Motif ID: SOX9
Z-value: 1.614
Transcription factors associated with SOX9:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| SOX9 | ENSG00000125398.5 | SOX9 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 3.6 | GO:2000096 | positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096) |
| 1.2 | 3.5 | GO:0010837 | regulation of keratinocyte proliferation(GO:0010837) |
| 0.6 | 3.5 | GO:2000172 | regulation of branching morphogenesis of a nerve(GO:2000172) |
| 0.5 | 1.4 | GO:0097709 | connective tissue replacement involved in inflammatory response wound healing(GO:0002248) connective tissue replacement(GO:0097709) |
| 0.4 | 1.4 | GO:0045110 | intermediate filament bundle assembly(GO:0045110) |
| 0.4 | 1.8 | GO:0033632 | regulation of cell-cell adhesion mediated by integrin(GO:0033632) |
| 0.3 | 1.3 | GO:2000114 | regulation of establishment of cell polarity(GO:2000114) |
| 0.2 | 1.3 | GO:0006931 | substrate-dependent cell migration, cell attachment to substrate(GO:0006931) |
| 0.2 | 2.3 | GO:0060216 | definitive hemopoiesis(GO:0060216) |
| 0.2 | 0.5 | GO:0021837 | motogenic signaling involved in postnatal olfactory bulb interneuron migration(GO:0021837) regulation of mesodermal cell fate specification(GO:0042661) lateral mesodermal cell fate commitment(GO:0048372) lateral mesodermal cell fate specification(GO:0048377) regulation of lateral mesodermal cell fate specification(GO:0048378) regulation of mesoderm development(GO:2000380) |
| 0.1 | 3.2 | GO:0007597 | blood coagulation, intrinsic pathway(GO:0007597) |
| 0.1 | 0.6 | GO:0070933 | histone H3 deacetylation(GO:0070932) histone H4 deacetylation(GO:0070933) |
| 0.1 | 0.9 | GO:0060414 | aorta development(GO:0035904) aorta morphogenesis(GO:0035909) aorta smooth muscle tissue morphogenesis(GO:0060414) |
| 0.1 | 0.8 | GO:0010842 | retina layer formation(GO:0010842) |
| 0.1 | 0.5 | GO:0046477 | glycosylceramide catabolic process(GO:0046477) |
| 0.1 | 0.8 | GO:0014049 | positive regulation of glutamate secretion(GO:0014049) |
| 0.1 | 0.8 | GO:0008354 | germ cell migration(GO:0008354) |
| 0.1 | 0.3 | GO:0051088 | PMA-inducible membrane protein ectodomain proteolysis(GO:0051088) |
| 0.1 | 1.3 | GO:0034446 | substrate adhesion-dependent cell spreading(GO:0034446) |
| 0.1 | 2.0 | GO:0010226 | response to lithium ion(GO:0010226) |
| 0.1 | 2.0 | GO:0001960 | negative regulation of cytokine-mediated signaling pathway(GO:0001960) |
| 0.1 | 0.4 | GO:0071277 | cellular response to calcium ion(GO:0071277) |
| 0.1 | 0.5 | GO:0007549 | dosage compensation(GO:0007549) |
| 0.1 | 0.4 | GO:0001302 | replicative cell aging(GO:0001302) negative regulation of keratinocyte differentiation(GO:0045617) female genitalia morphogenesis(GO:0048807) |
| 0.1 | 3.3 | GO:0090263 | positive regulation of canonical Wnt signaling pathway(GO:0090263) |
| 0.1 | 0.4 | GO:0022038 | corpus callosum development(GO:0022038) |
| 0.1 | 0.3 | GO:0035283 | rhombomere 5 development(GO:0021571) central nervous system segmentation(GO:0035283) brain segmentation(GO:0035284) |
