Motif ID: REL
Z-value: 1.586
Transcription factors associated with REL:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| REL | ENSG00000162924.9 | REL |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 6.7 | GO:0006927 | obsolete transformed cell apoptotic process(GO:0006927) |
| 1.2 | 3.7 | GO:0034135 | regulation of toll-like receptor 2 signaling pathway(GO:0034135) |
| 0.7 | 2.9 | GO:0090161 | Golgi ribbon formation(GO:0090161) |
| 0.7 | 2.7 | GO:1904037 | positive regulation of epithelial cell apoptotic process(GO:1904037) positive regulation of endothelial cell apoptotic process(GO:2000353) |
| 0.5 | 1.6 | GO:0019886 | antigen processing and presentation of exogenous peptide antigen via MHC class II(GO:0019886) |
| 0.4 | 2.5 | GO:0007499 | ectoderm and mesoderm interaction(GO:0007499) |
| 0.4 | 0.8 | GO:0060557 | positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559) |
| 0.4 | 1.1 | GO:0051097 | negative regulation of helicase activity(GO:0051097) |
| 0.3 | 2.5 | GO:0045071 | negative regulation of viral genome replication(GO:0045071) |
| 0.3 | 1.1 | GO:0002689 | negative regulation of leukocyte chemotaxis(GO:0002689) |
| 0.2 | 0.7 | GO:0034036 | purine ribonucleoside bisphosphate biosynthetic process(GO:0034036) 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process(GO:0050428) |
| 0.2 | 1.4 | GO:0042483 | negative regulation of odontogenesis(GO:0042483) |
| 0.2 | 0.8 | GO:0002268 | follicular dendritic cell activation(GO:0002266) follicular dendritic cell differentiation(GO:0002268) |
| 0.2 | 5.0 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.2 | 0.7 | GO:0046967 | cytosol to ER transport(GO:0046967) |
| 0.1 | 0.4 | GO:0043371 | negative regulation of CD4-positive, alpha-beta T cell differentiation(GO:0043371) negative regulation of T-helper cell differentiation(GO:0045623) negative regulation of CD4-positive, alpha-beta T cell activation(GO:2000515) |
| 0.1 | 1.3 | GO:0045078 | positive regulation of interferon-gamma biosynthetic process(GO:0045078) |
| 0.1 | 0.5 | GO:0070842 | aggresome assembly(GO:0070842) |
| 0.1 | 0.4 | GO:0042511 | positive regulation of tyrosine phosphorylation of Stat1 protein(GO:0042511) leukemia inhibitory factor signaling pathway(GO:0048861) |
| 0.1 | 3.7 | GO:0060334 | regulation of response to interferon-gamma(GO:0060330) regulation of interferon-gamma-mediated signaling pathway(GO:0060334) |
| 0.1 | 0.4 | GO:0070427 | cytoplasmic pattern recognition receptor signaling pathway(GO:0002753) nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway(GO:0035872) nucleotide-binding oligomerization domain containing signaling pathway(GO:0070423) nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070427) nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070431) |
| 0.1 | 0.2 | GO:0045350 | interferon-beta biosynthetic process(GO:0045350) regulation of interferon-beta biosynthetic process(GO:0045357) positive regulation of interferon-beta biosynthetic process(GO:0045359) |
| 0.1 | 0.8 | GO:0051894 | positive regulation of focal adhesion assembly(GO:0051894) positive regulation of cell junction assembly(GO:1901890) positive regulation of adherens junction organization(GO:1903393) |
| 0.1 | 2.4 | GO:0002474 | antigen processing and presentation of peptide antigen via MHC class I(GO:0002474) |
| 0.1 | 1.6 | GO:0060638 | mesenchymal-epithelial cell signaling(GO:0060638) |
| 0.1 | 0.3 | GO:0006348 | chromatin silencing at telomere(GO:0006348) |
| 0.1 | 0.3 | GO:0030812 | negative regulation of nucleotide catabolic process(GO:0030812) |
| 0.1 | 0.6 | GO:0000185 | activation of MAPKKK activity(GO:0000185) |
| 0.1 | 0.4 | GO:0007221 | positive regulation of transcription of Notch receptor target(GO:0007221) |
| 0.1 | 0.6 | GO:0045084 | positive regulation of interleukin-12 biosynthetic process(GO:0045084) |
| 0.1 | 0.6 | GO:0006983 | ER overload response(GO:0006983) |
