Motif ID: SOX6
Z-value: 1.998
Transcription factors associated with SOX6:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| SOX6 | ENSG00000110693.11 | SOX6 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 5.1 | GO:0042989 | sequestering of actin monomers(GO:0042989) |
| 0.4 | 1.9 | GO:0032696 | negative regulation of interleukin-13 production(GO:0032696) regulation of estrogen receptor binding(GO:0071898) negative regulation of estrogen receptor binding(GO:0071899) regulation of receptor binding(GO:1900120) negative regulation of receptor binding(GO:1900121) |
| 0.3 | 2.8 | GO:0045008 | depyrimidination(GO:0045008) |
| 0.3 | 1.4 | GO:0043162 | ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162) |
| 0.2 | 1.2 | GO:0051271 | negative regulation of cell migration(GO:0030336) negative regulation of locomotion(GO:0040013) negative regulation of cellular component movement(GO:0051271) negative regulation of cell motility(GO:2000146) |
| 0.2 | 1.9 | GO:0051205 | protein insertion into membrane(GO:0051205) |
| 0.2 | 4.1 | GO:0006825 | copper ion transport(GO:0006825) |
| 0.2 | 1.0 | GO:0043569 | negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569) |
| 0.2 | 0.5 | GO:0002541 | activation of plasma proteins involved in acute inflammatory response(GO:0002541) |
| 0.2 | 0.6 | GO:0001543 | ovarian follicle rupture(GO:0001543) |
| 0.1 | 1.1 | GO:0003065 | regulation of heart rate by chemical signal(GO:0003062) positive regulation of heart rate by epinephrine(GO:0003065) |
| 0.1 | 1.0 | GO:0070934 | CRD-mediated mRNA stabilization(GO:0070934) |
| 0.1 | 0.5 | GO:0071313 | cellular response to caffeine(GO:0071313) |
| 0.1 | 0.8 | GO:0007352 | zygotic specification of dorsal/ventral axis(GO:0007352) |
| 0.1 | 0.6 | GO:0090084 | negative regulation of inclusion body assembly(GO:0090084) |
| 0.1 | 0.4 | GO:0048852 | diencephalon morphogenesis(GO:0048852) |
| 0.1 | 2.7 | GO:0001516 | prostaglandin biosynthetic process(GO:0001516) prostanoid biosynthetic process(GO:0046457) |
| 0.1 | 0.3 | GO:2000096 | positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096) |
| 0.1 | 0.3 | GO:0042560 | 10-formyltetrahydrofolate metabolic process(GO:0009256) 10-formyltetrahydrofolate catabolic process(GO:0009258) folic acid-containing compound catabolic process(GO:0009397) pteridine-containing compound catabolic process(GO:0042560) |
| 0.1 | 1.5 | GO:0071577 | zinc II ion transmembrane transport(GO:0071577) |
| 0.1 | 0.2 | GO:0031018 | endocrine pancreas development(GO:0031018) |
| 0.1 | 0.4 | GO:0006290 | pyrimidine dimer repair(GO:0006290) |
| 0.1 | 0.2 | GO:0034498 | early endosome to Golgi transport(GO:0034498) |
| 0.1 | 1.1 | GO:0033687 | osteoblast proliferation(GO:0033687) |
| 0.1 | 0.3 | GO:0030259 | lipid glycosylation(GO:0030259) |
| 0.1 | 0.3 | GO:0071542 | dopaminergic neuron differentiation(GO:0071542) |
| 0.1 | 0.2 | GO:0072387 | flavin-containing compound biosynthetic process(GO:0042727) flavin adenine dinucleotide metabolic process(GO:0072387) |
| 0.1 | 0.6 | GO:0034638 | phosphatidylcholine catabolic process(GO:0034638) |
| 0.1 | 0.9 | GO:0031115 | negative regulation of microtubule polymerization(GO:0031115) |
| 0.1 | 1.4 | GO:0006378 | mRNA polyadenylation(GO:0006378) |
| 0.1 | 1.1 | GO:0032784 | regulation of DNA-templated transcription, elongation(GO:0032784) |
| 0.1 | 0.4 | GO:0060414 | aorta development(GO:0035904) aorta morphogenesis(GO:0035909) aorta smooth muscle tissue morphogenesis(GO:0060414) |
| 0.1 | 0.6 | GO:0035235 | ionotropic glutamate receptor signaling pathway(GO:0035235) |
| 0.0 | 2.7 | GO:0051084 | 'de novo' posttranslational protein folding(GO:0051084) |
| 0.0 | 0.0 | GO:0051970 | negative regulation of transmission of nerve impulse(GO:0051970) |
| 0.0 | 0.1 | GO:0060316 | positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316) |
