Motif ID: SOX8
Z-value: 1.373
Transcription factors associated with SOX8:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| SOX8 | ENSG00000005513.9 | SOX8 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 1.1 | GO:0002752 | cell surface pattern recognition receptor signaling pathway(GO:0002752) |
| 0.2 | 0.7 | GO:0007206 | phospholipase C-activating G-protein coupled glutamate receptor signaling pathway(GO:0007206) |
| 0.2 | 0.9 | GO:0072180 | mesonephric duct morphogenesis(GO:0072180) |
| 0.2 | 1.0 | GO:0072526 | pyridine-containing compound catabolic process(GO:0072526) |
| 0.2 | 0.6 | GO:0010430 | ethanol catabolic process(GO:0006068) fatty acid omega-oxidation(GO:0010430) |
| 0.2 | 0.7 | GO:0018352 | protein-pyridoxal-5-phosphate linkage(GO:0018352) |
| 0.1 | 2.5 | GO:0006359 | regulation of transcription from RNA polymerase III promoter(GO:0006359) |
| 0.1 | 0.4 | GO:0072677 | eosinophil chemotaxis(GO:0048245) eosinophil migration(GO:0072677) |
| 0.1 | 3.0 | GO:0002504 | antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002504) |
| 0.1 | 0.6 | GO:0072205 | collecting duct development(GO:0072044) metanephric tubule development(GO:0072170) metanephric collecting duct development(GO:0072205) metanephric epithelium development(GO:0072207) metanephric nephron tubule development(GO:0072234) metanephric nephron epithelium development(GO:0072243) |
| 0.1 | 0.4 | GO:0047484 | regulation of response to osmotic stress(GO:0047484) |
| 0.1 | 0.2 | GO:0070340 | detection of bacterial lipoprotein(GO:0042494) detection of triacyl bacterial lipopeptide(GO:0042495) detection of bacterial lipopeptide(GO:0070340) response to triacyl bacterial lipopeptide(GO:0071725) cellular response to triacyl bacterial lipopeptide(GO:0071727) |
| 0.1 | 0.2 | GO:0007181 | transforming growth factor beta receptor complex assembly(GO:0007181) |
| 0.1 | 1.1 | GO:0030388 | fructose 1,6-bisphosphate metabolic process(GO:0030388) |
| 0.1 | 0.4 | GO:0010447 | response to acidic pH(GO:0010447) |
| 0.1 | 0.7 | GO:0030277 | epithelial structure maintenance(GO:0010669) maintenance of gastrointestinal epithelium(GO:0030277) |
| 0.1 | 1.0 | GO:0030212 | hyaluronan metabolic process(GO:0030212) |
| 0.1 | 0.7 | GO:0006600 | creatine metabolic process(GO:0006600) |
| 0.1 | 0.7 | GO:0060314 | regulation of ryanodine-sensitive calcium-release channel activity(GO:0060314) |
| 0.1 | 0.5 | GO:0009396 | folic acid-containing compound biosynthetic process(GO:0009396) |
| 0.1 | 0.3 | GO:0030578 | nuclear body organization(GO:0030575) PML body organization(GO:0030578) |
| 0.1 | 0.3 | GO:0045589 | regulation of regulatory T cell differentiation(GO:0045589) |
| 0.1 | 0.5 | GO:0006546 | glycine catabolic process(GO:0006546) |
| 0.0 | 0.2 | GO:0032020 | ISG15-protein conjugation(GO:0032020) |
| 0.0 | 0.3 | GO:0030644 | cellular chloride ion homeostasis(GO:0030644) chloride ion homeostasis(GO:0055064) |
| 0.0 | 1.5 | GO:0031424 | keratinization(GO:0031424) |
| 0.0 | 0.2 | GO:0001575 | globoside metabolic process(GO:0001575) |
| 0.0 | 0.5 | GO:0006776 | vitamin A metabolic process(GO:0006776) |
| 0.0 | 0.1 | GO:0031117 | positive regulation of microtubule depolymerization(GO:0031117) |
