Motif ID: SOX30

Z-value: 0.955


Transcription factors associated with SOX30:

Gene SymbolEntrez IDGene Name
SOX30 ENSG00000039600.6 SOX30



Activity profile for motif SOX30.

activity profile for motif SOX30


Sorted Z-values histogram for motif SOX30

Sorted Z-values for motif SOX30



Network of associatons between targets according to the STRING database.



First level regulatory network of SOX30

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_+_12290586 1.656 ENST00000379375.5
 EDN1
endothelin 1
chr11_-_89224638 1.395 ENST00000535633.1
ENST00000263317.4
 NOX4

NADPH oxidase 4

chr11_+_46402744 1.015 ENST00000533952.1
 MDK
midkine (neurite growth-promoting factor 2)
chr12_-_10251603 0.858 ENST00000457018.2
 CLEC1A
C-type lectin domain family 1, member A
chr11_+_128563948 0.858 ENST00000534087.2
 FLI1
Fli-1 proto-oncogene, ETS transcription factor
chr11_+_128563652 0.854 ENST00000527786.2
 FLI1
Fli-1 proto-oncogene, ETS transcription factor
chr12_-_10251576 0.831 ENST00000315330.4
 CLEC1A
C-type lectin domain family 1, member A
chr5_-_141338627 0.814 ENST00000231484.3
 PCDH12
protocadherin 12
chr7_-_11871815 0.658 ENST00000423059.4
 THSD7A
thrombospondin, type I, domain containing 7A
chr12_-_10251539 0.610 ENST00000420265.2
 CLEC1A
C-type lectin domain family 1, member A
chr17_+_67498538 0.536 ENST00000589647.1
 MAP2K6
mitogen-activated protein kinase kinase 6
chr11_-_75236867 0.533 ENST00000376282.3
ENST00000336898.3
 GDPD5

glycerophosphodiester phosphodiesterase domain containing 5

chr20_-_45981138 0.437 ENST00000446994.2
 ZMYND8
zinc finger, MYND-type containing 8
chr11_-_102323489 0.398 ENST00000361236.3
 TMEM123
transmembrane protein 123
chr11_-_102323740 0.369 ENST00000398136.2
 TMEM123
transmembrane protein 123
chr11_+_125365110 0.350 ENST00000527818.1
 AP000708.1
AP000708.1
chr1_+_244998602 0.345 ENST00000411948.2
 COX20
COX20 cytochrome C oxidase assembly factor
chr17_+_47448102 0.343 ENST00000576461.1
 RP11-81K2.1
Uncharacterized protein
chr4_+_113152978 0.330 ENST00000309703.6
 AP1AR
adaptor-related protein complex 1 associated regulatory protein
chr1_+_93913713 0.327 ENST00000604705.1
ENST00000370253.2
 FNBP1L

formin binding protein 1-like

chrY_+_15016013 0.318 ENST00000360160.4
ENST00000454054.1
 DDX3Y

DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked

chr8_-_141810634 0.307 ENST00000521986.1
ENST00000523539.1
ENST00000538769.1
 PTK2


protein tyrosine kinase 2


chrX_-_15872914 0.306 ENST00000380291.1
ENST00000545766.1
ENST00000421527.2
ENST00000329235.2
 AP1S2



adaptor-related protein complex 1, sigma 2 subunit



chr2_+_143635067 0.251 ENST00000264170.4
 KYNU
kynureninase
chr3_-_8686479 0.249 ENST00000544814.1
ENST00000427408.1
 SSUH2

ssu-2 homolog (C. elegans)

chr2_+_232573222 0.236 ENST00000341369.7
ENST00000409683.1
 PTMA

prothymosin, alpha

chr2_+_232573208 0.231 ENST00000409115.3
 PTMA
prothymosin, alpha
chr2_-_169769787 0.212 ENST00000451987.1
 SPC25
SPC25, NDC80 kinetochore complex component
chr10_+_35484793 0.207 ENST00000488741.1
ENST00000474931.1
ENST00000468236.1
ENST00000344351.5
ENST00000490511.1
 CREM




cAMP responsive element modulator




chr9_+_103235365 0.200 ENST00000374879.4
 TMEFF1
transmembrane protein with EGF-like and two follistatin-like domains 1
chr1_+_74701062 0.196 ENST00000326637.3
 TNNI3K
TNNI3 interacting kinase
chr10_+_70480963 0.194 ENST00000265872.6
ENST00000535016.1
ENST00000538031.1
ENST00000543719.1
ENST00000539539.1
ENST00000543225.1
ENST00000536012.1
ENST00000494903.2
 CCAR1







