Motif ID: SMAD3
Z-value: 1.856
Transcription factors associated with SMAD3:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| SMAD3 | ENSG00000166949.11 | SMAD3 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 3.9 | GO:0002901 | mature B cell apoptotic process(GO:0002901) regulation of mature B cell apoptotic process(GO:0002905) negative regulation of mature B cell apoptotic process(GO:0002906) purine nucleotide salvage(GO:0032261) nucleotide salvage(GO:0043173) inosine metabolic process(GO:0046102) xanthine metabolic process(GO:0046110) |
| 1.0 | 7.3 | GO:0015755 | fructose transport(GO:0015755) |
| 0.9 | 3.6 | GO:0032929 | negative regulation of superoxide anion generation(GO:0032929) |
| 0.4 | 1.3 | GO:0002291 | T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:0002291) |
| 0.3 | 1.3 | GO:0010944 | negative regulation of transcription by competitive promoter binding(GO:0010944) |
| 0.3 | 2.2 | GO:0071267 | amino acid salvage(GO:0043102) L-methionine biosynthetic process(GO:0071265) L-methionine salvage(GO:0071267) |
| 0.3 | 0.9 | GO:0014063 | regulation of serotonin secretion(GO:0014062) negative regulation of serotonin secretion(GO:0014063) |
| 0.2 | 1.2 | GO:0046952 | ketone body catabolic process(GO:0046952) |
| 0.2 | 0.7 | GO:0090274 | positive regulation of somatostatin secretion(GO:0090274) |
| 0.2 | 0.7 | GO:0090206 | negative regulation of cholesterol biosynthetic process(GO:0045541) negative regulation of cholesterol metabolic process(GO:0090206) |
| 0.2 | 0.9 | GO:0045872 | positive regulation of rhodopsin gene expression(GO:0045872) |
| 0.2 | 1.0 | GO:0015693 | magnesium ion transport(GO:0015693) |
| 0.2 | 15.6 | GO:0006334 | nucleosome assembly(GO:0006334) |
| 0.1 | 1.0 | GO:0030644 | cellular chloride ion homeostasis(GO:0030644) chloride ion homeostasis(GO:0055064) |
| 0.1 | 0.8 | GO:0060261 | positive regulation of transcription initiation from RNA polymerase II promoter(GO:0060261) positive regulation of DNA-templated transcription, initiation(GO:2000144) |
| 0.1 | 0.3 | GO:0009992 | cellular water homeostasis(GO:0009992) |
| 0.1 | 1.8 | GO:0009303 | rRNA transcription(GO:0009303) |
| 0.1 | 0.2 | GO:0006420 | arginyl-tRNA aminoacylation(GO:0006420) |
| 0.1 | 1.1 | GO:0095500 | G-protein coupled acetylcholine receptor signaling pathway(GO:0007213) acetylcholine receptor signaling pathway(GO:0095500) postsynaptic signal transduction(GO:0098926) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145) |
| 0.1 | 0.8 | GO:0046653 | tetrahydrofolate metabolic process(GO:0046653) |
| 0.1 | 1.2 | GO:0050930 | induction of positive chemotaxis(GO:0050930) |
| 0.1 | 0.8 | GO:0006743 | ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744) |
| 0.1 | 0.5 | GO:0051096 | meiotic mismatch repair(GO:0000710) positive regulation of helicase activity(GO:0051096) |
| 0.1 | 0.4 | GO:0008228 | opsonization(GO:0008228) |
| 0.1 | 0.2 | GO:0048865 | stem cell fate commitment(GO:0048865) stem cell fate determination(GO:0048867) |
| 0.1 | 0.6 | GO:0030147 | obsolete natriuresis(GO:0030147) |
| 0.0 | 0.3 | GO:0006398 | mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398) |
| 0.0 | 0.1 | GO:0035234 | ectopic germ cell programmed cell death(GO:0035234) |
| 0.0 | 0.9 | GO:0016578 | histone deubiquitination(GO:0016578) |
| 0.0 | 0.1 | GO:0010107 | potassium ion import(GO:0010107) |
| 0.0 | 0.9 | GO:0000291 | nuclear-transcribed mRNA catabolic process, exonucleolytic(GO:0000291) exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928) |
| 0.0 | 0.3 | GO:0060346 | bone trabecula formation(GO:0060346) bone trabecula morphogenesis(GO:0061430) |
| 0.0 | 0.3 | GO:0046835 | carbohydrate phosphorylation(GO:0046835) |
| 0.0 | 0.2 | GO:0070050 | neuron cellular homeostasis(GO:0070050) |
| 0.0 | 0.2 | GO:0045589 | regulation of regulatory T cell differentiation(GO:0045589) |
| 0.0 | 0.2 | GO:0006562 | proline catabolic process(GO:0006562) |
| 0.0 | 0.1 | GO:0007181 | transforming growth factor beta receptor complex assembly(GO:0007181) |
| 0.0 | 0.3 | GO:0033523 | histone monoubiquitination(GO:0010390) histone H2B ubiquitination(GO:0033523) |
| 0.0 | 0.5 | GO:0034605 | cellular response to heat(GO:0034605) |
| 0.0 | 0.2 | GO:0022027 | interkinetic nuclear migration(GO:0022027) |
| 0.0 | 1.0 | GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) negative regulation of cellular response to transforming growth factor beta stimulus(GO:1903845) |
| 0.0 | 0.9 | GO:0006626 | protein targeting to mitochondrion(GO:0006626) |
| 0.0 | 0.9 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 0.0 | 4.4 | GO:0006417 | regulation of translation(GO:0006417) |
| 0.0 | 0.7 | GO:0043966 | histone H3 acetylation(GO:0043966) |
| 0.0 | 0.6 | GO:0000188 | inactivation of MAPK activity(GO:0000188) |
| 0.0 | 1.3 | GO:0007498 | mesoderm development(GO:0007498) |
| 0.0 | 0.1 | GO:0015722 | canalicular bile acid transport(GO:0015722) |
| 0.0 | 0.3 | GO:0046834 | lipid phosphorylation(GO:0046834) |
| 0.0 | 0.8 | GO:0006406 | mRNA export from nucleus(GO:0006406) mRNA-containing ribonucleoprotein complex export from nucleus(GO:0071427) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 4.6 | GO:0032839 | dendrite cytoplasm(GO:0032839) |
| 0.3 | 15.6 | GO:0000786 | nucleosome(GO:0000786) |
| 0.3 | 1.1 | GO:0016533 | cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533) |
| 0.2 | 0.5 | GO:0032302 | MutSbeta complex(GO:0032302) |
| 0.2 | 0.9 | GO:0005742 | mitochondrial outer membrane translocase complex(GO:0005742) |
| 0.1 | 4.4 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
| 0.1 | 0.5 | GO:0016593 | Cdc73/Paf1 complex(GO:0016593) |
| 0.1 | 0.3 | GO:0031229 | integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453) |
| 0.0 | 1.3 | GO:0001772 | immunological synapse(GO:0001772) |
| 0.0 | 0.2 | GO:0017101 | aminoacyl-tRNA synthetase multienzyme complex(GO:0017101) |
| 0.0 | 1.4 | GO:0055038 | recycling endosome membrane(GO:0055038) |
| 0.0 | 0.8 | GO:0005763 | organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763) |
| 0.0 | 0.7 | GO:0030914 | STAGA complex(GO:0030914) |
| 0.0 | 0.9 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.0 | 0.8 | GO:0005640 | nuclear outer membrane(GO:0005640) |
| 0.0 | 1.3 | GO:0032993 | protein-DNA complex(GO:0032993) |
| 0.0 | 0.7 | GO:0043195 | terminal bouton(GO:0043195) |
| 0.0 | 0.9 | GO:0030964 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.0 | 0.3 | GO:0001527 | microfibril(GO:0001527) |
| 0.0 | 3.0 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.0 | 0.3 | GO:0044306 | neuron projection terminus(GO:0044306) |
| 0.0 | 3.7 | GO:0005764 | lytic vacuole(GO:0000323) lysosome(GO:0005764) |
| 0.0 | 1.0 | GO:0070160 | bicellular tight junction(GO:0005923) occluding junction(GO:0070160) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 7.3 | GO:0005353 | fructose transmembrane transporter activity(GO:0005353) |
| 0.4 | 3.9 | GO:0004000 | adenosine deaminase activity(GO:0004000) |
| 0.4 | 1.1 | GO:0016534 | cyclin-dependent protein kinase 5 activator activity(GO:0016534) |
| 0.3 | 1.0 | GO:0004796 | thromboxane-A synthase activity(GO:0004796) |
| 0.3 | 1.3 | GO:0008190 | eukaryotic initiation factor 4E binding(GO:0008190) |
| 0.3 | 1.0 | GO:0015095 | magnesium ion transmembrane transporter activity(GO:0015095) |
| 0.3 | 3.6 | GO:0008199 | acid phosphatase activity(GO:0003993) ferric iron binding(GO:0008199) |
| 0.3 | 0.8 | GO:0004146 | dihydrofolate reductase activity(GO:0004146) |
| 0.2 | 0.7 | GO:0004951 | cholecystokinin receptor activity(GO:0004951) |
| 0.2 | 0.5 | GO:0000404 | heteroduplex DNA loop binding(GO:0000404) double-strand/single-strand DNA junction binding(GO:0000406) dinucleotide repeat insertion binding(GO:0032181) |
| 0.2 | 0.5 | GO:0015386 | potassium:proton antiporter activity(GO:0015386) |
| 0.1 | 0.9 | GO:0004969 | histamine receptor activity(GO:0004969) |
| 0.1 | 0.4 | GO:0033265 | choline binding(GO:0033265) |
| 0.1 | 0.7 | GO:0004784 | superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721) |
| 0.1 | 0.2 | GO:0004814 | arginine-tRNA ligase activity(GO:0004814) |
| 0.1 | 0.9 | GO:0015450 | P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450) |
| 0.1 | 0.6 | GO:0051428 | peptide hormone receptor binding(GO:0051428) |
| 0.1 | 0.9 | GO:0051537 | 2 iron, 2 sulfur cluster binding(GO:0051537) |
| 0.0 | 0.8 | GO:0017025 | TBP-class protein binding(GO:0017025) |
| 0.0 | 0.3 | GO:0015185 | gamma-aminobutyric acid:sodium symporter activity(GO:0005332) gamma-aminobutyric acid transmembrane transporter activity(GO:0015185) |
| 0.0 | 0.3 | GO:0004340 | glucokinase activity(GO:0004340) |
| 0.0 | 0.8 | GO:0008171 | O-methyltransferase activity(GO:0008171) |
| 0.0 | 0.2 | GO:0004657 | proline dehydrogenase activity(GO:0004657) |
| 0.0 | 0.7 | GO:0016500 | protein-hormone receptor activity(GO:0016500) |
| 0.0 | 1.9 | GO:0003899 | DNA-directed RNA polymerase activity(GO:0003899) RNA polymerase activity(GO:0034062) |
| 0.0 | 2.2 | GO:0016836 | hydro-lyase activity(GO:0016836) |
| 0.0 | 0.7 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 0.0 | 0.3 | GO:0001727 | lipid kinase activity(GO:0001727) |
| 0.0 | 0.9 | GO:0036459 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005) |
| 0.0 | 0.2 | GO:0004143 | diacylglycerol kinase activity(GO:0004143) |
| 0.0 | 1.2 | GO:0016782 | transferase activity, transferring sulfur-containing groups(GO:0016782) |
| 0.0 | 0.7 | GO:0004402 | histone acetyltransferase activity(GO:0004402) |
| 0.0 | 0.6 | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity(GO:0008138) |
| 0.0 | 0.5 | GO:0046966 | thyroid hormone receptor binding(GO:0046966) |
| 0.0 | 0.1 | GO:0045029 | UDP-activated nucleotide receptor activity(GO:0045029) |
| 0.0 | 1.0 | GO:0016563 | obsolete transcription activator activity(GO:0016563) |
| 0.0 | 0.2 | GO:0004806 | triglyceride lipase activity(GO:0004806) |
| 0.0 | 3.1 | GO:0030246 | carbohydrate binding(GO:0030246) |
