Motif ID: RARA
Z-value: 1.446
Transcription factors associated with RARA:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
RARA | ENSG00000131759.13 | RARA |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.3 | 5.1 | GO:0002689 | negative regulation of leukocyte chemotaxis(GO:0002689) |
1.0 | 6.9 | GO:2000111 | positive regulation of macrophage apoptotic process(GO:2000111) |
0.9 | 2.7 | GO:0060340 | pericardium morphogenesis(GO:0003344) optic cup formation involved in camera-type eye development(GO:0003408) diencephalon morphogenesis(GO:0048852) positive regulation of type I interferon-mediated signaling pathway(GO:0060340) lateral sprouting involved in mammary gland duct morphogenesis(GO:0060599) |
0.8 | 2.4 | GO:0002541 | activation of plasma proteins involved in acute inflammatory response(GO:0002541) |
0.4 | 1.7 | GO:0006701 | progesterone biosynthetic process(GO:0006701) |
0.3 | 1.0 | GO:0006348 | chromatin silencing at telomere(GO:0006348) |
0.3 | 0.9 | GO:0034036 | purine ribonucleoside bisphosphate biosynthetic process(GO:0034036) 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process(GO:0050428) |
0.3 | 1.3 | GO:0019471 | peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) 4-hydroxyproline metabolic process(GO:0019471) peptidyl-proline hydroxylation(GO:0019511) |
0.2 | 0.9 | GO:0050653 | chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0050653) |
0.2 | 1.2 | GO:0021520 | spinal cord motor neuron cell fate specification(GO:0021520) |
0.2 | 1.1 | GO:1901881 | positive regulation of protein depolymerization(GO:1901881) |
0.2 | 0.5 | GO:0010891 | negative regulation of sequestering of triglyceride(GO:0010891) |
0.1 | 1.5 | GO:0051014 | actin filament severing(GO:0051014) |
0.1 | 0.4 | GO:0071639 | positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559) positive regulation of monocyte chemotactic protein-1 production(GO:0071639) |
0.1 | 0.4 | GO:0042511 | positive regulation of tyrosine phosphorylation of Stat1 protein(GO:0042511) leukemia inhibitory factor signaling pathway(GO:0048861) |
0.1 | 1.1 | GO:0060665 | regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665) |
0.1 | 0.4 | GO:0010248 | establishment or maintenance of transmembrane electrochemical gradient(GO:0010248) |
0.1 | 2.0 | GO:0032456 | endocytic recycling(GO:0032456) |
0.1 | 0.4 | GO:0007403 | glial cell fate determination(GO:0007403) |
0.1 | 0.8 | GO:0034616 | response to laminar fluid shear stress(GO:0034616) |
0.1 | 0.7 | GO:0030186 | melatonin metabolic process(GO:0030186) melatonin biosynthetic process(GO:0030187) |
0.1 | 1.2 | GO:0014912 | negative regulation of smooth muscle cell migration(GO:0014912) |
0.1 | 0.3 | GO:0046495 | nicotinamide riboside catabolic process(GO:0006738) nicotinamide riboside metabolic process(GO:0046495) pyridine nucleoside metabolic process(GO:0070637) pyridine nucleoside catabolic process(GO:0070638) |
0.1 | 0.7 | GO:0033539 | fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539) |
0.1 | 0.8 | GO:0040037 | negative regulation of fibroblast growth factor receptor signaling pathway(GO:0040037) |
0.1 | 0.4 | GO:0006104 | succinyl-CoA metabolic process(GO:0006104) uroporphyrinogen III biosynthetic process(GO:0006780) |
0.1 | 2.4 | GO:0045103 | intermediate filament-based process(GO:0045103) |
0.1 | 0.5 | GO:0060242 | contact inhibition(GO:0060242) |
0.1 | 1.3 | GO:0050872 | white fat cell differentiation(GO:0050872) |
0.1 | 0.3 | GO:0071374 | cellular response to parathyroid hormone stimulus(GO:0071374) |
0.1 | 1.3 | GO:0042749 | regulation of circadian sleep/wake cycle(GO:0042749) regulation of circadian sleep/wake cycle, sleep(GO:0045187) |
0.1 | 0.4 | GO:0033145 | positive regulation of intracellular steroid hormone receptor signaling pathway(GO:0033145) |
0.1 | 0.1 | GO:2000309 | tumor necrosis factor (ligand) superfamily member 11 production(GO:0072535) regulation of tumor necrosis factor (ligand) superfamily member 11 production(GO:2000307) positive regulation of tumor necrosis factor (ligand) superfamily member 11 production(GO:2000309) |
0.1 | 0.4 | GO:0014819 | regulation of skeletal muscle contraction(GO:0014819) |
0.1 | 0.2 | GO:1903115 | regulation of muscle filament sliding(GO:0032971) regulation of actin filament-based movement(GO:1903115) |
0.1 | 0.5 | GO:0042989 | sequestering of actin monomers(GO:0042989) |
0.1 | 1.4 | GO:0035115 | embryonic forelimb morphogenesis(GO:0035115) |
0.1 | 0.4 | GO:0015014 | heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014) |
0.1 | 0.4 | GO:0042753 | positive regulation of circadian rhythm(GO:0042753) |
0.1 | 0.2 | GO:0017014 | protein nitrosylation(GO:0017014) peptidyl-cysteine S-nitrosylation(GO:0018119) |
0.1 | 0.2 | GO:0070527 | platelet aggregation(GO:0070527) |
0.1 | 0.2 | GO:0006530 | asparagine catabolic process(GO:0006530) asparagine catabolic process via L-aspartate(GO:0033345) |
0.1 | 0.2 | GO:0045719 | negative regulation of glycogen biosynthetic process(GO:0045719) |
0.1 | 0.5 | GO:0007217 | tachykinin receptor signaling pathway(GO:0007217) |
0.1 | 0.5 | GO:0021513 | spinal cord dorsal/ventral patterning(GO:0021513) |
0.0 | 0.1 | GO:0031558 | obsolete induction of apoptosis in response to chemical stimulus(GO:0031558) determination of dorsal/ventral asymmetry(GO:0048262) determination of dorsal identity(GO:0048263) |
0.0 | 1.4 | GO:0002040 | sprouting angiogenesis(GO:0002040) |
0.0 | 0.1 | GO:0032581 | ER-dependent peroxisome organization(GO:0032581) |
0.0 | 0.1 | GO:0060363 | cranial suture morphogenesis(GO:0060363) craniofacial suture morphogenesis(GO:0097094) |
0.0 | 0.2 | GO:0006668 | sphinganine-1-phosphate metabolic process(GO:0006668) |
0.0 | 0.2 | GO:0000394 | RNA splicing, via endonucleolytic cleavage and ligation(GO:0000394) tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388) |
0.0 | 0.6 | GO:0071230 | positive regulation of TOR signaling(GO:0032008) cellular response to amino acid stimulus(GO:0071230) |
0.0 | 0.2 | GO:0006007 | glucose catabolic process(GO:0006007) |
0.0 | 0.2 | GO:0001941 | postsynaptic membrane organization(GO:0001941) |
0.0 | 0.2 | GO:0009298 | GDP-mannose biosynthetic process(GO:0009298) |
0.0 | 0.2 | GO:0015904 | tetracycline transport(GO:0015904) |
0.0 | 0.5 | GO:0008635 | activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c(GO:0008635) |
0.0 | 0.7 | GO:0002474 | antigen processing and presentation of peptide antigen via MHC class I(GO:0002474) |
0.0 | 0.2 | GO:0043243 | translational frameshifting(GO:0006452) positive regulation of protein complex disassembly(GO:0043243) positive regulation of translational elongation(GO:0045901) positive regulation of translational termination(GO:0045905) |
0.0 | 0.1 | GO:0007285 | primary spermatocyte growth(GO:0007285) |
0.0 | 0.4 | GO:0007253 | cytoplasmic sequestering of NF-kappaB(GO:0007253) |
0.0 | 0.2 | GO:0009313 | oligosaccharide catabolic process(GO:0009313) |
0.0 | 0.1 | GO:0043249 | erythrocyte maturation(GO:0043249) |
0.0 | 4.5 | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043123) |
0.0 | 0.7 | GO:0018149 | peptide cross-linking(GO:0018149) |
0.0 | 0.6 | GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) |