cell division cycle and apoptosis regulator 1







chr2_+_86669118 0.167 ENST00000427678.1
ENST00000542128.1
 KDM3A

lysine (K)-specific demethylase 3A

chr8_-_82024290 0.166 ENST00000220597.4
 PAG1
phosphoprotein associated with glycosphingolipid microdomains 1
chr6_+_22146851 0.164 ENST00000606197.1
 CASC15
cancer susceptibility candidate 15 (non-protein coding)
chr13_-_41593425 0.154 ENST00000239882.3
 ELF1
E74-like factor 1 (ets domain transcription factor)
chr1_-_243418344 0.151 ENST00000366542.1
 CEP170
centrosomal protein 170kDa
chr22_-_43485381 0.149 ENST00000331018.7
ENST00000266254.7
ENST00000445824.1
 TTLL1


tubulin tyrosine ligase-like family, member 1


chr7_+_100770328 0.148 ENST00000223095.4
ENST00000445463.2
 SERPINE1

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

chr22_-_30970560 0.133 ENST00000402369.1
ENST00000406361.1
 GAL3ST1

galactose-3-O-sulfotransferase 1

chr6_-_89927151 0.127 ENST00000454853.2
 GABRR1
gamma-aminobutyric acid (GABA) A receptor, rho 1
chr1_+_185014496 0.123 ENST00000367510.3
 RNF2
ring finger protein 2
chr1_-_243418621 0.118 ENST00000366544.1
ENST00000366543.1
 CEP170

centrosomal protein 170kDa

chr10_+_35416090 0.116 ENST00000354759.3
 CREM
cAMP responsive element modulator
chr1_-_156828810 0.113 ENST00000368195.3
 INSRR
insulin receptor-related receptor
chr10_+_35415719 0.108 ENST00000474362.1
ENST00000374721.3
 CREM

cAMP responsive element modulator

chr5_+_66254698 0.104 ENST00000405643.1
ENST00000407621.1
ENST00000432426.1
 MAST4


microtubule associated serine/threonine kinase family member 4


chr2_-_157198860 0.102 ENST00000409572.1
 NR4A2
nuclear receptor subfamily 4, group A, member 2
chr4_-_70725856 0.093 ENST00000226444.3
 SULT1E1
sulfotransferase family 1E, estrogen-preferring, member 1
chr4_-_87028478 0.079 ENST00000515400.1
ENST00000395157.3
 MAPK10

mitogen-activated protein kinase 10

chr17_-_10372875 0.062 ENST00000255381.2
 MYH4
myosin, heavy chain 4, skeletal muscle
chr16_+_87636474 0.061 ENST00000284262.2
 JPH3
junctophilin 3
chr5_-_160279207 0.060 ENST00000327245.5
 ATP10B
ATPase, class V, type 10B
chr1_+_180897269 0.055 ENST00000367587.1
 KIAA1614
KIAA1614
chrX_+_41192595 0.055 ENST00000399959.2
 DDX3X
DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
chr10_+_35415978 0.053 ENST00000429130.3
ENST00000469949.2
ENST00000460270.1
 CREM


cAMP responsive element modulator


chr5_+_170288856 0.051 ENST00000523189.1
 RANBP17
RAN binding protein 17
chr11_-_102576537 0.051 ENST00000260229.4
 MMP27
matrix metallopeptidase 27
chr12_-_10282742 0.050 ENST00000298523.5
ENST00000396484.2
ENST00000310002.4
 CLEC7A


C-type lectin domain family 7, member A


chr10_+_35416223 0.046 ENST00000489321.1
ENST00000427847.2
ENST00000345491.3
ENST00000395895.2
ENST00000374728.3
ENST00000487132.1
 CREM





cAMP responsive element modulator





chr12_-_11422739 0.045 ENST00000279573.7
 PRB3
proline-rich protein BstNI subfamily 3
chr12_-_11036844 0.044 ENST00000428168.2
 PRH1
proline-rich protein HaeIII subfamily 1
chr1_-_167883327 0.044 ENST00000476818.2
ENST00000367851.4
ENST00000367848.1
 ADCY10


adenylate cyclase 10 (soluble)


