Motif ID: SMAD4
Z-value: 2.088
Transcription factors associated with SMAD4:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| SMAD4 | ENSG00000141646.9 | SMAD4 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 6.7 | GO:0050703 | interleukin-1 alpha secretion(GO:0050703) |
| 0.9 | 3.7 | GO:0061302 | smooth muscle cell-matrix adhesion(GO:0061302) |
| 0.8 | 3.2 | GO:0070208 | protein heterotrimerization(GO:0070208) |
| 0.8 | 2.3 | GO:0048631 | regulation of skeletal muscle tissue growth(GO:0048631) |
| 0.7 | 1.4 | GO:0001300 | chronological cell aging(GO:0001300) |
| 0.6 | 1.9 | GO:0070092 | regulation of glucagon secretion(GO:0070092) |
| 0.5 | 1.5 | GO:0007412 | axon target recognition(GO:0007412) |
| 0.4 | 2.2 | GO:1901881 | positive regulation of protein depolymerization(GO:1901881) |
| 0.4 | 1.1 | GO:0060028 | convergent extension involved in axis elongation(GO:0060028) |
| 0.3 | 0.7 | GO:0060298 | positive regulation of sarcomere organization(GO:0060298) |
| 0.3 | 4.5 | GO:0034446 | substrate adhesion-dependent cell spreading(GO:0034446) |
| 0.3 | 1.7 | GO:0006295 | nucleotide-excision repair, DNA incision, 3'-to lesion(GO:0006295) |
| 0.3 | 1.1 | GO:0046108 | uridine metabolic process(GO:0046108) |
| 0.3 | 2.2 | GO:0048251 | elastic fiber assembly(GO:0048251) |
| 0.3 | 0.3 | GO:1901343 | negative regulation of angiogenesis(GO:0016525) negative regulation of vasculature development(GO:1901343) negative regulation of blood vessel morphogenesis(GO:2000181) |
| 0.3 | 1.8 | GO:0030579 | ubiquitin-dependent SMAD protein catabolic process(GO:0030579) |
| 0.3 | 1.5 | GO:0043268 | positive regulation of potassium ion transport(GO:0043268) |
| 0.3 | 1.8 | GO:0060414 | aorta development(GO:0035904) aorta morphogenesis(GO:0035909) aorta smooth muscle tissue morphogenesis(GO:0060414) |
| 0.2 | 1.7 | GO:0042483 | negative regulation of odontogenesis(GO:0042483) |
| 0.2 | 0.7 | GO:0060729 | negative regulation of interleukin-23 production(GO:0032707) intestinal epithelial structure maintenance(GO:0060729) |
| 0.2 | 1.3 | GO:0006931 | substrate-dependent cell migration, cell attachment to substrate(GO:0006931) |
| 0.2 | 0.6 | GO:0051365 | cellular response to potassium ion starvation(GO:0051365) |
| 0.2 | 0.8 | GO:0008065 | establishment of blood-nerve barrier(GO:0008065) |
| 0.2 | 1.1 | GO:0014819 | regulation of skeletal muscle contraction(GO:0014819) |
| 0.2 | 0.9 | GO:0009235 | cobalamin metabolic process(GO:0009235) |
| 0.2 | 1.3 | GO:0035313 | wound healing, spreading of epidermal cells(GO:0035313) wound healing, spreading of cells(GO:0044319) epiboly(GO:0090504) epiboly involved in wound healing(GO:0090505) |
| 0.2 | 1.7 | GO:0071692 | sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116) |
| 0.2 | 2.5 | GO:1901797 | negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518) negative regulation of signal transduction by p53 class mediator(GO:1901797) |
| 0.2 | 2.8 | GO:0032331 | negative regulation of chondrocyte differentiation(GO:0032331) |
| 0.2 | 0.3 | GO:0021869 | forebrain ventricular zone progenitor cell division(GO:0021869) |
| 0.1 | 2.1 | GO:0051016 | barbed-end actin filament capping(GO:0051016) |
| 0.1 | 1.5 | GO:0032909 | transforming growth factor beta2 production(GO:0032906) regulation of transforming growth factor beta2 production(GO:0032909) |
| 0.1 | 0.4 | GO:0045082 | positive regulation of interleukin-10 biosynthetic process(GO:0045082) |
| 0.1 | 0.1 | GO:0071639 | positive regulation of monocyte chemotactic protein-1 production(GO:0071639) |
| 0.1 | 0.8 | GO:0002019 | angiotensin catabolic process in blood(GO:0002005) regulation of renal output by angiotensin(GO:0002019) multicellular organismal protein catabolic process(GO:0044254) protein digestion(GO:0044256) multicellular organismal macromolecule catabolic process(GO:0044266) multicellular organismal protein metabolic process(GO:0044268) |
| 0.1 | 0.4 | GO:0032196 | transposition, DNA-mediated(GO:0006313) transposition(GO:0032196) |
| 0.1 | 0.4 | GO:0046586 | regulation of calcium-dependent cell-cell adhesion(GO:0046586) |
| 0.1 | 0.5 | GO:0030035 | microspike assembly(GO:0030035) |
| 0.1 | 0.4 | GO:0035234 | ectopic germ cell programmed cell death(GO:0035234) |
