Motif ID: RORC

Z-value: 0.932


Transcription factors associated with RORC:

Gene SymbolEntrez IDGene Name
RORC ENSG00000143365.12 RORC



Activity profile for motif RORC.

activity profile for motif RORC


Sorted Z-values histogram for motif RORC

Sorted Z-values for motif RORC



Network of associatons between targets according to the STRING database.



First level regulatory network of RORC

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_+_93964158 2.707 ENST00000549206.1
 SOCS2
suppressor of cytokine signaling 2
chr12_+_93963590 2.669 ENST00000340600.2
 SOCS2
suppressor of cytokine signaling 2
chr10_-_121296045 1.413 ENST00000392865.1
 RGS10
regulator of G-protein signaling 10
chr17_-_46623441 1.405 ENST00000330070.4
 HOXB2
homeobox B2
chr3_+_185303962 0.816 ENST00000296257.5
 SENP2
SUMO1/sentrin/SMT3 specific peptidase 2
chr3_+_185304059 0.742 ENST00000427465.2
 SENP2
SUMO1/sentrin/SMT3 specific peptidase 2
chr9_-_110251836 0.688 ENST00000374672.4
 KLF4
Kruppel-like factor 4 (gut)
chr18_-_23671139 0.660 ENST00000579061.1
ENST00000542420.2
 SS18

synovial sarcoma translocation, chromosome 18

chr1_-_153522562 0.647 ENST00000368714.1
 S100A4
S100 calcium binding protein A4
chr16_-_1821496 0.569 ENST00000564628.1
ENST00000563498.1
 NME3

NME/NM23 nucleoside diphosphate kinase 3

chr2_+_160590469 0.564 ENST00000409591.1
 MARCH7
membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase
chr16_-_67514982 0.515 ENST00000565835.1
ENST00000540149.1
ENST00000290949.3
 ATP6V0D1


ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1


chr6_-_111927062 0.443 ENST00000359831.4
 TRAF3IP2
TRAF3 interacting protein 2
chr1_+_26869597 0.435 ENST00000530003.1
 RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr10_-_105845674 0.418 ENST00000353479.5
ENST00000369733.3
 COL17A1

collagen, type XVII, alpha 1

chr7_+_112063192 0.397 ENST00000005558.4
 IFRD1
interferon-related developmental regulator 1
chr11_-_19223523 0.391 ENST00000265968.3
 CSRP3
cysteine and glycine-rich protein 3 (cardiac LIM protein)
chr4_-_120243545 0.389 ENST00000274024.3
 FABP2
fatty acid binding protein 2, intestinal
chr1_+_114447763 0.382 ENST00000369563.3
 DCLRE1B
DNA cross-link repair 1B
chr19_-_10450287 0.361 ENST00000589261.1
ENST00000590569.1
ENST00000589580.1
ENST00000589249.1
 ICAM3



intercellular adhesion molecule 3



chr8_-_95449155 0.300 ENST00000481490.2
 FSBP
fibrinogen silencer binding protein
chr1_-_150207017 0.274 ENST00000369119.3
 ANP32E
acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
chr1_+_205197304 0.242 ENST00000358024.3
 TMCC2
transmembrane and coiled-coil domain family 2
chr1_-_185286461 0.222 ENST00000367498.3
 IVNS1ABP
influenza virus NS1A binding protein
chr11_+_13299186 0.205 ENST00000527998.1
ENST00000396441.3
ENST00000533520.1
ENST00000529825.1
ENST00000389707.4
ENST00000401424.1
ENST00000529388.1
ENST00000530357.1
ENST00000403290.1
ENST00000361003.4
ENST00000389708.3
ENST00000403510.3
ENST00000482049.1
 ARNTL












aryl hydrocarbon receptor nuclear translocator-like












chr7_+_20686946 0.201 ENST00000443026.2
ENST00000406935.1
 ABCB5

ATP-binding cassette, sub-family B (MDR/TAP), member 5

chr14_-_23451467 0.200 ENST00000361265.4
ENST00000555074.1
 AJUBA
RP11-298I3.5
ajuba LIM protein
RP11-298I3.5
chr12_+_7167980 0.192 ENST00000360817.5
ENST00000402681.3
 C1S

complement component 1, s subcomponent

chr10_-_103578182 0.191 ENST00000439817.1
 MGEA5
meningioma expressed antigen 5 (hyaluronidase)
chr1_-_145826450 0.190 ENST00000462900.2
 GPR89A
G protein-coupled receptor 89A
chr12_-_54652060 0.187 ENST00000552562.1
 CBX5
chromobox homolog 5
chr1_-_211752073 0.170 ENST00000367001.4
 SLC30A1
solute carrier family 30 (zinc transporter), member 1
chr10_-_103578162 0.170 ENST00000361464.3
ENST00000357797.5
ENST00000370094.3
 MGEA5


meningioma expressed antigen 5 (hyaluronidase)


chr2_-_148778323 0.159 ENST00000440042.1
ENST00000535373.1
ENST00000540442.1
ENST00000536575.1
 ORC4



origin recognition complex, subunit 4



chr3_-_164914640 0.158 ENST00000241274.3
 SLITRK3
SLIT and NTRK-like family, member 3
chr4_+_85504075 0.142 ENST00000295887.5
 CDS1
CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1
chr1_+_171810606 0.139 ENST00000358155.4
ENST00000367733.2
ENST00000355305.5
ENST00000367731.1
 DNM3



dynamin 3



chr17_-_3030875 0.137 ENST00000328890.2
 OR1G1
olfactory receptor, family 1, subfamily G, member 1
chr7_-_128415844 0.134 ENST00000249389.2
 OPN1SW
opsin 1 (cone pigments), short-wave-sensitive
chr3_-_65583561 0.132 ENST00000460329.2
 MAGI1
membrane associated guanylate kinase, WW and PDZ domain containing 1
chr13_+_109248500 0.126 ENST00000356711.2
 MYO16
myosin XVI
chr17_-_42992856 0.120 ENST00000588316.1
ENST00000435360.2
ENST00000586793.1
ENST00000588735.1
ENST00000588037.1
ENST00000592320.1
ENST00000253408.5
 GFAP






glial fibrillary acidic protein






chrX_-_110655391 0.106 ENST00000356915.2
ENST00000356220.3
 DCX

doublecortin

chrX_-_43832711 0.105 ENST00000378062.5
 NDP
Norrie disease (pseudoglioma)
chr1_+_159796534 0.097 ENST00000289707.5
 SLAMF8
SLAM family member 8
chr12_+_4671352 0.086 ENST00000542744.1
 DYRK4
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4
chrX_-_49089771 0.076 ENST00000376251.1
ENST00000323022.5
ENST00000376265.2
 CACNA1F


calcium channel, voltage-dependent, L type, alpha 1F subunit


chr19_+_1269324 0.068 ENST00000589710.1
ENST00000588230.1
ENST00000413636.2
ENST00000586472.1
ENST00000589686.1
ENST00000444172.2
ENST00000587323.1
ENST00000320936.5
ENST00000587896.1
ENST00000589235.1
ENST00000591659.1
 CIRBP










cold inducible RNA binding protein










chr19_-_49140609 0.067 ENST00000601104.1
 DBP
D site of albumin promoter (albumin D-box) binding protein
chr1_-_149908710 0.061 ENST00000439741.2
ENST00000361405.6
ENST00000406732.3
 MTMR11


myotubularin related protein 11


chr1_-_62190793 0.049 ENST00000371177.2
ENST00000606498.1
 TM2D1

TM2 domain containing 1

chr17_-_48785216 0.028 ENST00000285243.6
 ANKRD40
ankyrin repeat domain 40
chr19_+_38924316 0.022 ENST00000355481.4
ENST00000360985.3
ENST00000359596.3
 RYR1


ryanodine receptor 1 (skeletal)


chr2_-_30144432 0.018 ENST00000389048.3
 ALK
anaplastic lymphoma receptor tyrosine kinase
chr4_+_110749143 0.007 ENST00000317735.4
 RRH
retinal pigment epithelium-derived rhodopsin homolog

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.6 GO:0016926 protein desumoylation(GO:0016926)
0.5 1.4 GO:0021570 rhombomere 4 development(GO:0021570)
0.3 5.4 GO:0071378 growth hormone receptor signaling pathway(GO:0060396) cellular response to growth hormone stimulus(GO:0071378)
0.1 0.4 GO:0007518 myoblast fate determination(GO:0007518)
0.1 0.7 GO:0007500 mesodermal cell fate determination(GO:0007500)
0.1 0.4 GO:0043247 protection from non-homologous end joining at telomere(GO:0031848) telomere maintenance in response to DNA damage(GO:0043247)
0.1 0.7 GO:0048013 ephrin receptor signaling pathway(GO:0048013)
0.1 0.6 GO:0046051 GTP biosynthetic process(GO:0006183) UTP biosynthetic process(GO:0006228) CTP biosynthetic process(GO:0006241) pyrimidine ribonucleoside triphosphate metabolic process(GO:0009208) pyrimidine ribonucleoside triphosphate biosynthetic process(GO:0009209) CTP metabolic process(GO:0046036) UTP metabolic process(GO:0046051)
0.0 0.4 GO:0006516 glycoprotein catabolic process(GO:0006516)
0.0 0.1 GO:0090047 retina vasculature development in camera-type eye(GO:0061298) retina vasculature morphogenesis in camera-type eye(GO:0061299) obsolete positive regulation of transcription regulator activity(GO:0090047)
0.0 0.2 GO:0090281 negative regulation of neurotransmitter transport(GO:0051589) negative regulation of calcium ion import(GO:0090281)
0.0 0.1 GO:0050908 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.0 0.4 GO:0001974 blood vessel remodeling(GO:0001974)
0.0 0.4 GO:0050892 intestinal absorption(GO:0050892)
0.0 0.4 GO:0031581 hemidesmosome assembly(GO:0031581)
0.0 0.5 GO:0015991 energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) ATP hydrolysis coupled proton transport(GO:0015991) ATP hydrolysis coupled transmembrane transport(GO:0090662)
0.0 0.1 GO:0034063 stress granule assembly(GO:0034063)
0.0 0.4 GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0043154)
0.0 0.1 GO:0006657 CDP-choline pathway(GO:0006657)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0045179 apical cortex(GO:0045179)
0.1 0.5 GO:0033179 proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.0 0.4 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.2 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.0 0.2 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 1.6 GO:0016605 PML body(GO:0016605)
0.0 0.7 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 0.2 GO:0000808 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.0 0.2 GO:0030315 T-tubule(GO:0030315)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 5.4 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.5 1.6 GO:0016929 SUMO-specific protease activity(GO:0016929)
0.1 0.4 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.1 0.5 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.1 0.6 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.1 0.4 GO:0008409 5'-3' exonuclease activity(GO:0008409)
0.0 0.1 GO:0004605 phosphatidate cytidylyltransferase activity(GO:0004605)
0.0 0.4 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
0.0 0.6 GO:0050786 RAGE receptor binding(GO:0050786)
0.0 0.2 GO:0015562 efflux transmembrane transporter activity(GO:0015562)
0.0 0.2 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.0 0.2 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.0 0.7 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.0 0.2 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 0.2 GO:0016565 obsolete general transcriptional repressor activity(GO:0016565)
0.0 0.4 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 0.5 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.6 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.0 0.4 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.