.1 | 0.3 | GO:0005000 | vasopressin receptor activity(GO:0005000) |
0.1 | 1.1 | GO:0004383 | guanylate cyclase activity(GO:0004383) |
0.1 | 1.6 | GO:0035064 | methylated histone binding(GO:0035064) |
0.1 | 0.6 | GO:0035251 | UDP-glucosyltransferase activity(GO:0035251) |
0.0 | 4.6 | GO:0008307 | structural constituent of muscle(GO:0008307) |
0.0 | 0.6 | GO:0001727 | lipid kinase activity(GO:0001727) |
0.0 | 0.3 | GO:0004791 | thioredoxin-disulfide reductase activity(GO:0004791) |
0.0 | 0.6 | GO:0003711 | obsolete transcription elongation regulator activity(GO:0003711) |
0.0 | 0.4 | GO:0005094 | Rho GDP-dissociation inhibitor activity(GO:0005094) |
0.0 | 0.4 | GO:0005114 | type II transforming growth factor beta receptor binding(GO:0005114) |
0.0 | 0.3 | GO:0008553 | hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553) |
0.0 | 0.4 | GO:0001968 | fibronectin binding(GO:0001968) laminin binding(GO:0043236) |
0.0 | 1.0 | GO:0004697 | protein kinase C activity(GO:0004697) |
0.0 | 0.3 | GO:0000293 | ferric-chelate reductase activity(GO:0000293) |
0.0 | 0.5 | GO:0008641 | small protein activating enzyme activity(GO:0008641) |
0.0 | 0.3 | GO:0019966 | interleukin-1 binding(GO:0019966) |
0.0 | 0.1 | GO:0003896 | DNA primase activity(GO:0003896) |
0.0 | 0.1 | GO:0035242 | protein-arginine omega-N asymmetric methyltransferase activity(GO:0035242) |
0.0 | 0.1 | GO:0048256 | flap endonuclease activity(GO:0048256) |
0.0 | 0.7 | GO:0005109 | frizzled binding(GO:0005109) |
0.0 | 0.1 | GO:0008409 | 5'-3' exonuclease activity(GO:0008409) |
0.0 | 0.1 | GO:0061133 | endopeptidase activator activity(GO:0061133) |
0.0 | 0.2 | GO:0000217 | DNA secondary structure binding(GO:0000217) |
0.0 | 0.2 | GO:0015385 | sodium:proton antiporter activity(GO:0015385) |
0.0 | 1.6 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
0.0 | 0.3 | GO:0008266 | poly(U) RNA binding(GO:0008266) |
0.0 | 0.4 | GO:0043014 | alpha-tubulin binding(GO:0043014) |
0.0 | 0.1 | GO:0008384 | IkappaB kinase activity(GO:0008384) |
0.0 | 0.1 | GO:0032558 | purine deoxyribonucleotide binding(GO:0032554) adenyl deoxyribonucleotide binding(GO:0032558) |
0.0 | 0.3 | GO:0005522 | profilin binding(GO:0005522) |
0.0 | 0.7 | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity(GO:0008138) |
0.0 | 0.6 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
0.0 | 0.1 | GO:0004797 | thymidine kinase activity(GO:0004797) |
0.0 | 0.0 | GO:0003691 | double-stranded telomeric DNA binding(GO:0003691) |
0.0 | 0.2 | GO:0050840 | extracellular matrix binding(GO:0050840) |
0.0 | 0.7 | GO:0097472 | cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472) |
0.0 | 0.0 | GO:0034236 | protein kinase A catalytic subunit binding(GO:0034236) |
0.0 | 0.0 | GO:0003858 | 3-hydroxybutyrate dehydrogenase activity(GO:0003858) |
0.0 | 0.4 | GO:0005523 | tropomyosin binding(GO:0005523) |
0.0 | 0.1 | GO:0001849 | complement component C1q binding(GO:0001849) |
0.0 | 0.1 | GO:0031708 | bombesin receptor binding(GO:0031705) endothelin B receptor binding(GO:0031708) |
0.0 | 3.4 | GO:0008022 | protein C-terminus binding(GO:0008022) |
0.0 | 0.2 | GO:0004089 | carbonate dehydratase activity(GO:0004089) |
0.0 | 3.9 | GO:0003924 | GTPase activity(GO:0003924) |
0.0 | 0.2 | GO:0042605 | peptide antigen binding(GO:0042605) |
0.0 | 0.6 | GO:0008375 | acetylglucosaminyltransferase activity(GO:0008375) |
0.0 | 0.2 | GO:0043499 | obsolete eukaryotic cell surface binding(GO:0043499) |
0.0 | 0.8 | GO:0003743 | translation initiation factor activity(GO:0003743) |
0.0 | 0.2 | GO:0004683 | calmodulin-dependent protein kinase activity(GO:0004683) |
0.0 | 0.1 | GO:0005030 | neurotrophin receptor activity(GO:0005030) |
0.0 | 0.3 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.0 | 0.9 | SA_MMP_CYTOKINE_CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
0.0 | 0.3 | SA_PROGRAMMED_CELL_DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |