Motif ID: SIX6

Z-value: 1.508


Transcription factors associated with SIX6:

Gene SymbolEntrez IDGene Name
SIX6 ENSG00000184302.6 SIX6



Activity profile for motif SIX6.

activity profile for motif SIX6


Sorted Z-values histogram for motif SIX6

Sorted Z-values for motif SIX6



Network of associatons between targets according to the STRING database.



First level regulatory network of SIX6

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_-_88427568 4.973 ENST00000393750.3
ENST00000295834.3
 FABP1

fatty acid binding protein 1, liver

chr1_-_161193349 4.289 ENST00000469730.2
ENST00000463273.1
ENST00000464492.1
ENST00000367990.3
ENST00000470459.2
ENST00000468465.1
ENST00000463812.1
 APOA2






apolipoprotein A-II






chr4_-_155511887 2.851 ENST00000302053.3
ENST00000403106.3
 FGA

fibrinogen alpha chain

chr4_+_74301880 2.439 ENST00000395792.2
ENST00000226359.2
 AFP

alpha-fetoprotein

chr13_-_46679185 2.355 ENST00000439329.3
 CPB2
carboxypeptidase B2 (plasma)
chr13_-_46679144 2.014 ENST00000181383.4
 CPB2
carboxypeptidase B2 (plasma)
chr20_+_34802295 1.823 ENST00000432603.1
 EPB41L1
erythrocyte membrane protein band 4.1-like 1
chr16_+_72090053 1.589 ENST00000576168.2
ENST00000567185.3
ENST00000567612.2
 HP


haptoglobin


chr4_-_71532339 1.230 ENST00000254801.4
 IGJ
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
chr1_+_160709055 1.163 ENST00000368043.3
ENST00000368042.3
ENST00000458602.2
ENST00000458104.2
 SLAMF7



SLAM family member 7



chr14_+_21152259 1.097 ENST00000336811.6
ENST00000555835.1
 ANG
RNASE4
angiogenin, ribonuclease, RNase A family, 5
ribonuclease, RNase A family, 4
chr12_-_122018859 1.072 ENST00000536437.1
ENST00000377071.4
ENST00000538046.2
 KDM2B


lysine (K)-specific demethylase 2B


chr15_-_80263506 1.069 ENST00000335661.6
 BCL2A1
BCL2-related protein A1
chr12_-_28123206 1.009 ENST00000542963.1
ENST00000535992.1
 PTHLH

parathyroid hormone-like hormone

chr1_+_160709029 0.981 ENST00000444090.2
ENST00000441662.2
 SLAMF7

SLAM family member 7

chrX_-_20236970 0.898 ENST00000379548.4
 RPS6KA3
ribosomal protein S6 kinase, 90kDa, polypeptide 3
chr12_-_28122980 0.888 ENST00000395868.3
ENST00000534890.1
 PTHLH

parathyroid hormone-like hormone

chr8_+_101170257 0.771 ENST00000251809.3
 SPAG1
sperm associated antigen 1
chr16_+_22524844 0.761 ENST00000538606.1
ENST00000424340.1
ENST00000517539.1
ENST00000528249.1
 NPIPB5



nuclear pore complex interacting protein family, member B5



chr6_+_26240561 0.716 ENST00000377745.2
 HIST1H4F
histone cluster 1, H4f
chr3_-_9994021 0.656 ENST00000411976.2
ENST00000412055.1
 PRRT3

proline-rich transmembrane protein 3

chr1_+_156119798 0.637 ENST00000355014.2
 SEMA4A
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
chr19_+_3136115 0.635 ENST00000262958.3
 GNA15
guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
chr16_-_21868978 0.608 ENST00000357370.5
ENST00000451409.1
ENST00000341400.7
ENST00000518761.4
 NPIPB4



nuclear pore complex interacting protein family, member B4



chr16_-_21436459 0.577 ENST00000448012.2
ENST00000504841.2
ENST00000419180.2
 NPIPB3


nuclear pore complex interacting protein family, member B3


chr19_-_14628645 0.559 ENST00000598235.1
 DNAJB1
DnaJ (Hsp40) homolog, subfamily B, member 1
chr2_-_58468437 0.555 ENST00000403676.1
ENST00000427708.2
ENST00000403295.3
ENST00000446381.1
ENST00000417361.1
ENST00000233741.4
ENST00000402135.3
ENST00000540646.1
ENST00000449070.1
 FANCL








Fanconi anemia, complementation group L








chr1_-_67142710 0.552 ENST00000502413.2
 AL139147.1
Uncharacterized protein
chr21_-_43735446 0.514 ENST00000398431.2
 TFF3
trefoil factor 3 (intestinal)
chr12_-_498620 0.492 ENST00000399788.2
ENST00000382815.4
 KDM5A

lysine (K)-specific demethylase 5A

chr16_-_21868739 0.421 ENST00000415645.2
 NPIPB4
nuclear pore complex interacting protein family, member B4
chrX_+_12809463 0.413 ENST00000380663.3
ENST00000380668.5
ENST00000398491.2
ENST00000489404.1
 PRPS2



phosphoribosyl pyrophosphate synthetase 2



chr20_-_4990931 0.412 ENST00000379333.1
 SLC23A2
solute carrier family 23 (ascorbic acid transporter), member 2
chr3_-_111314230 0.399 ENST00000317012.4
 ZBED2
zinc finger, BED-type containing 2
chr19_-_16008880 0.386 ENST00000011989.7
ENST00000221700.6
 CYP4F2

cytochrome P450, family 4, subfamily F, polypeptide 2

chr9_-_99382065 0.375 ENST00000265659.2
ENST00000375241.1
ENST00000375236.1
 CDC14B


cell division cycle 14B


chr12_-_46385811 0.359 ENST00000419565.2
 SCAF11
SR-related CTD-associated factor 11
chr10_-_61720640 0.356 ENST00000521074.1
ENST00000444900.1
 C10orf40

chromosome 10 open reading frame 40

chr1_-_150669604 0.354 ENST00000427665.1
ENST00000540514.1
 GOLPH3L

golgi phosphoprotein 3-like

chr2_-_208989225 0.352 ENST00000264376.4
 CRYGD
crystallin, gamma D
chr1_+_53308398 0.341 ENST00000371528.1
 ZYG11A
zyg-11 family member A, cell cycle regulator
chr16_-_29517141 0.330 ENST00000550665.1
 RP11-231C14.4
Uncharacterized protein
chr3_+_151531810 0.322 ENST00000232892.7
 AADAC
arylacetamide deacetylase
chr5_+_140201183 0.320 ENST00000529619.1
ENST00000529859.1
ENST00000378126.3
 PCDHA5


protocadherin alpha 5


chr17_-_5342380 0.310 ENST00000225698.4
 C1QBP
complement component 1, q subcomponent binding protein
chr21_-_43735628 0.278 ENST00000291525.10
ENST00000518498.1
 TFF3

trefoil factor 3 (intestinal)

chrX_-_18238999 0.273 ENST00000380033.4
ENST00000380030.3
 BEND2

BEN domain containing 2

chr2_+_89184868 0.269 ENST00000390243.2
 IGKV4-1
immunoglobulin kappa variable 4-1
chr2_-_77749474 0.265 ENST00000409093.1
ENST00000409088.3
 LRRTM4

leucine rich repeat transmembrane neuronal 4

chr2_-_89266286 0.264 ENST00000464162.1
 IGKV1-6
immunoglobulin kappa variable 1-6
chr11_+_74699942 0.259 ENST00000526068.1
ENST00000532963.1
ENST00000531619.1
ENST00000534628.1
ENST00000545272.1
 NEU3




sialidase 3 (membrane sialidase)




chr6_+_26204825 0.246 ENST00000360441.4
 HIST1H4E
histone cluster 1, H4e
chr1_+_212738676 0.241 ENST00000366981.4
ENST00000366987.2
 ATF3

activating transcription factor 3

chr16_+_28648975 0.233 ENST00000529716.1
 NPIPB8
nuclear pore complex interacting protein family, member B8
chr17_-_42327236 0.229 ENST00000399246.2
 AC003102.1
AC003102.1
chr5_+_40909354 0.228 ENST00000313164.9
 C7
complement component 7
chr2_+_90192768 0.220 ENST00000390275.2
 IGKV1D-13
immunoglobulin kappa variable 1D-13
chr13_+_73629107 0.209 ENST00000539231.1
 KLF5
Kruppel-like factor 5 (intestinal)
chr17_+_60501228 0.204 ENST00000311506.5
 METTL2A
methyltransferase like 2A
chr6_-_26189304 0.202 ENST00000340756.2
 HIST1H4D
histone cluster 1, H4d
chr1_-_157014865 0.200 ENST00000361409.2
 ARHGEF11
Rho guanine nucleotide exchange factor (GEF) 11
chr13_+_34392185 0.199 ENST00000380071.3
 RFC3
replication factor C (activator 1) 3, 38kDa
chr9_-_21351377 0.189 ENST00000380210.1
 IFNA6
interferon, alpha 6
chr22_-_19137796 0.185 ENST00000086933.2
 GSC2
goosecoid homeobox 2
chr2_-_62081148 0.183 ENST00000404929.1
 FAM161A
family with sequence similarity 161, member A
chr12_-_87232644 0.181 ENST00000549405.2
 MGAT4C
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)
chr15_-_51397473 0.171 ENST00000327536.5
 TNFAIP8L3
tumor necrosis factor, alpha-induced protein 8-like 3
chrX_+_38660704 0.161 ENST00000378474.3
 MID1IP1
MID1 interacting protein 1
chrX_+_64708615 0.157 ENST00000338957.4
ENST00000423889.3
 ZC3H12B