chr14_-_90421028 0.035 ENST00000267544.9
ENST00000316738.7
ENST00000538485.2
ENST00000556609.1
 EFCAB11



EF-hand calcium binding domain 11



chr1_+_228337553 0.034 ENST00000366714.2
 GJC2
gap junction protein, gamma 2, 47kDa
chr18_+_32455201 0.032 ENST00000590831.2
 DTNA
dystrobrevin, alpha
chr11_+_63137251 0.027 ENST00000310969.4
ENST00000279178.3
 SLC22A9

solute carrier family 22 (organic anion transporter), member 9

chr14_+_101299520 0.023 ENST00000455531.1
 MEG3
maternally expressed 3 (non-protein coding)
chr2_+_27719697 0.020 ENST00000264717.2
ENST00000424318.2
 GCKR

glucokinase (hexokinase 4) regulator

chr3_-_167191814 0.014 ENST00000466903.1
ENST00000264677.4
 SERPINI2

serpin peptidase inhibitor, clade I (pancpin), member 2

chr14_+_52456327 0.005 ENST00000556760.1
 C14orf166
chromosome 14 open reading frame 166
chr6_+_126240442 0.005 ENST00000448104.1
ENST00000438495.1
ENST00000444128.1
 NCOA7


nuclear receptor coactivator 7


chr14_-_90420862 0.004 ENST00000556005.1
ENST00000555872.1
 EFCAB11

EF-hand calcium binding domain 11

chr12_-_11422630 0.002 ENST00000381842.3
ENST00000538488.1
 PRB3

proline-rich protein BstNI subfamily 3

chr1_+_154401791 0.002 ENST00000476006.1
 IL6R
interleukin 6 receptor

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.7 GO:0060024 rhythmic synaptic transmission(GO:0060024) regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
0.1 0.8 GO:0045793 positive regulation of cell size(GO:0045793)
0.1 0.3 GO:0019805 quinolinate biosynthetic process(GO:0019805)
0.1 0.2 GO:0046292 formaldehyde metabolic process(GO:0046292)
0.0 0.1 GO:0018095 protein polyglutamylation(GO:0018095)
0.0 0.1 GO:0010757 chronological cell aging(GO:0001300) arachidonic acid metabolite production involved in inflammatory response(GO:0002538) leukotriene production involved in inflammatory response(GO:0002540) negative regulation of plasminogen activation(GO:0010757) negative regulation of cell adhesion mediated by integrin(GO:0033629)
0.0 0.5 GO:0006975 DNA damage induced protein phosphorylation(GO:0006975)
0.0 1.4 GO:0042554 superoxide anion generation(GO:0042554)
0.0 0.1 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.0 0.5 GO:0006071 glycerol metabolic process(GO:0006071)
0.0 0.8 GO:0060711 labyrinthine layer development(GO:0060711)
0.0 1.0 GO:0030325 adrenal gland development(GO:0030325)
0.0 0.1 GO:0030238 male sex determination(GO:0030238)
0.0 0.1 GO:0016265 obsolete death(GO:0016265) dopamine biosynthetic process(GO:0042416) dopaminergic neuron differentiation(GO:0071542)
0.0 0.3 GO:0007172 signal complex assembly(GO:0007172)
0.0 0.2 GO:0050858 negative regulation of antigen receptor-mediated signaling pathway(GO:0050858) negative regulation of T cell receptor signaling pathway(GO:0050860)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0031262 Ndc80 complex(GO:0031262)
0.0 0.1 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.0 0.1 GO:0001739 sex chromatin(GO:0001739)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.7 GO:0031708 bombesin receptor binding(GO:0031705) endothelin B receptor binding(GO:0031708)
0.2 1.4 GO:0019826 oxygen sensor activity(GO:0019826)
0.1 0.5 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.1 0.3 GO:0016822 hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
0.0 0.5 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.0 0.6 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.0 0.1 GO:0001733 galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694)
0.0 0.2 GO:0031013 troponin I binding(GO:0031013)
0.0 0.1 GO:0004835 tubulin-tyrosine ligase activity(GO:0004835)
0.0 0.1 GO:0047894 flavonol 3-sulfotransferase activity(GO:0047894)
0.0 0.1 GO:0043548 phosphatidylinositol 3-kinase binding(GO:0043548)
0.0 0.5 GO:0042169 SH2 domain binding(GO:0042169)