Motif ID: SOX14
Z-value: 1.115
Transcription factors associated with SOX14:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| SOX14 | ENSG00000168875.1 | SOX14 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 6.6 | GO:0042989 | sequestering of actin monomers(GO:0042989) |
| 0.3 | 0.8 | GO:0060316 | positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316) |
| 0.3 | 0.8 | GO:0034139 | regulation of toll-like receptor 2 signaling pathway(GO:0034135) regulation of toll-like receptor 3 signaling pathway(GO:0034139) negative regulation of epithelial cell apoptotic process(GO:1904036) negative regulation of endothelial cell apoptotic process(GO:2000352) |
| 0.3 | 1.8 | GO:0043615 | astrocyte cell migration(GO:0043615) |
| 0.2 | 1.0 | GO:0046642 | negative regulation of alpha-beta T cell proliferation(GO:0046642) |
| 0.2 | 0.9 | GO:0090084 | negative regulation of inclusion body assembly(GO:0090084) |
| 0.2 | 0.9 | GO:0034501 | protein localization to kinetochore(GO:0034501) |
| 0.1 | 0.3 | GO:2000114 | regulation of establishment of cell polarity(GO:2000114) |
| 0.1 | 0.4 | GO:0090073 | positive regulation of protein homodimerization activity(GO:0090073) |
| 0.1 | 0.8 | GO:0002051 | osteoblast fate commitment(GO:0002051) |
| 0.1 | 0.4 | GO:0032328 | alanine transport(GO:0032328) |
| 0.1 | 1.4 | GO:0006975 | DNA damage induced protein phosphorylation(GO:0006975) |
| 0.1 | 1.1 | GO:0051290 | protein heterotetramerization(GO:0051290) |
| 0.1 | 0.5 | GO:0060292 | phosphorylated carbohydrate dephosphorylation(GO:0046838) inositol phosphate dephosphorylation(GO:0046855) long term synaptic depression(GO:0060292) |
| 0.1 | 0.6 | GO:0007386 | compartment pattern specification(GO:0007386) |
| 0.1 | 0.6 | GO:0009082 | branched-chain amino acid biosynthetic process(GO:0009082) |
| 0.1 | 0.6 | GO:0009820 | alkaloid metabolic process(GO:0009820) positive regulation of nitric-oxide synthase biosynthetic process(GO:0051770) |
| 0.1 | 0.5 | GO:0006003 | fructose 2,6-bisphosphate metabolic process(GO:0006003) |
| 0.1 | 1.7 | GO:0071577 | zinc II ion transmembrane transport(GO:0071577) |
| 0.1 | 1.1 | GO:0006198 | cAMP catabolic process(GO:0006198) |
| 0.1 | 0.6 | GO:0007141 | male meiosis I(GO:0007141) |
| 0.1 | 1.3 | GO:0002474 | antigen processing and presentation of peptide antigen via MHC class I(GO:0002474) |
| 0.0 | 0.7 | GO:0032012 | regulation of ARF protein signal transduction(GO:0032012) |
| 0.0 | 1.2 | GO:0006298 | mismatch repair(GO:0006298) |
| 0.0 | 0.4 | GO:0051103 | DNA ligation involved in DNA repair(GO:0051103) |
| 0.0 | 0.1 | GO:0051971 | positive regulation of transmission of nerve impulse(GO:0051971) |
| 0.0 | 0.3 | GO:0016246 | RNA interference(GO:0016246) |
| 0.0 | 0.1 | GO:0034498 | early endosome to Golgi transport(GO:0034498) |
| 0.0 | 0.1 | GO:0032696 | negative regulation of interleukin-13 production(GO:0032696) |
| 0.0 | 0.0 | GO:2000059 | negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000059) |
| 0.0 | 0.5 | GO:0006378 | mRNA polyadenylation(GO:0006378) |
| 0.0 | 0.3 | GO:0033523 | histone monoubiquitination(GO:0010390) histone H2B ubiquitination(GO:0033523) |
| 0.0 | 0.4 | GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146) |
| 0.0 | 0.2 | GO:0016198 | axon choice point recognition(GO:0016198) |
| 0.0 | 0.2 | GO:0060009 | Sertoli cell development(GO:0060009) |
| 0.0 | 0.2 | GO:0060968 | regulation of gene silencing(GO:0060968) |
| 0.0 | 0.1 | GO:0016265 | obsolete death(GO:0016265) |
| 0.0 | 0.8 | GO:0050690 | regulation of defense response to virus by virus(GO:0050690) |
| 0.0 | 0.1 | GO:0001969 | activation of membrane attack complex(GO:0001905) regulation of activation of membrane attack complex(GO:0001969) positive regulation of activation of membrane attack complex(GO:0001970) positive regulation of complement activation(GO:0045917) positive regulation of protein activation cascade(GO:2000259) |
| 0.0 | 0.1 | GO:0007064 | mitotic sister chromatid cohesion(GO:0007064) kinetochore assembly(GO:0051382) kinetochore organization(GO:0051383) |
| 0.0 | 0.2 | GO:0031115 | negative regulation of microtubule polymerization(GO:0031115) |
| 0.0 | 1.3 | GO:0060333 | interferon-gamma-mediated signaling pathway(GO:0060333) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 0.9 | GO:0032133 | chromosome passenger complex(GO:0032133) |
| 0.2 | 0.9 | GO:0070852 | cell body fiber(GO:0070852) |
| 0.1 | 0.6 | GO:0000800 | lateral element(GO:0000800) |
| 0.1 | 0.3 | GO:0016593 | Cdc73/Paf1 complex(GO:0016593) |
| 0.1 | 0.5 | GO:0019907 | cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907) |
| 0.1 | 0.3 | GO:0031229 | integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453) |
| 0.1 | 5.8 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.1 | 0.8 | GO:0043073 | germ cell nucleus(GO:0043073) |
| 0.1 | 1.3 | GO:0042612 | MHC class I protein complex(GO:0042612) |
| 0.1 | 2.8 | GO:0030863 | cortical cytoskeleton(GO:0030863) |
| 0.0 | 0.1 | GO:0045298 | tubulin complex(GO:0045298) |
| 0.0 | 0.3 | GO:0042382 | paraspeckles(GO:0042382) |
| 0.0 | 1.2 | GO:0005637 | nuclear inner membrane(GO:0005637) |
| 0.0 | 0.4 | GO:0005862 | muscle thin filament tropomyosin(GO:0005862) |
| 0.0 | 1.1 | GO:0030175 | filopodium(GO:0030175) |
| 0.0 | 0.8 | GO:0030119 | AP-type membrane coat adaptor complex(GO:0030119) |
| 0.0 | 0.5 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.0 | 0.2 | GO:0042598 | obsolete vesicular fraction(GO:0042598) |
| 0.0 | 1.6 | GO:0030426 | growth cone(GO:0030426) |
| 0.0 | 1.1 | GO:0005626 | obsolete insoluble fraction(GO:0005626) |
| 0.0 | 0.8 | GO:0005876 | spindle microtubule(GO:0005876) |
| 0.0 | 0.2 | GO:0031010 | ISWI-type complex(GO:0031010) |
| 0.0 | 0.4 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.0 | 0.6 | GO:0000786 | nucleosome(GO:0000786) |
| 0.0 | 1.1 | GO:1990204 | oxidoreductase complex(GO:1990204) |
| 0.0 | 0.2 | GO:0042611 | MHC protein complex(GO:0042611) MHC class II protein complex(GO:0042613) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 1.1 | GO:0061731 | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731) |
| 0.3 | 0.8 | GO:0031997 | N-terminal myristoylation domain binding(GO:0031997) |
| 0.2 | 1.2 | GO:0032558 | purine deoxyribonucleotide binding(GO:0032554) adenyl deoxyribonucleotide binding(GO:0032558) |
| 0.2 | 0.6 | GO:0004514 | nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514) |