| 0.1 | 1.4 | GO:0050435 | beta-amyloid metabolic process(GO:0050435) |
| 0.1 | 3.7 | GO:0006942 | regulation of striated muscle contraction(GO:0006942) |
| 0.1 | 0.8 | GO:0022614 | membrane to membrane docking(GO:0022614) chorio-allantoic fusion(GO:0060710) |
| 0.1 | 1.3 | GO:0019800 | peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800) |
| 0.1 | 0.6 | GO:0010002 | cardioblast differentiation(GO:0010002) |
| 0.1 | 0.8 | GO:0018345 | protein palmitoylation(GO:0018345) |
| 0.1 | 1.0 | GO:0006069 | ethanol metabolic process(GO:0006067) ethanol oxidation(GO:0006069) |
| 0.1 | 0.3 | GO:0043371 | negative regulation of CD4-positive, alpha-beta T cell differentiation(GO:0043371) negative regulation of T-helper cell differentiation(GO:0045623) negative regulation of CD4-positive, alpha-beta T cell activation(GO:2000515) |
| 0.1 | 0.5 | GO:0007221 | positive regulation of transcription of Notch receptor target(GO:0007221) |
| 0.1 | 0.3 | GO:0006427 | histidyl-tRNA aminoacylation(GO:0006427) |
| 0.1 | 0.3 | GO:0042268 | regulation of cytolysis(GO:0042268) |
| 0.1 | 3.1 | GO:0015949 | nucleobase-containing small molecule interconversion(GO:0015949) |
| 0.1 | 0.4 | GO:0032914 | positive regulation of transforming growth factor beta1 production(GO:0032914) |
| 0.1 | 1.1 | GO:0007141 | male meiosis I(GO:0007141) |
| 0.1 | 0.6 | GO:0032472 | cellular manganese ion homeostasis(GO:0030026) Golgi calcium ion homeostasis(GO:0032468) Golgi calcium ion transport(GO:0032472) manganese ion homeostasis(GO:0055071) |
| 0.1 | 1.8 | GO:0003407 | neural retina development(GO:0003407) |
| 0.1 | 0.3 | GO:0007195 | adenylate cyclase-inhibiting dopamine receptor signaling pathway(GO:0007195) |
| 0.1 | 0.2 | GO:0060346 | bone trabecula formation(GO:0060346) bone trabecula morphogenesis(GO:0061430) |
| 0.1 | 0.5 | GO:0017183 | peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183) |
| 0.1 | 1.9 | GO:0034605 | cellular response to heat(GO:0034605) |
| 0.1 | 0.4 | GO:2000794 | positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501) epithelial cell proliferation involved in lung morphogenesis(GO:0060502) regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000794) |
| 0.1 | 0.6 | GO:0044245 | polysaccharide digestion(GO:0044245) |
| 0.1 | 1.2 | GO:0015884 | folic acid transport(GO:0015884) |
| 0.1 | 0.3 | GO:0000103 | sulfate assimilation(GO:0000103) |
| 0.1 | 0.6 | GO:0051145 | smooth muscle cell differentiation(GO:0051145) |
| 0.1 | 0.1 | GO:0007033 | vacuole organization(GO:0007033) lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171) |
| 0.1 | 0.5 | GO:0048745 | smooth muscle tissue development(GO:0048745) |
| 0.1 | 5.3 | GO:0032387 | negative regulation of intracellular transport(GO:0032387) |
| 0.1 | 0.3 | GO:0046952 | ketone body catabolic process(GO:0046952) |
| 0.1 | 0.3 | GO:0030900 | forebrain development(GO:0030900) |
| 0.1 | 0.1 | GO:0043401 | steroid hormone mediated signaling pathway(GO:0043401) |
| 0.1 | 1.9 | GO:0015813 | L-glutamate transport(GO:0015813) |
| 0.1 | 0.3 | GO:0015891 | iron chelate transport(GO:0015688) siderophore transport(GO:0015891) |
| 0.1 | 0.4 | GO:0042989 | sequestering of actin monomers(GO:0042989) |
| 0.1 | 1.0 | GO:0045104 | intermediate filament cytoskeleton organization(GO:0045104) |
| 0.1 | 0.3 | GO:0045010 | actin nucleation(GO:0045010) |
| 0.1 | 0.3 | GO:0048680 | positive regulation of axon regeneration(GO:0048680) positive regulation of neuron projection regeneration(GO:0070572) |
| 0.1 | 0.2 | GO:0022417 | protein maturation by protein folding(GO:0022417) |
| 0.0 | 1.9 | GO:0001837 | epithelial to mesenchymal transition(GO:0001837) |
| 0.0 | 0.1 | GO:0045415 | negative regulation of interleukin-8 biosynthetic process(GO:0045415) |
| 0.0 | 3.3 | GO:0045454 | cell redox homeostasis(GO:0045454) |
| 0.0 | 0.4 | GO:0034638 | phosphatidylcholine catabolic process(GO:0034638) |
| 0.0 | 0.5 | GO:0021952 | central nervous system projection neuron axonogenesis(GO:0021952) |
| 0.0 | 1.0 | GO:0043567 | regulation of insulin-like growth factor receptor signaling pathway(GO:0043567) |
| 0.0 | 0.7 | GO:0042749 | regulation of circadian sleep/wake cycle(GO:0042749) regulation of circadian sleep/wake cycle, sleep(GO:0045187) |