| 0.0 | 0.5 | GO:0050858 | negative regulation of antigen receptor-mediated signaling pathway(GO:0050858) negative regulation of T cell receptor signaling pathway(GO:0050860) |
| 0.0 | 0.1 | GO:0006848 | pyruvate transport(GO:0006848) |
| 0.0 | 0.7 | GO:0043968 | histone H2A acetylation(GO:0043968) |
| 0.0 | 0.2 | GO:0046541 | saliva secretion(GO:0046541) |
| 0.0 | 1.6 | GO:0050771 | negative regulation of axonogenesis(GO:0050771) |
| 0.0 | 1.9 | GO:0006446 | regulation of translational initiation(GO:0006446) |
| 0.0 | 0.1 | GO:0008298 | intracellular mRNA localization(GO:0008298) minus-end-directed organelle transport along microtubule(GO:0072385) microtubule anchoring at microtubule organizing center(GO:0072393) |
| 0.0 | 1.2 | GO:0009060 | aerobic respiration(GO:0009060) |
| 0.0 | 0.5 | GO:0006906 | vesicle fusion(GO:0006906) |
| 0.0 | 2.8 | GO:0008360 | regulation of cell shape(GO:0008360) |
| 0.0 | 0.4 | GO:0016226 | iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163) |
| 0.0 | 0.1 | GO:0043371 | negative regulation of CD4-positive, alpha-beta T cell differentiation(GO:0043371) negative regulation of T-helper cell differentiation(GO:0045623) negative regulation of CD4-positive, alpha-beta T cell activation(GO:2000515) |
| 0.0 | 0.5 | GO:0006904 | vesicle docking involved in exocytosis(GO:0006904) |
| 0.0 | 0.1 | GO:0051895 | negative regulation of focal adhesion assembly(GO:0051895) negative regulation of cell junction assembly(GO:1901889) negative regulation of adherens junction organization(GO:1903392) |
| 0.0 | 0.1 | GO:0007195 | adenylate cyclase-inhibiting dopamine receptor signaling pathway(GO:0007195) |
| 0.0 | 0.6 | GO:0007340 | acrosome reaction(GO:0007340) |
| 0.0 | 0.1 | GO:0008535 | respiratory chain complex IV assembly(GO:0008535) |
| 0.0 | 0.6 | GO:0002474 | antigen processing and presentation of peptide antigen via MHC class I(GO:0002474) |
| 0.0 | 0.6 | GO:0071804 | cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805) |
| 0.0 | 0.3 | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome(GO:0000381) |
| 0.0 | 0.4 | GO:0061245 | establishment or maintenance of apical/basal cell polarity(GO:0035088) establishment or maintenance of bipolar cell polarity(GO:0061245) |
| 0.0 | 1.5 | GO:0031032 | actomyosin structure organization(GO:0031032) |
| 0.0 | 0.6 | GO:0007257 | activation of JUN kinase activity(GO:0007257) |
| 0.0 | 0.8 | GO:0045576 | mast cell activation(GO:0045576) |
| 0.0 | 0.4 | GO:0042551 | regulation of heart rate(GO:0002027) neuron maturation(GO:0042551) |
| 0.0 | 0.1 | GO:0006682 | galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375) |
| 0.0 | 0.3 | GO:0008038 | neuron recognition(GO:0008038) |
| 0.0 | 0.3 | GO:0006386 | transcription elongation from RNA polymerase III promoter(GO:0006385) termination of RNA polymerase III transcription(GO:0006386) |
| 0.0 | 0.1 | GO:0048024 | regulation of mRNA splicing, via spliceosome(GO:0048024) |
| 0.0 | 0.1 | GO:0045109 | intermediate filament organization(GO:0045109) |
| 0.0 | 0.2 | GO:0035329 | hippo signaling(GO:0035329) |
| 0.0 | 0.0 | GO:0010761 | fibroblast migration(GO:0010761) |
| 0.0 | 0.4 | GO:0048146 | positive regulation of fibroblast proliferation(GO:0048146) |
| 0.0 | 0.2 | GO:0007032 | endosome organization(GO:0007032) |
| 0.0 | 0.3 | GO:0015949 | nucleobase-containing small molecule interconversion(GO:0015949) |
| 0.0 | 0.9 | GO:0006986 | response to unfolded protein(GO:0006986) |
| 0.0 | 1.4 | GO:0032355 | response to estradiol(GO:0032355) |
| 0.0 | 0.3 | GO:0030866 | cortical actin cytoskeleton organization(GO:0030866) |
| 0.0 | 0.8 | GO:0051291 | protein heterooligomerization(GO:0051291) |
| 0.0 | 1.6 | GO:0043087 | regulation of GTPase activity(GO:0043087) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 5.6 | GO:0001527 | microfibril(GO:0001527) |