| 0.2 | 0.5 | GO:0016314 | phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314) |
| 0.1 | 0.4 | GO:0015193 | L-proline transmembrane transporter activity(GO:0015193) |
| 0.1 | 0.3 | GO:0000900 | translation repressor activity, nucleic acid binding(GO:0000900) |
| 0.1 | 0.3 | GO:0050613 | delta14-sterol reductase activity(GO:0050613) |
| 0.1 | 0.5 | GO:0017089 | glycolipid transporter activity(GO:0017089) |
| 0.1 | 0.6 | GO:0052654 | branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656) |
| 0.1 | 1.3 | GO:0032393 | MHC class I receptor activity(GO:0032393) |
| 0.1 | 0.5 | GO:0003873 | 6-phosphofructo-2-kinase activity(GO:0003873) |
| 0.1 | 0.4 | GO:0003910 | DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910) |
| 0.1 | 1.7 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.1 | 0.9 | GO:0070628 | proteasome binding(GO:0070628) |
| 0.1 | 0.8 | GO:0030618 | transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618) |
| 0.1 | 1.4 | GO:0004708 | MAP kinase kinase activity(GO:0004708) |
| 0.0 | 0.4 | GO:0008266 | poly(U) RNA binding(GO:0008266) |
| 0.0 | 0.5 | GO:0005521 | lamin binding(GO:0005521) |
| 0.0 | 0.9 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.0 | 0.4 | GO:0035251 | UDP-glucosyltransferase activity(GO:0035251) |
| 0.0 | 0.1 | GO:0005412 | glucose:sodium symporter activity(GO:0005412) |
| 0.0 | 0.8 | GO:0043621 | protein self-association(GO:0043621) |
| 0.0 | 0.7 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
| 0.0 | 0.1 | GO:0019834 | phospholipase A2 inhibitor activity(GO:0019834) |
| 0.0 | 0.2 | GO:0005005 | transmembrane-ephrin receptor activity(GO:0005005) |
| 0.0 | 1.1 | GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115) |
| 0.0 | 0.5 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
| 0.0 | 0.5 | GO:0046966 | thyroid hormone receptor binding(GO:0046966) |
| 0.0 | 0.2 | GO:0032395 | MHC class II receptor activity(GO:0032395) |
| 0.0 | 0.8 | GO:0005080 | protein kinase C binding(GO:0005080) |
| 0.0 | 1.5 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.0 | 0.4 | GO:0005001 | transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) |
| 0.0 | 0.6 | GO:0018024 | histone-lysine N-methyltransferase activity(GO:0018024) |
| 0.0 | 0.4 | GO:0008656 | cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656) |
| 0.0 | 0.4 | GO:0050699 | WW domain binding(GO:0050699) |
| 0.0 | 6.1 | GO:0003779 | actin binding(GO:0003779) |
| 0.0 | 0.5 | GO:0097472 | cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.5 | ST_ERK1_ERK2_MAPK_PATHWAY | ERK1/ERK2 MAPK Pathway |
| 0.0 | 1.4 | ST_P38_MAPK_PATHWAY | p38 MAPK Pathway |
| 0.0 | 0.5 | SA_PTEN_PATHWAY | PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. |
| 0.0 | 0.8 | ST_TUMOR_NECROSIS_FACTOR_PATHWAY | Tumor Necrosis Factor Pathway. |
| 0.0 | 0.5 | SA_REG_CASCADE_OF_CYCLIN_EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.0 | 0.5 | ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY | PI3K Pathway |
| 0.0 | 1.8 | ST_INTEGRIN_SIGNALING_PATHWAY | Integrin Signaling Pathway |
| 0.0 | 0.2 | SA_B_CELL_RECEPTOR_COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