| 0.1 | 1.0 | GO:0051016 | barbed-end actin filament capping(GO:0051016) |
| 0.1 | 0.3 | GO:0045338 | farnesyl diphosphate metabolic process(GO:0045338) |
| 0.1 | 2.2 | GO:0000188 | inactivation of MAPK activity(GO:0000188) |
| 0.1 | 1.7 | GO:0016339 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339) |
| 0.0 | 0.3 | GO:0008038 | neuron recognition(GO:0008038) |
| 0.0 | 0.2 | GO:0070050 | neuron cellular homeostasis(GO:0070050) |
| 0.0 | 1.2 | GO:0007398 | ectoderm development(GO:0007398) |
| 0.0 | 0.3 | GO:0040037 | negative regulation of fibroblast growth factor receptor signaling pathway(GO:0040037) |
| 0.0 | 1.0 | GO:0045026 | plasma membrane fusion(GO:0045026) |
| 0.0 | 3.8 | GO:0008064 | regulation of actin polymerization or depolymerization(GO:0008064) |
| 0.0 | 1.2 | GO:0060326 | cell chemotaxis(GO:0060326) |
| 0.0 | 0.1 | GO:0048311 | mitochondrion distribution(GO:0048311) |
| 0.0 | 0.7 | GO:0006198 | cAMP catabolic process(GO:0006198) |
| 0.0 | 0.3 | GO:0002553 | histamine production involved in inflammatory response(GO:0002349) histamine secretion involved in inflammatory response(GO:0002441) histamine secretion by mast cell(GO:0002553) |
| 0.0 | 1.0 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.0 | 0.3 | GO:0006646 | phosphatidylethanolamine biosynthetic process(GO:0006646) phosphatidylethanolamine metabolic process(GO:0046337) |
| 0.0 | 0.6 | GO:0006071 | glycerol metabolic process(GO:0006071) |
| 0.0 | 0.1 | GO:0021873 | forebrain neuroblast division(GO:0021873) neuronal stem cell division(GO:0036445) neuroblast division(GO:0055057) |
| 0.0 | 0.2 | GO:0035335 | peptidyl-tyrosine dephosphorylation(GO:0035335) |
| 0.0 | 1.0 | GO:0051925 | obsolete regulation of calcium ion transport via voltage-gated calcium channel activity(GO:0051925) |
| 0.0 | 0.3 | GO:0006621 | protein retention in ER lumen(GO:0006621) maintenance of protein localization in endoplasmic reticulum(GO:0035437) |
| 0.0 | 0.3 | GO:0007016 | cytoskeletal anchoring at plasma membrane(GO:0007016) |
| 0.0 | 0.8 | GO:0016338 | calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338) |
| 0.0 | 0.1 | GO:0033025 | mast cell homeostasis(GO:0033023) mast cell apoptotic process(GO:0033024) regulation of mast cell apoptotic process(GO:0033025) |
| 0.0 | 0.4 | GO:0031115 | negative regulation of microtubule polymerization(GO:0031115) negative regulation of protein polymerization(GO:0032272) |
| 0.0 | 0.5 | GO:0050807 | regulation of synapse organization(GO:0050807) |
| 0.0 | 1.3 | GO:0048678 | response to axon injury(GO:0048678) |
| 0.0 | 0.9 | GO:0008154 | actin polymerization or depolymerization(GO:0008154) |
| 0.0 | 0.6 | GO:0015701 | bicarbonate transport(GO:0015701) |
| 0.0 | 0.6 | GO:0009954 | proximal/distal pattern formation(GO:0009954) |
| 0.0 | 0.6 | GO:0050873 | brown fat cell differentiation(GO:0050873) |
| 0.0 | 0.3 | GO:0007128 | meiotic prophase I(GO:0007128) |
| 0.0 | 0.1 | GO:0033197 | response to vitamin E(GO:0033197) |
| 0.0 | 0.4 | GO:0032012 | regulation of ARF protein signal transduction(GO:0032012) |
| 0.0 | 0.2 | GO:0000266 | mitochondrial fission(GO:0000266) |
| 0.0 | 0.2 | GO:0007141 | male meiosis I(GO:0007141) |
| 0.0 | 1.0 | GO:0070374 | positive regulation of ERK1 and ERK2 cascade(GO:0070374) |
| 0.0 | 0.1 | GO:0018344 | protein geranylgeranylation(GO:0018344) |
| 0.0 | 0.3 | GO:0048566 | embryonic digestive tract development(GO:0048566) |
| 0.0 | 0.1 | GO:0006346 | methylation-dependent chromatin silencing(GO:0006346) |
| 0.0 | 0.3 | GO:0000045 | autophagosome assembly(GO:0000045) autophagosome organization(GO:1905037) |
| 0.0 | 0.3 | GO:0006376 | mRNA splice site selection(GO:0006376) |
| 0.0 | 0.1 | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome(GO:0000381) |
| 0.0 | 0.0 | GO:0031558 | obsolete induction of apoptosis in response to chemical stimulus(GO:0031558) |
| 0.0 | 0.1 | GO:0031536 | positive regulation of exit from mitosis(GO:0031536) |
| 0.0 | 0.1 | GO:0009822 | alkaloid catabolic process(GO:0009822) |
| 0.0 | 1.3 | GO:0035023 | regulation of Rho protein signal transduction(GO:0035023) |
| 0.0 | 0.2 | GO:0032456 | endocytic recycling(GO:0032456) |
| 0.0 | 0.1 | GO:0042797 | 5S class rRNA transcription from RNA polymerase III type 1 promoter(GO:0042791) tRNA transcription from RNA polymerase III promoter(GO:0042797) |
| 0.0 | 1.2 | GO:0007218 | neuropeptide signaling pathway(GO:0007218) |
| 0.0 | 0.1 | GO:0048268 | clathrin coat assembly(GO:0048268) |
| 0.0 | 0.2 | GO:0035115 | embryonic forelimb morphogenesis(GO:0035115) |
| 0.0 | 0.2 | GO:0046854 | phosphatidylinositol phosphorylation(GO:0046854) |
| 0.0 | 0.2 | GO:0071479 | cellular response to ionizing radiation(GO:0071479) |
| 0.0 | 0.6 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 3.2 | GO:0033093 | Weibel-Palade body(GO:0033093) |
| 0.4 | 1.3 | GO:0005607 | laminin-2 complex(GO:0005607) |
| 0.1 | 0.5 | GO:0001740 | Barr body(GO:0001740) |
| 0.1 | 1.4 | GO:0031094 | platelet dense tubular network(GO:0031094) |
| 0.1 | 1.0 | GO:0030056 | hemidesmosome(GO:0030056) |
| 0.1 | 0.5 | GO:0000138 | Golgi trans cisterna(GO:0000138) |
| 0.1 | 1.8 | GO:0031528 | microvillus membrane(GO:0031528) |
| 0.1 | 0.4 | GO:0019718 | obsolete rough microsome(GO:0019718) |
| 0.1 | 1.2 | GO:0001527 | microfibril(GO:0001527) |
| 0.1 | 0.3 | GO:0070938 | contractile ring(GO:0070938) |
| 0.1 | 2.5 | GO:0045095 | keratin filament(GO:0045095) |
| 0.1 | 1.2 | GO:0032420 | stereocilium(GO:0032420) |
| 0.1 | 0.5 | GO:0033018 | sarcoplasmic reticulum lumen(GO:0033018) |
| 0.1 | 4.5 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 0.1 | 1.2 | GO:0005902 | microvillus(GO:0005902) |
| 0.1 | 0.2 | GO:0000800 | lateral element(GO:0000800) |
| 0.1 | 3.7 | GO:0030665 | clathrin-coated vesicle membrane(GO:0030665) |
| 0.0 | 0.6 | GO:0009925 | basal plasma membrane(GO:0009925) |
| 0.0 | 0.3 | GO:0034045 | pre-autophagosomal structure membrane(GO:0034045) |
| 0.0 | 10.1 | GO:0005912 | adherens junction(GO:0005912) |
| 0.0 | 3.1 | GO:0030426 | growth cone(GO:0030426) |
| 0.0 | 0.6 | GO:0005862 | muscle thin filament tropomyosin(GO:0005862) |