0.0 | 0.4 | GO:0030511 | positive regulation of transforming growth factor beta receptor signaling pathway(GO:0030511) positive regulation of cellular response to transforming growth factor beta stimulus(GO:1903846) |
0.0 | 0.8 | GO:0042384 | cilium assembly(GO:0042384) |
0.0 | 0.1 | GO:0042518 | negative regulation of tyrosine phosphorylation of Stat3 protein(GO:0042518) |
0.0 | 1.4 | GO:0000910 | cytokinesis(GO:0000910) |
0.0 | 1.5 | GO:0019722 | calcium-mediated signaling(GO:0019722) |
0.0 | 0.1 | GO:0046487 | glyoxylate metabolic process(GO:0046487) |
0.0 | 0.1 | GO:0045116 | protein neddylation(GO:0045116) |
0.0 | 0.1 | GO:0006572 | tyrosine catabolic process(GO:0006572) |
0.0 | 0.4 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
0.0 | 0.1 | GO:0016075 | rRNA catabolic process(GO:0016075) |
0.0 | 0.0 | GO:0072369 | regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter(GO:0072369) |
0.0 | 0.2 | GO:0006004 | fucose metabolic process(GO:0006004) |
0.0 | 0.5 | GO:0042059 | negative regulation of epidermal growth factor receptor signaling pathway(GO:0042059) negative regulation of ERBB signaling pathway(GO:1901185) |
0.0 | 2.9 | GO:0006184 | obsolete GTP catabolic process(GO:0006184) |
0.0 | 0.3 | GO:0001662 | behavioral fear response(GO:0001662) |
0.0 | 0.5 | GO:1900181 | negative regulation of protein import into nucleus(GO:0042308) negative regulation of protein localization to nucleus(GO:1900181) negative regulation of protein import(GO:1904590) |
0.0 | 0.1 | GO:0002281 | macrophage activation involved in immune response(GO:0002281) |
0.0 | 0.5 | GO:0042594 | response to starvation(GO:0042594) |
0.0 | 0.2 | GO:0006911 | phagocytosis, engulfment(GO:0006911) membrane invagination(GO:0010324) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.2 | 2.4 | GO:0031233 | intrinsic component of external side of plasma membrane(GO:0031233) |
0.2 | 1.2 | GO:0019907 | cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907) |
0.1 | 0.4 | GO:0001650 | fibrillar center(GO:0001650) |
0.1 | 0.4 | GO:0005900 | oncostatin-M receptor complex(GO:0005900) |
0.1 | 1.2 | GO:0016942 | insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454) |
0.1 | 1.0 | GO:0005677 | chromatin silencing complex(GO:0005677) |
0.1 | 0.7 | GO:0031305 | integral component of mitochondrial inner membrane(GO:0031305) |
0.1 | 1.4 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
0.1 | 0.2 | GO:0031091 | platelet alpha granule(GO:0031091) |
0.1 | 0.8 | GO:0034464 | BBSome(GO:0034464) |
0.1 | 0.7 | GO:0005916 | fascia adherens(GO:0005916) |
0.1 | 0.4 | GO:0032311 | angiogenin-PRI complex(GO:0032311) |
0.1 | 0.6 | GO:0031430 | M band(GO:0031430) |
0.0 | 0.1 | GO:0071065 | alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex(GO:0071065) |
0.0 | 0.1 | GO:0005826 | actomyosin contractile ring(GO:0005826) |
0.0 | 0.2 | GO:0005889 | hydrogen:potassium-exchanging ATPase complex(GO:0005889) |
0.0 | 0.2 | GO:0000214 | tRNA-intron endonuclease complex(GO:0000214) |
0.0 | 0.6 | GO:0005868 | cytoplasmic dynein complex(GO:0005868) |
0.0 | 3.4 | GO:0005882 | intermediate filament(GO:0005882) |
0.0 | 1.9 | GO:0030175 | filopodium(GO:0030175) |
0.0 | 1.4 | GO:0005791 | rough endoplasmic reticulum(GO:0005791) |
0.0 | 0.2 | GO:0005642 | annulate lamellae(GO:0005642) |
0.0 | 0.4 | GO:0005697 | telomerase holoenzyme complex(GO:0005697) |
0.0 | 0.4 | GO:0005606 | laminin-1 complex(GO:0005606) |
0.0 | 0.7 | GO:0042612 | MHC class I protein complex(GO:0042612) |
0.0 | 0.8 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
0.0 | 0.4 | GO:0046930 | pore complex(GO:0046930) |
0.0 | 0.1 | GO:0008537 | proteasome activator complex(GO:0008537) |
0.0 | 0.2 | GO:0005853 | eukaryotic translation elongation factor 1 complex(GO:0005853) |
0.0 | 0.9 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
0.0 | 0.5 | GO:0005811 | lipid particle(GO:0005811) |
0.0 | 0.4 | GO:0030131 | clathrin adaptor complex(GO:0030131) |
0.0 | 0.4 | GO:0016592 | mediator complex(GO:0016592) |
0.0 | 1.1 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
0.0 | 3.7 | GO:0016604 | nuclear body(GO:0016604) |
0.0 | 0.9 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
0.0 | 0.2 | GO:0030132 | clathrin coat of coated pit(GO:0030132) |
0.0 | 5.8 | GO:0009986 | cell surface(GO:0009986) |
0.0 | 0.3 | GO:0031594 | neuromuscular junction(GO:0031594) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.0 | 6.9 | GO:0055105 | ubiquitin-protein transferase inhibitor activity(GO:0055105) |
0.4 | 1.1 | GO:0019215 | intermediate filament binding(GO:0019215) |
0.4 | 1.4 | GO:0004667 | prostaglandin-D synthase activity(GO:0004667) |
0.3 | 2.7 | GO:0005110 | frizzled-2 binding(GO:0005110) |
0.3 | 0.9 | GO:0004781 | adenylylsulfate kinase activity(GO:0004020) sulfate adenylyltransferase activity(GO:0004779) sulfate adenylyltransferase (ATP) activity(GO:0004781) |
0.3 | 1.2 | GO:0008160 | protein tyrosine phosphatase activator activity(GO:0008160) protein phosphatase activator activity(GO:0072542) |
0.3 | 1.3 | GO:0004656 | procollagen-proline 4-dioxygenase activity(GO:0004656) peptidyl-proline 4-dioxygenase activity(GO:0031545) |
0.3 | 1.0 | GO:0042903 | tubulin deacetylase activity(GO:0042903) |
0.2 | 0.9 | GO:0047237 | glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047237) |
0.2 | 0.7 | GO:0048039 | ubiquinone binding(GO:0048039) |
0.1 | 0.4 | GO:0019981 | interleukin-6 receptor activity(GO:0004915) oncostatin-M receptor activity(GO:0004924) ciliary neurotrophic factor receptor binding(GO:0005127) interleukin-6 binding(GO:0019981) interleukin-17 receptor activity(GO:0030368) |
0.1 | 0.7 | GO:0017096 | acetylserotonin O-methyltransferase activity(GO:0017096) |
0.1 | 0.5 | GO:0050265 | RNA uridylyltransferase activity(GO:0050265) |
0.1 | 0.3 | GO:0004731 | purine-nucleoside phosphorylase activity(GO:0004731) |
0.1 | 1.4 | GO:0019841 | retinol binding(GO:0019841) |
0.1 | 0.4 | GO:0043398 | HLH domain binding(GO:0043398) |
0.1 | 1.5 | GO:0030346 | protein phosphatase 2B binding(GO:0030346) |
0.1 | 0.4 | GO:0008428 | ribonuclease inhibitor activity(GO:0008428) |
0.1 | 0.4 | GO:0042328 | heparan sulfate N-acetylglucosaminyltransferase activity(GO:0042328) N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity(GO:0050509) |
0.1 | 1.6 | GO:0043014 | alpha-tubulin binding(GO:0043014) |
0.1 | 0.4 | GO:0051434 | BH3 domain binding(GO:0051434) |
0.1 | 0.4 | GO:0004775 | succinate-CoA ligase (ADP-forming) activity(GO:0004775) |
0.1 | 0.5 | GO:0004703 | G-protein coupled receptor kinase activity(GO:0004703) |
0.1 | 1.6 | GO:0043498 | obsolete cell surface binding(GO:0043498) |
0.1 | 0.4 | GO:0048406 | nerve growth factor binding(GO:0048406) |
0.1 | 0.5 | GO:0080025 | phosphatidylinositol-3,5-bisphosphate binding(GO:0080025) |
0.1 | 0.2 | GO:0043891 | glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891) |
0.1 | 0.7 | GO:0004862 | cAMP-dependent protein kinase inhibitor activity(GO:0004862) |
0.1 | 0.8 | GO:0004065 | arylsulfatase activity(GO:0004065) |
0.1 | 0.2 | GO:0000213 | tRNA-intron endonuclease activity(GO:0000213) |