| 0.0 | 0.6 | GO:0006787 | porphyrin-containing compound catabolic process(GO:0006787) tetrapyrrole catabolic process(GO:0033015) heme catabolic process(GO:0042167) pigment catabolic process(GO:0046149) |
| 0.0 | 0.4 | GO:0033327 | Leydig cell differentiation(GO:0033327) |
| 0.0 | 0.3 | GO:0035335 | peptidyl-tyrosine dephosphorylation(GO:0035335) |
| 0.0 | 0.9 | GO:0015804 | neutral amino acid transport(GO:0015804) |
| 0.0 | 0.2 | GO:0032099 | negative regulation of appetite(GO:0032099) |
| 0.0 | 0.3 | GO:0016998 | cell wall macromolecule catabolic process(GO:0016998) |
| 0.0 | 0.1 | GO:0033262 | regulation of nuclear cell cycle DNA replication(GO:0033262) replication fork protection(GO:0048478) |
| 0.0 | 0.5 | GO:0006386 | transcription elongation from RNA polymerase III promoter(GO:0006385) termination of RNA polymerase III transcription(GO:0006386) |
| 0.0 | 0.4 | GO:0007205 | protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205) |
| 0.0 | 0.2 | GO:0001550 | ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165) |
| 0.0 | 0.1 | GO:0046477 | glycosylceramide catabolic process(GO:0046477) |
| 0.0 | 0.2 | GO:0008653 | lipopolysaccharide metabolic process(GO:0008653) |
| 0.0 | 0.2 | GO:0051918 | negative regulation of fibrinolysis(GO:0051918) |
| 0.0 | 0.2 | GO:0006196 | AMP catabolic process(GO:0006196) |
| 0.0 | 0.2 | GO:0001954 | positive regulation of cell-matrix adhesion(GO:0001954) |
| 0.0 | 1.1 | GO:0006309 | DNA catabolic process, endonucleolytic(GO:0000737) apoptotic DNA fragmentation(GO:0006309) |
| 0.0 | 1.7 | GO:0008033 | tRNA processing(GO:0008033) |
| 0.0 | 0.2 | GO:0046514 | ceramide catabolic process(GO:0046514) |
| 0.0 | 1.0 | GO:0043124 | negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124) |
| 0.0 | 2.7 | GO:0007162 | negative regulation of cell adhesion(GO:0007162) |
| 0.0 | 0.7 | GO:0006730 | one-carbon metabolic process(GO:0006730) |
| 0.0 | 0.3 | GO:0006071 | glycerol metabolic process(GO:0006071) |
| 0.0 | 0.1 | GO:0016080 | synaptic vesicle targeting(GO:0016080) |
| 0.0 | 0.3 | GO:0050798 | activated T cell proliferation(GO:0050798) |
| 0.0 | 0.2 | GO:0045822 | negative regulation of heart contraction(GO:0045822) |
| 0.0 | 0.2 | GO:0042273 | ribosomal large subunit biogenesis(GO:0042273) |
| 0.0 | 0.2 | GO:0015939 | pantothenate metabolic process(GO:0015939) |
| 0.0 | 0.3 | GO:0000291 | nuclear-transcribed mRNA catabolic process, exonucleolytic(GO:0000291) exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928) |
| 0.0 | 0.1 | GO:0032528 | microvillus assembly(GO:0030033) microvillus organization(GO:0032528) |
| 0.0 | 0.2 | GO:0007274 | neuromuscular synaptic transmission(GO:0007274) |
| 0.0 | 0.3 | GO:0008299 | isoprenoid biosynthetic process(GO:0008299) |
| 0.0 | 0.2 | GO:0006613 | cotranslational protein targeting to membrane(GO:0006613) |
| 0.0 | 0.0 | GO:0017121 | phospholipid scrambling(GO:0017121) |
| 0.0 | 0.1 | GO:0070584 | positive regulation of helicase activity(GO:0051096) mitochondrion morphogenesis(GO:0070584) |
| 0.0 | 0.4 | GO:1904894 | positive regulation of JAK-STAT cascade(GO:0046427) positive regulation of STAT cascade(GO:1904894) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 2.5 | GO:0005666 | DNA-directed RNA polymerase III complex(GO:0005666) |
