Motif ID: SPI1

Z-value: 4.359


Transcription factors associated with SPI1:

Gene SymbolEntrez IDGene Name
SPI1 ENSG00000066336.7 SPI1



Activity profile for motif SPI1.

activity profile for motif SPI1


Sorted Z-values histogram for motif SPI1

Sorted Z-values for motif SPI1



Network of associatons between targets according to the STRING database.



First level regulatory network of SPI1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr13_-_46756351 12.920 ENST00000323076.2
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr1_+_198608146 11.932 ENST00000367376.2
ENST00000352140.3
ENST00000594404.1
ENST00000598951.1
ENST00000530727.1
ENST00000442510.2
ENST00000367367.4
ENST00000348564.6
ENST00000367364.1
ENST00000413409.2
PTPRC









protein tyrosine phosphatase, receptor type, C









chr10_-_98031310 10.021 ENST00000427367.2
ENST00000413476.2
BLNK

B-cell linker

chr10_-_98031265 9.705 ENST00000224337.5
ENST00000371176.2
BLNK

B-cell linker

chr3_-_121379739 8.905 ENST00000428394.2
ENST00000314583.3
HCLS1

hematopoietic cell-specific Lyn substrate 1

chr12_-_15114492 8.655 ENST00000541546.1
ARHGDIB
Rho GDP dissociation inhibitor (GDI) beta
chr12_-_15114603 8.581 ENST00000228945.4
ARHGDIB
Rho GDP dissociation inhibitor (GDI) beta
chr11_+_60223225 8.113 ENST00000524807.1
ENST00000345732.4
MS4A1

membrane-spanning 4-domains, subfamily A, member 1

chr11_+_60223312 8.098 ENST00000532491.1
ENST00000532073.1
ENST00000534668.1
ENST00000528313.1
ENST00000533306.1
MS4A1




membrane-spanning 4-domains, subfamily A, member 1




chr1_-_207095324 7.927 ENST00000530505.1
ENST00000367091.3
ENST00000442471.2
FAIM3


Fas apoptotic inhibitory molecule 3


chr2_+_33661382 7.531 ENST00000402538.3
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr17_-_62084241 7.398 ENST00000449662.2
ICAM2
intercellular adhesion molecule 2
chr1_-_183560011 7.203 ENST00000367536.1
NCF2
neutrophil cytosolic factor 2
chr1_+_111415757 6.976 ENST00000429072.2
ENST00000271324.5
CD53

CD53 molecule

chr2_-_175499294 6.742 ENST00000392547.2
WIPF1
WAS/WASL interacting protein family, member 1
chr1_-_207095212 6.741 ENST00000420007.2
FAIM3
Fas apoptotic inhibitory molecule 3
chr21_-_15918618 6.713 ENST00000400564.1
ENST00000400566.1
SAMSN1

SAM domain, SH3 domain and nuclear localization signals 1

chr20_+_44746885 6.615 ENST00000372285.3
CD40
CD40 molecule, TNF receptor superfamily member 5
chr14_-_23285011 6.287 ENST00000397532.3
SLC7A7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr15_-_80263506 6.165 ENST00000335661.6
BCL2A1
BCL2-related protein A1
chr14_-_23285069 6.095 ENST00000554758.1
ENST00000397528.4
SLC7A7

solute carrier family 7 (amino acid transporter light chain, y+L system), member 7

chr1_-_183559693 5.859 ENST00000367535.3
ENST00000413720.1
ENST00000418089.1
NCF2


neutrophil cytosolic factor 2


chr8_+_56792355 5.812 ENST00000519728.1
LYN
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog
chr20_+_44746939 5.791 ENST00000372276.3
CD40
CD40 molecule, TNF receptor superfamily member 5
chr1_-_150738261 5.755 ENST00000448301.2
ENST00000368985.3
CTSS

cathepsin S

chr2_+_143886877 5.698 ENST00000295095.6
ARHGAP15
Rho GTPase activating protein 15
chr6_-_154677900 5.685 ENST00000265198.4
ENST00000520261.1
IPCEF1

interaction protein for cytohesin exchange factors 1

chr11_+_128563652 5.528 ENST00000527786.2
FLI1
Fli-1 proto-oncogene, ETS transcription factor
chr6_-_32160622 5.513 ENST00000487761.1
ENST00000375040.3
GPSM3

G-protein signaling modulator 3

chr4_-_40631859 5.316 ENST00000295971.7
ENST00000319592.4
RBM47

RNA binding motif protein 47

chr5_-_88178964 5.275 ENST00000513252.1
ENST00000508569.1
ENST00000510942.1
ENST00000506554.1
MEF2C



myocyte enhancer factor 2C



chr18_-_53177984 5.272 ENST00000543082.1
TCF4
transcription factor 4
chr5_-_169725231 5.245 ENST00000046794.5
LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr12_+_25205568 5.167 ENST00000548766.1
ENST00000556887.1
LRMP

lymphoid-restricted membrane protein

chr12_+_25205666 5.142 ENST00000547044.1
LRMP
lymphoid-restricted membrane protein
chr8_+_56792377 5.131 ENST00000520220.2
LYN
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog
chr1_-_25256368 5.095 ENST00000308873.6
RUNX3
runt-related transcription factor 3
chr17_-_29641104 5.013 ENST00000577894.1
ENST00000330927.4
EVI2B

ecotropic viral integration site 2B

chr15_+_81589254 5.000 ENST00000394652.2
IL16
interleukin 16
chr19_+_42381173 4.999 ENST00000221972.3
CD79A
CD79a molecule, immunoglobulin-associated alpha
chr12_+_54891495 4.919 ENST00000293373.6
NCKAP1L
NCK-associated protein 1-like
chr12_+_7055767 4.867 ENST00000447931.2
PTPN6
protein tyrosine phosphatase, non-receptor type 6
chr12_+_7055631 4.861 ENST00000543115.1
ENST00000399448.1
PTPN6

protein tyrosine phosphatase, non-receptor type 6

chrX_+_128913906 4.758 ENST00000356892.3
SASH3
SAM and SH3 domain containing 3
chr5_-_88179017 4.729 ENST00000514028.1
ENST00000514015.1
ENST00000503075.1
ENST00000437473.2
MEF2C



myocyte enhancer factor 2C



chr2_-_96811170 4.682 ENST00000288943.4
DUSP2
dual specificity phosphatase 2
chr1_-_111743285 4.642 ENST00000357640.4
DENND2D
DENN/MADD domain containing 2D
chr6_+_31543334 4.467 ENST00000449264.2
TNF
tumor necrosis factor
chr5_-_88179302 4.463 ENST00000504921.2
MEF2C
myocyte enhancer factor 2C
chr22_-_37545972 4.430 ENST00000216223.5
IL2RB
interleukin 2 receptor, beta
chr12_+_25205446 4.395 ENST00000557489.1
ENST00000354454.3
ENST00000536173.1
LRMP


lymphoid-restricted membrane protein


chr1_-_31230650 4.387 ENST00000294507.3
LAPTM5
lysosomal protein transmembrane 5
chr16_-_89043377 4.105 ENST00000436887.2
ENST00000448839.1
ENST00000360302.2
CBFA2T3


core-binding factor, runt domain, alpha subunit 2; translocated to, 3


chr11_-_3862059 4.104 ENST00000396978.1
RHOG
ras homolog family member G
chr17_-_29641084 4.041 ENST00000544462.1
EVI2B
ecotropic viral integration site 2B
chr3_-_16555150 4.002 ENST00000334133.4
RFTN1
raftlin, lipid raft linker 1
chr17_+_72462525 3.981 ENST00000360141.3
CD300A
CD300a molecule
chr5_+_169064245 3.979 ENST00000256935.8
DOCK2
dedicator of cytokinesis 2
chr17_-_38721711 3.899 ENST00000578085.1
ENST00000246657.2
CCR7

chemokine (C-C motif) receptor 7

chr19_+_42381337 3.771 ENST00000597454.1
ENST00000444740.2
CD79A

CD79a molecule, immunoglobulin-associated alpha

chr16_-_89043605 3.700 ENST00000268679.4
CBFA2T3
core-binding factor, runt domain, alpha subunit 2; translocated to, 3
chr17_-_34417479 3.679 ENST00000225245.5
CCL3
chemokine (C-C motif) ligand 3
chr11_-_3862206 3.644 ENST00000351018.4
RHOG
ras homolog family member G
chr19_+_49838653 3.575 ENST00000598095.1
ENST00000426897.2
ENST00000323906.4
ENST00000535669.2
ENST00000597602.1
ENST00000595660.1
CD37





CD37 molecule





chr1_+_32716840 3.530 ENST00000336890.5
LCK
lymphocyte-specific protein tyrosine kinase
chr2_-_64371546 3.515 ENST00000358912.4
PELI1
pellino E3 ubiquitin protein ligase 1
chr4_+_68424434 3.495 ENST00000265404.2
ENST00000396225.1
STAP1

signal transducing adaptor family member 1

chr22_-_37640277 3.492 ENST00000401529.3
ENST00000249071.6
RAC2

ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)

chr19_-_6481776 3.492 ENST00000543576.1
ENST00000590173.1
ENST00000381480.2
DENND1C


DENN/MADD domain containing 1C


chr17_+_72462766 3.476 ENST00000392625.3
ENST00000361933.3
ENST00000310828.5
CD300A


CD300a molecule


chrX_-_70331298 3.448 ENST00000456850.2
ENST00000473378.1
ENST00000487883.1
ENST00000374202.2
IL2RG



interleukin 2 receptor, gamma



chr16_+_30483962 3.435 ENST00000356798.6
ITGAL
integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
chr1_+_32716857 3.297 ENST00000482949.1
ENST00000495610.2
LCK

lymphocyte-specific protein tyrosine kinase

chr22_-_37640456 3.220 ENST00000405484.1
ENST00000441619.1
ENST00000406508.1
RAC2


ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)


chr1_+_32739733 3.206 ENST00000333070.4
LCK
lymphocyte-specific protein tyrosine kinase
chr18_-_53070913 3.198 ENST00000568186.1
ENST00000564228.1
TCF4

transcription factor 4

chr18_-_53068911 3.170 ENST00000537856.3
TCF4
transcription factor 4
chr11_+_128563948 3.143 ENST00000534087.2
FLI1
Fli-1 proto-oncogene, ETS transcription factor
chr11_+_102188224 3.127 ENST00000263464.3
BIRC3
baculoviral IAP repeat containing 3
chrX_+_78200913 3.066 ENST00000171757.2
P2RY10
purinergic receptor P2Y, G-protein coupled, 10
chr9_+_2158485 3.040 ENST00000417599.1
ENST00000382185.1
ENST00000382183.1
SMARCA2


SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2


chr11_+_102188272 3.035 ENST00000532808.1
BIRC3
baculoviral IAP repeat containing 3
chr9_+_2158443 3.005 ENST00000302401.3
ENST00000324954.5
ENST00000423555.1
ENST00000382186.1
SMARCA2



SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2



chrX_+_78200829 2.993 ENST00000544091.1
P2RY10
purinergic receptor P2Y, G-protein coupled, 10
chr1_+_236305826 2.979 ENST00000366592.3
ENST00000366591.4
GPR137B

G protein-coupled receptor 137B

chr19_+_6772710 2.893 ENST00000304076.2
ENST00000602142.1
ENST00000596764.1
VAV1


vav 1 guanine nucleotide exchange factor


chr12_-_53601055 2.892 ENST00000552972.1
ENST00000422257.3
ENST00000267082.5
ITGB7


integrin, beta 7


chr12_-_53601000 2.864 ENST00000338737.4
ENST00000549086.2
ITGB7

integrin, beta 7

chr2_-_175462934 2.837 ENST00000392546.2
ENST00000436221.1
WIPF1

WAS/WASL interacting protein family, member 1

chr6_+_32811885 2.827 ENST00000458296.1
ENST00000413039.1
ENST00000429600.1
ENST00000412095.1
ENST00000415067.1
ENST00000395330.1
TAPSAR1




PSMB9
TAP1 and PSMB8 antisense RNA 1




proteasome (prosome, macropain) subunit, beta type, 9
chr18_-_53069419 2.766 ENST00000570177.2
TCF4
transcription factor 4
chr8_-_82395461 2.762 ENST00000256104.4
FABP4
fatty acid binding protein 4, adipocyte
chr11_-_58343319 2.748 ENST00000395074.2
LPXN
leupaxin
chr7_-_5569588 2.723 ENST00000417101.1
ACTB
actin, beta
chr15_+_75074410 2.714 ENST00000439220.2
CSK
c-src tyrosine kinase
chr22_+_37257015 2.652 ENST00000447071.1
ENST00000248899.6
ENST00000397147.4
NCF4


neutrophil cytosolic factor 4, 40kDa


chr3_-_105588231 2.605 ENST00000545639.1
ENST00000394027.3
ENST00000438603.1
ENST00000447441.1
ENST00000443752.1
CBLB




Cbl proto-oncogene B, E3 ubiquitin protein ligase




chr1_+_161632937 2.582 ENST00000236937.9
ENST00000367961.4
ENST00000358671.5
FCGR2B


Fc fragment of IgG, low affinity IIb, receptor (CD32)


chr3_+_142838091 2.557 ENST00000309575.3
CHST2
carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
chr2_-_175462456 2.471 ENST00000409891.1
ENST00000410117.1
WIPF1

WAS/WASL interacting protein family, member 1

chr6_-_32811771 2.468 ENST00000395339.3
ENST00000374882.3
PSMB8

proteasome (prosome, macropain) subunit, beta type, 8

chr15_+_75335604 2.460 ENST00000563393.1
PPCDC
phosphopantothenoylcysteine decarboxylase
chr14_-_23451467 2.457 ENST00000361265.4
ENST00000555074.1
AJUBA
RP11-298I3.5
ajuba LIM protein
RP11-298I3.5
chr19_-_10450328 2.408 ENST00000160262.5
ICAM3
intercellular adhesion molecule 3
chr18_-_52989217 2.364 ENST00000570287.2
TCF4
transcription factor 4
chr19_-_10450287 2.357 ENST00000589261.1
ENST00000590569.1
ENST00000589580.1
ENST00000589249.1
ICAM3



intercellular adhesion molecule 3



chr3_+_119316689 2.355 ENST00000273371.4
PLA1A
phospholipase A1 member A
chr15_+_75074385 2.319 ENST00000220003.9
CSK
c-src tyrosine kinase
chr10_+_12391481 2.316 ENST00000378847.3
CAMK1D
calcium/calmodulin-dependent protein kinase ID
chr18_-_52989525 2.310 ENST00000457482.3
TCF4
transcription factor 4
chr19_+_1077393 2.267 ENST00000590577.1
HMHA1
histocompatibility (minor) HA-1
chr4_+_103423055 2.255 ENST00000505458.1
NFKB1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
chr6_+_31582961 2.248 ENST00000376059.3
ENST00000337917.7
AIF1

allograft inflammatory factor 1

chr1_-_184943610 2.240 ENST00000367511.3
FAM129A
family with sequence similarity 129, member A
chr1_-_202129704 2.224 ENST00000476061.1
ENST00000544762.1
ENST00000467283.1
ENST00000464870.1
ENST00000435759.2
ENST00000486116.1
ENST00000543735.1
ENST00000308986.5
ENST00000477625.1
PTPN7








protein tyrosine phosphatase, non-receptor type 7








chr4_+_103422471 2.224 ENST00000226574.4
ENST00000394820.4
NFKB1

nuclear factor of kappa light polypeptide gene enhancer in B-cells 1

chr8_+_86089460 2.215 ENST00000418930.2
E2F5
E2F transcription factor 5, p130-binding
chr17_-_20370847 2.208 ENST00000423676.3
ENST00000324290.5
LGALS9B

lectin, galactoside-binding, soluble, 9B

chrX_+_48542168 2.202 ENST00000376701.4
WAS
Wiskott-Aldrich syndrome
chr12_-_92539614 2.151 ENST00000256015.3
BTG1
B-cell translocation gene 1, anti-proliferative
chr6_+_26156551 2.151 ENST00000304218.3
HIST1H1E
histone cluster 1, H1e
chr7_-_37488834 2.124 ENST00000310758.4
ELMO1
engulfment and cell motility 1
chr7_+_74188309 2.067 ENST00000289473.4
ENST00000433458.1
NCF1

neutrophil cytosolic factor 1

chr17_-_16875371 2.032 ENST00000437538.2
ENST00000583789.1
ENST00000261652.2
ENST00000579315.1
TNFRSF13B



tumor necrosis factor receptor superfamily, member 13B



chr3_-_98241358 1.985 ENST00000503004.1
ENST00000506575.1
ENST00000513452.1
ENST00000515620.1
CLDND1



claudin domain containing 1



chr2_+_198669365 1.977 ENST00000428675.1
PLCL1
phospholipase C-like 1
chr2_+_182321925 1.934 ENST00000339307.4
ENST00000397033.2
ITGA4

integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)

chr7_+_50344289 1.927 ENST00000413698.1
ENST00000359197.5
ENST00000331340.3
ENST00000357364.4
ENST00000343574.5
ENST00000349824.4
ENST00000346667.4
ENST00000440768.2
IKZF1







IKAROS family zinc finger 1 (Ikaros)







chr1_-_154909329 1.911 ENST00000368467.3
PMVK
phosphomevalonate kinase
chr2_-_214016314 1.907 ENST00000434687.1
ENST00000374319.4
IKZF2

IKAROS family zinc finger 2 (Helios)

chr7_+_99971129 1.906 ENST00000394000.2
ENST00000350573.2
PILRA

paired immunoglobin-like type 2 receptor alpha

chr2_-_225811747 1.870 ENST00000409592.3
DOCK10
dedicator of cytokinesis 10
chr12_-_6233828 1.833 ENST00000572068.1
ENST00000261405.5
VWF

von Willebrand factor

chr3_+_119316721 1.829 ENST00000488919.1
ENST00000495992.1
PLA1A

phospholipase A1 member A

chr7_-_120498357 1.823 ENST00000415871.1
ENST00000222747.3
ENST00000430985.1
TSPAN12


tetraspanin 12


chr10_-_121302195 1.819 ENST00000369103.2
RGS10
regulator of G-protein signaling 10
chr22_+_40322595 1.801 ENST00000420971.1
ENST00000544756.1
GRAP2

GRB2-related adaptor protein 2

chr22_+_40322623 1.778 ENST00000399090.2
GRAP2
GRB2-related adaptor protein 2
chr11_+_19138670 1.776 ENST00000446113.2
ENST00000399351.3
ZDHHC13

zinc finger, DHHC-type containing 13

chr1_-_226926864 1.774 ENST00000429204.1
ENST00000366784.1
ITPKB

inositol-trisphosphate 3-kinase B

chr8_+_86089619 1.761 ENST00000256117.5
ENST00000416274.2
E2F5

E2F transcription factor 5, p130-binding

chr4_+_106629929 1.752 ENST00000512828.1
ENST00000394730.3
ENST00000507281.1
ENST00000515279.1
GSTCD



glutathione S-transferase, C-terminal domain containing



chr17_-_41738931 1.722 ENST00000329168.3
ENST00000549132.1
MEOX1

mesenchyme homeobox 1

chr8_+_27183033 1.722 ENST00000420218.2
PTK2B
protein tyrosine kinase 2 beta
chr5_-_131826457 1.720 ENST00000437654.1
ENST00000245414.4
IRF1

interferon regulatory factor 1

chr14_+_88471468 1.714 ENST00000267549.3
GPR65
G protein-coupled receptor 65
chr19_-_47220335 1.711 ENST00000601806.1
ENST00000593363.1
ENST00000598633.1
ENST00000595515.1
ENST00000433867.1
PRKD2




protein kinase D2




chr12_+_11802753 1.698 ENST00000396373.4
ETV6
ets variant 6
chr14_-_35344093 1.697 ENST00000382422.2
BAZ1A
bromodomain adjacent to zinc finger domain, 1A
chr1_+_66797687 1.675 ENST00000371045.5
ENST00000531025.1
ENST00000526197.1
PDE4B


phosphodiesterase 4B, cAMP-specific


chr3_+_151986709 1.673 ENST00000495875.2
ENST00000493459.1
ENST00000324210.5
ENST00000459747.1
MBNL1



muscleblind-like splicing regulator 1



chr16_+_67063262 1.660 ENST00000565389.1
CBFB
core-binding factor, beta subunit
chr1_-_150669500 1.638 ENST00000271732.3
GOLPH3L
golgi phosphoprotein 3-like
chr17_+_43299241 1.630 ENST00000328118.3
FMNL1
formin-like 1
chr1_+_43766642 1.627 ENST00000372476.3
TIE1
tyrosine kinase with immunoglobulin-like and EGF-like domains 1
chr3_-_98241760 1.618 ENST00000507874.1
ENST00000502299.1
ENST00000508659.1
ENST00000510545.1
ENST00000511667.1
ENST00000394185.2
ENST00000394181.2
ENST00000508902.1
ENST00000341181.6
ENST00000437922.1
ENST00000394180.2
CLDND1










claudin domain containing 1










chr3_+_48507210 1.606 ENST00000433541.1
ENST00000422277.2
ENST00000436480.2
ENST00000444177.1
TREX1



three prime repair exonuclease 1



chr17_+_43299156 1.571 ENST00000331495.3
FMNL1
formin-like 1
chr19_+_36203830 1.533 ENST00000262630.3
ZBTB32
zinc finger and BTB domain containing 32
chr16_-_88717482 1.528 ENST00000261623.3
CYBA
cytochrome b-245, alpha polypeptide
chr14_+_102276192 1.524 ENST00000557714.1
PPP2R5C
protein phosphatase 2, regulatory subunit B', gamma
chr15_-_55611306 1.504 ENST00000563262.1
RAB27A
RAB27A, member RAS oncogene family
chr2_+_231280908 1.497 ENST00000427101.2
ENST00000432979.1
SP100

SP100 nuclear antigen

chr8_+_27182862 1.495 ENST00000521164.1
ENST00000346049.5
PTK2B

protein tyrosine kinase 2 beta

chr19_-_19754404 1.488 ENST00000587205.1
ENST00000445806.2
ENST00000203556.4
GMIP


GEM interacting protein


chr19_-_8642289 1.480 ENST00000596675.1
ENST00000338257.8
MYO1F

myosin IF

chr1_-_202129105 1.471 ENST00000367279.4
PTPN7
protein tyrosine phosphatase, non-receptor type 7
chr6_-_42016385 1.467 ENST00000502771.1
ENST00000508143.1
ENST00000514588.1
ENST00000510503.1
ENST00000415497.2
ENST00000372988.4
CCND3





cyclin D3





chr21_-_46340770 1.445 ENST00000397854.3
ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr1_-_160549235 1.444 ENST00000368054.3
ENST00000368048.3
ENST00000311224.4
ENST00000368051.3
ENST00000534968.1
CD84




CD84 molecule




chrX_+_37639264 1.438 ENST00000378588.4
CYBB
cytochrome b-245, beta polypeptide
chr16_-_88717423 1.427 ENST00000568278.1
ENST00000569359.1
ENST00000567174.1
CYBA


cytochrome b-245, alpha polypeptide


chr16_-_68002456 1.426 ENST00000576616.1
ENST00000572037.1
ENST00000338335.3
ENST00000422611.2
ENST00000316341.3
SLC12A4




solute carrier family 12 (potassium/chloride transporter), member 4




chr11_+_22688150 1.423 ENST00000454584.2
GAS2
growth arrest-specific 2
chr3_+_113465866 1.409 ENST00000273398.3
ENST00000538620.1
ENST00000496747.1
ENST00000475322.1
ATP6V1A



ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A



chr9_+_77703414 1.401 ENST00000346234.6
OSTF1
osteoclast stimulating factor 1
chr8_+_74903580 1.399 ENST00000284818.2
ENST00000518893.1
LY96

lymphocyte antigen 96

chr12_+_98909260 1.357 ENST00000556029.1
TMPO
thymopoietin
chr1_+_161551101 1.350 ENST00000367962.4
ENST00000367960.5
ENST00000403078.3
ENST00000428605.2
FCGR2B



Fc fragment of IgG, low affinity IIb, receptor (CD32)



chr2_+_97203082 1.348 ENST00000454558.2
ARID5A
AT rich interactive domain 5A (MRF1-like)
chr12_-_118797475 1.347 ENST00000541786.1
ENST00000419821.2
ENST00000541878.1
TAOK3


TAO kinase 3


chr3_+_20081515 1.346 ENST00000263754.4
KAT2B
K(lysine) acetyltransferase 2B
chr17_-_37934466 1.339 ENST00000583368.1
IKZF3
IKAROS family zinc finger 3 (Aiolos)
chr12_+_94071341 1.337 ENST00000542893.2
CRADD
CASP2 and RIPK1 domain containing adaptor with death domain
chr13_+_111806083 1.311 ENST00000375736.4
ARHGEF7
Rho guanine nucleotide exchange factor (GEF) 7
chr13_+_111806055 1.303 ENST00000218789.5
ARHGEF7
Rho guanine nucleotide exchange factor (GEF) 7
chr4_-_10117949 1.297 ENST00000508079.1
WDR1
WD repeat domain 1
chr11_+_65407331 1.296 ENST00000527525.1
SIPA1
signal-induced proliferation-associated 1
chr7_-_26904317 1.292 ENST00000345317.2
SKAP2
src kinase associated phosphoprotein 2
chr8_+_110552337 1.291 ENST00000337573.5
EBAG9
estrogen receptor binding site associated, antigen, 9
chr16_+_29674277 1.288 ENST00000395389.2
SPN
sialophorin
chr3_-_46249878 1.279 ENST00000296140.3
CCR1
chemokine (C-C motif) receptor 1
chr1_-_159894319 1.259 ENST00000320307.4
TAGLN2
transgelin 2
chr16_+_30484021 1.257 ENST00000358164.5
ITGAL
integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
chr8_+_110551925 1.255 ENST00000395785.2
EBAG9
estrogen receptor binding site associated, antigen, 9
chr7_+_101928380 1.247 ENST00000536178.1
SH2B2
SH2B adaptor protein 2
chr11_+_1874200 1.238 ENST00000311604.3
LSP1
lymphocyte-specific protein 1
chr7_+_99971068 1.237 ENST00000198536.2
ENST00000453419.1
PILRA

paired immunoglobin-like type 2 receptor alpha

chr1_+_186798073 1.233 ENST00000367466.3
ENST00000442353.2
PLA2G4A

phospholipase A2, group IVA (cytosolic, calcium-dependent)

chr6_-_6007200 1.216 ENST00000244766.2
NRN1
neuritin 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
4.0 11.9 GO:0002378 immunoglobulin biosynthetic process(GO:0002378)
3.6 10.9 GO:0070445 Fc receptor mediated stimulatory signaling pathway(GO:0002431) regulation of Fc receptor mediated stimulatory signaling pathway(GO:0060368) positive regulation of Fc receptor mediated stimulatory signaling pathway(GO:0060369) oligodendrocyte progenitor proliferation(GO:0070444) regulation of oligodendrocyte progenitor proliferation(GO:0070445) positive regulation of oligodendrocyte progenitor proliferation(GO:0070447)
3.6 14.5 GO:0060025 regulation of synaptic activity(GO:0060025)
3.2 12.8 GO:1904037 positive regulation of epithelial cell apoptotic process(GO:1904037) positive regulation of endothelial cell apoptotic process(GO:2000353)
1.9 13.1 GO:0034616 response to laminar fluid shear stress(GO:0034616)
1.6 4.7 GO:0002291 T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:0002291)
1.5 4.5 GO:0060557 regulation of chronic inflammatory response to antigenic stimulus(GO:0002874) positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559) necroptotic process(GO:0070266) programmed necrotic cell death(GO:0097300)
1.4 10.0 GO:0050862 positive regulation of T cell receptor signaling pathway(GO:0050862)
1.2 3.5 GO:0034139 regulation of toll-like receptor 3 signaling pathway(GO:0034139)
1.1 6.7 GO:0060263 regulation of respiratory burst(GO:0060263)
1.0 7.0 GO:0036037 CD8-positive, alpha-beta T cell activation(GO:0036037) CD8-positive, alpha-beta T cell differentiation(GO:0043374)
1.0 4.0 GO:0031580 membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
1.0 1.0 GO:0046449 allantoin metabolic process(GO:0000255) creatinine metabolic process(GO:0046449) cellular lactam metabolic process(GO:0072338)
0.9 16.6 GO:0006906 vesicle fusion(GO:0006906)
0.9 1.8 GO:1904035 endothelial cell apoptotic process(GO:0072577) epithelial cell apoptotic process(GO:1904019) regulation of epithelial cell apoptotic process(GO:1904035) negative regulation of epithelial cell apoptotic process(GO:1904036) regulation of endothelial cell apoptotic process(GO:2000351) negative regulation of endothelial cell apoptotic process(GO:2000352)
0.8 10.9 GO:0046827 positive regulation of protein export from nucleus(GO:0046827)
0.8 5.7 GO:0015671 oxygen transport(GO:0015671)
0.7 3.7 GO:0010957 negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137)
0.7 2.2 GO:0045603 positive regulation of endothelial cell differentiation(GO:0045603)
0.7 2.1 GO:0060178 exocyst assembly(GO:0001927) regulation of exocyst assembly(GO:0001928) exocyst localization(GO:0051601) regulation of exocyst localization(GO:0060178)
0.7 4.2 GO:0006658 phosphatidylserine metabolic process(GO:0006658)
0.7 4.8 GO:0002726 positive regulation of T cell cytokine production(GO:0002726)
0.6 1.9 GO:0050983 spermidine catabolic process(GO:0046203) deoxyhypusine biosynthetic process from spermidine(GO:0050983)
0.6 3.0 GO:0014805 smooth muscle adaptation(GO:0014805)
0.6 2.9 GO:0046642 negative regulation of alpha-beta T cell proliferation(GO:0046642)
0.6 1.7 GO:0001757 somite specification(GO:0001757)
0.6 10.3 GO:0016601 Rac protein signal transduction(GO:0016601)
0.6 2.3 GO:0001807 type IV hypersensitivity(GO:0001806) regulation of type IV hypersensitivity(GO:0001807)
0.5 3.1 GO:0048296 isotype switching to IgA isotypes(GO:0048290) regulation of isotype switching to IgA isotypes(GO:0048296) positive regulation of isotype switching to IgA isotypes(GO:0048298)
0.5 1.0 GO:0070483 detection of hypoxia(GO:0070483)
0.5 5.0 GO:0001782 B cell homeostasis(GO:0001782)
0.5 31.4 GO:0030183 B cell differentiation(GO:0030183)
0.5 3.4 GO:0043615 astrocyte cell migration(GO:0043615)
0.5 0.5 GO:0051447 tyrosine phosphorylation of Stat1 protein(GO:0042508) negative regulation of meiotic nuclear division(GO:0045835) negative regulation of meiotic cell cycle(GO:0051447)
0.4 1.3 GO:0018076 N-terminal peptidyl-lysine acetylation(GO:0018076)
0.4 4.7 GO:0001706 endoderm formation(GO:0001706)
0.4 1.3 GO:0043921 modulation by host of viral transcription(GO:0043921) positive regulation by host of viral transcription(GO:0043923) modulation by host of symbiont transcription(GO:0052472)
0.4 4.4 GO:0045885 obsolete positive regulation of survival gene product expression(GO:0045885)
0.4 4.4 GO:0045730 respiratory burst(GO:0045730)
0.4 1.6 GO:0030223 neutrophil differentiation(GO:0030223)
0.4 1.1 GO:0034770 histone H4-K20 methylation(GO:0034770)
0.4 1.1 GO:0060547 negative regulation of necrotic cell death(GO:0060547)
0.4 14.0 GO:0002286 T cell activation involved in immune response(GO:0002286)
0.4 8.8 GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein(GO:0042531)
0.4 9.8 GO:0060334 regulation of response to interferon-gamma(GO:0060330) regulation of interferon-gamma-mediated signaling pathway(GO:0060334)
0.4 1.8 GO:0015693 magnesium ion transport(GO:0015693)
0.3 4.1 GO:0002639 positive regulation of immunoglobulin production(GO:0002639)
0.3 2.7 GO:0042976 activation of Janus kinase activity(GO:0042976)
0.3 1.0 GO:0008300 isoprenoid catabolic process(GO:0008300)
0.3 2.6 GO:0032897 negative regulation of viral transcription(GO:0032897)
0.3 1.6 GO:0010447 response to acidic pH(GO:0010447)
0.3 2.2 GO:0016584 nucleosome positioning(GO:0016584)
0.3 1.8 GO:0010842 retina layer formation(GO:0010842)
0.3 0.9 GO:0051823 regulation of synapse structural plasticity(GO:0051823)
0.3 5.0 GO:0050930 induction of positive chemotaxis(GO:0050930)
0.3 1.1 GO:0001955 blood vessel maturation(GO:0001955)
0.3 0.8 GO:0001732 formation of cytoplasmic translation initiation complex(GO:0001732) cytoplasmic translation(GO:0002181) cytoplasmic translational initiation(GO:0002183)
0.3 1.4 GO:0043402 glucocorticoid mediated signaling pathway(GO:0043402)
0.3 0.8 GO:0045601 regulation of endothelial cell differentiation(GO:0045601)
0.3 0.3 GO:0010224 response to UV-B(GO:0010224)
0.3 1.0 GO:0032486 Rap protein signal transduction(GO:0032486)
0.3 1.8 GO:0045059 positive thymic T cell selection(GO:0045059)
0.2 0.7 GO:0006167 AMP biosynthetic process(GO:0006167)
0.2 0.7 GO:0045091 regulation of single stranded viral RNA replication via double stranded DNA intermediate(GO:0045091)
0.2 1.0 GO:0010157 response to chlorate(GO:0010157)
0.2 2.4 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.2 0.7 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.2 14.7 GO:0006968 cellular defense response(GO:0006968)
0.2 3.8 GO:0045069 regulation of viral genome replication(GO:0045069)
0.2 2.3 GO:0034260 negative regulation of GTPase activity(GO:0034260)
0.2 0.2 GO:0044843 G1/S transition of mitotic cell cycle(GO:0000082) cell cycle G1/S phase transition(GO:0044843)
0.2 0.6 GO:1904742 regulation of single-stranded telomeric DNA binding(GO:0060380) positive regulation of single-stranded telomeric DNA binding(GO:0060381) regulation of telomeric DNA binding(GO:1904742) positive regulation of telomeric DNA binding(GO:1904744)
0.2 1.5 GO:0043982 histone H4-K5 acetylation(GO:0043981) histone H4-K8 acetylation(GO:0043982)
0.2 0.6 GO:0070816 phosphorylation of RNA polymerase II C-terminal domain(GO:0070816)
0.2 0.8 GO:0043653 mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.2 0.6 GO:0010572 positive regulation of platelet activation(GO:0010572)
0.2 0.5 GO:0045085 negative regulation of interleukin-2 biosynthetic process(GO:0045085)
0.2 0.2 GO:0032754 positive regulation of interleukin-5 production(GO:0032754)
0.2 1.1 GO:0045654 positive regulation of megakaryocyte differentiation(GO:0045654) positive regulation of hematopoietic progenitor cell differentiation(GO:1901534)
0.2 3.2 GO:0006929 substrate-dependent cell migration(GO:0006929)
0.2 0.7 GO:0048680 positive regulation of axon regeneration(GO:0048680) positive regulation of neuron projection regeneration(GO:0070572)
0.2 7.4 GO:0042113 B cell activation(GO:0042113)
0.2 1.2 GO:0010815 bradykinin catabolic process(GO:0010815)
0.2 2.3 GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors(GO:0008625) extrinsic apoptotic signaling pathway(GO:0097191)
0.2 19.5 GO:0065004 protein-DNA complex assembly(GO:0065004)
0.1 14.9 GO:0007162 negative regulation of cell adhesion(GO:0007162)
0.1 0.6 GO:0061032 visceral serous pericardium development(GO:0061032)
0.1 0.6 GO:0031635 adenylate cyclase-inhibiting opioid receptor signaling pathway(GO:0031635) opioid receptor signaling pathway(GO:0038003)
0.1 2.8 GO:0030851 granulocyte differentiation(GO:0030851)
0.1 15.3 GO:0050852 T cell receptor signaling pathway(GO:0050852)
0.1 0.8 GO:0043984 histone H4-K16 acetylation(GO:0043984)
0.1 1.7 GO:0071285 cellular response to lithium ion(GO:0071285)
0.1 1.9 GO:0007498 mesoderm development(GO:0007498)
0.1 0.8 GO:0015853 adenine transport(GO:0015853)
0.1 1.9 GO:0010042 response to manganese ion(GO:0010042)
0.1 1.7 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.1 0.5 GO:0021759 globus pallidus development(GO:0021759) forebrain dorsal/ventral pattern formation(GO:0021798) menarche(GO:0042696)
0.1 7.6 GO:0006338 chromatin remodeling(GO:0006338)
0.1 0.4 GO:0060120 auditory receptor cell fate commitment(GO:0009912) inner ear receptor cell fate commitment(GO:0060120)
0.1 1.9 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.1 0.4 GO:0071168 protein localization to chromatin(GO:0071168)
0.1 1.2 GO:0007143 female meiotic division(GO:0007143)
0.1 0.6 GO:0042637 catagen(GO:0042637)
0.1 0.6 GO:0060124 positive regulation of growth hormone secretion(GO:0060124)
0.1 0.3 GO:0000917 barrier septum assembly(GO:0000917) cell septum assembly(GO:0090529) mitotic cytokinetic process(GO:1902410)
0.1 6.9 GO:0061025 membrane fusion(GO:0061025)
0.1 4.0 GO:0031295 lymphocyte costimulation(GO:0031294) T cell costimulation(GO:0031295)
0.1 1.6 GO:0048169 regulation of long-term neuronal synaptic plasticity(GO:0048169)
0.1 1.5 GO:1904031 positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737) positive regulation of cyclin-dependent protein kinase activity(GO:1904031)
0.1 0.5 GO:0060438 trachea development(GO:0060438)
0.1 1.0 GO:0070664 negative regulation of mononuclear cell proliferation(GO:0032945) negative regulation of lymphocyte proliferation(GO:0050672) negative regulation of leukocyte proliferation(GO:0070664)
0.1 0.2 GO:0035106 operant conditioning(GO:0035106)
0.1 0.9 GO:0070327 thyroid hormone transport(GO:0070327)
0.1 0.3 GO:0048852 diencephalon morphogenesis(GO:0048852)
0.1 1.0 GO:0048661 positive regulation of smooth muscle cell proliferation(GO:0048661)
0.1 0.5 GO:0002707 negative regulation of lymphocyte mediated immunity(GO:0002707)
0.1 1.5 GO:0006044 N-acetylglucosamine metabolic process(GO:0006044)
0.1 2.7 GO:0007194 negative regulation of adenylate cyclase activity(GO:0007194) negative regulation of cyclase activity(GO:0031280) negative regulation of lyase activity(GO:0051350)
0.1 0.3 GO:0070935 3'-UTR-mediated mRNA stabilization(GO:0070935)
0.1 7.8 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest(GO:0006977) signal transduction involved in cell cycle checkpoint(GO:0072395) signal transduction involved in DNA integrity checkpoint(GO:0072401) signal transduction involved in mitotic cell cycle checkpoint(GO:0072413) signal transduction involved in DNA damage checkpoint(GO:0072422) signal transduction involved in mitotic G1 DNA damage checkpoint(GO:0072431) intracellular signal transduction involved in G1 DNA damage checkpoint(GO:1902400) signal transduction involved in mitotic DNA damage checkpoint(GO:1902402) signal transduction involved in mitotic DNA integrity checkpoint(GO:1902403)
0.1 1.2 GO:0032876 regulation of DNA endoreduplication(GO:0032875) negative regulation of DNA endoreduplication(GO:0032876) DNA endoreduplication(GO:0042023)
0.1 1.7 GO:0007597 blood coagulation, intrinsic pathway(GO:0007597)
0.1 1.0 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.1 0.9 GO:0033261 obsolete regulation of S phase(GO:0033261)
0.1 0.4 GO:0000380 alternative mRNA splicing, via spliceosome(GO:0000380)
0.1 2.0 GO:0006084 acetyl-CoA metabolic process(GO:0006084)
0.1 0.6 GO:0007090 obsolete regulation of S phase of mitotic cell cycle(GO:0007090)
0.1 0.7 GO:0016180 snRNA processing(GO:0016180)
0.1 0.7 GO:0098927 early endosome to late endosome transport(GO:0045022) vesicle-mediated transport between endosomal compartments(GO:0098927)
0.1 0.4 GO:0071569 protein ufmylation(GO:0071569)
0.1 0.3 GO:0002860 natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002420) natural killer cell mediated immune response to tumor cell(GO:0002423) regulation of natural killer cell mediated immune response to tumor cell(GO:0002855) positive regulation of natural killer cell mediated immune response to tumor cell(GO:0002857) regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002858) positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002860)
0.1 1.1 GO:0045540 regulation of cholesterol biosynthetic process(GO:0045540)
0.1 1.4 GO:0030593 neutrophil chemotaxis(GO:0030593) neutrophil migration(GO:1990266)
0.1 0.6 GO:0097061 dendritic spine morphogenesis(GO:0060997) regulation of dendritic spine morphogenesis(GO:0061001) dendritic spine organization(GO:0097061)
0.1 0.9 GO:0071044 histone mRNA catabolic process(GO:0071044)
0.1 1.0 GO:0044243 collagen catabolic process(GO:0030574) multicellular organism catabolic process(GO:0044243)
0.1 0.2 GO:1903961 positive regulation of plasma membrane long-chain fatty acid transport(GO:0010747) positive regulation of anion transmembrane transport(GO:1903961)
0.1 1.0 GO:0006297 nucleotide-excision repair, DNA gap filling(GO:0006297)
0.1 0.3 GO:0030259 lipid glycosylation(GO:0030259)
0.1 1.0 GO:0006198 cAMP catabolic process(GO:0006198)
0.1 2.2 GO:0033572 ferric iron transport(GO:0015682) transferrin transport(GO:0033572) trivalent inorganic cation transport(GO:0072512)
0.1 8.2 GO:0006865 amino acid transport(GO:0006865)
0.1 0.1 GO:1902170 cellular response to nitric oxide(GO:0071732) cellular response to reactive nitrogen species(GO:1902170)
0.1 1.2 GO:0006493 protein O-linked glycosylation(GO:0006493)
0.1 1.5 GO:0042098 T cell proliferation(GO:0042098)
0.1 1.6 GO:0006298 mismatch repair(GO:0006298)
0.1 0.7 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.1 0.3 GO:0042769 DNA damage response, detection of DNA damage(GO:0042769)
0.1 1.1 GO:0046329 negative regulation of JNK cascade(GO:0046329)
0.1 1.9 GO:0050680 negative regulation of epithelial cell proliferation(GO:0050680)
0.1 3.1 GO:0051084 'de novo' posttranslational protein folding(GO:0051084)
0.1 0.3 GO:0030157 pancreatic juice secretion(GO:0030157)
0.1 2.6 GO:0045727 positive regulation of cellular amide metabolic process(GO:0034250) positive regulation of translation(GO:0045727)
0.1 0.3 GO:0035019 somatic stem cell population maintenance(GO:0035019)
0.1 0.4 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
0.1 0.4 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
0.0 1.1 GO:0021983 pituitary gland development(GO:0021983)
0.0 0.2 GO:0002507 tolerance induction(GO:0002507)
0.0 1.3 GO:0051899 membrane depolarization(GO:0051899)
0.0 0.9 GO:0000291 nuclear-transcribed mRNA catabolic process, exonucleolytic(GO:0000291) exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928)
0.0 0.8 GO:0048207 vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208) COPII-coated vesicle budding(GO:0090114)
0.0 0.9 GO:0006378 mRNA polyadenylation(GO:0006378)
0.0 1.9 GO:0000245 spliceosomal complex assembly(GO:0000245)
0.0 0.7 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.0 0.6 GO:0033138 positive regulation of peptidyl-serine phosphorylation(GO:0033138)
0.0 0.6 GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity(GO:0045197)
0.0 0.2 GO:0001880 Mullerian duct regression(GO:0001880) anatomical structure regression(GO:0060033)
0.0 0.8 GO:0006884 cell volume homeostasis(GO:0006884)
0.0 0.9 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.0 0.2 GO:0045019 negative regulation of nitric oxide biosynthetic process(GO:0045019) glycosylceramide catabolic process(GO:0046477) negative regulation of reactive oxygen species biosynthetic process(GO:1903427) negative regulation of nitric oxide metabolic process(GO:1904406)
0.0 0.8 GO:0051966 regulation of synaptic transmission, glutamatergic(GO:0051966)
0.0 0.4 GO:0008105 asymmetric protein localization(GO:0008105)
0.0 0.2 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.0 0.3 GO:0050830 defense response to Gram-positive bacterium(GO:0050830)
0.0 1.4 GO:0001503 ossification(GO:0001503)
0.0 0.1 GO:0030917 midbrain-hindbrain boundary development(GO:0030917)
0.0 0.3 GO:0042267 natural killer cell mediated immunity(GO:0002228) natural killer cell mediated cytotoxicity(GO:0042267)
0.0 0.4 GO:1903523 negative regulation of blood circulation(GO:1903523)
0.0 0.2 GO:0008228 opsonization(GO:0008228)
0.0 1.2 GO:0001756 somitogenesis(GO:0001756) somite development(GO:0061053)
0.0 0.3 GO:0050912 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580) detection of chemical stimulus involved in sensory perception of taste(GO:0050912)
0.0 3.7 GO:0007204 positive regulation of cytosolic calcium ion concentration(GO:0007204)
0.0 1.1 GO:0000080 mitotic G1 phase(GO:0000080)
0.0 1.4 GO:0060041 retina development in camera-type eye(GO:0060041)
0.0 1.3 GO:0046134 pyrimidine nucleobase metabolic process(GO:0006206) pyrimidine nucleoside biosynthetic process(GO:0046134)
0.0 0.1 GO:0006427 histidyl-tRNA aminoacylation(GO:0006427)
0.0 6.6 GO:0016337 single organismal cell-cell adhesion(GO:0016337)
0.0 0.6 GO:0048678 response to axon injury(GO:0048678)
0.0 0.2 GO:0001821 histamine secretion(GO:0001821) histamine production involved in inflammatory response(GO:0002349) histamine secretion involved in inflammatory response(GO:0002441) histamine secretion by mast cell(GO:0002553)
0.0 0.1 GO:0000114 obsolete regulation of transcription involved in G1 phase of mitotic cell cycle(GO:0000114) positive regulation of transcription elongation from RNA polymerase II promoter(GO:0032968) regulation of transcription elongation from RNA polymerase II promoter(GO:0034243)
0.0 0.2 GO:0042753 positive regulation of circadian rhythm(GO:0042753)
0.0 1.4 GO:0006333 chromatin assembly or disassembly(GO:0006333)
0.0 0.9 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.0 0.8 GO:0048477 oogenesis(GO:0048477)
0.0 0.7 GO:0070588 calcium ion transmembrane transport(GO:0070588)
0.0 0.4 GO:0007492 endoderm development(GO:0007492)
0.0 0.7 GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway(GO:0007189)
0.0 2.0 GO:0051291 protein heterooligomerization(GO:0051291)
0.0 1.0 GO:0006626 protein targeting to mitochondrion(GO:0006626)
0.0 0.0 GO:0014742 positive regulation of cardiac muscle hypertrophy(GO:0010613) positive regulation of muscle hypertrophy(GO:0014742)
0.0 3.3 GO:0007050 cell cycle arrest(GO:0007050)
0.0 0.6 GO:0030316 osteoclast differentiation(GO:0030316)
0.0 0.4 GO:0007020 microtubule nucleation(GO:0007020)
0.0 0.1 GO:0043628 ncRNA 3'-end processing(GO:0043628)
0.0 0.5 GO:0009954 proximal/distal pattern formation(GO:0009954)
0.0 0.4 GO:0021879 forebrain neuron differentiation(GO:0021879)
0.0 0.9 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
0.0 0.2 GO:0035196 production of miRNAs involved in gene silencing by miRNA(GO:0035196)
0.0 0.5 GO:0031572 G2 DNA damage checkpoint(GO:0031572)
0.0 5.3 GO:0008015 circulatory system process(GO:0003013) blood circulation(GO:0008015)
0.0 0.8 GO:0006513 protein monoubiquitination(GO:0006513)
0.0 0.4 GO:0034249 negative regulation of translation(GO:0017148) negative regulation of cellular amide metabolic process(GO:0034249)
0.0 0.4 GO:0006471 protein ADP-ribosylation(GO:0006471)
0.0 0.2 GO:0044819 mitotic G1 DNA damage checkpoint(GO:0031571) G1 DNA damage checkpoint(GO:0044783) mitotic G1/S transition checkpoint(GO:0044819)
0.0 0.2 GO:0033673 negative regulation of kinase activity(GO:0033673)
0.0 0.3 GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway(GO:0007188)
0.0 0.4 GO:0042462 eye photoreceptor cell development(GO:0042462)
0.0 0.1 GO:1901224 activation of NF-kappaB-inducing kinase activity(GO:0007250) NIK/NF-kappaB signaling(GO:0038061) regulation of NIK/NF-kappaB signaling(GO:1901222) positive regulation of NIK/NF-kappaB signaling(GO:1901224)
0.0 0.5 GO:0050772 positive regulation of axonogenesis(GO:0050772)
0.0 0.4 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.0 0.4 GO:0016254 preassembly of GPI anchor in ER membrane(GO:0016254)
0.0 0.5 GO:0030520 intracellular estrogen receptor signaling pathway(GO:0030520)
0.0 2.4 GO:0023014 MAPK cascade(GO:0000165) signal transduction by protein phosphorylation(GO:0023014)
0.0 1.0 GO:0051781 positive regulation of cell division(GO:0051781)
0.0 0.1 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197)
0.0 0.0 GO:0010216 maintenance of DNA methylation(GO:0010216)
0.0 0.1 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.0 0.5 GO:0006024 glycosaminoglycan biosynthetic process(GO:0006024)
0.0 0.9 GO:0007605 sensory perception of sound(GO:0007605)
0.0 1.1 GO:0008277 regulation of G-protein coupled receptor protein signaling pathway(GO:0008277)
0.0 1.0 GO:0006986 response to unfolded protein(GO:0006986)
0.0 0.6 GO:0051092 positive regulation of NF-kappaB transcription factor activity(GO:0051092)
0.0 0.3 GO:0006611 protein export from nucleus(GO:0006611)
0.0 0.6 GO:0046777 protein autophosphorylation(GO:0046777)
0.0 0.2 GO:0006570 tyrosine metabolic process(GO:0006570)
0.0 0.9 GO:0008286 insulin receptor signaling pathway(GO:0008286)
0.0 0.6 GO:0060333 interferon-gamma-mediated signaling pathway(GO:0060333)
0.0 0.5 GO:0006446 regulation of translational initiation(GO:0006446)
0.0 0.3 GO:0001570 vasculogenesis(GO:0001570)
0.0 0.3 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.0 0.3 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.0 0.2 GO:0050873 brown fat cell differentiation(GO:0050873)
0.0 0.2 GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway(GO:0007200)
0.0 0.1 GO:0007389 pattern specification process(GO:0007389)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
2.5 17.4 GO:0001891 phagocytic cup(GO:0001891)
2.1 23.0 GO:0043020 NADPH oxidase complex(GO:0043020)
1.5 8.8 GO:0019815 immunoglobulin complex(GO:0019814) B cell receptor complex(GO:0019815)
0.9 10.9 GO:0030061 mitochondrial crista(GO:0030061)
0.8 9.7 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.8 11.2 GO:0035631 CD40 receptor complex(GO:0035631)
0.6 9.2 GO:0000242 pericentriolar material(GO:0000242)
0.5 4.2 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.5 2.9 GO:0005954 calcium- and calmodulin-dependent protein kinase complex(GO:0005954)
0.5 1.4 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.4 6.0 GO:0071778 obsolete WINAC complex(GO:0071778)
0.4 1.8 GO:0033093 Weibel-Palade body(GO:0033093)
0.3 17.6 GO:0005884 actin filament(GO:0005884)
0.2 1.5 GO:0016461 unconventional myosin complex(GO:0016461)
0.2 1.0 GO:0097651 phosphatidylinositol 3-kinase complex, class IA(GO:0005943) phosphatidylinositol 3-kinase complex, class I(GO:0097651)
0.2 2.7 GO:0070688 MLL5-L complex(GO:0070688)
0.2 8.1 GO:0098636 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.2 5.3 GO:0005839 proteasome core complex(GO:0005839)
0.2 1.0 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.2 0.5 GO:0005900 oncostatin-M receptor complex(GO:0005900)
0.2 1.9 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.2 1.9 GO:1903561 extracellular exosome(GO:0070062) extracellular vesicle(GO:1903561)
0.2 1.7 GO:0031010 ISWI-type complex(GO:0031010)
0.1 0.4 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.1 1.9 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.1 0.8 GO:0072487 MSL complex(GO:0072487)
0.1 1.3 GO:0000125 PCAF complex(GO:0000125)
0.1 1.2 GO:0005766 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.1 1.0 GO:0055038 recycling endosome membrane(GO:0055038)
0.1 4.1 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.1 0.9 GO:0002102 podosome(GO:0002102)
0.1 1.2 GO:0032039 integrator complex(GO:0032039)
0.1 0.3 GO:0032584 growth cone membrane(GO:0032584)
0.1 0.9 GO:0030897 HOPS complex(GO:0030897)
0.1 1.4 GO:0008290 F-actin capping protein complex(GO:0008290)
0.1 0.9 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.1 8.8 GO:0030426 growth cone(GO:0030426)
0.1 0.9 GO:0005849 mRNA cleavage factor complex(GO:0005849)
0.1 13.9 GO:0016607 nuclear speck(GO:0016607)
0.1 1.2 GO:0031088 platelet dense granule membrane(GO:0031088)
0.1 1.2 GO:0061200 clathrin-sculpted gamma-aminobutyric acid transport vesicle(GO:0061200) clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane(GO:0061202)
0.1 0.4 GO:0071817 MMXD complex(GO:0071817)
0.1 13.2 GO:0098857 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.1 11.5 GO:0009897 external side of plasma membrane(GO:0009897)
0.1 1.5 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1 0.6 GO:0030126 COPI vesicle coat(GO:0030126)
0.1 3.6 GO:0043197 dendritic spine(GO:0043197)
0.1 1.8 GO:0030660 Golgi-associated vesicle membrane(GO:0030660)
0.1 0.5 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.1 6.1 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898) cytoplasmic side of membrane(GO:0098562)
0.1 0.2 GO:0098563 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.1 0.2 GO:0033011 perinuclear theca(GO:0033011) cytoskeletal calyx(GO:0033150)
0.1 2.4 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.1 0.4 GO:0030056 hemidesmosome(GO:0030056)
0.1 18.7 GO:0005667 transcription factor complex(GO:0005667)
0.1 1.9 GO:0005637 nuclear inner membrane(GO:0005637)
0.1 1.5 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.1 3.1 GO:0031228 intrinsic component of Golgi membrane(GO:0031228)
0.1 0.8 GO:0030127 COPII vesicle coat(GO:0030127)
0.1 0.4 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
0.0 1.1 GO:0031231 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.0 8.4 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 0.4 GO:0033179 proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.0 0.4 GO:0008278 cohesin complex(GO:0008278)
0.0 0.6 GO:0046930 pore complex(GO:0046930)
0.0 1.6 GO:0030530 obsolete heterogeneous nuclear ribonucleoprotein complex(GO:0030530)
0.0 2.2 GO:0000786 nucleosome(GO:0000786)
0.0 0.8 GO:0008287 protein serine/threonine phosphatase complex(GO:0008287) phosphatase complex(GO:1903293)
0.0 1.4 GO:0015030 Cajal body(GO:0015030)
0.0 0.8 GO:0031201 SNARE complex(GO:0031201)
0.0 0.8 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0 0.7 GO:0000795 synaptonemal complex(GO:0000795)
0.0 0.8 GO:0090568 NuRD complex(GO:0016581) CHD-type complex(GO:0090545) nuclear transcriptional repressor complex(GO:0090568)
0.0 0.1 GO:0031904 endosome lumen(GO:0031904)
0.0 0.6 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 0.2 GO:0005869 dynactin complex(GO:0005869)
0.0 0.4 GO:0000808 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.0 0.4 GO:0030867 rough endoplasmic reticulum membrane(GO:0030867)
0.0 0.9 GO:0032993 protein-DNA complex(GO:0032993)
0.0 0.2 GO:0060076 postsynaptic density(GO:0014069) excitatory synapse(GO:0060076) postsynaptic specialization(GO:0099572)
0.0 1.0 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.0 4.4 GO:0005911 cell-cell junction(GO:0005911)
0.0 1.5 GO:0005789 endoplasmic reticulum membrane(GO:0005789) nuclear outer membrane-endoplasmic reticulum membrane network(GO:0042175)
0.0 0.1 GO:0042599 lamellar body(GO:0042599)
0.0 0.4 GO:0043209 myelin sheath(GO:0043209)
0.0 0.8 GO:0043025 neuronal cell body(GO:0043025)
0.0 0.2 GO:0016272 prefoldin complex(GO:0016272)
0.0 1.2 GO:0005626 obsolete insoluble fraction(GO:0005626)
0.0 0.2 GO:0005732 small nucleolar ribonucleoprotein complex(GO:0005732)
0.0 29.7 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 0.2 GO:0033162 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.0 6.5 GO:0005625 obsolete soluble fraction(GO:0005625)
0.0 4.6 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.0 8.4 GO:0000139 Golgi membrane(GO:0000139)
0.0 1.3 GO:0030496 midbody(GO:0030496)
0.0 1.1 GO:0005802 trans-Golgi network(GO:0005802)
0.0 0.7 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 0.3 GO:0005801 cis-Golgi network(GO:0005801)
0.0 0.1 GO:0008537 proteasome activator complex(GO:0008537)
0.0 0.9 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 0.3 GO:0001533 cornified envelope(GO:0001533)
0.0 0.5 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 0.7 GO:0000123 histone acetyltransferase complex(GO:0000123) protein acetyltransferase complex(GO:0031248) acetyltransferase complex(GO:1902493)
0.0 1.1 GO:0000793 condensed chromosome(GO:0000793)
0.0 0.4 GO:0005814 centriole(GO:0005814)
0.0 21.4 GO:0005886 plasma membrane(GO:0005886)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
3.3 10.0 GO:0042610 CD8 receptor binding(GO:0042610)
2.6 7.9 GO:0019976 interleukin-2 binding(GO:0019976)
1.8 21.6 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
1.7 17.2 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
1.6 20.4 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
1.5 19.1 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, RNA polymerase II basal transcription factor binding(GO:0001083) transcription factor activity, TFIIB-class binding(GO:0001087) RNA polymerase II basal transcription factor binding(GO:0001091) TFIIB-class transcription factor binding(GO:0001093)
1.4 4.2 GO:0008970 phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
1.2 11.5 GO:0043208 glycosphingolipid binding(GO:0043208)
0.9 15.3 GO:0005522 profilin binding(GO:0005522)
0.8 4.1 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
0.8 3.3 GO:0042608 T cell receptor binding(GO:0042608)
0.8 3.2 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.8 5.4 GO:0001784 phosphotyrosine binding(GO:0001784)
0.6 1.9 GO:0034038 deoxyhypusine synthase activity(GO:0034038)
0.6 1.8 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.5 2.7 GO:0001641 group II metabotropic glutamate receptor activity(GO:0001641)
0.5 2.6 GO:0001517 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517)
0.5 1.9 GO:0004998 transferrin receptor activity(GO:0004998)
0.4 5.7 GO:0005344 oxygen transporter activity(GO:0005344)
0.4 7.2 GO:0019992 diacylglycerol binding(GO:0019992)
0.4 1.2 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.4 1.2 GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.4 1.6 GO:0035326 enhancer binding(GO:0035326)
0.4 1.1 GO:0015217 purine ribonucleotide transmembrane transporter activity(GO:0005346) ATP transmembrane transporter activity(GO:0005347) ATP:ADP antiporter activity(GO:0005471) ADP transmembrane transporter activity(GO:0015217)
0.4 0.4 GO:0050613 delta14-sterol reductase activity(GO:0050613)
0.4 5.4 GO:0016493 C-C chemokine receptor activity(GO:0016493)
0.3 2.6 GO:0070087 chromo shadow domain binding(GO:0070087)
0.3 1.0 GO:0004514 nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514)
0.3 1.6 GO:0032558 purine deoxyribonucleotide binding(GO:0032554) adenyl deoxyribonucleotide binding(GO:0032558)
0.3 1.3 GO:0004132 dCMP deaminase activity(GO:0004132)
0.3 8.6 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.3 1.8 GO:0051766 inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440) inositol trisphosphate kinase activity(GO:0051766)
0.3 7.4 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.3 1.1 GO:0042799 histone methyltransferase activity (H4-K20 specific)(GO:0042799)
0.3 0.8 GO:0033743 peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.3 1.4 GO:0004883 glucocorticoid receptor activity(GO:0004883)
0.3 1.6 GO:0008649 rRNA methyltransferase activity(GO:0008649)
0.3 0.8 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.3 6.1 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.2 0.7 GO:0061505 DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.2 2.7 GO:0070513 death domain binding(GO:0070513)
0.2 2.7 GO:0019864 IgG binding(GO:0019864)
0.2 1.9 GO:0001968 fibronectin binding(GO:0001968)
0.2 2.7 GO:0050998 nitric-oxide synthase binding(GO:0050998)
0.2 0.6 GO:0035198 miRNA binding(GO:0035198)
0.2 1.2 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.2 1.0 GO:0005534 galactose binding(GO:0005534)
0.2 1.4 GO:0008409 5'-3' exonuclease activity(GO:0008409)
0.2 0.8 GO:0034701 tripeptidase activity(GO:0034701)
0.2 3.3 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.2 1.0 GO:0043559 insulin binding(GO:0043559)