| 0.0 | 1.3 | GO:0050850 | positive regulation of calcium-mediated signaling(GO:0050850) |
| 0.0 | 0.4 | GO:0042474 | middle ear morphogenesis(GO:0042474) |
| 0.0 | 0.8 | GO:0007520 | myoblast fusion(GO:0007520) |
| 0.0 | 0.1 | GO:0050908 | detection of light stimulus involved in visual perception(GO:0050908) sensory perception of umami taste(GO:0050917) detection of light stimulus involved in sensory perception(GO:0050962) |
| 0.0 | 0.1 | GO:0006089 | lactate metabolic process(GO:0006089) |
| 0.0 | 0.6 | GO:0048268 | clathrin coat assembly(GO:0048268) |
| 0.0 | 1.2 | GO:0016486 | peptide hormone processing(GO:0016486) |
| 0.0 | 0.9 | GO:0008347 | glial cell migration(GO:0008347) |
| 0.0 | 0.2 | GO:0018410 | C-terminal protein amino acid modification(GO:0018410) |
| 0.0 | 0.2 | GO:0015722 | canalicular bile acid transport(GO:0015722) |
| 0.0 | 0.2 | GO:0043045 | DNA methylation involved in embryo development(GO:0043045) changes to DNA methylation involved in embryo development(GO:1901538) |
| 0.0 | 1.3 | GO:0042384 | cilium assembly(GO:0042384) |
| 0.0 | 0.1 | GO:0034587 | piRNA metabolic process(GO:0034587) |
| 0.0 | 2.2 | GO:0043542 | endothelial cell migration(GO:0043542) |
| 0.0 | 0.2 | GO:0046579 | positive regulation of Ras protein signal transduction(GO:0046579) |
| 0.0 | 0.6 | GO:0009954 | proximal/distal pattern formation(GO:0009954) |
| 0.0 | 0.9 | GO:0051496 | positive regulation of stress fiber assembly(GO:0051496) |
| 0.0 | 0.8 | GO:0007566 | embryo implantation(GO:0007566) |
| 0.0 | 0.2 | GO:0015824 | proline transport(GO:0015824) |
| 0.0 | 0.1 | GO:0032119 | sequestering of zinc ion(GO:0032119) antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003) regulation of sequestering of zinc ion(GO:0061088) |
| 0.0 | 0.9 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.0 | 0.9 | GO:0007368 | determination of left/right symmetry(GO:0007368) |
| 0.0 | 2.1 | GO:0007229 | integrin-mediated signaling pathway(GO:0007229) |
| 0.0 | 0.4 | GO:0032456 | endocytic recycling(GO:0032456) |
| 0.0 | 3.2 | GO:0035023 | regulation of Rho protein signal transduction(GO:0035023) |
| 0.0 | 7.9 | GO:0007517 | muscle organ development(GO:0007517) |
| 0.0 | 0.2 | GO:0099515 | nuclear migration along microfilament(GO:0031022) actin filament-based transport(GO:0099515) |
| 0.0 | 0.1 | GO:0071415 | cellular response to purine-containing compound(GO:0071415) |
| 0.0 | 0.1 | GO:0001822 | kidney development(GO:0001822) renal system development(GO:0072001) |
| 0.0 | 0.1 | GO:0007389 | pattern specification process(GO:0007389) |
| 0.0 | 0.4 | GO:0045773 | positive regulation of axon extension(GO:0045773) |
| 0.0 | 0.1 | GO:1901160 | serotonin metabolic process(GO:0042428) primary amino compound metabolic process(GO:1901160) |
| 0.0 | 0.2 | GO:0031122 | cytoplasmic microtubule organization(GO:0031122) |
| 0.0 | 0.4 | GO:0045745 | positive regulation of G-protein coupled receptor protein signaling pathway(GO:0045745) |
| 0.0 | 0.1 | GO:0006540 | glutamate decarboxylation to succinate(GO:0006540) |
| 0.0 | 0.2 | GO:0033344 | cholesterol efflux(GO:0033344) |
| 0.0 | 0.1 | GO:0043012 | regulation of fusion of sperm to egg plasma membrane(GO:0043012) |
| 0.0 | 0.1 | GO:0034390 | muscle cell apoptotic process(GO:0010657) regulation of muscle cell apoptotic process(GO:0010660) positive regulation of muscle cell apoptotic process(GO:0010661) smooth muscle cell apoptotic process(GO:0034390) regulation of smooth muscle cell apoptotic process(GO:0034391) positive regulation of smooth muscle cell apoptotic process(GO:0034393) |
| 0.0 | 0.2 | GO:0031112 | positive regulation of microtubule polymerization or depolymerization(GO:0031112) positive regulation of microtubule polymerization(GO:0031116) |
| 0.0 | 0.1 | GO:0051967 | negative regulation of synaptic transmission, glutamatergic(GO:0051967) |
| 0.0 | 0.2 | GO:0048486 | pons development(GO:0021548) parasympathetic nervous system development(GO:0048486) |
| 0.0 | 0.1 | GO:0045162 | clustering of voltage-gated sodium channels(GO:0045162) |
| 0.0 | 0.6 | GO:0006297 | nucleotide-excision repair, DNA gap filling(GO:0006297) |
| 0.0 | 0.2 | GO:0016075 | rRNA catabolic process(GO:0016075) |
| 0.0 | 0.1 | GO:0051281 | positive regulation of release of sequestered calcium ion into cytosol(GO:0051281) |