| 0.1 | 0.7 | GO:0015074 | DNA integration(GO:0015074) |
| 0.1 | 0.5 | GO:0044413 | evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834) |
| 0.1 | 0.5 | GO:0040037 | negative regulation of fibroblast growth factor receptor signaling pathway(GO:0040037) |
| 0.0 | 0.1 | GO:0060318 | CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0002361) definitive erythrocyte differentiation(GO:0060318) |
| 0.0 | 0.3 | GO:0006196 | AMP catabolic process(GO:0006196) |
| 0.0 | 0.2 | GO:0031033 | positive regulation of lamellipodium assembly(GO:0010592) myosin filament organization(GO:0031033) positive regulation of lamellipodium organization(GO:1902745) |
| 0.0 | 0.3 | GO:0010002 | cardioblast differentiation(GO:0010002) |
| 0.0 | 0.3 | GO:0007185 | transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185) |
| 0.0 | 1.2 | GO:0018208 | peptidyl-proline modification(GO:0018208) |
| 0.0 | 3.5 | GO:0051291 | protein heterooligomerization(GO:0051291) |
| 0.0 | 0.2 | GO:0032329 | serine transport(GO:0032329) |
| 0.0 | 0.5 | GO:0016540 | protein autoprocessing(GO:0016540) |
| 0.0 | 0.2 | GO:0048302 | isotype switching to IgG isotypes(GO:0048291) regulation of isotype switching to IgG isotypes(GO:0048302) |
| 0.0 | 0.1 | GO:0048262 | determination of dorsal/ventral asymmetry(GO:0048262) determination of dorsal identity(GO:0048263) |
| 0.0 | 0.9 | GO:0008347 | glial cell migration(GO:0008347) |
| 0.0 | 1.0 | GO:0090003 | regulation of establishment of protein localization to plasma membrane(GO:0090003) regulation of protein localization to plasma membrane(GO:1903076) regulation of protein localization to cell periphery(GO:1904375) |
| 0.0 | 0.2 | GO:0009313 | oligosaccharide catabolic process(GO:0009313) |
| 0.0 | 1.3 | GO:0045445 | myoblast differentiation(GO:0045445) |
| 0.0 | 0.2 | GO:0051294 | establishment of mitotic spindle orientation(GO:0000132) establishment of spindle orientation(GO:0051294) |
| 0.0 | 0.1 | GO:0070254 | mucus secretion(GO:0070254) |
| 0.0 | 1.0 | GO:0048286 | lung alveolus development(GO:0048286) |
| 0.0 | 0.4 | GO:0046697 | decidualization(GO:0046697) cellular response to cAMP(GO:0071320) |
| 0.0 | 0.2 | GO:0097384 | cellular lipid biosynthetic process(GO:0097384) |
| 0.0 | 0.1 | GO:0035024 | negative regulation of Rho protein signal transduction(GO:0035024) |
| 0.0 | 0.5 | GO:0033540 | fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540) |
| 0.0 | 2.1 | GO:0016358 | dendrite development(GO:0016358) |
| 0.0 | 0.2 | GO:0035964 | COPI-coated vesicle budding(GO:0035964) Golgi vesicle budding(GO:0048194) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205) |
| 0.0 | 0.1 | GO:0060737 | prostate epithelial cord elongation(GO:0060523) prostate gland morphogenetic growth(GO:0060737) |
| 0.0 | 0.3 | GO:0042273 | ribosomal large subunit biogenesis(GO:0042273) |
| 0.0 | 0.4 | GO:0007620 | copulation(GO:0007620) |
| 0.0 | 1.3 | GO:0031668 | cellular response to extracellular stimulus(GO:0031668) |
| 0.0 | 0.3 | GO:0031529 | ruffle organization(GO:0031529) |
| 0.0 | 0.6 | GO:0000188 | inactivation of MAPK activity(GO:0000188) |
| 0.0 | 0.4 | GO:0030866 | cortical actin cytoskeleton organization(GO:0030866) |
| 0.0 | 0.9 | GO:0032480 | negative regulation of type I interferon production(GO:0032480) |
| 0.0 | 0.1 | GO:0006776 | vitamin A metabolic process(GO:0006776) |
| 0.0 | 0.4 | GO:0006892 | post-Golgi vesicle-mediated transport(GO:0006892) |
| 0.0 | 1.0 | GO:0006521 | regulation of cellular amino acid metabolic process(GO:0006521) |
| 0.0 | 0.1 | GO:0060122 | auditory receptor cell morphogenesis(GO:0002093) auditory receptor cell stereocilium organization(GO:0060088) inner ear receptor stereocilium organization(GO:0060122) |
| 0.0 | 0.2 | GO:0009790 | embryo development(GO:0009790) |
| 0.0 | 0.3 | GO:0045103 | intermediate filament-based process(GO:0045103) |