| 0.0 | 0.3 | GO:0005929 | cilium(GO:0005929) |
| 0.0 | 1.0 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 0.0 | 0.2 | GO:0033179 | proton-transporting V-type ATPase, V0 domain(GO:0033179) |
| 0.0 | 0.8 | GO:0030018 | Z disc(GO:0030018) |
| 0.0 | 1.8 | GO:0001726 | ruffle(GO:0001726) |
| 0.0 | 0.3 | GO:0043073 | germ cell nucleus(GO:0043073) |
| 0.0 | 0.3 | GO:0005798 | Golgi-associated vesicle(GO:0005798) |
| 0.0 | 1.5 | GO:0005938 | cell cortex(GO:0005938) |
| 0.0 | 5.3 | GO:0015629 | actin cytoskeleton(GO:0015629) |
| 0.0 | 0.4 | GO:0097014 | axoneme(GO:0005930) ciliary plasm(GO:0097014) |
| 0.0 | 0.1 | GO:0000127 | transcription factor TFIIIC complex(GO:0000127) |
| 0.0 | 0.3 | GO:0005795 | Golgi stack(GO:0005795) |
| 0.0 | 0.8 | GO:0005778 | peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903) |
| 0.0 | 0.1 | GO:0005742 | mitochondrial outer membrane translocase complex(GO:0005742) |
| 0.0 | 0.5 | GO:0030425 | dendrite(GO:0030425) |
| 0.0 | 5.7 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.0 | 0.2 | GO:0005892 | acetylcholine-gated channel complex(GO:0005892) |
| 0.0 | 3.5 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 2.0 | GO:0005152 | interleukin-1 receptor antagonist activity(GO:0005152) |
| 0.4 | 1.3 | GO:0044325 | ion channel binding(GO:0044325) |
| 0.4 | 3.7 | GO:0004157 | dihydropyrimidinase activity(GO:0004157) |
| 0.2 | 1.4 | GO:0015057 | thrombin receptor activity(GO:0015057) |
| 0.2 | 1.0 | GO:0031995 | insulin-like growth factor II binding(GO:0031995) |
| 0.2 | 5.1 | GO:0005001 | transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) |
| 0.2 | 0.9 | GO:0004687 | myosin light chain kinase activity(GO:0004687) |
| 0.2 | 4.4 | GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding(GO:0005546) |
| 0.2 | 4.8 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 0.1 | 0.4 | GO:0004768 | stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215) |
| 0.1 | 3.2 | GO:0019865 | immunoglobulin binding(GO:0019865) |
| 0.1 | 1.0 | GO:0017049 | GTP-Rho binding(GO:0017049) |
| 0.1 | 0.7 | GO:0004957 | prostaglandin E receptor activity(GO:0004957) |
| 0.1 | 0.6 | GO:0008889 | glycerophosphodiester phosphodiesterase activity(GO:0008889) |
| 0.1 | 0.2 | GO:0004756 | selenide, water dikinase activity(GO:0004756) phosphotransferase activity, paired acceptors(GO:0016781) |
| 0.1 | 0.8 | GO:0004726 | non-membrane spanning protein tyrosine phosphatase activity(GO:0004726) |
| 0.1 | 0.3 | GO:0051996 | farnesyl-diphosphate farnesyltransferase activity(GO:0004310) squalene synthase activity(GO:0051996) |
| 0.1 | 0.2 | GO:0047288 | monosialoganglioside sialyltransferase activity(GO:0047288) |
| 0.1 | 1.2 | GO:0048365 | Rac GTPase binding(GO:0048365) |
| 0.1 | 0.7 | GO:0001011 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, RNA polymerase II basal transcription factor binding(GO:0001083) transcription factor activity, TFIIB-class binding(GO:0001087) RNA polymerase II basal transcription factor binding(GO:0001091) TFIIB-class transcription factor binding(GO:0001093) |