| 0.0 | 1.7 | GO:0008360 | regulation of cell shape(GO:0008360) |
| 0.0 | 0.1 | GO:0023058 | desensitization of G-protein coupled receptor protein signaling pathway(GO:0002029) negative adaptation of signaling pathway(GO:0022401) adaptation of signaling pathway(GO:0023058) |
| 0.0 | 1.1 | GO:0030336 | negative regulation of cell migration(GO:0030336) negative regulation of cell motility(GO:2000146) |
| 0.0 | 0.4 | GO:0045600 | positive regulation of fat cell differentiation(GO:0045600) |
| 0.0 | 0.7 | GO:0002208 | somatic recombination of immunoglobulin genes involved in immune response(GO:0002204) somatic diversification of immunoglobulins involved in immune response(GO:0002208) isotype switching(GO:0045190) |
| 0.0 | 0.2 | GO:0042119 | granulocyte activation(GO:0036230) neutrophil activation(GO:0042119) |
| 0.0 | 0.5 | GO:0016339 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339) |
| 0.0 | 0.1 | GO:0018149 | peptide cross-linking(GO:0018149) |
| 0.0 | 0.1 | GO:0034650 | cortisol metabolic process(GO:0034650) cortisol biosynthetic process(GO:0034651) |
| 0.0 | 0.8 | GO:0030282 | bone mineralization(GO:0030282) |
| 0.0 | 0.1 | GO:0001921 | positive regulation of receptor recycling(GO:0001921) |
| 0.0 | 0.3 | GO:0051693 | actin filament capping(GO:0051693) |
| 0.0 | 0.1 | GO:0050910 | detection of mechanical stimulus involved in sensory perception of sound(GO:0050910) |
| 0.0 | 0.6 | GO:0048813 | dendrite morphogenesis(GO:0048813) |
| 0.0 | 0.2 | GO:0031000 | response to caffeine(GO:0031000) |
| 0.0 | 0.1 | GO:0033148 | positive regulation of intracellular estrogen receptor signaling pathway(GO:0033148) |
| 0.0 | 0.1 | GO:0060678 | dichotomous subdivision of terminal units involved in ureteric bud branching(GO:0060678) |
| 0.0 | 0.1 | GO:0016098 | monoterpenoid metabolic process(GO:0016098) |
| 0.0 | 2.3 | GO:0043281 | regulation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0043281) |
| 0.0 | 0.1 | GO:0007512 | adult heart development(GO:0007512) |
| 0.0 | 0.0 | GO:0014831 | intestine smooth muscle contraction(GO:0014827) gastro-intestinal system smooth muscle contraction(GO:0014831) |
| 0.0 | 0.4 | GO:0007026 | negative regulation of microtubule depolymerization(GO:0007026) regulation of microtubule depolymerization(GO:0031114) |
| 0.0 | 0.6 | GO:0006636 | unsaturated fatty acid biosynthetic process(GO:0006636) |
| 0.0 | 0.6 | GO:0050690 | regulation of defense response to virus by virus(GO:0050690) |
| 0.0 | 0.5 | GO:0048477 | oogenesis(GO:0048477) |
| 0.0 | 0.4 | GO:0070374 | positive regulation of ERK1 and ERK2 cascade(GO:0070374) |
| 0.0 | 0.1 | GO:0001824 | blastocyst development(GO:0001824) |
| 0.0 | 0.5 | GO:0030166 | proteoglycan biosynthetic process(GO:0030166) |
| 0.0 | 0.1 | GO:0060334 | regulation of response to interferon-gamma(GO:0060330) regulation of interferon-gamma-mediated signaling pathway(GO:0060334) |
| 0.0 | 0.1 | GO:0006515 | misfolded or incompletely synthesized protein catabolic process(GO:0006515) |
| 0.0 | 0.2 | GO:0070536 | protein K63-linked deubiquitination(GO:0070536) |
| 0.0 | 0.2 | GO:0002070 | epithelial cell maturation(GO:0002070) |
| 0.0 | 0.2 | GO:0035116 | embryonic hindlimb morphogenesis(GO:0035116) |
| 0.0 | 0.2 | GO:0043984 | histone H4-K16 acetylation(GO:0043984) |
| 0.0 | 1.5 | GO:0007565 | female pregnancy(GO:0007565) |
| 0.0 | 0.7 | GO:0030814 | regulation of cAMP metabolic process(GO:0030814) |
| 0.0 | 0.1 | GO:0006398 | mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398) |
| 0.0 | 0.2 | GO:0071804 | cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805) |
| 0.0 | 0.4 | GO:0016079 | synaptic vesicle exocytosis(GO:0016079) |
| 0.0 | 0.1 | GO:0051607 | defense response to virus(GO:0051607) |
| 0.0 | 0.0 | GO:0051169 | nuclear transport(GO:0051169) |
| 0.0 | 0.3 | GO:0006891 | intra-Golgi vesicle-mediated transport(GO:0006891) |
| 0.0 | 0.5 | GO:0071772 | BMP signaling pathway(GO:0030509) response to BMP(GO:0071772) cellular response to BMP stimulus(GO:0071773) |
| 0.0 | 0.1 | GO:0009404 | toxin metabolic process(GO:0009404) |
| 0.0 | 0.2 | GO:0030317 | sperm motility(GO:0030317) |
| 0.0 | 0.1 | GO:0017156 | calcium ion regulated exocytosis(GO:0017156) |