| 0.0 | 0.1 | GO:0006880 | intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 6.7 | GO:0031265 | CD95 death-inducing signaling complex(GO:0031265) |
| 0.3 | 0.9 | GO:0005610 | laminin-5 complex(GO:0005610) |
| 0.3 | 4.2 | GO:0005606 | laminin-1 complex(GO:0005606) |
| 0.2 | 0.8 | GO:0033257 | Bcl3/NF-kappaB2 complex(GO:0033257) |
| 0.1 | 0.6 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
| 0.1 | 0.4 | GO:0005900 | oncostatin-M receptor complex(GO:0005900) |
| 0.1 | 1.8 | GO:0035631 | CD40 receptor complex(GO:0035631) |
| 0.1 | 0.4 | GO:0033256 | I-kappaB/NF-kappaB complex(GO:0033256) |
| 0.1 | 0.7 | GO:0042825 | TAP complex(GO:0042825) |
| 0.1 | 2.4 | GO:0042612 | MHC class I protein complex(GO:0042612) |
| 0.1 | 1.6 | GO:0042611 | MHC protein complex(GO:0042611) MHC class II protein complex(GO:0042613) |
| 0.1 | 2.1 | GO:0000299 | obsolete integral to membrane of membrane fraction(GO:0000299) |
| 0.1 | 0.2 | GO:0005889 | hydrogen:potassium-exchanging ATPase complex(GO:0005889) |
| 0.0 | 1.3 | GO:0005839 | proteasome core complex(GO:0005839) |
| 0.0 | 2.5 | GO:0005884 | actin filament(GO:0005884) |
| 0.0 | 1.1 | GO:0005669 | transcription factor TFIID complex(GO:0005669) |
| 0.0 | 0.0 | GO:0012510 | trans-Golgi network transport vesicle membrane(GO:0012510) |
| 0.0 | 1.9 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.0 | 0.4 | GO:0001950 | obsolete plasma membrane enriched fraction(GO:0001950) |
| 0.0 | 1.0 | GO:0090568 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) nuclear transcriptional repressor complex(GO:0090568) |
| 0.0 | 0.5 | GO:0016235 | aggresome(GO:0016235) |
| 0.0 | 0.5 | GO:0008180 | COP9 signalosome(GO:0008180) |
| 0.0 | 2.8 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 0.0 | 0.4 | GO:0008091 | spectrin(GO:0008091) |
| 0.0 | 0.5 | GO:0043034 | costamere(GO:0043034) |
| 0.0 | 0.3 | GO:0034518 | mRNA cap binding complex(GO:0005845) RNA cap binding complex(GO:0034518) |
| 0.0 | 1.7 | GO:0005604 | basement membrane(GO:0005604) |
| 0.0 | 0.2 | GO:0031616 | spindle pole centrosome(GO:0031616) |
| 0.0 | 0.2 | GO:0030126 | COPI vesicle coat(GO:0030126) |
| 0.0 | 0.5 | GO:0030425 | dendrite(GO:0030425) |
| 0.0 | 0.3 | GO:0030127 | COPII vesicle coat(GO:0030127) |
| 0.0 | 0.2 | GO:0043190 | ATP-binding cassette (ABC) transporter complex(GO:0043190) |
| 0.0 | 2.4 | GO:0005938 | cell cortex(GO:0005938) |
| 0.0 | 0.1 | GO:0070288 | intracellular ferritin complex(GO:0008043) ferritin complex(GO:0070288) |
| 0.0 | 0.7 | GO:0005637 | nuclear inner membrane(GO:0005637) |
| 0.0 | 2.8 | GO:0098857 | membrane raft(GO:0045121) membrane microdomain(GO:0098857) |
| 0.0 | 0.1 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.0 | 3.1 | GO:0005813 | centrosome(GO:0005813) |
| 0.0 | 0.5 | GO:0005782 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 1.6 | GO:0042289 | MHC class II protein binding(GO:0042289) |
| 0.4 | 2.3 | GO:0051371 | muscle alpha-actinin binding(GO:0051371) |
| 0.4 | 6.7 | GO:0005031 | tumor necrosis factor-activated receptor activity(GO:0005031) |
| 0.3 | 1.6 | GO:0045545 | syndecan binding(GO:0045545) |
| 0.3 | 1.1 | GO:0000739 | obsolete DNA strand annealing activity(GO:0000739) |
| 0.2 | 0.7 | GO:0004781 | adenylylsulfate kinase activity(GO:0004020) sulfate adenylyltransferase activity(GO:0004779) sulfate adenylyltransferase (ATP) activity(GO:0004781) |
| 0.2 | 1.1 | GO:0004906 | interferon-gamma receptor activity(GO:0004906) |
| 0.2 | 1.0 | GO:0031995 | insulin-like growth factor II binding(GO:0031995) |
| 0.2 | 0.6 | GO:0030368 | interleukin-17 receptor activity(GO:0030368) |
| 0.2 | 0.7 | GO:0008907 | integrase activity(GO:0008907) |
| 0.2 | 2.4 | GO:0032393 | MHC class I receptor activity(GO:0032393) |
| 0.1 | 0.4 | GO:0004913 | interleukin-4 receptor activity(GO:0004913) |
| 0.1 | 1.0 | GO:0043422 | protein kinase B binding(GO:0043422) |