| 0.1 | 0.9 | GO:0005522 | profilin binding(GO:0005522) |
| 0.1 | 0.3 | GO:0031694 | alpha-2A adrenergic receptor binding(GO:0031694) |
| 0.0 | 0.3 | GO:0043237 | laminin-1 binding(GO:0043237) |
| 0.0 | 0.5 | GO:0005007 | fibroblast growth factor-activated receptor activity(GO:0005007) |
| 0.0 | 1.9 | GO:0005080 | protein kinase C binding(GO:0005080) |
| 0.0 | 0.3 | GO:0046923 | ER retention sequence binding(GO:0046923) |
| 0.0 | 0.2 | GO:0031014 | troponin T binding(GO:0031014) |
| 0.0 | 0.3 | GO:0004305 | ethanolamine kinase activity(GO:0004305) |
| 0.0 | 0.2 | GO:0051766 | inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440) inositol trisphosphate kinase activity(GO:0051766) |
| 0.0 | 1.3 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 0.0 | 0.2 | GO:0046875 | ephrin receptor binding(GO:0046875) |
| 0.0 | 2.6 | GO:0004714 | transmembrane receptor protein tyrosine kinase activity(GO:0004714) |
| 0.0 | 0.5 | GO:0017048 | Rho GTPase binding(GO:0017048) |
| 0.0 | 4.7 | GO:0030674 | protein binding, bridging(GO:0030674) |
| 0.0 | 2.3 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.0 | 0.2 | GO:0008553 | hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553) |
| 0.0 | 1.0 | GO:0005245 | voltage-gated calcium channel activity(GO:0005245) |
| 0.0 | 0.3 | GO:0051879 | Hsp90 protein binding(GO:0051879) |
| 0.0 | 0.2 | GO:0030306 | ADP-ribosylation factor binding(GO:0030306) |
| 0.0 | 1.0 | GO:0005504 | fatty acid binding(GO:0005504) |
| 0.0 | 0.1 | GO:0004663 | Rab geranylgeranyltransferase activity(GO:0004663) |
| 0.0 | 2.2 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.0 | 0.6 | GO:0005452 | inorganic anion exchanger activity(GO:0005452) |
| 0.0 | 0.3 | GO:0000339 | RNA cap binding(GO:0000339) |
| 0.0 | 0.3 | GO:0015377 | cation:chloride symporter activity(GO:0015377) |
| 0.0 | 0.2 | GO:0042166 | acetylcholine binding(GO:0042166) |
| 0.0 | 0.4 | GO:0003708 | retinoic acid receptor activity(GO:0003708) |
| 0.0 | 0.4 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
| 0.0 | 0.1 | GO:0008271 | secondary active sulfate transmembrane transporter activity(GO:0008271) |
| 0.0 | 0.7 | GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115) |
| 0.0 | 0.4 | GO:0005247 | voltage-gated chloride channel activity(GO:0005247) |
| 0.0 | 0.7 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.0 | 0.4 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 0.0 | 0.1 | GO:0070548 | L-glutamine aminotransferase activity(GO:0070548) |
| 0.0 | 0.1 | GO:0034481 | chondroitin sulfotransferase activity(GO:0034481) proteoglycan sulfotransferase activity(GO:0050698) |
| 0.0 | 0.6 | GO:0005044 | scavenger receptor activity(GO:0005044) |
| 0.0 | 1.2 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.0 | 3.2 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.0 | 2.9 | GO:0030246 | carbohydrate binding(GO:0030246) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.3 | SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 0.3 | ST_PAC1_RECEPTOR_PATHWAY | PAC1 Receptor Pathway |