| 0.0 | 0.2 | GO:0032886 | regulation of microtubule-based process(GO:0032886) |
| 0.0 | 0.2 | GO:0008333 | endosome to lysosome transport(GO:0008333) |
| 0.0 | 0.1 | GO:0006029 | proteoglycan metabolic process(GO:0006029) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 1.9 | GO:0005607 | laminin-2 complex(GO:0005607) |
| 0.4 | 1.5 | GO:0005955 | calcineurin complex(GO:0005955) |
| 0.4 | 1.8 | GO:0005899 | insulin receptor complex(GO:0005899) |
| 0.3 | 1.3 | GO:0071062 | alphav-beta3 integrin-vitronectin complex(GO:0071062) |
| 0.3 | 3.4 | GO:0098643 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
| 0.3 | 4.3 | GO:0001527 | microfibril(GO:0001527) |
| 0.3 | 0.8 | GO:0071065 | alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex(GO:0071065) |
| 0.2 | 1.4 | GO:0070022 | transforming growth factor beta receptor homodimeric complex(GO:0070022) |
| 0.2 | 2.7 | GO:0031527 | filopodium membrane(GO:0031527) |
| 0.2 | 1.2 | GO:1990752 | microtubule plus-end(GO:0035371) microtubule end(GO:1990752) |
| 0.2 | 4.0 | GO:0005861 | troponin complex(GO:0005861) |
| 0.2 | 0.5 | GO:0071953 | elastic fiber(GO:0071953) |
| 0.2 | 1.7 | GO:0000109 | nucleotide-excision repair complex(GO:0000109) |
| 0.2 | 0.6 | GO:0044298 | neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298) |
| 0.1 | 0.7 | GO:0046696 | lipopolysaccharide receptor complex(GO:0046696) |
| 0.1 | 0.7 | GO:0002102 | podosome(GO:0002102) |
| 0.1 | 1.5 | GO:0001518 | voltage-gated sodium channel complex(GO:0001518) |
| 0.1 | 1.0 | GO:0034464 | BBSome(GO:0034464) |
| 0.1 | 0.4 | GO:0033257 | Bcl3/NF-kappaB2 complex(GO:0033257) |
| 0.1 | 0.6 | GO:0000138 | Golgi trans cisterna(GO:0000138) |
| 0.1 | 1.8 | GO:0030867 | rough endoplasmic reticulum membrane(GO:0030867) |
| 0.1 | 1.3 | GO:0098647 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 0.1 | 3.3 | GO:0098636 | integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636) |
| 0.1 | 0.3 | GO:0071546 | pi-body(GO:0071546) |
| 0.1 | 15.9 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.1 | 0.8 | GO:0032588 | trans-Golgi network membrane(GO:0032588) |
| 0.1 | 0.1 | GO:0009295 | nucleoid(GO:0009295) |
| 0.1 | 0.4 | GO:0098984 | asymmetric synapse(GO:0032279) neuron to neuron synapse(GO:0098984) |
| 0.1 | 1.0 | GO:0001673 | male germ cell nucleus(GO:0001673) |
| 0.0 | 0.8 | GO:0008180 | COP9 signalosome(GO:0008180) |
| 0.0 | 0.3 | GO:0005964 | phosphorylase kinase complex(GO:0005964) |
| 0.0 | 1.3 | GO:0030057 | desmosome(GO:0030057) |
| 0.0 | 0.4 | GO:0033179 | proton-transporting V-type ATPase, V0 domain(GO:0033179) |
| 0.0 | 0.6 | GO:0030122 | AP-2 adaptor complex(GO:0030122) clathrin coat of endocytic vesicle(GO:0030128) |
| 0.0 | 0.4 | GO:0042824 | MHC class I peptide loading complex(GO:0042824) |
| 0.0 | 0.1 | GO:0042622 | photoreceptor outer segment membrane(GO:0042622) |
| 0.0 | 0.2 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
| 0.0 | 0.1 | GO:0070938 | actomyosin contractile ring(GO:0005826) contractile ring(GO:0070938) |
| 0.0 | 1.2 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.0 | 0.1 | GO:0043198 | dendritic shaft(GO:0043198) |
| 0.0 | 0.3 | GO:0031258 | lamellipodium membrane(GO:0031258) |
| 0.0 | 2.7 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 0.0 | 0.4 | GO:0019898 | extrinsic component of membrane(GO:0019898) |
| 0.0 | 1.5 | GO:0005637 | nuclear inner membrane(GO:0005637) |
| 0.0 | 0.3 | GO:0000145 | exocyst(GO:0000145) |
| 0.0 | 0.2 | GO:0072487 | MSL complex(GO:0072487) |
| 0.0 | 0.2 | GO:0070552 | BRISC complex(GO:0070552) |
| 0.0 | 0.3 | GO:0005869 | dynactin complex(GO:0005869) |
| 0.0 | 0.8 | GO:0005859 | muscle myosin complex(GO:0005859) |
| 0.0 | 0.7 | GO:0005791 | rough endoplasmic reticulum(GO:0005791) |
| 0.0 | 0.3 | GO:0005885 | Arp2/3 protein complex(GO:0005885) |
| 0.0 | 0.3 | GO:0009925 | basal plasma membrane(GO:0009925) |
| 0.0 | 0.4 | GO:0000421 | autophagosome membrane(GO:0000421) |
| 0.0 | 1.3 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
| 0.0 | 0.3 | GO:0031588 | nucleotide-activated protein kinase complex(GO:0031588) |
| 0.0 | 0.4 | GO:0008091 | spectrin(GO:0008091) |
| 0.0 | 0.4 | GO:0045335 | phagocytic vesicle(GO:0045335) |