0.1 | 0.2 | GO:0004802 | transketolase activity(GO:0004802) |
0.0 | 0.3 | GO:0004800 | thyroxine 5'-deiodinase activity(GO:0004800) |
0.0 | 0.2 | GO:0003945 | N-acetyllactosamine synthase activity(GO:0003945) |
0.0 | 0.7 | GO:0032393 | MHC class I receptor activity(GO:0032393) |
0.0 | 0.3 | GO:0001515 | opioid peptide activity(GO:0001515) |
0.0 | 0.4 | GO:0004861 | cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861) |
0.0 | 1.2 | GO:0050699 | WW domain binding(GO:0050699) |
0.0 | 0.4 | GO:0005149 | interleukin-1 receptor binding(GO:0005149) |
0.0 | 0.5 | GO:0003841 | 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) lysophosphatidic acid acyltransferase activity(GO:0042171) lysophospholipid acyltransferase activity(GO:0071617) |
0.0 | 0.1 | GO:0004607 | phosphatidylcholine-sterol O-acyltransferase activity(GO:0004607) |
0.0 | 0.2 | GO:0008493 | tetracycline transporter activity(GO:0008493) |
0.0 | 0.1 | GO:0019788 | NEDD8 transferase activity(GO:0019788) |
0.0 | 0.2 | GO:0004528 | phosphodiesterase I activity(GO:0004528) 3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656) |
0.0 | 0.1 | GO:0016909 | JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909) |
0.0 | 0.5 | GO:0070064 | proline-rich region binding(GO:0070064) |
0.0 | 0.2 | GO:0004157 | dihydropyrimidinase activity(GO:0004157) |
0.0 | 5.4 | GO:0005125 | cytokine activity(GO:0005125) |
0.0 | 0.2 | GO:0042392 | sphingosine-1-phosphate phosphatase activity(GO:0042392) |
0.0 | 0.2 | GO:0031013 | troponin I binding(GO:0031013) |
0.0 | 2.7 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
0.0 | 1.4 | GO:0051287 | NAD binding(GO:0051287) |
0.0 | 1.1 | GO:0016504 | peptidase activator activity(GO:0016504) |
0.0 | 0.2 | GO:0004563 | beta-N-acetylhexosaminidase activity(GO:0004563) |
0.0 | 0.3 | GO:0015271 | outward rectifier potassium channel activity(GO:0015271) |
0.0 | 2.1 | GO:0031072 | heat shock protein binding(GO:0031072) |
0.0 | 0.1 | GO:0005112 | Notch binding(GO:0005112) |
0.0 | 0.3 | GO:0016888 | endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888) |
0.0 | 0.6 | GO:0015035 | protein disulfide oxidoreductase activity(GO:0015035) |
0.0 | 0.1 | GO:0001965 | G-protein alpha-subunit binding(GO:0001965) |
0.0 | 0.2 | GO:0017070 | U6 snRNA binding(GO:0017070) |
0.0 | 0.4 | GO:0042162 | telomeric DNA binding(GO:0042162) |
0.0 | 0.4 | GO:0001104 | RNA polymerase II transcription cofactor activity(GO:0001104) |
0.0 | 0.1 | GO:0008271 | secondary active sulfate transmembrane transporter activity(GO:0008271) |
0.0 | 0.0 | GO:0005047 | signal recognition particle binding(GO:0005047) |
0.0 | 4.4 | GO:0003924 | GTPase activity(GO:0003924) |
0.0 | 0.2 | GO:0016868 | intramolecular transferase activity, phosphotransferases(GO:0016868) |
0.0 | 0.3 | GO:0043621 | protein self-association(GO:0043621) |
0.0 | 0.1 | GO:0033691 | sialic acid binding(GO:0033691) |
0.0 | 1.4 | GO:0016616 | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor(GO:0016616) |
0.0 | 0.2 | GO:0008417 | fucosyltransferase activity(GO:0008417) |
0.0 | 0.2 | GO:0004383 | guanylate cyclase activity(GO:0004383) |
0.0 | 0.2 | GO:0042166 | acetylcholine binding(GO:0042166) |
0.0 | 1.2 | GO:0001664 | G-protein coupled receptor binding(GO:0001664) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.3 | 6.9 | SA_REG_CASCADE_OF_CYCLIN_EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
0.0 | 0.6 | SA_CASPASE_CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
0.0 | 0.3 | SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES | Genes related to regulation of the actin cytoskeleton |