Motif ID: REST

Z-value: 0.770


Transcription factors associated with REST:

Gene SymbolEntrez IDGene Name
REST ENSG00000084093.11 REST



Activity profile for motif REST.

activity profile for motif REST


Sorted Z-values histogram for motif REST

Sorted Z-values for motif REST



Network of associatons between targets according to the STRING database.



First level regulatory network of REST

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrX_-_153141302 1.239 ENST00000361699.4
ENST00000543994.1
ENST00000370057.3
ENST00000538883.1
ENST00000361981.3
 L1CAM




L1 cell adhesion molecule




chr9_-_123812542 1.196 ENST00000223642.1
 C5
complement component 5
chr12_+_71833550 1.081 ENST00000266674.5
 LGR5
leucine-rich repeat containing G protein-coupled receptor 5
chr3_+_193853927 0.842 ENST00000232424.3
 HES1
hes family bHLH transcription factor 1
chr3_-_8686479 0.840 ENST00000544814.1
ENST00000427408.1
 SSUH2

ssu-2 homolog (C. elegans)

chr13_-_111214015 0.821 ENST00000267328.3
 RAB20
RAB20, member RAS oncogene family
chr14_-_94759595 0.655 ENST00000261994.4
 SERPINA10
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr14_-_94759361 0.653 ENST00000393096.1
 SERPINA10
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr14_-_94759408 0.651 ENST00000554723.1
 SERPINA10
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr3_-_48700310 0.598 ENST00000164024.4
ENST00000544264.1
 CELSR3

cadherin, EGF LAG seven-pass G-type receptor 3

chr11_-_66115032 0.494 ENST00000311181.4
 B3GNT1
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1
chr6_+_25652432 0.466 ENST00000377961.2
 SCGN
secretagogin, EF-hand calcium binding protein
chrX_-_47479246 0.391 ENST00000295987.7
ENST00000340666.4
 SYN1

synapsin I

chr12_+_71833756 0.373 ENST00000536515.1
ENST00000540815.2
 LGR5

leucine-rich repeat containing G protein-coupled receptor 5

chr20_+_62327996 0.368 ENST00000369996.1
 TNFRSF6B
tumor necrosis factor receptor superfamily, member 6b, decoy
chr10_-_50970382 0.363 ENST00000419399.1
ENST00000432695.1
 OGDHL

oxoglutarate dehydrogenase-like

chr10_-_50970322 0.363 ENST00000374103.4
 OGDHL
oxoglutarate dehydrogenase-like
chr20_+_36012051 0.362 ENST00000373567.2
 SRC
v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
chr12_+_175930 0.320 ENST00000538872.1
ENST00000326261.4
 IQSEC3

IQ motif and Sec7 domain 3

chr4_+_158141899 0.296 ENST00000264426.9
ENST00000506284.1
 GRIA2

glutamate receptor, ionotropic, AMPA 2

chr7_+_145813453 0.293 ENST00000361727.3
 CNTNAP2
contactin associated protein-like 2
chr2_+_46524537 0.278 ENST00000263734.3
 EPAS1
endothelial PAS domain protein 1
chr15_+_75287861 0.275 ENST00000425597.3
ENST00000562327.1
ENST00000568018.1
ENST00000562212.1
ENST00000567920.1
ENST00000566872.1
ENST00000361900.6
ENST00000545456.1
 SCAMP5







secretory carrier membrane protein 5







chr2_-_51259292 0.270 ENST00000401669.2
 NRXN1
neurexin 1
chr5_+_175298573 0.268 ENST00000512824.1
 CPLX2
complexin 2
chr2_-_51259229 0.252 ENST00000405472.3
 NRXN1
neurexin 1
chr12_-_12837423 0.249 ENST00000540510.1
 GPR19
G protein-coupled receptor 19
chr15_-_83378611 0.242 ENST00000542200.1
 AP3B2
adaptor-related protein complex 3, beta 2 subunit
chr2_-_47798044 0.233 ENST00000327876.4
 KCNK12
potassium channel, subfamily K, member 12
chr2_-_30143525 0.224 ENST00000431873.1
 ALK
anaplastic lymphoma receptor tyrosine kinase
chr6_+_25652501 0.221 ENST00000334979.6
 SCGN
secretagogin, EF-hand calcium binding protein
chr4_+_158141806 0.182 ENST00000393815.2
 GRIA2
glutamate receptor, ionotropic, AMPA 2
chr6_+_110299501 0.176 ENST00000414000.2
 GPR6
G protein-coupled receptor 6
chr4_+_158141843 0.173 ENST00000509417.1
ENST00000296526.7
 GRIA2