| 0.0 | 2.1 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.0 | 0.2 | GO:0031143 | pseudopodium(GO:0031143) |
| 0.0 | 0.1 | GO:0034750 | Scrib-APC-beta-catenin complex(GO:0034750) |
| 0.0 | 0.8 | GO:0005814 | centriole(GO:0005814) |
| 0.0 | 0.4 | GO:0097610 | cell division site(GO:0032153) cleavage furrow(GO:0032154) cell division site part(GO:0032155) cell surface furrow(GO:0097610) |
| 0.0 | 1.3 | GO:0005746 | mitochondrial respiratory chain(GO:0005746) |
| 0.0 | 0.4 | GO:0030018 | Z disc(GO:0030018) |
| 0.0 | 0.4 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
| 0.0 | 0.2 | GO:0031265 | CD95 death-inducing signaling complex(GO:0031265) |
| 0.0 | 1.2 | GO:0008021 | synaptic vesicle(GO:0008021) |
| 0.0 | 0.1 | GO:0034045 | pre-autophagosomal structure membrane(GO:0034045) |
| 0.0 | 0.1 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.0 | 0.1 | GO:0032838 | cell projection cytoplasm(GO:0032838) dendrite cytoplasm(GO:0032839) |
| 0.0 | 0.2 | GO:0031674 | I band(GO:0031674) |
| 0.0 | 0.1 | GO:0008290 | F-actin capping protein complex(GO:0008290) |
| 0.0 | 0.6 | GO:0005912 | adherens junction(GO:0005912) |
| 0.0 | 0.0 | GO:0036452 | ESCRT III complex(GO:0000815) ESCRT complex(GO:0036452) |
| 0.0 | 22.7 | GO:0005576 | extracellular region(GO:0005576) |
| 0.0 | 0.2 | GO:0044224 | juxtaparanode region of axon(GO:0044224) |
| 0.0 | 0.0 | GO:0016593 | Cdc73/Paf1 complex(GO:0016593) |
| 0.0 | 0.1 | GO:0035631 | CD40 receptor complex(GO:0035631) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 2.2 | GO:0019215 | intermediate filament binding(GO:0019215) |
| 0.6 | 1.9 | GO:0005010 | insulin-like growth factor-activated receptor activity(GO:0005010) |
| 0.6 | 3.7 | GO:0051371 | muscle alpha-actinin binding(GO:0051371) |
| 0.6 | 9.5 | GO:0050786 | RAGE receptor binding(GO:0050786) |
| 0.5 | 1.6 | GO:0008475 | procollagen-lysine 5-dioxygenase activity(GO:0008475) |
| 0.4 | 1.9 | GO:0031694 | alpha-2A adrenergic receptor binding(GO:0031694) |
| 0.4 | 1.8 | GO:0004687 | myosin light chain kinase activity(GO:0004687) |
| 0.4 | 3.9 | GO:0048407 | platelet-derived growth factor binding(GO:0048407) |
| 0.3 | 1.4 | GO:0016972 | thiol oxidase activity(GO:0016972) |
| 0.3 | 0.6 | GO:0004939 | beta-adrenergic receptor activity(GO:0004939) |
| 0.3 | 1.2 | GO:0004667 | prostaglandin-D synthase activity(GO:0004667) |
| 0.3 | 2.7 | GO:0005006 | epidermal growth factor-activated receptor activity(GO:0005006) |
| 0.3 | 1.1 | GO:0004850 | uridine phosphorylase activity(GO:0004850) |
| 0.3 | 1.4 | GO:0005534 | galactose binding(GO:0005534) |
| 0.3 | 0.8 | GO:0032422 | purine-rich negative regulatory element binding(GO:0032422) |
| 0.3 | 1.5 | GO:0001102 | RNA polymerase II activating transcription factor binding(GO:0001102) |
| 0.2 | 6.4 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.2 | 1.7 | GO:0048495 | Roundabout binding(GO:0048495) |
| 0.2 | 1.7 | GO:0016717 | oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water(GO:0016717) |
| 0.2 | 6.4 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 0.2 | 1.0 | GO:0031995 | insulin-like growth factor II binding(GO:0031995) |
| 0.2 | 2.8 | GO:0004017 | adenylate kinase activity(GO:0004017) |
| 0.2 | 0.9 | GO:0043184 | vascular endothelial growth factor receptor 2 binding(GO:0043184) |
| 0.2 | 0.5 | GO:0000150 | recombinase activity(GO:0000150) |
| 0.2 | 0.5 | GO:0010861 | thyroid hormone receptor activator activity(GO:0010861) thyroid hormone receptor coactivator activity(GO:0030375) |
| 0.2 | 4.8 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.2 | 0.7 | GO:0050698 | proteoglycan sulfotransferase activity(GO:0050698) |
| 0.1 | 1.9 | GO:0001011 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, RNA polymerase II basal transcription factor binding(GO:0001083) transcription factor activity, TFIIB-class binding(GO:0001087) RNA polymerase II basal transcription factor binding(GO:0001091) TFIIB-class transcription factor binding(GO:0001093) |
| 0.1 | 1.3 | GO:0005110 | frizzled-2 binding(GO:0005110) |
| 0.1 | 0.4 | GO:0047391 | alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391) |
| 0.1 | 0.8 | GO:0008241 | peptidyl-dipeptidase activity(GO:0008241) |
| 0.1 | 0.4 | GO:0044183 | protein binding involved in protein folding(GO:0044183) |
