Motif ID: RORA
Z-value: 1.248
Transcription factors associated with RORA:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| RORA | ENSG00000069667.11 | RORA |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 1.4 | GO:0007518 | myoblast fate determination(GO:0007518) |
| 0.4 | 2.0 | GO:0003093 | regulation of glomerular filtration(GO:0003093) glomerular filtration(GO:0003094) renal filtration(GO:0097205) regulation of renal system process(GO:0098801) |
| 0.4 | 1.2 | GO:2000105 | positive regulation of DNA-dependent DNA replication initiation(GO:0032298) positive regulation of DNA-dependent DNA replication(GO:2000105) |
| 0.4 | 1.1 | GO:0071104 | response to interleukin-9(GO:0071104) response to interleukin-11(GO:0071105) |
| 0.3 | 6.3 | GO:0071378 | growth hormone receptor signaling pathway(GO:0060396) cellular response to growth hormone stimulus(GO:0071378) |
| 0.2 | 0.7 | GO:0016554 | cytidine to uridine editing(GO:0016554) |
| 0.2 | 0.6 | GO:0014063 | regulation of serotonin secretion(GO:0014062) negative regulation of serotonin secretion(GO:0014063) |
| 0.2 | 1.1 | GO:0006883 | cellular sodium ion homeostasis(GO:0006883) |
| 0.1 | 0.7 | GO:0032780 | negative regulation of ATPase activity(GO:0032780) |
| 0.1 | 0.4 | GO:0008050 | female courtship behavior(GO:0008050) |
| 0.1 | 0.4 | GO:0045618 | positive regulation of keratinocyte differentiation(GO:0045618) |
| 0.1 | 0.4 | GO:0060013 | righting reflex(GO:0060013) |
| 0.1 | 0.4 | GO:0045040 | outer mitochondrial membrane organization(GO:0007008) protein import into mitochondrial outer membrane(GO:0045040) |
| 0.1 | 1.0 | GO:0046902 | regulation of mitochondrial membrane permeability(GO:0046902) regulation of membrane permeability(GO:0090559) |
| 0.1 | 0.5 | GO:0070059 | intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress(GO:0070059) |
| 0.1 | 0.2 | GO:0032929 | negative regulation of superoxide anion generation(GO:0032929) |
| 0.0 | 1.1 | GO:0019370 | leukotriene biosynthetic process(GO:0019370) |
| 0.0 | 0.2 | GO:0046051 | GTP biosynthetic process(GO:0006183) UTP biosynthetic process(GO:0006228) CTP biosynthetic process(GO:0006241) pyrimidine ribonucleoside triphosphate metabolic process(GO:0009208) pyrimidine ribonucleoside triphosphate biosynthetic process(GO:0009209) CTP metabolic process(GO:0046036) UTP metabolic process(GO:0046051) |
| 0.0 | 0.1 | GO:0010727 | negative regulation of hydrogen peroxide metabolic process(GO:0010727) |
| 0.0 | 0.9 | GO:0015949 | nucleobase-containing small molecule interconversion(GO:0015949) |
| 0.0 | 0.2 | GO:0009313 | oligosaccharide catabolic process(GO:0009313) |
| 0.0 | 0.8 | GO:0043278 | response to isoquinoline alkaloid(GO:0014072) response to morphine(GO:0043278) |
| 0.0 | 0.2 | GO:0006102 | isocitrate metabolic process(GO:0006102) |
| 0.0 | 1.1 | GO:0000080 | mitotic G1 phase(GO:0000080) |
| 0.0 | 0.3 | GO:0008635 | activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c(GO:0008635) |
| 0.0 | 1.0 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 0.0 | 0.3 | GO:0097031 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
| 0.0 | 0.9 | GO:0006611 | protein export from nucleus(GO:0006611) |
| 0.0 | 0.7 | GO:0009060 | aerobic respiration(GO:0009060) |
| 0.0 | 0.2 | GO:0006474 | N-terminal protein amino acid acetylation(GO:0006474) |
| 0.0 | 0.4 | GO:0009070 | serine family amino acid biosynthetic process(GO:0009070) |
| 0.0 | 0.1 | GO:0046340 | diacylglycerol catabolic process(GO:0046340) |
| 0.0 | 0.3 | GO:0032012 | regulation of ARF protein signal transduction(GO:0032012) |
| 0.0 | 0.2 | GO:0005513 | detection of calcium ion(GO:0005513) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 0.7 | GO:0030895 | apolipoprotein B mRNA editing enzyme complex(GO:0030895) |
| 0.2 | 2.0 | GO:0043020 | NADPH oxidase complex(GO:0043020) |
| 0.1 | 0.4 | GO:0045257 | mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283) |
| 0.0 | 0.3 | GO:0005750 | mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275) |
| 0.0 | 0.1 | GO:0031838 | haptoglobin-hemoglobin complex(GO:0031838) |