| 0.2 | 0.6 | GO:0016533 | cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533) |
| 0.1 | 1.0 | GO:0070937 | CRD-mediated mRNA stability complex(GO:0070937) |
| 0.1 | 1.0 | GO:0016942 | insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454) |
| 0.1 | 0.5 | GO:0042272 | nuclear RNA export factor complex(GO:0042272) |
| 0.1 | 0.6 | GO:0070852 | cell body fiber(GO:0070852) |
| 0.1 | 1.1 | GO:0032059 | bleb(GO:0032059) |
| 0.1 | 0.9 | GO:0005832 | chaperonin-containing T-complex(GO:0005832) |
| 0.1 | 0.9 | GO:0098651 | basement membrane collagen trimer(GO:0098651) |
| 0.1 | 1.9 | GO:0016281 | eukaryotic translation initiation factor 4F complex(GO:0016281) |
| 0.1 | 0.7 | GO:0042382 | paraspeckles(GO:0042382) |
| 0.1 | 5.1 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.1 | 3.1 | GO:0030175 | filopodium(GO:0030175) |
| 0.1 | 2.7 | GO:0005791 | rough endoplasmic reticulum(GO:0005791) |
| 0.1 | 0.6 | GO:0043190 | ATP-binding cassette (ABC) transporter complex(GO:0043190) |
| 0.1 | 0.6 | GO:0005862 | muscle thin filament tropomyosin(GO:0005862) |
| 0.0 | 0.1 | GO:0033655 | host(GO:0018995) host cell cytoplasm(GO:0030430) host cell part(GO:0033643) host intracellular part(GO:0033646) host cell cytoplasm part(GO:0033655) intracellular region of host(GO:0043656) host cell(GO:0043657) other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217) |
| 0.0 | 0.7 | GO:0070822 | Sin3 complex(GO:0016580) Sin3-type complex(GO:0070822) |
| 0.0 | 0.4 | GO:0042555 | MCM complex(GO:0042555) |
| 0.0 | 0.8 | GO:0005839 | proteasome core complex(GO:0005839) |
| 0.0 | 0.6 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
| 0.0 | 0.8 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.0 | 0.6 | GO:0042612 | MHC class I protein complex(GO:0042612) |
| 0.0 | 0.5 | GO:0005657 | replication fork(GO:0005657) |
| 0.0 | 0.5 | GO:0000299 | obsolete integral to membrane of membrane fraction(GO:0000299) |
| 0.0 | 1.9 | GO:0032993 | protein-DNA complex(GO:0032993) |
| 0.0 | 0.4 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.0 | 0.9 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.0 | 0.4 | GO:0005902 | microvillus(GO:0005902) |
| 0.0 | 0.3 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.0 | 0.3 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.0 | 0.0 | GO:0036452 | ESCRT III complex(GO:0000815) ESCRT complex(GO:0036452) |
| 0.0 | 0.3 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
| 0.0 | 0.4 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.0 | 0.3 | GO:0001772 | immunological synapse(GO:0001772) |
| 0.0 | 0.6 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 0.0 | 0.2 | GO:0042581 | specific granule(GO:0042581) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 2.8 | GO:0008263 | pyrimidine-specific mismatch base pair DNA N-glycosylase activity(GO:0008263) |
| 0.7 | 2.6 | GO:0004667 | prostaglandin-D synthase activity(GO:0004667) |
| 0.5 | 1.9 | GO:0035326 | enhancer binding(GO:0035326) |
| 0.3 | 1.7 | GO:0034597 | phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316) phosphatidylinositol phosphate 4-phosphatase activity(GO:0034596) phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity(GO:0034597) |
| 0.2 | 1.5 | GO:0017162 | aryl hydrocarbon receptor binding(GO:0017162) |
| 0.2 | 0.6 | GO:0016534 | cyclin-dependent protein kinase 5 activator activity(GO:0016534) |
| 0.2 | 0.6 | GO:0047391 | alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391) |
| 0.1 | 1.0 | GO:0031994 | insulin-like growth factor I binding(GO:0031994) |
| 0.1 | 1.9 | GO:0003841 | 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) lysophosphatidic acid acyltransferase activity(GO:0042171) lysophospholipid acyltransferase activity(GO:0071617) |
| 0.1 | 0.4 | GO:0035198 | miRNA binding(GO:0035198) |