| 0.2 | 0.7 | GO:0014701 | junctional sarcoplasmic reticulum membrane(GO:0014701) |
| 0.1 | 3.0 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.1 | 1.1 | GO:1903561 | extracellular exosome(GO:0070062) extracellular vesicle(GO:1903561) |
| 0.1 | 0.2 | GO:0000120 | RNA polymerase I transcription factor complex(GO:0000120) |
| 0.1 | 0.8 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.1 | 0.2 | GO:0035354 | Toll-like receptor 1-Toll-like receptor 2 protein complex(GO:0035354) |
| 0.1 | 0.5 | GO:0030681 | nucleolar ribonuclease P complex(GO:0005655) ribonuclease P complex(GO:0030677) multimeric ribonuclease P complex(GO:0030681) |
| 0.1 | 1.5 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.0 | 0.4 | GO:0005797 | Golgi medial cisterna(GO:0005797) |
| 0.0 | 0.3 | GO:0070081 | clathrin-sculpted monoamine transport vesicle(GO:0070081) clathrin-sculpted monoamine transport vesicle membrane(GO:0070083) |
| 0.0 | 0.7 | GO:0043034 | costamere(GO:0043034) |
| 0.0 | 0.4 | GO:0071778 | obsolete WINAC complex(GO:0071778) |
| 0.0 | 0.2 | GO:0005766 | primary lysosome(GO:0005766) azurophil granule(GO:0042582) |
| 0.0 | 0.3 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
| 0.0 | 0.2 | GO:0010369 | chromocenter(GO:0010369) |
| 0.0 | 0.1 | GO:0008385 | IkappaB kinase complex(GO:0008385) |
| 0.0 | 0.3 | GO:0045334 | clathrin-coated endocytic vesicle(GO:0045334) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 2.5 | GO:0047179 | platelet-activating factor acetyltransferase activity(GO:0047179) |
| 0.4 | 1.2 | GO:0008489 | UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity(GO:0008489) |
| 0.3 | 1.0 | GO:0004514 | nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514) |
| 0.3 | 2.8 | GO:0005094 | Rho GDP-dissociation inhibitor activity(GO:0005094) |
| 0.2 | 0.9 | GO:0060422 | peptidyl-dipeptidase inhibitor activity(GO:0060422) |
| 0.2 | 1.1 | GO:0004910 | interleukin-1, Type II, blocking receptor activity(GO:0004910) |
| 0.2 | 0.6 | GO:0035276 | ethanol binding(GO:0035276) |
| 0.2 | 1.3 | GO:0001846 | opsonin binding(GO:0001846) |
| 0.2 | 0.5 | GO:0004477 | methenyltetrahydrofolate cyclohydrolase activity(GO:0004477) |
| 0.1 | 0.7 | GO:0004111 | creatine kinase activity(GO:0004111) |
| 0.1 | 2.0 | GO:0032395 | MHC class II receptor activity(GO:0032395) |
| 0.1 | 0.6 | GO:0019862 | IgA binding(GO:0019862) |
| 0.1 | 0.6 | GO:0005499 | vitamin D binding(GO:0005499) |
| 0.1 | 0.4 | GO:0048020 | CCR chemokine receptor binding(GO:0048020) |
| 0.1 | 1.1 | GO:0004332 | fructose-bisphosphate aldolase activity(GO:0004332) |
| 0.1 | 0.3 | GO:0004796 | thromboxane-A synthase activity(GO:0004796) |
| 0.1 | 1.1 | GO:0016888 | endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888) |
| 0.1 | 0.2 | GO:0050528 | acyloxyacyl hydrolase activity(GO:0050528) |
| 0.1 | 0.5 | GO:0004047 | aminomethyltransferase activity(GO:0004047) |
| 0.1 | 0.2 | GO:0071723 | lipopeptide binding(GO:0071723) |
| 0.1 | 0.3 | GO:0004337 | dimethylallyltranstransferase activity(GO:0004161) geranyltranstransferase activity(GO:0004337) |