| 0.0 | 0.7 | GO:0005665 | DNA-directed RNA polymerase II, core complex(GO:0005665) |
| 0.0 | 0.7 | GO:0005861 | troponin complex(GO:0005861) |
| 0.0 | 1.7 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 0.0 | 0.3 | GO:0033180 | proton-transporting V-type ATPase, V1 domain(GO:0033180) |
| 0.0 | 0.1 | GO:0032584 | growth cone membrane(GO:0032584) |
| 0.0 | 1.2 | GO:0030964 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.0 | 1.3 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.0 | 1.1 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.0 | 0.2 | GO:0000276 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) |
| 0.0 | 0.1 | GO:0014731 | spectrin-associated cytoskeleton(GO:0014731) |
| 0.0 | 0.4 | GO:0045095 | keratin filament(GO:0045095) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 6.3 | GO:0008269 | JAK pathway signal transduction adaptor activity(GO:0008269) |
| 0.2 | 1.1 | GO:0050693 | LBD domain binding(GO:0050693) |
| 0.2 | 2.0 | GO:0016175 | superoxide-generating NADPH oxidase activity(GO:0016175) |
| 0.1 | 0.7 | GO:0008131 | primary amine oxidase activity(GO:0008131) |
| 0.1 | 0.6 | GO:0004727 | prenylated protein tyrosine phosphatase activity(GO:0004727) |
| 0.1 | 0.4 | GO:0050613 | delta14-sterol reductase activity(GO:0050613) |
| 0.1 | 0.4 | GO:0004756 | selenide, water dikinase activity(GO:0004756) phosphotransferase activity, paired acceptors(GO:0016781) |
| 0.1 | 0.3 | GO:0008192 | RNA guanylyltransferase activity(GO:0008192) |
| 0.1 | 0.3 | GO:0045155 | electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity(GO:0045155) |
| 0.1 | 1.0 | GO:0016018 | cyclosporin A binding(GO:0016018) |
| 0.1 | 0.4 | GO:0048039 | succinate dehydrogenase activity(GO:0000104) ubiquinone binding(GO:0048039) |
| 0.1 | 0.4 | GO:0004663 | Rab geranylgeranyltransferase activity(GO:0004663) |
| 0.1 | 0.6 | GO:0019855 | calcium channel inhibitor activity(GO:0019855) |
| 0.1 | 1.1 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.1 | 1.3 | GO:0019992 | diacylglycerol binding(GO:0019992) |
| 0.1 | 0.3 | GO:0004449 | isocitrate dehydrogenase (NAD+) activity(GO:0004449) |
| 0.1 | 0.9 | GO:0004017 | adenylate kinase activity(GO:0004017) |
| 0.1 | 0.6 | GO:0004550 | nucleoside diphosphate kinase activity(GO:0004550) |
| 0.1 | 0.4 | GO:0030911 | TPR domain binding(GO:0030911) |
| 0.0 | 0.2 | GO:0008526 | phosphatidylinositol transporter activity(GO:0008526) |
| 0.0 | 0.9 | GO:0005487 | nucleocytoplasmic transporter activity(GO:0005487) |
| 0.0 | 0.2 | GO:0004985 | opioid receptor activity(GO:0004985) |
| 0.0 | 0.4 | GO:0004887 | thyroid hormone receptor activity(GO:0004887) |
| 0.0 | 0.3 | GO:0016884 | carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884) |
| 0.0 | 0.1 | GO:0033878 | hormone-sensitive lipase activity(GO:0033878) |
| 0.0 | 0.7 | GO:0019239 | deaminase activity(GO:0019239) |
| 0.0 | 0.1 | GO:0030492 | hemoglobin binding(GO:0030492) |
| 0.0 | 1.0 | GO:0050136 | NADH dehydrogenase activity(GO:0003954) NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.0 | 0.3 | GO:0016493 | C-C chemokine receptor activity(GO:0016493) |
| 0.0 | 0.2 | GO:0004568 | chitinase activity(GO:0004568) |
| 0.0 | 0.2 | GO:0008199 | acid phosphatase activity(GO:0003993) ferric iron binding(GO:0008199) |
| 0.0 | 0.7 | GO:0019212 | phosphatase inhibitor activity(GO:0019212) |
| 0.0 | 0.3 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
| 0.0 | 0.9 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
| 0.0 | 0.1 | GO:0047006 | 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity(GO:0047006) |
| 0.0 | 0.2 | GO:0000030 | mannosyltransferase activity(GO:0000030) |
| 0.0 | 0.0 | GO:0017057 | glucose-6-phosphate dehydrogenase activity(GO:0004345) 6-phosphogluconolactonase activity(GO:0017057) |
| 0.0 | 0.1 | GO:0008432 | JUN kinase binding(GO:0008432) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.1 | ST_P38_MAPK_PATHWAY | p38 MAPK Pathway |
| 0.0 | 1.3 | ST_T_CELL_SIGNAL_TRANSDUCTION | T Cell Signal Transduction |