| 0.1 | 0.4 | GO:0000150 | recombinase activity(GO:0000150) |
| 0.1 | 3.2 | GO:0043621 | protein self-association(GO:0043621) |
| 0.1 | 0.7 | GO:0046980 | oligopeptide-transporting ATPase activity(GO:0015421) tapasin binding(GO:0046980) |
| 0.1 | 1.1 | GO:0055056 | D-glucose transmembrane transporter activity(GO:0055056) |
| 0.1 | 1.6 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 0.1 | 2.1 | GO:0070064 | proline-rich region binding(GO:0070064) |
| 0.1 | 2.7 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 0.1 | 0.8 | GO:0070053 | thrombospondin receptor activity(GO:0070053) |
| 0.1 | 0.5 | GO:0042834 | peptidoglycan binding(GO:0042834) CARD domain binding(GO:0050700) |
| 0.1 | 0.5 | GO:0001102 | RNA polymerase II activating transcription factor binding(GO:0001102) |
| 0.1 | 0.3 | GO:0042903 | tubulin deacetylase activity(GO:0042903) |
| 0.1 | 0.8 | GO:0005149 | interleukin-1 receptor binding(GO:0005149) |
| 0.1 | 0.4 | GO:0042731 | PH domain binding(GO:0042731) |
| 0.1 | 0.2 | GO:0000247 | C-8 sterol isomerase activity(GO:0000247) |
| 0.0 | 0.3 | GO:0031624 | ubiquitin conjugating enzyme binding(GO:0031624) ubiquitin-like protein conjugating enzyme binding(GO:0044390) |
| 0.0 | 0.1 | GO:0004535 | poly(A)-specific ribonuclease activity(GO:0004535) |
| 0.0 | 0.6 | GO:0047617 | acyl-CoA hydrolase activity(GO:0047617) |
| 0.0 | 1.2 | GO:0005528 | macrolide binding(GO:0005527) FK506 binding(GO:0005528) |
| 0.0 | 1.3 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.0 | 0.3 | GO:0052658 | lipid phosphatase activity(GO:0042577) inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658) inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity(GO:0052659) |
| 0.0 | 0.5 | GO:0005131 | growth hormone receptor binding(GO:0005131) |
| 0.0 | 0.5 | GO:0070628 | proteasome binding(GO:0070628) |
| 0.0 | 1.2 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
| 0.0 | 0.3 | GO:0015279 | store-operated calcium channel activity(GO:0015279) |
| 0.0 | 0.9 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.0 | 0.5 | GO:0004065 | arylsulfatase activity(GO:0004065) |
| 0.0 | 0.3 | GO:0003876 | AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623) |
| 0.0 | 0.9 | GO:0019003 | GDP binding(GO:0019003) |
| 0.0 | 0.2 | GO:0004563 | beta-N-acetylhexosaminidase activity(GO:0004563) |
| 0.0 | 0.4 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
| 0.0 | 0.2 | GO:0050811 | GABA receptor binding(GO:0050811) |
| 0.0 | 0.3 | GO:0004386 | helicase activity(GO:0004386) |
| 0.0 | 0.0 | GO:0032564 | dATP binding(GO:0032564) |
| 0.0 | 0.7 | GO:0003725 | double-stranded RNA binding(GO:0003725) |
| 0.0 | 0.4 | GO:0005484 | SNAP receptor activity(GO:0005484) |
| 0.0 | 0.1 | GO:0034056 | estrogen response element binding(GO:0034056) |
| 0.0 | 0.1 | GO:0016909 | JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909) |
| 0.0 | 0.3 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.0 | 0.1 | GO:0016724 | ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724) |
| 0.0 | 0.6 | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity(GO:0008138) |
| 0.0 | 0.1 | GO:0017049 | GTP-Rho binding(GO:0017049) |
| 0.0 | 3.0 | GO:0008022 | protein C-terminus binding(GO:0008022) |
| 0.0 | 0.3 | GO:0004697 | protein kinase C activity(GO:0004697) |
| 0.0 | 0.1 | GO:0008140 | cAMP response element binding protein binding(GO:0008140) |
| 0.0 | 0.6 | GO:0004860 | protein kinase inhibitor activity(GO:0004860) |
| 0.0 | 0.1 | GO:0019841 | retinol binding(GO:0019841) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 8.1 | ST_TUMOR_NECROSIS_FACTOR_PATHWAY | Tumor Necrosis Factor Pathway. |
| 0.1 | 1.7 | ST_TYPE_I_INTERFERON_PATHWAY | Type I Interferon (alpha/beta IFN) Pathway |
| 0.0 | 1.1 | SA_G1_AND_S_PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
| 0.0 | 0.5 | ST_GA13_PATHWAY | G alpha 13 Pathway |