| 0.1 | 0.7 | GO:0004030 | aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030) |
| 0.1 | 0.4 | GO:0032795 | heterotrimeric G-protein binding(GO:0032795) |
| 0.1 | 1.4 | GO:0008242 | omega peptidase activity(GO:0008242) |
| 0.1 | 1.0 | GO:0005497 | androgen binding(GO:0005497) |
| 0.1 | 0.4 | GO:0032050 | clathrin heavy chain binding(GO:0032050) |
| 0.1 | 0.3 | GO:0004821 | histidine-tRNA ligase activity(GO:0004821) |
| 0.1 | 0.5 | GO:0019956 | chemokine binding(GO:0019956) |
| 0.1 | 1.3 | GO:0000014 | single-stranded DNA endodeoxyribonuclease activity(GO:0000014) |
| 0.1 | 0.5 | GO:0031708 | bombesin receptor binding(GO:0031705) endothelin B receptor binding(GO:0031708) |
| 0.1 | 0.4 | GO:0004882 | androgen receptor activity(GO:0004882) |
| 0.1 | 0.6 | GO:0015410 | manganese-transporting ATPase activity(GO:0015410) |
| 0.1 | 0.3 | GO:0004607 | phosphatidylcholine-sterol O-acyltransferase activity(GO:0004607) |
| 0.1 | 0.9 | GO:0031419 | cobalamin binding(GO:0031419) |
| 0.1 | 1.7 | GO:0005388 | calcium-transporting ATPase activity(GO:0005388) |
| 0.1 | 1.5 | GO:1905030 | voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030) |
| 0.1 | 0.3 | GO:0004307 | ethanolaminephosphotransferase activity(GO:0004307) |
| 0.1 | 0.4 | GO:0004803 | transposase activity(GO:0004803) |
| 0.1 | 0.3 | GO:0004449 | isocitrate dehydrogenase (NAD+) activity(GO:0004449) |
| 0.1 | 0.7 | GO:0001530 | lipopolysaccharide binding(GO:0001530) |
| 0.1 | 3.5 | GO:0005518 | collagen binding(GO:0005518) |
| 0.1 | 0.2 | GO:0042285 | UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285) |
| 0.1 | 0.3 | GO:0017160 | Ral GTPase binding(GO:0017160) |
| 0.1 | 1.2 | GO:0005542 | folic acid binding(GO:0005542) |
| 0.1 | 0.4 | GO:0016167 | glial cell-derived neurotrophic factor receptor activity(GO:0016167) |
| 0.1 | 1.4 | GO:0070064 | proline-rich region binding(GO:0070064) |
| 0.1 | 1.0 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.1 | 0.2 | GO:0015193 | L-proline transmembrane transporter activity(GO:0015193) |
| 0.1 | 0.1 | GO:0003707 | steroid hormone receptor activity(GO:0003707) |
| 0.1 | 0.5 | GO:0044548 | S100 protein binding(GO:0044548) |
| 0.1 | 5.6 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.1 | 0.3 | GO:0015280 | ligand-gated sodium channel activity(GO:0015280) |
| 0.1 | 1.8 | GO:0019003 | GDP binding(GO:0019003) |
| 0.1 | 2.0 | GO:0015035 | protein disulfide oxidoreductase activity(GO:0015035) |
| 0.1 | 1.5 | GO:0004129 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.1 | 2.5 | GO:0017048 | Rho GTPase binding(GO:0017048) |
| 0.1 | 1.0 | GO:0017166 | vinculin binding(GO:0017166) |
| 0.0 | 0.4 | GO:0030306 | ADP-ribosylation factor binding(GO:0030306) |
| 0.0 | 0.3 | GO:0004689 | phosphorylase kinase activity(GO:0004689) |
| 0.0 | 0.9 | GO:0030332 | cyclin binding(GO:0030332) |
| 0.0 | 0.1 | GO:0004947 | bradykinin receptor activity(GO:0004947) |
| 0.0 | 0.4 | GO:0008553 | hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553) |
| 0.0 | 2.8 | GO:0043028 | cysteine-type endopeptidase regulator activity involved in apoptotic process(GO:0043028) |
| 0.0 | 1.4 | GO:0005024 | transforming growth factor beta-activated receptor activity(GO:0005024) |
| 0.0 | 0.2 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
| 0.0 | 0.4 | GO:0004716 | receptor signaling protein tyrosine kinase activity(GO:0004716) |
| 0.0 | 0.2 | GO:0004991 | parathyroid hormone receptor activity(GO:0004991) |
| 0.0 | 0.1 | GO:0005113 | patched binding(GO:0005113) |
| 0.0 | 0.8 | GO:0051861 | glycolipid binding(GO:0051861) |
| 0.0 | 0.8 | GO:0030553 | cGMP binding(GO:0030553) |
| 0.0 | 7.3 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.0 | 1.3 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
| 0.0 | 0.2 | GO:0051636 | obsolete Gram-negative bacterial cell surface binding(GO:0051636) |
| 0.0 | 3.2 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.0 | 1.1 | GO:0003887 | DNA-directed DNA polymerase activity(GO:0003887) |
| 0.0 | 0.1 | GO:0051393 | alpha-actinin binding(GO:0051393) |
| 0.0 | 0.1 | GO:0008384 | IkappaB kinase activity(GO:0008384) |
| 0.0 | 0.7 | GO:0005520 | insulin-like growth factor binding(GO:0005520) |
