Motif ID: SOX21

Z-value: 0.424


Transcription factors associated with SOX21:

Gene SymbolEntrez IDGene Name
SOX21 ENSG00000125285.4 SOX21



Activity profile for motif SOX21.

activity profile for motif SOX21


Sorted Z-values histogram for motif SOX21

Sorted Z-values for motif SOX21



Network of associatons between targets according to the STRING database.



First level regulatory network of SOX21

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr10_+_5005445 0.753 ENST00000380872.4
 AKR1C1
aldo-keto reductase family 1, member C1
chr6_-_112575912 0.563 ENST00000522006.1
ENST00000230538.7
ENST00000519932.1
 LAMA4


laminin, alpha 4


chr12_+_69742121 0.384 ENST00000261267.2
ENST00000549690.1
ENST00000548839.1
 LYZ


lysozyme


chr2_+_102759199 0.353 ENST00000409288.1
ENST00000410023.1
 IL1R1

interleukin 1 receptor, type I

chr6_-_112575838 0.347 ENST00000455073.1
 LAMA4
laminin, alpha 4
chr8_-_19459993 0.290 ENST00000454498.2
ENST00000520003.1
 CSGALNACT1

chondroitin sulfate N-acetylgalactosaminyltransferase 1

chr20_+_43343886 0.287 ENST00000190983.4
 WISP2
WNT1 inducible signaling pathway protein 2
chr5_-_95158644 0.284 ENST00000237858.6
 GLRX
glutaredoxin (thioltransferase)
chr12_-_7261772 0.278 ENST00000545280.1
ENST00000543933.1
ENST00000545337.1
ENST00000544702.1
ENST00000266542.4
 C1RL




complement component 1, r subcomponent-like




chr6_-_112575758 0.262 ENST00000431543.2
ENST00000453937.2
ENST00000368638.4
ENST00000389463.4
 LAMA4



laminin, alpha 4



chrY_+_16634483 0.228 ENST00000382872.1
 NLGN4Y
neuroligin 4, Y-linked
chr7_+_120702819 0.225 ENST00000423795.1
 CPED1
cadherin-like and PC-esterase domain containing 1
chr1_+_221051699 0.224 ENST00000366903.6
 HLX
H2.0-like homeobox
chr5_-_95158375 0.211 ENST00000512469.2
ENST00000379979.4
ENST00000505427.1
ENST00000508780.1
 GLRX



glutaredoxin (thioltransferase)



chr15_+_58702742 0.184 ENST00000356113.6
ENST00000414170.3
 LIPC

lipase, hepatic

chr1_-_169455169 0.164 ENST00000367804.4
ENST00000236137.5
 SLC19A2

solute carrier family 19 (thiamine transporter), member 2

chr7_-_86849883 0.150 ENST00000433078.1
 TMEM243
transmembrane protein 243, mitochondrial
chr3_-_155524049 0.140 ENST00000534941.1
ENST00000340171.2
 C3orf33

chromosome 3 open reading frame 33

chr6_+_131894284 0.129 ENST00000368087.3
ENST00000356962.2
 ARG1

arginase 1

chr3_-_37034702 0.127 ENST00000322716.5
 EPM2AIP1
EPM2A (laforin) interacting protein 1
chr12_-_10324716 0.118 ENST00000545927.1
ENST00000432556.2
ENST00000309539.3
ENST00000544577.1
 OLR1



oxidized low density lipoprotein (lectin-like) receptor 1



chr1_+_146714291 0.117 ENST00000431239.1
ENST00000369259.3
ENST00000369258.4
ENST00000361293.5
 CHD1L



chromodomain helicase DNA binding protein 1-like



chr12_+_123011776 0.105 ENST00000450485.2
ENST00000333479.7
 KNTC1

kinetochore associated 1

chr5_-_55529115 0.101 ENST00000513241.2
ENST00000341048.4
 ANKRD55

ankyrin repeat domain 55

chr17_-_18266660 0.098 ENST00000582653.1
ENST00000352886.6
 SHMT1

serine hydroxymethyltransferase 1 (soluble)

chr19_+_42381337 0.097 ENST00000597454.1
ENST00000444740.2
 CD79A

CD79a molecule, immunoglobulin-associated alpha

chr6_-_52926539 0.067 ENST00000350082.5
ENST00000356971.3
 ICK

intestinal cell (MAK-like) kinase

chr6_+_42531798 0.056 ENST00000372903.2
ENST00000372899.1
ENST00000372901.1
 UBR2


ubiquitin protein ligase E3 component n-recognin 2


chr16_-_15149828 0.052 ENST00000566419.1
ENST00000568320.1
 NTAN1

N-terminal asparagine amidase

chr19_+_42381173 0.046 ENST00000221972.3
 CD79A
CD79a molecule, immunoglobulin-associated alpha
chr8_+_67687413 0.037 ENST00000521960.1
ENST00000522398.1
ENST00000522629.1
ENST00000520976.1
ENST00000396596.1
 SGK3




serum/glucocorticoid regulated kinase family, member 3




chr9_+_105757590 0.033 ENST00000374798.3
ENST00000487798.1
 CYLC2

cylicin, basic protein of sperm head cytoskeleton 2

chr3_-_186288097 0.030 ENST00000446782.1
 TBCCD1
TBCC domain containing 1
chr10_-_71169031 0.029 ENST00000373307.1
 TACR2
tachykinin receptor 2
chr15_-_80263506 0.026 ENST00000335661.6
 BCL2A1
BCL2-related protein A1
chr1_+_158901329 0.023 ENST00000368140.1
ENST00000368138.3
ENST00000392254.2
ENST00000392252.3
ENST00000368135.4
 PYHIN1




pyrin and HIN domain family, member 1




chr11_-_8285405 0.023 ENST00000335790.3
ENST00000534484.1
 LMO1

LIM domain only 1 (rhombotin 1)

chr1_+_203764742 0.022 ENST00000432282.1
ENST00000453771.1
ENST00000367214.1
ENST00000367212.3
ENST00000332127.4
 ZC3H11A




zinc finger CCCH-type containing 11A




chr12_-_89746173 0.019 ENST00000308385.6
 DUSP6
dual specificity phosphatase 6
chr10_-_17243579 0.017 ENST00000525762.1
ENST00000412821.3
ENST00000351358.4
ENST00000377766.5
ENST00000358282.7
ENST00000488990.1
ENST00000377799.3
 TRDMT1






tRNA aspartic acid methyltransferase 1






chr6_+_31371337 0.016 ENST00000449934.2
ENST00000421350.1
 MICA

MHC class I polypeptide-related sequence A

chr3_-_164875850 0.011 ENST00000472120.1
 RP11-747D18.1
RP11-747D18.1
chr4_-_122854193 0.010 ENST00000513531.1
 TRPC3
transient receptor potential cation channel, subfamily C, member 3
chr20_+_56964253 0.009 ENST00000395802.3
 VAPB
VAMP (vesicle-associated membrane protein)-associated protein B and C
chr1_+_151171012 0.008 ENST00000349792.5
ENST00000409426.1
ENST00000441902.2
ENST00000368890.4
ENST00000424999.1
ENST00000368888.4
 PIP5K1A





phosphatidylinositol-4-phosphate 5-kinase, type I, alpha





chr4_+_81951957 0.007 ENST00000282701.2
 BMP3
bone morphogenetic protein 3
chrX_+_2984874 0.006 ENST00000359361.2
 ARSF
arylsulfatase F
chr14_-_107170409 0.006 ENST00000390633.2
 IGHV1-69
immunoglobulin heavy variable 1-69
chr2_+_3705785 0.005 ENST00000252505.3
 ALLC
allantoicase
chr1_+_67632083 0.005 ENST00000347310.5
ENST00000371002.1
 IL23R

interleukin 23 receptor

chrX_-_153210107 0.005 ENST00000369997.3
ENST00000393700.3
ENST00000412763.1
 RENBP


renin binding protein


chr12_-_1058685 0.004 ENST00000397230.2
ENST00000542785.1
ENST00000544742.1
ENST00000536177.1
ENST00000539046.1
ENST00000541619.1
 RAD52





RAD52 homolog (S. cerevisiae)






Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0002124 territorial aggressive behavior(GO:0002124) brainstem development(GO:0003360) vocalization behavior(GO:0071625)
0.1 0.3 GO:0050653 UDP-N-acetylgalactosamine metabolic process(GO:0019276) chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0050653)
0.1 0.2 GO:0035461 vitamin transmembrane transport(GO:0035461)
0.1 0.8 GO:0030299 intestinal cholesterol absorption(GO:0030299) intestinal lipid absorption(GO:0098856)
0.1 0.4 GO:0071731 response to nitric oxide(GO:0071731)
0.0 0.4 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.0 1.2 GO:0050873 brown fat cell differentiation(GO:0050873)
0.0 0.2 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.0 0.5 GO:0015949 nucleobase-containing small molecule interconversion(GO:0015949)
0.0 0.1 GO:0019264 L-serine catabolic process(GO:0006565) glycine biosynthetic process from serine(GO:0019264)
0.0 0.1 GO:0000050 urea cycle(GO:0000050)
0.0 0.0 GO:0051661 Golgi localization(GO:0051645) maintenance of centrosome location(GO:0051661)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.2 GO:0005606 laminin-1 complex(GO:0005606)
0.0 0.1 GO:0019815 immunoglobulin complex(GO:0019814) B cell receptor complex(GO:0019815)
0.0 0.0 GO:0033011 perinuclear theca(GO:0033011) cytoskeletal calyx(GO:0033150)
0.0 0.1 GO:0005828 kinetochore microtubule(GO:0005828)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0047042 androsterone dehydrogenase (B-specific) activity(GO:0047042) indanol dehydrogenase activity(GO:0047718)
0.1 0.3 GO:0008955 peptidoglycan glycosyltransferase activity(GO:0008955)
0.1 0.4 GO:0003796 lysozyme activity(GO:0003796)
0.1 0.4 GO:0004909 interleukin-1, Type I, activating receptor activity(GO:0004909)
0.1 0.5 GO:0015038 glutathione disulfide oxidoreductase activity(GO:0015038)
0.0 0.2 GO:0090482 vitamin transmembrane transporter activity(GO:0090482)
0.0 0.2 GO:0034185 apolipoprotein binding(GO:0034185)
0.0 0.1 GO:0008732 glycine hydroxymethyltransferase activity(GO:0004372) threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
0.0 1.2 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.3 GO:0005520 insulin-like growth factor binding(GO:0005520)