Motif ID: RREB1
Z-value: 2.073
Transcription factors associated with RREB1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| RREB1 | ENSG00000124782.15 | RREB1 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 2.7 | GO:0060120 | auditory receptor cell fate commitment(GO:0009912) inner ear receptor cell fate commitment(GO:0060120) |
| 0.6 | 1.7 | GO:0051151 | negative regulation of smooth muscle cell differentiation(GO:0051151) |
| 0.4 | 1.8 | GO:0060662 | tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662) |
| 0.4 | 10.7 | GO:0045745 | positive regulation of G-protein coupled receptor protein signaling pathway(GO:0045745) |
| 0.4 | 1.6 | GO:0033197 | response to vitamin E(GO:0033197) |
| 0.4 | 0.8 | GO:0060769 | positive regulation of epithelial cell proliferation involved in prostate gland development(GO:0060769) |
| 0.3 | 4.1 | GO:0010658 | striated muscle cell apoptotic process(GO:0010658) cardiac muscle cell apoptotic process(GO:0010659) regulation of striated muscle cell apoptotic process(GO:0010662) negative regulation of striated muscle cell apoptotic process(GO:0010664) regulation of cardiac muscle cell apoptotic process(GO:0010665) negative regulation of cardiac muscle cell apoptotic process(GO:0010667) |
| 0.3 | 3.6 | GO:0007216 | G-protein coupled glutamate receptor signaling pathway(GO:0007216) |
| 0.3 | 0.9 | GO:0060340 | pericardium morphogenesis(GO:0003344) optic cup formation involved in camera-type eye development(GO:0003408) diencephalon morphogenesis(GO:0048852) positive regulation of type I interferon-mediated signaling pathway(GO:0060340) lateral sprouting involved in mammary gland duct morphogenesis(GO:0060599) |
| 0.3 | 2.1 | GO:2000111 | positive regulation of macrophage apoptotic process(GO:2000111) |
| 0.3 | 4.5 | GO:0050872 | white fat cell differentiation(GO:0050872) |
| 0.3 | 3.5 | GO:0051927 | obsolete negative regulation of calcium ion transport via voltage-gated calcium channel activity(GO:0051927) |
| 0.3 | 1.8 | GO:0030579 | ubiquitin-dependent SMAD protein catabolic process(GO:0030579) |
| 0.2 | 0.8 | GO:0009296 | obsolete flagellum assembly(GO:0009296) |
| 0.2 | 2.6 | GO:0002544 | chronic inflammatory response(GO:0002544) |
| 0.2 | 0.6 | GO:0043371 | negative regulation of CD4-positive, alpha-beta T cell differentiation(GO:0043371) negative regulation of T-helper cell differentiation(GO:0045623) negative regulation of CD4-positive, alpha-beta T cell activation(GO:2000515) |
| 0.2 | 1.2 | GO:0070934 | CRD-mediated mRNA stabilization(GO:0070934) |
| 0.2 | 2.4 | GO:0050718 | positive regulation of interleukin-1 beta secretion(GO:0050718) |
| 0.2 | 4.2 | GO:0045103 | intermediate filament-based process(GO:0045103) |
| 0.2 | 0.9 | GO:0030240 | skeletal muscle thin filament assembly(GO:0030240) |
| 0.1 | 0.4 | GO:0060297 | regulation of sarcomere organization(GO:0060297) |
| 0.1 | 2.2 | GO:0051016 | barbed-end actin filament capping(GO:0051016) |
| 0.1 | 1.1 | GO:0035335 | peptidyl-tyrosine dephosphorylation(GO:0035335) |
| 0.1 | 0.4 | GO:0014724 | regulation of twitch skeletal muscle contraction(GO:0014724) fast-twitch skeletal muscle fiber contraction(GO:0031443) regulation of fast-twitch skeletal muscle fiber contraction(GO:0031446) positive regulation of fast-twitch skeletal muscle fiber contraction(GO:0031448) positive regulation of endoplasmic reticulum calcium ion concentration(GO:0032470) mitochondrial calcium ion homeostasis(GO:0051560) positive regulation of mitochondrial calcium ion concentration(GO:0051561) relaxation of skeletal muscle(GO:0090076) |
| 0.1 | 0.4 | GO:0048295 | positive regulation of isotype switching to IgE isotypes(GO:0048295) |
| 0.1 | 1.1 | GO:0001867 | complement activation, lectin pathway(GO:0001867) |
| 0.1 | 1.3 | GO:0010633 | negative regulation of epithelial cell migration(GO:0010633) |
| 0.1 | 0.3 | GO:0051102 | DNA ligation involved in DNA recombination(GO:0051102) |
| 0.1 | 1.4 | GO:0048268 | negative regulation of receptor-mediated endocytosis(GO:0048261) clathrin coat assembly(GO:0048268) |
| 0.1 | 0.8 | GO:0060363 | cranial suture morphogenesis(GO:0060363) craniofacial suture morphogenesis(GO:0097094) |
| 0.1 | 0.4 | GO:0061003 | positive regulation of dendritic spine morphogenesis(GO:0061003) |
| 0.1 | 5.2 | GO:0006821 | chloride transport(GO:0006821) |
| 0.1 | 0.5 | GO:0042074 | cell migration involved in gastrulation(GO:0042074) |
| 0.1 | 0.7 | GO:0010739 | positive regulation of protein kinase A signaling(GO:0010739) |
| 0.1 | 2.1 | GO:0018149 | peptide cross-linking(GO:0018149) |
| 0.1 | 1.2 | GO:0007172 | signal complex assembly(GO:0007172) |
| 0.1 | 1.0 | GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146) |
| 0.1 | 0.3 | GO:0032780 | negative regulation of ATPase activity(GO:0032780) |
| 0.1 | 4.9 | GO:0043542 | endothelial cell migration(GO:0043542) |
| 0.1 | 0.3 | GO:0046121 | deoxyribonucleoside catabolic process(GO:0046121) |
| 0.0 | 0.3 | GO:0031665 | negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665) |
| 0.0 | 1.4 | GO:0051925 | obsolete regulation of calcium ion transport via voltage-gated calcium channel activity(GO:0051925) |
| 0.0 | 0.8 | GO:0050812 | acetyl-CoA biosynthetic process from pyruvate(GO:0006086) regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510) regulation of acyl-CoA biosynthetic process(GO:0050812) |
| 0.0 | 0.3 | GO:0060119 | auditory receptor cell development(GO:0060117) inner ear receptor cell development(GO:0060119) |
| 0.0 | 0.3 | GO:0006177 | GMP biosynthetic process(GO:0006177) |
| 0.0 | 1.6 | GO:0030520 | intracellular estrogen receptor signaling pathway(GO:0030520) |
| 0.0 | 0.5 | GO:0006906 | vesicle fusion(GO:0006906) |
| 0.0 | 2.2 | GO:0006446 | regulation of translational initiation(GO:0006446) |
| 0.0 | 0.3 | GO:0006561 | proline biosynthetic process(GO:0006561) |
| 0.0 | 0.4 | GO:0007016 | cytoskeletal anchoring at plasma membrane(GO:0007016) |
| 0.0 | 0.3 | GO:0045542 | positive regulation of cholesterol biosynthetic process(GO:0045542) |
| 0.0 | 0.2 | GO:0009313 | oligosaccharide catabolic process(GO:0009313) |
| 0.0 | 0.9 | GO:0042554 | superoxide anion generation(GO:0042554) |
| 0.0 | 0.1 | GO:0035025 | positive regulation of Rho protein signal transduction(GO:0035025) |
| 0.0 | 0.2 | GO:0006983 | ER overload response(GO:0006983) |
| 0.0 | 0.1 | GO:0072202 | forebrain ventricular zone progenitor cell division(GO:0021869) cell differentiation involved in metanephros development(GO:0072202) |
| 0.0 | 0.5 | GO:0007398 | ectoderm development(GO:0007398) |
| 0.0 | 0.4 | GO:0007597 | blood coagulation, intrinsic pathway(GO:0007597) |
| 0.0 | 3.1 | GO:0043281 | regulation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0043281) |
| 0.0 | 0.2 | GO:0007171 | activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171) |
| 0.0 | 0.1 | GO:0046856 | phosphatidylinositol dephosphorylation(GO:0046856) |
| 0.0 | 0.3 | GO:0006491 | N-glycan processing(GO:0006491) |
| 0.0 | 0.2 | GO:0045885 | obsolete positive regulation of survival gene product expression(GO:0045885) |
| 0.0 | 3.4 | GO:0008544 | epidermis development(GO:0008544) |
| 0.0 | 0.2 | GO:0001522 | pseudouridine synthesis(GO:0001522) |
| 0.0 | 0.5 | GO:0007052 | mitotic spindle organization(GO:0007052) |
| 0.0 | 4.5 | GO:0006260 | DNA replication(GO:0006260) |
| 0.0 | 0.2 | GO:0031290 | retinal ganglion cell axon guidance(GO:0031290) |
| 0.0 | 0.6 | GO:0090090 | negative regulation of canonical Wnt signaling pathway(GO:0090090) |
| 0.0 | 0.2 | GO:0007603 | phototransduction, visible light(GO:0007603) |
| 0.0 | 0.8 | GO:0016579 | protein deubiquitination(GO:0016579) |
| 0.0 | 0.1 | GO:0035162 | embryonic hemopoiesis(GO:0035162) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 1.2 | GO:0016342 | catenin complex(GO:0016342) |
| 0.3 | 3.1 | GO:0005916 | fascia adherens(GO:0005916) |
| 0.2 | 1.2 | GO:0070937 | CRD-mediated mRNA stability complex(GO:0070937) histone pre-mRNA 3'end processing complex(GO:0071204) |
| 0.1 | 2.2 | GO:0008290 | F-actin capping protein complex(GO:0008290) |
| 0.1 | 0.7 | GO:0033093 | Weibel-Palade body(GO:0033093) |
| 0.1 | 0.8 | GO:0031512 | motile primary cilium(GO:0031512) |
| 0.1 | 1.2 | GO:0000145 | exocyst(GO:0000145) |
| 0.1 | 0.4 | GO:0031673 | H zone(GO:0031673) |
| 0.1 | 1.4 | GO:0030122 | AP-2 adaptor complex(GO:0030122) clathrin coat of endocytic vesicle(GO:0030128) |
| 0.1 | 1.3 | GO:0031088 | platelet dense granule membrane(GO:0031088) |
| 0.1 | 0.3 | GO:0005641 | nuclear envelope lumen(GO:0005641) |
| 0.1 | 8.1 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.1 | 0.7 | GO:0005869 | dynactin complex(GO:0005869) |
| 0.1 | 1.2 | GO:0001527 | microfibril(GO:0001527) |
| 0.1 | 5.2 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.1 | 0.3 | GO:0032807 | DNA ligase IV complex(GO:0032807) |
| 0.1 | 5.2 | GO:0034707 | chloride channel complex(GO:0034707) |
| 0.1 | 0.2 | GO:0005889 | hydrogen:potassium-exchanging ATPase complex(GO:0005889) |
| 0.1 | 7.9 | GO:0014069 | postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572) |
| 0.1 | 1.0 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.1 | 1.4 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 0.0 | 2.9 | GO:0031674 | I band(GO:0031674) |
| 0.0 | 1.5 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.0 | 0.2 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
| 0.0 | 1.0 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.0 | 0.5 | GO:0008180 | COP9 signalosome(GO:0008180) |
| 0.0 | 0.5 | GO:0042588 | zymogen granule(GO:0042588) |
| 0.0 | 0.2 | GO:0070069 | cytochrome complex(GO:0070069) |
| 0.0 | 0.6 | GO:0016281 | eukaryotic translation initiation factor 4F complex(GO:0016281) |
| 0.0 | 0.7 | GO:0030530 | obsolete heterogeneous nuclear ribonucleoprotein complex(GO:0030530) |
| 0.0 | 1.1 | GO:0008287 | protein serine/threonine phosphatase complex(GO:0008287) phosphatase complex(GO:1903293) |
| 0.0 | 0.4 | GO:0016010 | dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665) |
| 0.0 | 0.2 | GO:0001518 | voltage-gated sodium channel complex(GO:0001518) |
| 0.0 | 13.4 | GO:0005615 | extracellular space(GO:0005615) |
| 0.0 | 0.3 | GO:0030131 | clathrin adaptor complex(GO:0030131) |
| 0.0 | 1.5 | GO:0005875 | microtubule associated complex(GO:0005875) |
| 0.0 | 0.3 | GO:0005861 | troponin complex(GO:0005861) |
| 0.0 | 2.4 | GO:0030424 | axon(GO:0030424) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 3.6 | GO:0032422 | purine-rich negative regulatory element binding(GO:0032422) |
| 0.8 | 2.4 | GO:0032090 | Pyrin domain binding(GO:0032090) |
| 0.5 | 4.1 | GO:0030297 | transmembrane receptor protein tyrosine kinase activator activity(GO:0030297) |
| 0.4 | 2.7 | GO:0005112 | Notch binding(GO:0005112) |
| 0.4 | 1.4 | GO:0032050 | clathrin heavy chain binding(GO:0032050) |
| 0.3 | 1.0 | GO:0004913 | interleukin-4 receptor activity(GO:0004913) |
| 0.3 | 2.1 | GO:0055105 | ubiquitin-protein transferase inhibitor activity(GO:0055105) |
| 0.3 | 1.1 | GO:0019870 | potassium channel inhibitor activity(GO:0019870) |
| 0.3 | 0.8 | GO:0044325 | ion channel binding(GO:0044325) |
| 0.2 | 1.1 | GO:0004741 | magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724) [pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741) |
| 0.2 | 1.9 | GO:0019826 | oxygen sensor activity(GO:0019826) |
| 0.2 | 1.2 | GO:0042153 | obsolete RPTP-like protein binding(GO:0042153) |
| 0.2 | 5.3 | GO:0051117 | ATPase binding(GO:0051117) |
| 0.1 | 0.4 | GO:0031877 | somatostatin receptor binding(GO:0031877) |
| 0.1 | 0.4 | GO:0004730 | pseudouridylate synthase activity(GO:0004730) |
| 0.1 | 0.9 | GO:0005110 | frizzled-2 binding(GO:0005110) |
| 0.1 | 0.3 | GO:0004139 | deoxyribose-phosphate aldolase activity(GO:0004139) |
| 0.1 | 0.9 | GO:0051400 | BH domain binding(GO:0051400) |
| 0.1 | 0.5 | GO:0031821 | G-protein coupled serotonin receptor binding(GO:0031821) |
| 0.1 | 10.8 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.1 | 1.6 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 0.1 | 0.6 | GO:0003810 | protein-glutamine gamma-glutamyltransferase activity(GO:0003810) |
| 0.1 | 0.7 | GO:0008179 | adenylate cyclase binding(GO:0008179) |
| 0.1 | 14.5 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.1 | 1.1 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
| 0.1 | 0.3 | GO:0003938 | IMP dehydrogenase activity(GO:0003938) |
| 0.1 | 3.3 | GO:0008009 | chemokine activity(GO:0008009) |
| 0.1 | 0.4 | GO:0030280 | structural constituent of epidermis(GO:0030280) |
| 0.1 | 1.3 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
| 0.1 | 4.5 | GO:0051287 | NAD binding(GO:0051287) |
| 0.1 | 0.3 | GO:0004735 | pyrroline-5-carboxylate reductase activity(GO:0004735) |
| 0.1 | 1.3 | GO:0004004 | ATP-dependent RNA helicase activity(GO:0004004) |
| 0.1 | 0.3 | GO:0003910 | DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910) |
| 0.0 | 0.9 | GO:0008143 | poly(A) binding(GO:0008143) |
| 0.0 | 1.3 | GO:0005520 | insulin-like growth factor binding(GO:0005520) |
| 0.0 | 0.2 | GO:0003951 | NAD+ kinase activity(GO:0003951) |
| 0.0 | 0.4 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.0 | 0.3 | GO:0016206 | catechol O-methyltransferase activity(GO:0016206) |
| 0.0 | 0.4 | GO:0005432 | calcium:sodium antiporter activity(GO:0005432) |
| 0.0 | 0.2 | GO:0004925 | prolactin receptor activity(GO:0004925) |
| 0.0 | 0.3 | GO:0008454 | alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454) |
| 0.0 | 0.7 | GO:0019865 | immunoglobulin binding(GO:0019865) |
| 0.0 | 0.3 | GO:0044548 | S100 protein binding(GO:0044548) |
| 0.0 | 0.2 | GO:0004563 | beta-N-acetylhexosaminidase activity(GO:0004563) |
| 0.0 | 0.8 | GO:0070888 | E-box binding(GO:0070888) |
| 0.0 | 6.6 | GO:0008022 | protein C-terminus binding(GO:0008022) |
| 0.0 | 0.1 | GO:0004439 | phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity(GO:0004439) |
| 0.0 | 1.8 | GO:0046332 | SMAD binding(GO:0046332) |
| 0.0 | 0.6 | GO:0008484 | sulfuric ester hydrolase activity(GO:0008484) |
| 0.0 | 1.0 | GO:0005245 | voltage-gated calcium channel activity(GO:0005245) |
| 0.0 | 0.9 | GO:0017022 | myosin binding(GO:0017022) |
| 0.0 | 0.4 | GO:0005388 | calcium-transporting ATPase activity(GO:0005388) |
| 0.0 | 1.0 | GO:0043130 | ubiquitin binding(GO:0043130) |
| 0.0 | 0.8 | GO:0036459 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005) |
| 0.0 | 0.4 | GO:0005001 | transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) |
| 0.0 | 0.1 | GO:0034701 | tripeptidase activity(GO:0034701) |
| 0.0 | 0.2 | GO:0003785 | actin monomer binding(GO:0003785) |
| 0.0 | 0.2 | GO:0000339 | RNA cap binding(GO:0000339) |
| 0.0 | 0.3 | GO:0030159 | receptor signaling complex scaffold activity(GO:0030159) |
| 0.0 | 0.2 | GO:1905030 | voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030) |
| 0.0 | 0.1 | GO:0031701 | angiotensin receptor binding(GO:0031701) |
| 0.0 | 8.2 | GO:0005509 | calcium ion binding(GO:0005509) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 4.1 | SA_REG_CASCADE_OF_CYCLIN_EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.1 | 1.0 | ST_IL_13_PATHWAY | Interleukin 13 (IL-13) Pathway |
| 0.0 | 1.2 | ST_WNT_BETA_CATENIN_PATHWAY | Wnt/beta-catenin Pathway |
| 0.0 | 1.3 | ST_P38_MAPK_PATHWAY | p38 MAPK Pathway |
| 0.0 | 0.4 | ST_MYOCYTE_AD_PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 0.0 | 0.4 | SIG_IL4RECEPTOR_IN_B_LYPHOCYTES | Genes related to IL4 rceptor signaling in B lymphocytes |