| 0.1 | 0.3 | GO:0031177 | formyltetrahydrofolate dehydrogenase activity(GO:0016155) phosphopantetheine binding(GO:0031177) |
| 0.1 | 0.7 | GO:0008159 | obsolete positive transcription elongation factor activity(GO:0008159) |
| 0.1 | 0.4 | GO:0017159 | pantetheine hydrolase activity(GO:0017159) |
| 0.1 | 1.1 | GO:0003711 | obsolete transcription elongation regulator activity(GO:0003711) |
| 0.1 | 0.1 | GO:0005522 | profilin binding(GO:0005522) |
| 0.1 | 0.6 | GO:0035259 | glucocorticoid receptor binding(GO:0035259) |
| 0.1 | 0.4 | GO:0004687 | myosin light chain kinase activity(GO:0004687) |
| 0.1 | 2.4 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) |
| 0.1 | 0.4 | GO:0005499 | vitamin D binding(GO:0005499) |
| 0.1 | 1.5 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.1 | 0.2 | GO:0046848 | hydroxyapatite binding(GO:0046848) |
| 0.1 | 4.0 | GO:0005507 | copper ion binding(GO:0005507) |
| 0.1 | 0.6 | GO:0008140 | cAMP response element binding protein binding(GO:0008140) |
| 0.0 | 0.1 | GO:0005412 | glucose:sodium symporter activity(GO:0005412) |
| 0.0 | 1.0 | GO:0004004 | ATP-dependent RNA helicase activity(GO:0004004) |
| 0.0 | 1.0 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.0 | 0.1 | GO:0031997 | N-terminal myristoylation domain binding(GO:0031997) |
| 0.0 | 0.6 | GO:0032393 | MHC class I receptor activity(GO:0032393) |
| 0.0 | 4.1 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.0 | 0.1 | GO:0050833 | pyruvate secondary active transmembrane transporter activity(GO:0005477) pyruvate transmembrane transporter activity(GO:0050833) |
| 0.0 | 0.6 | GO:0030544 | Hsp70 protein binding(GO:0030544) |
| 0.0 | 0.4 | GO:0003906 | DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906) |
| 0.0 | 1.4 | GO:0018024 | histone-lysine N-methyltransferase activity(GO:0018024) |
| 0.0 | 0.5 | GO:0051787 | misfolded protein binding(GO:0051787) |
| 0.0 | 2.3 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 0.0 | 0.2 | GO:0003847 | 1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847) |
| 0.0 | 0.1 | GO:0017160 | Ral GTPase binding(GO:0017160) |
| 0.0 | 0.3 | GO:0008499 | UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity(GO:0008499) |
| 0.0 | 0.8 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.0 | 0.6 | GO:0004707 | MAP kinase activity(GO:0004707) |
| 0.0 | 1.2 | GO:0043130 | ubiquitin binding(GO:0043130) |
| 0.0 | 0.7 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
| 0.0 | 2.4 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.0 | 0.3 | GO:0004726 | non-membrane spanning protein tyrosine phosphatase activity(GO:0004726) |
| 0.0 | 0.8 | GO:0008601 | protein phosphatase type 2A regulator activity(GO:0008601) |
| 0.0 | 0.5 | GO:0005487 | nucleocytoplasmic transporter activity(GO:0005487) |
| 0.0 | 0.3 | GO:0004017 | adenylate kinase activity(GO:0004017) |
| 0.0 | 0.1 | GO:0034452 | dynactin binding(GO:0034452) |
| 0.0 | 0.2 | GO:0008432 | JUN kinase binding(GO:0008432) |
| 0.0 | 0.3 | GO:0043621 | protein self-association(GO:0043621) |
| 0.0 | 0.1 | GO:0004796 | thromboxane-A synthase activity(GO:0004796) |
| 0.0 | 0.4 | GO:0005247 | voltage-gated chloride channel activity(GO:0005247) |
| 0.0 | 0.2 | GO:0070566 | adenylyltransferase activity(GO:0070566) |
| 0.0 | 0.1 | GO:0017091 | AU-rich element binding(GO:0017091) |
| 0.0 | 1.4 | GO:0044822 | mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822) |
| 0.0 | 0.1 | GO:0008271 | secondary active sulfate transmembrane transporter activity(GO:0008271) |
| 0.0 | 1.2 | GO:0052689 | carboxylic ester hydrolase activity(GO:0052689) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.5 | SA_G2_AND_M_PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.0 | 0.9 | SA_REG_CASCADE_OF_CYCLIN_EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