glutamate receptor, ionotropic, AMPA 2

chr11_+_64808675 0.171 ENST00000529996.1
 SAC3D1
SAC3 domain containing 1
chr11_+_22359562 0.167 ENST00000263160.3
 SLC17A6
solute carrier family 17 (vesicular glutamate transporter), member 6
chr12_+_113229543 0.160 ENST00000447659.2
 RPH3A
rabphilin 3A homolog (mouse)
chr5_+_175298674 0.159 ENST00000514150.1
 CPLX2
complexin 2
chr17_-_3301704 0.158 ENST00000322608.2
 OR1E1
olfactory receptor, family 1, subfamily E, member 1
chr5_+_175298487 0.149 ENST00000393745.3
 CPLX2
complexin 2
chr10_+_26505179 0.149 ENST00000376261.3
 GAD2
glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
chrX_+_153237740 0.146 ENST00000369982.4
 TMEM187
transmembrane protein 187
chrX_-_153237258 0.142 ENST00000310441.7
 HCFC1
host cell factor C1 (VP16-accessory protein)
chr2_+_226265364 0.141 ENST00000272907.6
 NYAP2
neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2
chr3_-_113897545 0.133 ENST00000467632.1
 DRD3
dopamine receptor D3
chr7_-_100808394 0.123 ENST00000445482.2
 VGF
VGF nerve growth factor inducible
chr12_+_113229737 0.119 ENST00000551052.1
ENST00000415485.3
 RPH3A

rabphilin 3A homolog (mouse)

chr12_+_113229452 0.110 ENST00000389385.4
 RPH3A
rabphilin 3A homolog (mouse)
chr3_-_113897899 0.104 ENST00000383673.2
ENST00000295881.7
 DRD3

dopamine receptor D3

chr1_-_175712665 0.103 ENST00000263525.2
 TNR
tenascin R
chr10_-_102790852 0.092 ENST00000470414.1
ENST00000370215.3
 PDZD7

PDZ domain containing 7

chr12_+_52695617 0.088 ENST00000293525.5
 KRT86
keratin 86
chr17_+_42385927 0.087 ENST00000426726.3
ENST00000590941.1
ENST00000225441.7
 RUNDC3A


RUN domain containing 3A


chr4_+_96012614 0.086 ENST00000264568.4
 BMPR1B
bone morphogenetic protein receptor, type IB
chr9_+_140033862 0.085 ENST00000350902.5
ENST00000371550.4
ENST00000371546.4
ENST00000371555.4
ENST00000371553.3
ENST00000371559.4
ENST00000371560.3
 GRIN1






glutamate receptor, ionotropic, N-methyl D-aspartate 1






chr6_+_153071925 0.084 ENST00000367244.3
ENST00000367243.3
 VIP

vasoactive intestinal peptide

chr12_-_57443886 0.076 ENST00000300119.3
 MYO1A
myosin IA
chr10_+_102790980 0.075 ENST00000393459.1
ENST00000224807.5
 SFXN3

sideroflexin 3

chr16_+_335680 0.074 ENST00000435833.1
 PDIA2
protein disulfide isomerase family A, member 2
chr15_-_83378526 0.069 ENST00000535348.1
ENST00000535359.1
 AP3B2

adaptor-related protein complex 3, beta 2 subunit

chr2_-_51259528 0.069 ENST00000404971.1
 NRXN1
neurexin 1
chr20_-_62284766 0.064 ENST00000370053.1
 STMN3
stathmin-like 3
chr1_-_151689259 0.062 ENST00000420342.1
ENST00000290583.4
 CELF3

CUGBP, Elav-like family member 3

chr2_-_27531313 0.061 ENST00000296099.2
 UCN
urocortin
chr1_+_154540246 0.056 ENST00000368476.3
 CHRNB2
cholinergic receptor, nicotinic, beta 2 (neuronal)
chr20_+_44657845 0.052 ENST00000243964.3
 SLC12A5
solute carrier family 12 (potassium/chloride transporter), member 5
chr1_+_212606219 0.051 ENST00000366988.3
 NENF
neudesin neurotrophic factor
chr11_+_637246 0.047 ENST00000176183.5
 DRD4
dopamine receptor D4
chr20_+_5892037 0.044 ENST00000378961.4
 CHGB
chromogranin B (secretogranin 1)
chr16_+_3019246 0.044 ENST00000318782.8
ENST00000293978.8
 PAQR4

progestin and adipoQ receptor family member IV

chr17_-_3337135 0.043 ENST00000248384.1
 OR1E2
olfactory receptor, family 1, subfamily E, member 2
chr15_-_83378638 0.040 ENST00000261722.3
 AP3B2
adaptor-related protein complex 3, beta 2 subunit
chr7_-_100808843 0.039 ENST00000249330.2
 VGF
VGF nerve growth factor inducible
chrX_-_49056635 0.039 ENST00000472598.1
ENST00000538567.1
ENST00000479808.1
ENST00000263233.4
 SYP



synaptophysin



chr2_-_51259641 0.037 ENST00000406316.2
ENST00000405581.1
 NRXN1

neurexin 1

chr7_+_150748288 0.033 ENST00000490540.1
 ASIC3
acid-sensing (proton-gated) ion channel 3
chr1_-_40105617 0.028 ENST00000372852.3
 HEYL
hes-related family bHLH transcription factor with YRPW motif-like
chr19_-_45927622 0.026 ENST00000300853.3
ENST00000589165.1
 ERCC1

excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)

chr10_+_26505594 0.020 ENST00000259271.3
 GAD2
glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
chr4_-_175750364 0.018 ENST00000340217.5
ENST00000274093.3
 GLRA3

glycine receptor, alpha 3

chr20_-_60795316 0.015 ENST00000317393.6
 HRH3
histamine receptor H3
chr9_-_139096955 0.011 ENST00000371748.5
 LHX3
LIM homeobox 3
chr12_-_99288536 0.008 ENST00000549797.1
ENST00000333732.7
ENST00000341752.7
 ANKS1B


ankyrin repeat and sterile alpha motif domain containing 1B


chr15_-_22473353 0.007 ENST00000557788.2
 IGHV4OR15-8
immunoglobulin heavy variable 4/OR15-8 (non-functional)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.2 GO:0002689 negative regulation of leukocyte chemotaxis(GO:0002689)
0.3 0.8 GO:0060120 auditory receptor cell fate commitment(GO:0009912) inner ear receptor cell fate commitment(GO:0060120)
0.2 1.9 GO:0060046 regulation of acrosome reaction(GO:0060046)
0.1 0.3 GO:0045956 positive regulation of calcium ion-dependent exocytosis(GO:0045956)
0.1 1.2 GO:0033631 cell-cell adhesion mediated by integrin(GO:0033631)
0.1 0.3 GO:0071109 superior temporal gyrus development(GO:0071109)
0.1 0.4 GO:0033622 integrin activation(GO:0033622) regulation of integrin activation(GO:0033623) positive regulation of integrin activation(GO:0033625)
0.1 0.2 GO:0032416 negative regulation of sodium:proton antiporter activity(GO:0032416) negative regulation of sodium ion transmembrane transport(GO:1902306) negative regulation of sodium ion transmembrane transporter activity(GO:2000650)
0.1 0.6 GO:0023041 neuronal signal transduction(GO:0023041)
0.0 0.2 GO:0006540 glutamate decarboxylation to succinate(GO:0006540)
0.0 0.1 GO:0019046 release from viral latency(GO:0019046)
0.0 0.3 GO:0048625 myoblast fate commitment(GO:0048625)
0.0 0.6 GO:0007413 axonal fasciculation(GO:0007413)
0.0 0.1 GO:0035021 negative regulation of Rac protein signal transduction(GO:0035021)
0.0 0.1 GO:0021794 thalamus development(GO:0021794)
0.0 0.6 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.0 0.1 GO:0001550 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.0 0.3 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.0 0.0 GO:0060080 inhibitory postsynaptic potential(GO:0060080)
0.0 0.5 GO:0006023 aminoglycan biosynthetic process(GO:0006023)
0.0 0.0 GO:0016188 synaptic vesicle maturation(GO:0016188)
0.0 0.2 GO:0043084 penile erection(GO:0043084)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.2 GO:0005579 membrane attack complex(GO:0005579)
0.0 0.3 GO:0070852 cell body fiber(GO:0070852)
0.0 0.4 GO:0048786 presynaptic active zone(GO:0048786)
0.0 1.2 GO:0043195 terminal bouton(GO:0043195)
0.0 0.9 GO:0031201 SNARE complex(GO:0031201)
0.0 0.1 GO:0032590 dendrite membrane(GO:0032590)
0.0 0.4 GO:0030137 COPI-coated vesicle(GO:0030137)
0.0 0.1 GO:0042597 NMDA selective glutamate receptor complex(GO:0017146) outer membrane-bounded periplasmic space(GO:0030288) periplasmic space(GO:0042597)
0.0 0.8 GO:0042734 presynaptic membrane(GO:0042734)
0.0 0.1 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.0 1.1 GO:0030658 transport vesicle membrane(GO:0030658)
0.0 0.7 GO:0030666 endocytic vesicle membrane(GO:0030666)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.2 GO:0033691 sialic acid binding(GO:0033691)
0.2 0.8 GO:0043398 HLH domain binding(GO:0043398)
0.1 0.7 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.1 0.7 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.1 0.4 GO:0070679 inositol 1,4,5 trisphosphate binding(GO:0070679)
0.1 1.5 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.0 0.3 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.0 0.6 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.2 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.0 0.6 GO:0005246 calcium channel regulator activity(GO:0005246)
0.0 0.3 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 1.9 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.8 GO:0008009 chemokine activity(GO:0008009)
0.0 0.3 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.1 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.0 0.2 GO:0001619 obsolete lysosphingolipid and lysophosphatidic acid receptor activity(GO:0001619)
0.0 0.1 GO:0030250 cyclase activator activity(GO:0010853) guanylate cyclase activator activity(GO:0030250)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 ST_STAT3_PATHWAY STAT3 Pathway