zinc finger CCCH-type containing 12B

chr11_+_33902189 0.155 ENST00000330381.2
 AC132216.1
HCG1785179; PRO1787; Uncharacterized protein
chr5_-_66492562 0.153 ENST00000256447.4
 CD180
CD180 molecule
chr19_+_55235969 0.153 ENST00000402254.2
ENST00000538269.1
ENST00000541392.1
ENST00000396284.2
ENST00000291860.1
 KIR3DL1


KIR2DL4
KIR3DL3
killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1


killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4
killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 3
chr11_-_102496063 0.124 ENST00000260228.2
 MMP20
matrix metallopeptidase 20
chrY_-_24038660 0.121 ENST00000382677.3
 RBMY1D
RNA binding motif protein, Y-linked, family 1, member D
chr11_-_45307817 0.120 ENST00000020926.3
 SYT13
synaptotagmin XIII
chr11_+_122709200 0.118 ENST00000227348.4
 CRTAM
cytotoxic and regulatory T cell molecule
chr8_-_141774467 0.115 ENST00000520151.1
ENST00000519024.1
ENST00000519465.1
 PTK2


protein tyrosine kinase 2


chr6_-_26285737 0.109 ENST00000377727.1
ENST00000289352.1
 HIST1H4H

histone cluster 1, H4h

chrX_+_8433376 0.107 ENST00000440654.2
ENST00000381029.4
 VCX3B

variable charge, X-linked 3B

chr10_+_52094298 0.101 ENST00000595931.1
 AC069547.1
HCG1745369; PRO3073; Uncharacterized protein
chr6_+_52051171 0.100 ENST00000340057.1
 IL17A
interleukin 17A
chrY_+_23698778 0.079 ENST00000303902.5
 RBMY1A1
RNA binding motif protein, Y-linked, family 1, member A1
chr6_+_146348810 0.077 ENST00000492807.2
 GRM1
glutamate receptor, metabotropic 1
chr12_-_121477039 0.075 ENST00000257570.5
 OASL
2'-5'-oligoadenylate synthetase-like
chr4_-_123377880 0.071 ENST00000226730.4
 IL2
interleukin 2
chr16_-_20364030 0.071 ENST00000396134.2
ENST00000573567.1
ENST00000570757.1
ENST00000424589.1
ENST00000302509.4
ENST00000571174.1
ENST00000576688.1
 UMOD






uromodulin






chr16_+_19467772 0.067 ENST00000219821.5
ENST00000561503.1
ENST00000564959.1
 TMC5


transmembrane channel-like 5


chr8_+_1993173 0.060 ENST00000523438.1
 MYOM2
myomesin 2
chr6_+_146348782 0.056 ENST00000361719.2
ENST00000392299.2
 GRM1

glutamate receptor, metabotropic 1

chr16_-_20364122 0.055 ENST00000396138.4
ENST00000577168.1
 UMOD

uromodulin

chr2_+_177134134 0.053 ENST00000249442.6
ENST00000392529.2
ENST00000443241.1
 MTX2


metaxin 2


chr2_+_177134201 0.046 ENST00000452865.1
 MTX2
metaxin 2
chr12_-_10978957 0.042 ENST00000240619.2
 TAS2R10
taste receptor, type 2, member 10
chrX_-_55020511 0.040 ENST00000375006.3
ENST00000374992.2
 PFKFB1

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1

chr1_+_159557607 0.039 ENST00000255040.2
 APCS
amyloid P component, serum
chr12_-_121476750 0.039 ENST00000543677.1
 OASL
2'-5'-oligoadenylate synthetase-like
chr6_-_26018007 0.037 ENST00000244573.3
 HIST1H1A
histone cluster 1, H1a
chr4_+_88532028 0.030 ENST00000282478.7
 DSPP
dentin sialophosphoprotein
chrX_+_128674213 0.025 ENST00000371113.4
ENST00000357121.5
 OCRL

oculocerebrorenal syndrome of Lowe

chrX_-_118699325 0.022 ENST00000320339.4
ENST00000371594.4
ENST00000536133.1
 CXorf56


chromosome X open reading frame 56



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 4.3 GO:2000910 regulation of cholesterol import(GO:0060620) negative regulation of cholesterol import(GO:0060621) regulation of sterol import(GO:2000909) negative regulation of sterol import(GO:2000910)
0.5 5.0 GO:0032000 positive regulation of fatty acid beta-oxidation(GO:0032000)
0.5 1.9 GO:0060649 nipple development(GO:0060618) mammary gland bud elongation(GO:0060649) nipple morphogenesis(GO:0060658) nipple sheath formation(GO:0060659)
0.4 4.4 GO:0051918 negative regulation of fibrinolysis(GO:0051918)
0.4 1.6 GO:0010727 negative regulation of hydrogen peroxide metabolic process(GO:0010727)
0.3 2.3 GO:0042448 progesterone metabolic process(GO:0042448)
0.2 1.1 GO:0006651 diacylglycerol biosynthetic process(GO:0006651)
0.2 0.6 GO:0007207 phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.1 2.0 GO:0032814 regulation of natural killer cell activation(GO:0032814)
0.1 0.4 GO:0019852 L-ascorbic acid metabolic process(GO:0019852)
0.1 1.8 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
0.1 0.6 GO:0051085 chaperone mediated protein folding requiring cofactor(GO:0051085)
0.0 0.3 GO:0010896 regulation of triglyceride catabolic process(GO:0010896) positive regulation of triglyceride catabolic process(GO:0010898)
0.0 0.3 GO:0007597 blood coagulation, intrinsic pathway(GO:0007597)
0.0 0.1 GO:0045591 positive regulation of regulatory T cell differentiation(GO:0045591)
0.0 0.2 GO:0032528 microvillus assembly(GO:0030033) microvillus organization(GO:0032528)
0.0 0.9 GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0043154)
0.0 0.1 GO:0032747 positive regulation of interleukin-23 production(GO:0032747)
0.0 2.9 GO:0002576 platelet degranulation(GO:0002576)
0.0 0.1 GO:0002860 natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002420) natural killer cell mediated immune response to tumor cell(GO:0002423) regulation of natural killer cell mediated immune response to tumor cell(GO:0002855) positive regulation of natural killer cell mediated immune response to tumor cell(GO:0002857) regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002858) positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002860)
0.0 0.4 GO:0000038 very long-chain fatty acid metabolic process(GO:0000038)
0.0 0.2 GO:0045652 regulation of megakaryocyte differentiation(GO:0045652) regulation of hematopoietic progenitor cell differentiation(GO:1901532)
0.0 0.2 GO:0000731 DNA synthesis involved in DNA repair(GO:0000731)
0.0 0.2 GO:0045723 positive regulation of fatty acid biosynthetic process(GO:0045723)
0.0 0.1 GO:0070170 regulation of tooth mineralization(GO:0070170)
0.0 0.2 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.0 0.3 GO:0031572 G2 DNA damage checkpoint(GO:0031572)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 5.0 GO:0045179 apical cortex(GO:0045179)
0.4 1.6 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.3 4.3 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.3 2.9 GO:0005577 fibrinogen complex(GO:0005577)
0.2 1.1 GO:0032311 angiogenin-PRI complex(GO:0032311)
0.1 0.5 GO:0019907 cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907)
0.0 0.2 GO:0005663 DNA replication factor C complex(GO:0005663)
0.0 0.2 GO:0005579 membrane attack complex(GO:0005579)
0.0 2.6 GO:0019898 extrinsic component of membrane(GO:0019898)
0.0 0.4 GO:0009925 basal plasma membrane(GO:0009925)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 5.0 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
1.1 4.3 GO:0034190 apolipoprotein receptor binding(GO:0034190) high-density lipoprotein particle receptor binding(GO:0070653)
0.2 1.6 GO:0030492 hemoglobin binding(GO:0030492)
0.2 4.4 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.2 1.1 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.1 0.4 GO:0008523 sodium-dependent multivitamin transmembrane transporter activity(GO:0008523)
0.1 1.1 GO:0004522 ribonuclease A activity(GO:0004522)
0.1 0.4 GO:0050051 leukotriene-B4 20-monooxygenase activity(GO:0050051)
0.1 2.9 GO:0043499 obsolete eukaryotic cell surface binding(GO:0043499)
0.1 0.3 GO:0001849 complement component C1q binding(GO:0001849)
0.1 0.1 GO:0031628 opioid receptor binding(GO:0031628)
0.1 0.4 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
0.0 0.2 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.0 0.9 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 0.2 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0 1.5 GO:0003823 antigen binding(GO:0003823)
0.0 0.6 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.0 0.1 GO:0016997 exo-alpha-sialidase activity(GO:0004308) alpha-sialidase activity(GO:0016997)
0.0 1.7 GO:0005179 hormone activity(GO:0005179)
0.0 0.3 GO:0004806 triglyceride lipase activity(GO:0004806)
0.0 0.4 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.2 GO:0032393 MHC class I receptor activity(GO:0032393)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.9 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 0.6 ST_ADRENERGIC Adrenergic Pathway