| 0.0 | 0.1 | GO:0005111 | type 2 fibroblast growth factor receptor binding(GO:0005111) |
| 0.0 | 0.1 | GO:0004321 | fatty-acyl-CoA synthase activity(GO:0004321) |
| 0.0 | 0.8 | GO:0004623 | phospholipase A2 activity(GO:0004623) |
| 0.0 | 0.5 | GO:0070063 | RNA polymerase binding(GO:0070063) |
| 0.0 | 0.7 | GO:0005247 | voltage-gated chloride channel activity(GO:0005247) |
| 0.0 | 2.6 | GO:0005178 | integrin binding(GO:0005178) |
| 0.0 | 2.7 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.0 | 0.4 | GO:0016641 | oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641) |
| 0.0 | 11.9 | GO:0003779 | actin binding(GO:0003779) |
| 0.0 | 0.1 | GO:0047288 | monosialoganglioside sialyltransferase activity(GO:0047288) |
| 0.0 | 0.3 | GO:0016208 | AMP binding(GO:0016208) |
| 0.0 | 0.7 | GO:0050699 | WW domain binding(GO:0050699) |
| 0.0 | 0.4 | GO:0015271 | outward rectifier potassium channel activity(GO:0015271) |
| 0.0 | 0.6 | GO:0070412 | R-SMAD binding(GO:0070412) |
| 0.0 | 2.7 | GO:0008201 | heparin binding(GO:0008201) |
| 0.0 | 0.3 | GO:0045502 | dynein binding(GO:0045502) |
| 0.0 | 0.9 | GO:0004364 | glutathione transferase activity(GO:0004364) |
| 0.0 | 0.1 | GO:0015252 | hydrogen ion channel activity(GO:0015252) |
| 0.0 | 0.4 | GO:0005537 | mannose binding(GO:0005537) |
| 0.0 | 0.1 | GO:0004566 | beta-glucuronidase activity(GO:0004566) |
| 0.0 | 0.3 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
| 0.0 | 0.1 | GO:0033829 | O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829) |
| 0.0 | 0.1 | GO:0001784 | phosphotyrosine binding(GO:0001784) |
| 0.0 | 0.1 | GO:0003873 | 6-phosphofructo-2-kinase activity(GO:0003873) |
| 0.0 | 0.1 | GO:0003827 | alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827) |
| 0.0 | 1.8 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.0 | 0.3 | GO:0030169 | low-density lipoprotein particle binding(GO:0030169) |
| 0.0 | 0.1 | GO:0045030 | A1 adenosine receptor binding(GO:0031686) UTP-activated nucleotide receptor activity(GO:0045030) |
| 0.0 | 0.2 | GO:0008379 | thioredoxin peroxidase activity(GO:0008379) |
| 0.0 | 0.1 | GO:0004925 | prolactin receptor activity(GO:0004925) |
| 0.0 | 0.1 | GO:0046935 | 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935) |
| 0.0 | 0.6 | GO:0008134 | transcription factor binding(GO:0008134) |
| 0.0 | 0.0 | GO:0004528 | phosphodiesterase I activity(GO:0004528) |
| 0.0 | 0.1 | GO:0004351 | glutamate decarboxylase activity(GO:0004351) |
| 0.0 | 0.1 | GO:0019862 | IgA binding(GO:0019862) |
| 0.0 | 6.0 | GO:0005525 | GTP binding(GO:0005525) |
| 0.0 | 0.1 | GO:0051378 | serotonin binding(GO:0051378) |
| 0.0 | 0.1 | GO:0008271 | secondary active sulfate transmembrane transporter activity(GO:0008271) |
| 0.0 | 0.2 | GO:0015250 | water channel activity(GO:0015250) |
| 0.0 | 1.1 | GO:0004197 | cysteine-type endopeptidase activity(GO:0004197) |
| 0.0 | 0.2 | GO:0001076 | transcription factor activity, RNA polymerase II transcription factor binding(GO:0001076) |
| 0.0 | 0.1 | GO:0016174 | NAD(P)H oxidase activity(GO:0016174) |
| 0.0 | 0.1 | GO:0005149 | interleukin-1 receptor binding(GO:0005149) |
| 0.0 | 0.2 | GO:0005095 | GTPase inhibitor activity(GO:0005095) |
| 0.0 | 6.7 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.0 | 0.2 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
| 0.0 | 0.2 | GO:0005545 | 1-phosphatidylinositol binding(GO:0005545) |
| 0.0 | 0.1 | GO:0008432 | JUN kinase binding(GO:0008432) |
| 0.0 | 0.0 | GO:0008336 | gamma-butyrobetaine dioxygenase activity(GO:0008336) |
| 0.0 | 0.0 | GO:0034584 | piRNA binding(GO:0034584) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.0 | SA_MMP_CYTOKINE_CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.1 | 0.4 | ST_IL_13_PATHWAY | Interleukin 13 (IL-13) Pathway |
| 0.0 | 2.7 | SIG_CHEMOTAXIS | Genes related to chemotaxis |
| 0.0 | 2.0 | SIG_IL4RECEPTOR_IN_B_LYPHOCYTES | Genes related to IL4 rceptor signaling in B lymphocytes |
| 0.0 | 0.6 | ST_GA12_PATHWAY | G alpha 12 Pathway |
| 0.0 | 0.3 | SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 0.2 | SA_FAS_SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
| 0.0 | 1.4 | ST_FAS_SIGNALING_PATHWAY | Fas Signaling Pathway |
| 0.0 | 1.0 | ST_INTEGRIN_SIGNALING_PATHWAY | Integrin Signaling Pathway |