0.2 1.0 GO:0005113 patched binding(GO:0005113)
0.2 1.3 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.2 1.1 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.2 0.5 GO:0042289 MHC class II protein binding(GO:0042289)
0.2 0.9 GO:0042156 obsolete zinc-mediated transcriptional activator activity(GO:0042156)
0.2 5.3 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.2 1.5 GO:0015379 potassium:chloride symporter activity(GO:0015379)
0.2 13.4 GO:0051015 actin filament binding(GO:0051015)
0.2 1.5 GO:0031489 myosin V binding(GO:0031489)
0.2 1.8 GO:0019865 immunoglobulin binding(GO:0019865)
0.2 4.0 GO:0042056 chemoattractant activity(GO:0042056)
0.2 12.2 GO:0015171 amino acid transmembrane transporter activity(GO:0015171)
0.2 0.5 GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
0.1 0.6 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.1 0.6 GO:0004988 obsolete mu-opioid receptor activity(GO:0004988)
0.1 0.4 GO:0043515 kinetochore binding(GO:0043515)
0.1 2.0 GO:0005521 lamin binding(GO:0005521)
0.1 0.4 GO:0004376 glycolipid mannosyltransferase activity(GO:0004376)
0.1 14.5 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.1 0.8 GO:0005345 purine nucleobase transmembrane transporter activity(GO:0005345)
0.1 0.7 GO:0031702 type 1 angiotensin receptor binding(GO:0031702)
0.1 2.9 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.1 2.8 GO:0030295 protein kinase activator activity(GO:0030295)
0.1 0.6 GO:0051400 BH domain binding(GO:0051400)
0.1 0.7 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.1 0.3 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.1 0.5 GO:0050265 RNA uridylyltransferase activity(GO:0050265)
0.1 0.9 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.1 1.3 GO:0051635 obsolete bacterial cell surface binding(GO:0051635)
0.1 0.4 GO:0033265 choline binding(GO:0033265)
0.1 2.1 GO:0042169 SH2 domain binding(GO:0042169)
0.1 0.6 GO:0070182 DNA polymerase binding(GO:0070182)
0.1 0.3 GO:0004967 glucagon receptor activity(GO:0004967)
0.1 4.1 GO:0008601 protein phosphatase type 2A regulator activity(GO:0008601)
0.1 0.4 GO:0043398 HLH domain binding(GO:0043398)
0.1 0.7 GO:0016842 amidine-lyase activity(GO:0016842)
0.1 17.5 GO:0003702 obsolete RNA polymerase II transcription factor activity(GO:0003702)
0.1 0.4 GO:0004974 leukotriene receptor activity(GO:0004974)
0.1 6.9 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.1 0.5 GO:0031701 angiotensin receptor binding(GO:0031701)
0.1 1.9 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.1 4.7 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.1 0.4 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.1 0.8 GO:0008266 poly(U) RNA binding(GO:0008266)
0.1 10.2 GO:0017124 SH3 domain binding(GO:0017124)
0.1 0.4 GO:0003680 AT DNA binding(GO:0003680)
0.1 0.8 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.1 1.3 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.1 0.2 GO:0008174 mRNA methyltransferase activity(GO:0008174)
0.1 2.8 GO:0005504 fatty acid binding(GO:0005504)
0.1 0.6 GO:0031434 mitogen-activated protein kinase kinase binding(GO:0031434)
0.1 0.4 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.1 0.6 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.1 1.4 GO:0004697 protein kinase C activity(GO:0004697)
0.1 1.1 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.1 0.8 GO:0017070 U6 snRNA binding(GO:0017070)
0.1 0.5 GO:0019826 oxygen sensor activity(GO:0019826)
0.1 16.4 GO:0003924 GTPase activity(GO:0003924)
0.1 0.7 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.1 0.9 GO:0017091 AU-rich element binding(GO:0017091)
0.1 0.2 GO:0005026 transforming growth factor beta receptor activity, type II(GO:0005026)
0.1 0.8 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391)
0.1 1.1 GO:0004860 protein kinase inhibitor activity(GO:0004860) kinase inhibitor activity(GO:0019210)
0.1 1.0 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.1 1.6 GO:0015026 coreceptor activity(GO:0015026)
0.0 4.6 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 4.2 GO:0008094 DNA-dependent ATPase activity(GO:0008094)
0.0 0.6 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0 0.6 GO:0017025 TBP-class protein binding(GO:0017025)
0.0 0.2 GO:0015925 galactosidase activity(GO:0015925)
0.0 0.2 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0 0.3 GO:0016565 obsolete general transcriptional repressor activity(GO:0016565)
0.0 0.3 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism(GO:0044769) proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.0 0.4 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 0.5 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0 0.1 GO:0019788 NEDD8 transferase activity(GO:0019788)
0.0 1.8 GO:0016566 obsolete specific transcriptional repressor activity(GO:0016566)
0.0 0.1 GO:0004821 histidine-tRNA ligase activity(GO:0004821)
0.0 0.9 GO:0035064 methylated histone binding(GO:0035064)
0.0 0.4 GO:0008175 tRNA methyltransferase activity(GO:0008175)
0.0 3.2 GO:0003704 obsolete specific RNA polymerase II transcription factor activity(GO:0003704)
0.0 3.4 GO:0047485 protein N-terminus binding(GO:0047485)
0.0 0.9 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.0 1.0 GO:0019825 oxygen binding(GO:0019825)
0.0 0.6 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.0 1.0 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 10.8 GO:0030695 GTPase regulator activity(GO:0030695)
0.0 0.5 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.2 GO:0004167 dopachrome isomerase activity(GO:0004167)
0.0 0.3 GO:0050750 low-density lipoprotein particle receptor binding(GO:0050750)
0.0 0.3 GO:0008499 UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity(GO:0008499)
0.0 0.1 GO:0050811 GABA receptor binding(GO:0050811)
0.0 1.6 GO:0016776 phosphotransferase activity, phosphate group as acceptor(GO:0016776)
0.0 0.4 GO:0008143 poly(A) binding(GO:0008143) poly-purine tract binding(GO:0070717)
0.0 0.9 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.0 0.3 GO:0008503 benzodiazepine receptor activity(GO:0008503)
0.0 5.9 GO:0019787 ubiquitin-like protein transferase activity(GO:0019787)
0.0 0.1 GO:0003827 alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827)
0.0 0.1 GO:0036442 hydrogen-exporting ATPase activity(GO:0036442)
0.0 0.1 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.0 0.4 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 0.1 GO:0034713 type I transforming growth factor beta receptor binding(GO:0034713)
0.0 0.2 GO:0003678 DNA helicase activity(GO:0003678)
0.0 18.6 GO:0003700 transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.0 0.2 GO:0008106 alcohol dehydrogenase (NADP+) activity(GO:0008106)
0.0 0.1 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.0 0.9 GO:0050136 NADH dehydrogenase activity(GO:0003954) NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 2.8 GO:0019900 kinase binding(GO:0019900)
0.0 0.3 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.7 GO:0031072 heat shock protein binding(GO:0031072)
0.0 0.4 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 0.2 GO:0001727 lipid kinase activity(GO:0001727)
0.0 0.4 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 0.5 GO:0016831 carboxy-lyase activity(GO:0016831)
0.0 0.7 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 0.2 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 0.3 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 33.6 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.6 51.4 ST_T_CELL_SIGNAL_TRANSDUCTION T Cell Signal Transduction
0.3 10.4 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor Necrosis Factor Pathway.
0.2 3.9 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.2 4.6 ST_INTERLEUKIN_4_PATHWAY Interleukin 4 (IL-4) Pathway
0.1 1.0 ST_B_CELL_ANTIGEN_RECEPTOR B Cell Antigen Receptor
0.0 1.0 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 0.9 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.6 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.0 0.8 ST_GA13_PATHWAY G alpha 13 Pathway
0.0 0.6 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes