Motif ID: SIX4

Z-value: 0.941


Transcription factors associated with SIX4:

Gene SymbolEntrez IDGene Name
SIX4 ENSG00000100625.8 SIX4



Activity profile for motif SIX4.

activity profile for motif SIX4


Sorted Z-values histogram for motif SIX4

Sorted Z-values for motif SIX4



Network of associatons between targets according to the STRING database.



First level regulatory network of SIX4

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr14_-_106406090 2.264 ENST00000390593.2
 IGHV6-1
immunoglobulin heavy variable 6-1
chr15_-_20193370 0.971 ENST00000558565.2
 IGHV3OR15-7
immunoglobulin heavy variable 3/OR15-7 (pseudogene)
chr14_-_106692191 0.969 ENST00000390607.2
 IGHV3-21
immunoglobulin heavy variable 3-21
chr1_-_173176452 0.583 ENST00000281834.3
 TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr2_+_85811525 0.578 ENST00000306384.4
 VAMP5
vesicle-associated membrane protein 5
chrX_+_108780347 0.565 ENST00000372103.1
 NXT2
nuclear transport factor 2-like export factor 2
chr11_+_117049854 0.539 ENST00000278951.7
 SIDT2
SID1 transmembrane family, member 2
chr11_-_64511575 0.523 ENST00000431822.1
ENST00000377486.3
ENST00000394432.3
 RASGRP2


RAS guanyl releasing protein 2 (calcium and DAG-regulated)


chr3_-_52488048 0.521 ENST00000232975.3
 TNNC1
troponin C type 1 (slow)
chr11_+_117049445 0.510 ENST00000324225.4
ENST00000532960.1
 SIDT2

SID1 transmembrane family, member 2

chr12_-_102874102 0.496 ENST00000392905.2
 IGF1
insulin-like growth factor 1 (somatomedin C)
chr8_+_56014949 0.485 ENST00000327381.6
 XKR4
XK, Kell blood group complex subunit-related family, member 4
chr1_-_114414316 0.465 ENST00000528414.1
ENST00000538253.1
ENST00000460620.1
ENST00000420377.2
ENST00000525799.1
ENST00000359785.5
 PTPN22





protein tyrosine phosphatase, non-receptor type 22 (lymphoid)





chr1_-_247335269 0.435 ENST00000543802.2
ENST00000491356.1
ENST00000472531.1
ENST00000340684.6
 ZNF124



zinc finger protein 124



chr10_+_89622870 0.431 ENST00000371953.3
 PTEN
phosphatase and tensin homolog
chr19_+_30414551 0.423 ENST00000360605.4
ENST00000570564.1
ENST00000574233.1
ENST00000585655.1
 URI1



URI1, prefoldin-like chaperone



chr11_+_125462690 0.381 ENST00000392708.4
ENST00000529196.1
ENST00000531491.1
 STT3A


STT3A, subunit of the oligosaccharyltransferase complex (catalytic)


chr6_-_31704282 0.376 ENST00000375784.3
ENST00000375779.2
 CLIC1

chloride intracellular channel 1

chr19_+_50887585 0.366 ENST00000440232.2
ENST00000601098.1
ENST00000599857.1
ENST00000593887.1
 POLD1



polymerase (DNA directed), delta 1, catalytic subunit



chr11_+_34073269 0.363 ENST00000389645.3
 CAPRIN1
cell cycle associated protein 1
chr11_+_117049910 0.337 ENST00000431081.2
ENST00000524842.1
 SIDT2

SID1 transmembrane family, member 2

chr11_+_34073195 0.312 ENST00000341394.4
 CAPRIN1
cell cycle associated protein 1
chr22_-_39268308 0.308 ENST00000407418.3
 CBX6
chromobox homolog 6
chr1_+_35734562 0.307 ENST00000314607.6
ENST00000373297.2
 ZMYM4

zinc finger, MYM-type 4

chr7_+_69064300 0.272 ENST00000342771.4
 AUTS2
autism susceptibility candidate 2
chr11_-_2906979 0.271 ENST00000380725.1
ENST00000313407.6
ENST00000430149.2
ENST00000440480.2
ENST00000414822.3
 CDKN1C




cyclin-dependent kinase inhibitor 1C (p57, Kip2)




chr9_+_132427883 0.256 ENST00000372469.4
 PRRX2
paired related homeobox 2
chr1_+_26737292 0.254 ENST00000254231.4
 LIN28A
lin-28 homolog A (C. elegans)
chr1_-_38061522 0.246 ENST00000373062.3
 GNL2
guanine nucleotide binding protein-like 2 (nucleolar)
chr17_+_7465216 0.229 ENST00000321337.7
 SENP3
SUMO1/sentrin/SMT3 specific peptidase 3
chr20_-_52687059 0.229 ENST00000371435.2
ENST00000395961.3
 BCAS1

breast carcinoma amplified sequence 1

chr13_+_33160553 0.228 ENST00000315596.10
 PDS5B
PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)
chr6_-_41040195 0.219 ENST00000463088.1
ENST00000469104.1
ENST00000486443.1
 OARD1


O-acyl-ADP-ribose deacylase 1


chrX_-_119763835 0.217 ENST00000371313.2
ENST00000304661.5
 C1GALT1C1

C1GALT1-specific chaperone 1

chr8_-_95907423 0.197 ENST00000396133.3
ENST00000308108.4
 CCNE2

cyclin E2

chr3_+_32147997 0.188 ENST00000282541.5
 GPD1L
glycerol-3-phosphate dehydrogenase 1-like
chr6_-_41040268 0.187 ENST00000373154.2
ENST00000244558.9
ENST00000464633.1
ENST00000424266.2
ENST00000479950.1
ENST00000482515.1
 OARD1





O-acyl-ADP-ribose deacylase 1





chr1_+_116915855 0.175 ENST00000295598.5
 ATP1A1
ATPase, Na+/K+ transporting, alpha 1 polypeptide
chr11_-_46615498 0.174 ENST00000533727.1
ENST00000534300.1
ENST00000528950.1
ENST00000526606.1
 AMBRA1



autophagy/beclin-1 regulator 1



chr1_+_26737253 0.172 ENST00000326279.6
 LIN28A
lin-28 homolog A (C. elegans)
chr22_-_39268192 0.172 ENST00000216083.6
 CBX6
chromobox homolog 6
chr1_+_226250379 0.149 ENST00000366815.3
ENST00000366814.3
 H3F3A

H3 histone, family 3A

chr11_-_113644491 0.148 ENST00000200135.3
 ZW10
zw10 kinetochore protein
chr15_+_59279851 0.133 ENST00000348370.4
ENST00000434298.1
ENST00000559160.1
 RNF111


ring finger protein 111


chr11_+_46958248 0.127 ENST00000536126.1
ENST00000278460.7
ENST00000378618.2
ENST00000395460.2
ENST00000378615.3
ENST00000543718.1
 C11orf49





chromosome 11 open reading frame 49





chrX_-_110655391 0.121 ENST00000356915.2
ENST00000356220.3
 DCX

doublecortin

chr4_-_13546632 0.120 ENST00000382438.5
 NKX3-2
NK3 homeobox 2
chr1_+_161123536 0.119 ENST00000368003.5
 UFC1
ubiquitin-fold modifier conjugating enzyme 1
chr14_-_107083690 0.118 ENST00000455737.1
ENST00000390629.2
 IGHV4-59

immunoglobulin heavy variable 4-59

chr20_+_57875457 0.106 ENST00000337938.2
ENST00000311585.7
ENST00000371028.2
 EDN3


endothelin 3


chr1_-_78148324 0.097 ENST00000370801.3
ENST00000433749.1
 ZZZ3

zinc finger, ZZ-type containing 3

chr16_-_15180257 0.095 ENST00000540462.1
 RRN3
RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae)
chr7_-_99063769 0.095 ENST00000430982.1
ENST00000555673.1
ENST00000394186.3
ENST00000359832.4
ENST00000449683.1
ENST00000488775.1
ENST00000523680.1
ENST00000292475.3
ENST00000413834.1
 PTCD1

ATP5J2





ATP5J2-PTCD1
pentatricopeptide repeat domain 1

ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F2





ATP5J2-PTCD1 readthrough
chr14_-_92413353 0.094 ENST00000556154.1
 FBLN5
fibulin 5
chr3_-_87325612 0.093 ENST00000561167.1
ENST00000560656.1
ENST00000344265.3
 POU1F1


POU class 1 homeobox 1


chrX_+_54466829 0.089 ENST00000375151.4
 TSR2
TSR2, 20S rRNA accumulation, homolog (S. cerevisiae)
chr7_+_97361388 0.081 ENST00000350485.4
ENST00000346867.4
 TAC1

tachykinin, precursor 1

chr1_-_42800614 0.078 ENST00000372572.1
 FOXJ3
forkhead box J3
chr12_+_133758115 0.078 ENST00000541009.2
ENST00000592241.1
 ZNF268

zinc finger protein 268

chr20_+_57875658 0.076 ENST00000371025.3
 EDN3
endothelin 3
chr11_+_33279850 0.075 ENST00000531504.1
ENST00000456517.1
 HIPK3

homeodomain interacting protein kinase 3

chr1_-_42801540 0.074 ENST00000372573.1
 FOXJ3
forkhead box J3
chr6_+_41040678 0.073 ENST00000341376.6
ENST00000353205.5
 NFYA

nuclear transcription factor Y, alpha

chr19_-_47128294 0.068 ENST00000596260.1
ENST00000597185.1
ENST00000598865.1
ENST00000594275.1
ENST00000291294.2
 PTGIR




prostaglandin I2 (prostacyclin) receptor (IP)




chr10_+_26505594 0.064 ENST00000259271.3
 GAD2
glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
chr9_+_138437985 0.059 ENST00000340780.3
ENST00000342114.4
ENST00000371776.1
ENST00000539850.1
 OBP2A



odorant binding protein 2A



chr2_-_113999260 0.059 ENST00000468980.2
 PAX8
paired box 8
chr12_-_10282742 0.058 ENST00000298523.5
ENST00000396484.2
ENST00000310002.4
 CLEC7A


C-type lectin domain family 7, member A


chr1_+_117297007 0.058 ENST00000369478.3
ENST00000369477.1
 CD2

CD2 molecule

chr11_-_35547572 0.051 ENST00000378880.2
 PAMR1
peptidase domain containing associated with muscle regeneration 1
chr1_-_42800860 0.050 ENST00000445886.1
ENST00000361346.1
ENST00000361776.1
 FOXJ3


forkhead box J3


chr3_-_183966717 0.048 ENST00000446569.1
ENST00000418734.2
ENST00000397676.3
 ALG3


ALG3, alpha-1,3- mannosyltransferase


chr5_+_149569520 0.046 ENST00000230671.2
ENST00000524041.1
 SLC6A7

solute carrier family 6 (neurotransmitter transporter), member 7

chr9_-_136084628 0.044 ENST00000372034.3
ENST00000372032.2
 OBP2B

odorant binding protein 2B

chr7_+_97361218 0.041 ENST00000319273.5
 TAC1
tachykinin, precursor 1
chr1_+_116184566 0.040 ENST00000355485.2
ENST00000369510.4
 VANGL1

VANGL planar cell polarity protein 1

chr1_+_38022572 0.037 ENST00000541606.1
 DNALI1
dynein, axonemal, light intermediate chain 1
chr7_-_26578407 0.035 ENST00000242109.3
 KIAA0087
KIAA0087
chr1_+_17559776 0.033 ENST00000537499.1
ENST00000413717.2
ENST00000536552.1
 PADI1


peptidyl arginine deiminase, type I


chr19_+_55235969 0.032 ENST00000402254.2
ENST00000538269.1
ENST00000541392.1
ENST00000396284.2
ENST00000291860.1
 KIR3DL1


KIR2DL4
KIR3DL3
killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1


killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4
killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 3
chr1_+_156611704 0.020 ENST00000329117.5
 BCAN
brevican
chr5_+_85913721 0.019 ENST00000247655.3
ENST00000509578.1
ENST00000515763.1
 COX7C


cytochrome c oxidase subunit VIIc


chr1_+_160097462 0.016 ENST00000447527.1
 ATP1A2
ATPase, Na+/K+ transporting, alpha 2 polypeptide
chr10_-_75255724 0.014 ENST00000342558.3
ENST00000360663.5
ENST00000394829.2
ENST00000394828.2
ENST00000394822.2
 PPP3CB




protein phosphatase 3, catalytic subunit, beta isozyme




chr19_+_13135386 0.012 ENST00000360105.4
ENST00000588228.1
ENST00000591028.1
 NFIX


nuclear factor I/X (CCAAT-binding transcription factor)


chr5_-_1295104 0.004 ENST00000334602.6
ENST00000508104.2
ENST00000310581.5
ENST00000296820.5
 TERT



telomerase reverse transcriptase



chr19_+_55249969 0.001 ENST00000342376.3
ENST00000434419.2
 KIR2DL3

killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0071380 cellular response to prostaglandin E stimulus(GO:0071380)
0.2 0.5 GO:1903115 regulation of muscle filament sliding(GO:0032971) regulation of actin filament-based movement(GO:1903115)
0.1 0.4 GO:0010586 miRNA metabolic process(GO:0010586) miRNA catabolic process(GO:0010587)
0.1 0.7 GO:0061003 positive regulation of dendritic spine morphogenesis(GO:0061003)
0.1 0.4 GO:0006273 lagging strand elongation(GO:0006273)
0.1 0.4 GO:0060292 phosphorylated carbohydrate dephosphorylation(GO:0046838) inositol phosphate dephosphorylation(GO:0046855) long term synaptic depression(GO:0060292)
0.1 0.5 GO:0035630 glycolate metabolic process(GO:0009441) bone mineralization involved in bone maturation(GO:0035630)
0.0 0.5 GO:0032817 regulation of natural killer cell proliferation(GO:0032817)
0.0 0.3 GO:0045880 positive regulation of smoothened signaling pathway(GO:0045880)
0.0 0.1 GO:2000121 regulation of removal of superoxide radicals(GO:2000121)
0.0 0.2 GO:0014820 tonic smooth muscle contraction(GO:0014820) artery smooth muscle contraction(GO:0014824)
0.0 0.2 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
0.0 0.1 GO:0034501 protein localization to kinetochore(GO:0034501)
0.0 0.1 GO:0071569 protein ufmylation(GO:0071569)
0.0 0.2 GO:0006072 glycerol-3-phosphate metabolic process(GO:0006072)
0.0 0.1 GO:0042474 middle ear morphogenesis(GO:0042474)
0.0 0.1 GO:0031580 membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.0 0.1 GO:0007217 tachykinin receptor signaling pathway(GO:0007217)
0.0 0.3 GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway(GO:0030511) positive regulation of cellular response to transforming growth factor beta stimulus(GO:1903846)
0.0 0.0 GO:0002752 cell surface pattern recognition receptor signaling pathway(GO:0002752)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0016942 insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454)
0.1 1.1 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 0.4 GO:0042575 DNA polymerase complex(GO:0042575)
0.0 0.4 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.2 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.0 0.1 GO:0071953 elastic fiber(GO:0071953)
0.0 0.5 GO:0005861 troponin complex(GO:0005861)
0.0 0.1 GO:0005828 kinetochore microtubule(GO:0005828)
0.0 0.2 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.1 0.4 GO:0008296 3'-5'-exodeoxyribonuclease activity(GO:0008296)
0.0 0.5 GO:0031013 troponin I binding(GO:0031013)
0.0 0.4 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0 0.2 GO:0031708 bombesin receptor binding(GO:0031705) endothelin B receptor binding(GO:0031708)
0.0 0.4 GO:0031369 translation initiation factor binding(GO:0031369)
0.0 0.2 GO:0004367 glycerol-3-phosphate dehydrogenase [NAD+] activity(GO:0004367)
0.0 0.5 GO:0019992 diacylglycerol binding(GO:0019992)
0.0 0.6 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.5 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 0.1 GO:0019237 centromeric DNA binding(GO:0019237)
0.0 0.0 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
0.0 0.4 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 0.5 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.0 0.2 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.