| 0.1 | 2.9 | GO:0003899 | DNA-directed RNA polymerase activity(GO:0003899) RNA polymerase activity(GO:0034062) |
| 0.1 | 0.2 | GO:0017040 | ceramidase activity(GO:0017040) |
| 0.0 | 0.3 | GO:0008889 | glycerophosphodiester phosphodiesterase activity(GO:0008889) |
| 0.0 | 0.7 | GO:0016846 | carbon-sulfur lyase activity(GO:0016846) |
| 0.0 | 0.4 | GO:0001758 | retinal dehydrogenase activity(GO:0001758) |
| 0.0 | 0.9 | GO:0017153 | sodium:dicarboxylate symporter activity(GO:0017153) |
| 0.0 | 1.0 | GO:0005095 | GTPase inhibitor activity(GO:0005095) |
| 0.0 | 0.4 | GO:0005148 | prolactin receptor binding(GO:0005148) |
| 0.0 | 0.2 | GO:0047006 | 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity(GO:0047006) |
| 0.0 | 0.3 | GO:0008504 | monoamine transmembrane transporter activity(GO:0008504) |
| 0.0 | 0.2 | GO:0017159 | pantetheine hydrolase activity(GO:0017159) |
| 0.0 | 0.7 | GO:0004089 | carbonate dehydratase activity(GO:0004089) |
| 0.0 | 0.5 | GO:0004526 | ribonuclease P activity(GO:0004526) |
| 0.0 | 0.3 | GO:0005237 | inhibitory extracellular ligand-gated ion channel activity(GO:0005237) |
| 0.0 | 0.4 | GO:0019864 | IgG binding(GO:0019864) |
| 0.0 | 0.8 | GO:0043499 | obsolete eukaryotic cell surface binding(GO:0043499) |
| 0.0 | 0.1 | GO:0015925 | galactosidase activity(GO:0015925) |
| 0.0 | 1.3 | GO:0008009 | chemokine activity(GO:0008009) |
| 0.0 | 0.1 | GO:0004911 | interleukin-2 receptor activity(GO:0004911) |
| 0.0 | 0.2 | GO:1901567 | icosanoid binding(GO:0050542) arachidonic acid binding(GO:0050544) fatty acid derivative binding(GO:1901567) |
| 0.0 | 2.6 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 0.2 | GO:0003701 | obsolete RNA polymerase I transcription factor activity(GO:0003701) |
| 0.0 | 0.3 | GO:0008641 | small protein activating enzyme activity(GO:0008641) |
| 0.0 | 0.1 | GO:0042043 | neurexin family protein binding(GO:0042043) |
| 0.0 | 0.1 | GO:0016165 | linoleate 13S-lipoxygenase activity(GO:0016165) |
| 0.0 | 0.1 | GO:0008568 | microtubule-severing ATPase activity(GO:0008568) |
| 0.0 | 0.3 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
| 0.0 | 0.4 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
| 0.0 | 0.2 | GO:0003876 | AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623) |
| 0.0 | 0.3 | GO:0004602 | glutathione peroxidase activity(GO:0004602) |
| 0.0 | 0.1 | GO:0016918 | retinal binding(GO:0016918) |
| 0.0 | 0.2 | GO:0043236 | laminin binding(GO:0043236) |
| 0.0 | 0.2 | GO:0004000 | adenosine deaminase activity(GO:0004000) |
| 0.0 | 0.4 | GO:0004143 | diacylglycerol kinase activity(GO:0004143) |
| 0.0 | 0.2 | GO:0060590 | ATPase regulator activity(GO:0060590) |
| 0.0 | 1.0 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.0 | 0.1 | GO:0004028 | 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028) |
| 0.0 | 0.1 | GO:0005132 | type I interferon receptor binding(GO:0005132) |
| 0.0 | 0.8 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.0 | 0.9 | GO:0016779 | nucleotidyltransferase activity(GO:0016779) |
| 0.0 | 0.2 | GO:0003857 | 3-hydroxyacyl-CoA dehydrogenase activity(GO:0003857) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.4 | SA_REG_CASCADE_OF_CYCLIN_EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
